Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Heyman E et al. | Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | 2012 | Psychoneuroendocrinology | pmid:22029953 |
Izumi Y and Zorumski CF | NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. | 2012 | Neuropsychopharmacology | pmid:21993209 |
Malinowska B et al. | Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? | 2012 | Br. J. Pharmacol. | pmid:22022923 |
Marsicano G and Chaouloff F | Moving bliss: a new anandamide transporter. | 2012 | Nat. Neurosci. | pmid:22193249 |
Battista N et al. | Abnormal anandamide metabolism in celiac disease. | 2012 | J. Nutr. Biochem. | pmid:22209002 |
Schulte K et al. | Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22215206 |
Wu X et al. | Alteration of endocannabinoid system in human gliomas. | 2012 | J. Neurochem. | pmid:22176552 |
Starowicz K et al. | Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. | 2012 | Neuropharmacology | pmid:22178705 |
Harvey BS et al. | Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. | 2012 | Neurotoxicology | pmid:22233683 |
Gebeh AK et al. | Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22701012 |
Chianese R et al. | Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22669247 |
Chicca A et al. | The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. | 2012 | Br. J. Pharmacol. | pmid:22646533 |
Hernangómez M et al. | CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. | 2012 | Glia | pmid:22653796 |
Tsumura M et al. | TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. | 2012 | Cell Calcium | pmid:22656960 |
Fogaça MV et al. | Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. | 2012 | Braz. J. Med. Biol. Res. | pmid:22392189 |
Lisboa SF and Guimarães FS | Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. | 2012 | Neuropharmacology | pmid:22394688 |
Méndez-DÃaz M et al. | The endocannabinoid system modulates the valence of the emotion associated to food ingestion. | 2012 | Addict Biol | pmid:21182571 |
Berger WT et al. | Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. | 2012 | PLoS ONE | pmid:23236415 |
Butti E et al. | Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. | 2012 | Brain | pmid:23008234 |
Roa-Coria JE et al. | N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception. | 2012 | Life Sci. | pmid:23069585 |
Schmidt W et al. | Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia. | 2012 | Neuroscience | pmid:23069763 |
Pastuhov SI et al. | Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling. | 2012 | Nat Commun | pmid:23072806 |
Fu J et al. | A catalytically silent FAAH-1 variant drives anandamide transport in neurons. | 2012 | Nat. Neurosci. | pmid:22101642 |
Feuerecker M et al. | Effects of exercise stress on the endocannabinoid system in humans under field conditions. | 2012 | Eur. J. Appl. Physiol. | pmid:22101870 |
Reyes-Cabello C et al. | Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration. | 2012 | Pharmacol. Biochem. Behav. | pmid:22133635 |
Goonawardena AV et al. | Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. | 2011 Oct-Nov | Neuropharmacology | pmid:21767554 |
Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
Andrianova EL et al. | In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. | 2011 | Bull. Exp. Biol. Med. | pmid:22442796 |
Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Walentiny DM et al. | The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. | 2011 | Eur. J. Pharmacol. | pmid:21300050 |
Naidoo V et al. | A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. | 2011 | J. Mol. Neurosci. | pmid:21069475 |
Gomes FV et al. | Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice. | 2011 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:21111767 |
Bari M et al. | Characterization of the endocannabinoid system in mouse embryonic stem cells. | 2011 | Stem Cells Dev. | pmid:20446814 |
Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
MartÃn-Couce L et al. | Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. | 2011 | J. Med. Chem. | pmid:21675776 |
Romani R et al. | Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? | 2011 | Biochimie | pmid:21664223 |
Weller K et al. | TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release. | 2011 | Neuropeptides | pmid:21868092 |
Khanna IK and Alexander CW | Fatty acid amide hydrolase inhibitors--progress and potential. | 2011 | CNS Neurol Disord Drug Targets | pmid:21631410 |
Busquets-Garcia A et al. | Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | 2011 | Biol. Psychiatry | pmid:21684528 |
Warzecha Z et al. | Role of sensory nerves in gastroprotective effect of anandamide in rats. | 2011 | J. Physiol. Pharmacol. | pmid:21673369 |
Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
Munguba H et al. | Pre-training anandamide infusion within the basolateral amygdala impairs plus-maze discriminative avoidance task in rats. | 2011 | Neurobiol Learn Mem | pmid:21440651 |
Stewart JL and McMahon LR | The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. | 2011 | Br. J. Pharmacol. | pmid:21449917 |
Aberturas MR et al. | Anandamide-loaded nanoparticles: preparation and characterization. | 2011 | J Microencapsul | pmid:21425945 |
Pinar-Sueiro S et al. | [Cannabinoid applications in glaucoma]. | 2011 | Arch Soc Esp Oftalmol | pmid:21414525 |
Mukhopadhyay B et al. | Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21383171 |
Rossi S et al. | Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:21473912 |
Gamaleddin I et al. | The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. | 2011 | Br. J. Pharmacol. | pmid:21501143 |
Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
Qi J et al. | Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. | 2011 | J. Immunol. | pmid:21515789 |
Steiner AA et al. | The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. | 2011 | J. Physiol. (Lond.) | pmid:21486787 |
Izzo AA and Deutsch DG | Unique pathway for anandamide synthesis and liver regeneration. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21490298 |
Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
Huang L et al. | Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. | 2011 | Lab. Invest. | pmid:21464819 |
Ishiguro H et al. | Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. | 2011 | Synapse | pmid:20506567 |
Zschenderlein C et al. | Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. | 2011 | PLoS ONE | pmid:21249195 |
Garami A et al. | Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. | 2011 | J. Neurosci. | pmid:21289181 |
Wang W et al. | Enhancement of apamin-sensitive medium afterhyperpolarization current by anandamide and its role in excitability control in cultured hippocampal neurons. | 2011 | Neuropharmacology | pmid:21272594 |
Reis GM et al. | Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. | 2011 | Life Sci. | pmid:21277864 |
Kawahara H et al. | Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. | 2011 | Br. J. Pharmacol. | pmid:21175570 |
De Petrocellis L et al. | Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. | 2011 | Br. J. Pharmacol. | pmid:21175579 |
Jumpertz R et al. | Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21177788 |
De Petrocellis L et al. | N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. | 2011 | Pharmacol. Res. | pmid:21215315 |
Kotsikorou E et al. | Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55. | 2011 | Chem. Phys. Lipids | pmid:21185816 |
Zaccagnino P et al. | Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. | 2011 | FEBS Lett. | pmid:21187088 |
Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
Bari M et al. | The manifold actions of endocannabinoids on female and male reproductive events. | 2011 | Front Biosci (Landmark Ed) | pmid:21196184 |
Guindon J et al. | Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | 2011 | Br. J. Pharmacol. | pmid:21198549 |
Liao YS et al. | [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575494 |
Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
Umathe SN et al. | Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. | 2011 | Behav. Brain Res. | pmid:21549765 |
Arias-Carrión O et al. | Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors. | 2011 | J. Neurosci. Res. | pmid:21557294 |
Sordelli MS et al. | The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. | 2011 | PLoS ONE | pmid:21559512 |
Engel MA et al. | Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. | 2011 | Neuropeptides | pmid:21514666 |
Hutchins HL et al. | Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. | 2011 | J. Nutr. Biochem. | pmid:20951563 |
Gervasi MG et al. | Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. | 2011 | PLoS ONE | pmid:21347292 |
Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |
Correa F et al. | The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. | 2011 | Brain Behav. Immun. | pmid:21310228 |
Latek D et al. | Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR. | 2011 | J Mol Model | pmid:21365223 |
Signorello MG et al. | The anandamide effect on NO/cGMP pathway in human platelets. | 2011 | J. Cell. Biochem. | pmid:21328466 |
Greco R et al. | Effects of anandamide in migraine: data from an animal model. | 2011 | J Headache Pain | pmid:21331757 |
Hamtiaux L et al. | Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. | 2011 | PLoS ONE | pmid:22046372 |
Lin QS et al. | Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. | 2011 | Brain Res. Bull. | pmid:21801815 |
Tsuboi K et al. | Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. | 2011 | Biochim. Biophys. Acta | pmid:21801852 |
Chianese R et al. | Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. | 2011 | Gen. Comp. Endocrinol. | pmid:21802420 |
Clugston RD et al. | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | J. Lipid Res. | pmid:21856784 |
Dollery C | Investigative clinical pharmacology. | 2011 | Clin. Pharmacol. Ther. | pmid:21862965 |
Kopczyńska B et al. | Anandamide enhances expression of heat shock proteins Hsp70 and Hsp25 in rat lungs. | 2011 | Eur. J. Pharmacol. | pmid:21756900 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
Theile JW and Cummins TR | Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. | 2011 | Mol. Pharmacol. | pmid:21788423 |
Ndong C et al. | Cloning and pharmacological characterization of the dog cannabinoid CBâ‚‚receptor. | 2011 | Eur. J. Pharmacol. | pmid:21871882 |
Altinsoy A et al. | A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. | 2011 | J Ocul Pharmacol Ther | pmid:21848425 |
Mestre L et al. | Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. | 2011 | J Neuroinflammation | pmid:21851608 |
Feledziak M et al. | SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. | 2011 | J. Med. Chem. | pmid:21899370 |
Palermo G et al. | Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. | 2011 | J. Med. Chem. | pmid:21830831 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
Zoerner AA et al. | Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma. | 2011 | Clin. Pharmacol. Ther. | pmid:21716266 |
Brailoiu GC et al. | Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. | 2011 | J. Biol. Chem. | pmid:21719698 |
Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |