Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
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Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zenor BN et al. | Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. | 1999 | Life Sci. | pmid:10416818 |
| Ralevic V et al. | Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function. | 2002 | Life Sci. | pmid:12354577 |
| Glaser ST et al. | Anandamide transport: a critical review. | 2005 | Life Sci. | pmid:15979096 |
| Ueda N et al. | N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines. | 2005 | Life Sci. | pmid:15949819 |
| Lam FF et al. | Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. | 2007 | Life Sci. | pmid:17275857 |
| Romero TR et al. | Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors. | 2013 | Life Sci. | pmid:23123446 |
| Tóth A et al. | Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. | 2005 | Life Sci. | pmid:15820503 |
| Chen JZ et al. | Preferred conformations of endogenous cannabinoid ligand anandamide. | 2005 | Life Sci. | pmid:15826873 |
| Wenger T et al. | The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats. | 2002 | Life Sci. | pmid:11883716 |
| Murillo-Rodriguez E et al. | Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. | 2006 | Life Sci. | pmid:16434061 |
| Liu WM et al. | Effects of anandamide on embryo implantation in the mouse. | 2002 | Life Sci. | pmid:12137909 |
| Tóth A et al. | Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. | 2003 | Life Sci. | pmid:12759142 |
| Mazzola C et al. | Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. | 2009 | Learn. Mem. | pmid:19403796 |
| Gurwitz D and Weizman A | Fatty acid amide hydrolase inhibitors and the marijuana debate. | 2001 | Lancet | pmid:11705595 |
| Senior K | Endogenously produced cannabinoids and liver cirrhosis. | 2001 | Lancet | pmid:11454385 |
| Bradbury J | Small part of cannabis puzzle solved by animal studies. | 2001 | Lancet | pmid:11498223 |
| Lockwood CJ | Prediction of pregnancy loss. | 2000 | Lancet | pmid:10776739 |
| Maccarrone M et al. | Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage. | 2000 | Lancet | pmid:10776746 |
| Huang L et al. | Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. | 2011 | Lab. Invest. | pmid:21464819 |
| Ito T et al. | Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells. | 2011 | Kurume Med J | pmid:22027193 |
| Haruta C | [Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells]. | 2012 | Kokubyo Gakkai Zasshi | pmid:22568077 |
| Kurihara J et al. | 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves. | 2001 | Jpn. J. Pharmacol. | pmid:11676206 |
| Mikawa Y et al. | Ocular activity of topically administered anandamide in the rabbit. | 1997 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9304433 |
| Habayeb OM et al. | Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage. | 2008 | JAMA | pmid:18334688 |
| Maccarrone M | Anandamide as a marker of human disease. | 2008 | JAMA | pmid:18632539 |
| Gratzke C et al. | Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder. | 2009 | J. Urol. | pmid:19237169 |
| Miyato H et al. | Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. | 2009 | J. Surg. Res. | pmid:19394652 |
| Maia J et al. | The endocannabinoid system expression in the female reproductive tract is modulated by estrogen. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28743542 |
| Bai X et al. | TASK channel expression in human placenta and cytotrophoblast cells. | 2006 | J. Soc. Gynecol. Investig. | pmid:16378911 |
| Vinklerová J et al. | Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251. | 2002 | J. Psychopharmacol. (Oxford) | pmid:12095072 |
| Ashton CH et al. | Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. | 2005 | J. Psychopharmacol. (Oxford) | pmid:15888515 |
| Aguilar DD et al. | THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia. | 2016 | J. Psychopharmacol. (Oxford) | pmid:26510449 |
| Almeida-Santos AF et al. | 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | 2017 | J. Psychopharmacol. (Oxford) | pmid:28440729 |
| Pamplona FA and Takahashi RN | Psychopharmacology of the endocannabinoids: far beyond anandamide. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21652605 |
| Potvin S et al. | Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. | 2008 | J. Psychopharmacol. (Oxford) | pmid:18308802 |
| Butler RK et al. | Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21926424 |
| Warzecha Z et al. | Role of sensory nerves in gastroprotective effect of anandamide in rats. | 2011 | J. Physiol. Pharmacol. | pmid:21673369 |
| Engel MA et al. | Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide. | 2008 | J. Physiol. Pharmacol. | pmid:19212003 |
| Grzeda E et al. | Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. | 2015 | J. Physiol. Pharmacol. | pmid:26084216 |
| Dembiński A et al. | Cannabinoids in acute gastric damage and pancreatitis. | 2006 | J. Physiol. Pharmacol. | pmid:17218765 |
| Gamelin FX et al. | Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. | 2016 | J. Physiol. Biochem. | pmid:26880264 |
| Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
| Chaytor AT et al. | The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. | 1999 | J. Physiol. (Lond.) | pmid:10523421 |
| Kollarik M and Undem BJ | Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice. | 2004 | J. Physiol. (Lond.) | pmid:14634201 |
| Campanucci VA et al. | A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. | 2003 | J. Physiol. (Lond.) | pmid:12640017 |
| Han J et al. | Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. | 2003 | J. Physiol. (Lond.) | pmid:12807991 |
| Szabo B et al. | Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. | 2006 | J. Physiol. (Lond.) | pmid:16973696 |
| Perrier JF et al. | 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. | 2003 | J. Physiol. (Lond.) | pmid:12626670 |
| Pacher P et al. | Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. | 2004 | J. Physiol. (Lond.) | pmid:15121805 |
| Jennings EA et al. | The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. | 2003 | J. Physiol. (Lond.) | pmid:12562891 |
| Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
| Steiner AA et al. | The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. | 2011 | J. Physiol. (Lond.) | pmid:21486787 |
| Poblete IM et al. | Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. | 2005 | J. Physiol. (Lond.) | pmid:16081483 |
| Vellani V et al. | Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. | 2001 | J. Physiol. (Lond.) | pmid:11483711 |
| Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
| Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
| Harris D et al. | Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. | 2002 | J. Physiol. (Lond.) | pmid:11897858 |
| Lin YS and Lee LY | Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. | 2002 | J. Physiol. (Lond.) | pmid:11897863 |
| Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
| Di S et al. | Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. | 2005 | J. Physiol. (Lond.) | pmid:16239276 |
| Van der Kloot W et al. | Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions. | 1998 | J. Physiol. (Lond.) | pmid:9508830 |
| Alger BE | Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. | 2012 | J. Physiol. (Lond.) | pmid:22289914 |
| Williams MA et al. | The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor. | 2008 | J. Physiol. (Lond.) | pmid:18063665 |
| Tamaki C et al. | Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilatation in the rat mesenteric vascular bed. | 2012 | J. Pharmacol. Sci. | pmid:22510966 |
| Sun Y et al. | Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes. | 2012 | J. Pharmacol. Sci. | pmid:22293299 |
| Ross RA et al. | Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12023517 |
| Oz M et al. | Additive effects of endogenous cannabinoid anandamide and ethanol on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15687372 |
| Kangas BD et al. | Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26826191 |
| Vanheel B and Van de Voorde J | Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11160613 |
| Aceto MD et al. | Anandamide, an endogenous cannabinoid, has a very low physical dependence potential. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808686 |
| Esposito G et al. | Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17545311 |
| Gavva NR et al. | AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15615864 |
| Karanian DA et al. | Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17545313 |
| Fulton D and Quilley J | Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9732371 |
| Welch SP et al. | Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9732392 |
| Kinsey SG et al. | Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19502530 |
| Anikwue R et al. | Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235269 |
| Rockwell CE and Kaminski NE | A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15284281 |
| Solinas M et al. | Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17351107 |
| Fride E et al. | Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7853184 |
| Caprioli A et al. | The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514334 |
| Adams IB et al. | Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791088 |
| Welch SP et al. | Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791096 |
| Ritter JK et al. | Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22685343 |
| Akerman S et al. | Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17018694 |
| Orliac ML et al. | Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490589 |
| Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
| Showalter VM et al. | Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819477 |
| Rösch S et al. | R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16330497 |
| Kraft B and Kress HG | Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16055676 |
| Snider NT et al. | Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17272674 |
| Solinas M et al. | The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17210800 |
| Martin BR et al. | Cannabinoid properties of methylfluorophosphonate analogs. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10945879 |
| Lake KD et al. | Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190833 |
| Willoughby KA et al. | The biodisposition and metabolism of anandamide in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9223560 |
| Griffin G et al. | Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688601 |
| Rakhshan F et al. | Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688610 |
| Muthian S et al. | Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734181 |
| Scherma M et al. | Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18725543 |
| Fowler CJ et al. | Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9353392 |