Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kukushkin ML et al. | Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. | 2006 | Bull. Exp. Biol. Med. | pmid:17369898 |
Szabo B et al. | Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. | 2006 | J. Physiol. (Lond.) | pmid:16973696 |
Wiley JL et al. | Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. | 2006 | Life Sci. | pmid:16978656 |
Thors L and Fowler CJ | Is there a temperature-dependent uptake of anandamide into cells? | 2006 | Br. J. Pharmacol. | pmid:16865094 |
Waku K | [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. | 2006 | Yakugaku Zasshi | pmid:16462096 |
Petersen G et al. | Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. | 2006 | Biochim. Biophys. Acta | pmid:16478679 |
Guindon J et al. | Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. | 2006 | Pain | pmid:16480822 |
Busch L et al. | Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16487271 |
Schelling G et al. | Effects of general anesthesia on anandamide blood levels in humans. | 2006 | Anesthesiology | pmid:16436846 |
Guindon J and Beaulieu P | Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. | 2006 | Neuropharmacology | pmid:16442133 |
Bermúdez-Siva FJ et al. | Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. | 2006 | Eur. J. Pharmacol. | pmid:16423347 |
Guagnini F et al. | Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. | 2006 | Gut | pmid:16423891 |
Meuth SG et al. | The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. | 2006 | Mol. Pharmacol. | pmid:16424077 |
Marx J | Drug development. Drugs inspired by a drug. | 2006 | Science | pmid:16424309 |
Cupini LM et al. | Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. | 2006 | Cephalalgia | pmid:16472333 |
GarcÃa Mdel C et al. | Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats. | 2006 | Eur. J. Pharmacol. | pmid:16472800 |
Romano MR and Lograno MD | Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels. | 2006 | Br. J. Pharmacol. | pmid:16474412 |
Tuccinardi T et al. | Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis. | 2006 | J. Med. Chem. | pmid:16451064 |
Monterrubio S and Solowij N | Chronic stress and adaptation. | 2006 | Am J Psychiatry | pmid:16513893 |
Bari M et al. | New insights into endocannabinoid degradation and its therapeutic potential. | 2006 | Mini Rev Med Chem | pmid:16515464 |
Overton HA et al. | Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. | 2006 | Cell Metab. | pmid:16517404 |
Matias I et al. | Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011761 |
Stefano GB and Salamon EJ | Nitric oxide and anandamide in OMT research. | 2006 | J Am Osteopath Assoc | pmid:17122026 |
Lambert RC et al. | Modulation of neuronal T-type calcium channels. | 2006 | CNS Neurol Disord Drug Targets | pmid:17168746 |
Fowler CJ | The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. | 2006 | Fundam Clin Pharmacol | pmid:17109648 |
De Lago E et al. | Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. | 2006 | J. Neurochem. | pmid:16899063 |
Laezza C et al. | Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. | 2006 | FEBS Lett. | pmid:17055492 |
Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
Migliarini B et al. | Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics. | 2006 | FEBS Lett. | pmid:16519888 |
Wang J et al. | Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. | 2006 | J. Biol. Chem. | pmid:16527816 |
Bortolato M et al. | Anxiolytic-like properties of the anandamide transport inhibitor AM404. | 2006 | Neuropsychopharmacology | pmid:16541083 |
Maccarrone M et al. | Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. | 2006 | Thromb. Haemost. | pmid:16543970 |
Siegmund SV et al. | Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. | 2006 | J. Biol. Chem. | pmid:16418162 |
Salo OM et al. | 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data. | 2006 | J. Med. Chem. | pmid:16420041 |
Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
Wei BQ et al. | A second fatty acid amide hydrolase with variable distribution among placental mammals. | 2006 | J. Biol. Chem. | pmid:17015445 |
Wagner JA et al. | 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16775503 |
Bonechi C et al. | Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. | 2006 | Eur J Med Chem | pmid:16837109 |
Costa B et al. | AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. | 2006 | Br. J. Pharmacol. | pmid:16770320 |
Felder CC et al. | Cannabinoids biology: the search for new therapeutic targets. | 2006 | Mol. Interv. | pmid:16809476 |
Yeh JH et al. | Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16623868 |
Rösch S et al. | R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16330497 |
Laviolette SR and Grace AA | The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. | 2006 | Cell. Mol. Life Sci. | pmid:16699809 |
Balas L et al. | Synthesis of a potential photoactivatable anandamide analog. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16682198 |
Shouman B et al. | Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. | 2006 | Br. J. Pharmacol. | pmid:16682966 |
Zaniewska M et al. | Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. | 2006 | Eur. J. Pharmacol. | pmid:16730696 |
Harada N et al. | Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. | 2006 | Thromb. Haemost. | pmid:16732381 |
van der Stelt M et al. | Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. | 2006 | Cell. Mol. Life Sci. | pmid:16732431 |
Fisyunov A et al. | Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. | 2006 | J. Neurophysiol. | pmid:16738209 |
Vogeser M et al. | Release of anandamide from blood cells. | 2006 | Clin. Chem. Lab. Med. | pmid:16599845 |
Kopczyńska B and Szereda-Przestaszewska M | Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. | 2006 | Respir Physiol Neurobiol | pmid:16144778 |
Wang H et al. | Fatty acid amide hydrolase deficiency limits early pregnancy events. | 2006 | J. Clin. Invest. | pmid:16886060 |
Wiles AL et al. | N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. | 2006 | J. Neurochem. | pmid:16899062 |
Bai X et al. | TASK channel expression in human placenta and cytotrophoblast cells. | 2006 | J. Soc. Gynecol. Investig. | pmid:16378911 |
Hejazi N et al. | Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. | 2006 | Mol. Pharmacol. | pmid:16332990 |
Bojesen IN and Hansen HS | Effect of an unstirred layer on the membrane permeability of anandamide. | 2006 | J. Lipid Res. | pmid:16365480 |
Dembiński A et al. | Cannabinoids in acute gastric damage and pancreatitis. | 2006 | J. Physiol. Pharmacol. | pmid:17218765 |
D'Argenio G et al. | Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. | 2006 | FASEB J. | pmid:16403786 |
Nakajima Y et al. | Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. | 2006 | FEBS Lett. | pmid:16406050 |
Suplita RL et al. | Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. | 2006 | Neuropharmacology | pmid:16316669 |
Avelino A and Cruz F | TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16721555 |
Murillo-Rodriguez E et al. | Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. | 2006 | Life Sci. | pmid:16434061 |
Juan-Picó P et al. | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. | 2006 | Cell Calcium | pmid:16321437 |
Cannizzaro C et al. | Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. | 2006 | Neurochem. Int. | pmid:16325966 |
Lizanecz E et al. | Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1. | 2006 | Mol. Pharmacol. | pmid:16338989 |
Moezi L et al. | Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. | 2006 | Br. J. Pharmacol. | pmid:17043671 |
Grimaldi C et al. | Anandamide inhibits adhesion and migration of breast cancer cells. | 2006 | Exp. Cell Res. | pmid:16343481 |
Eljaschewitsch E et al. | The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. | 2006 | Neuron | pmid:16387640 |
Ligresti A et al. | New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. | 2006 | Br. J. Pharmacol. | pmid:16284631 |
Bir LS and Ercan S | Effects of intrathecal anandamide on somatosensory evoked responses in rats. | 2006 | Exp. Neurol. | pmid:16289169 |
Yang YY et al. | Roles of anandamide in the hepatic microcirculation in cirrhotic rats. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16407591 |
Urbani P et al. | New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16213718 |
Glaser ST et al. | Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16278311 |
Appendino G et al. | First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. | 2006 | FEBS Lett. | pmid:16406364 |
Glaser ST et al. | Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. | 2005 Nov-Dec | Vis. Neurosci. | pmid:16469181 |
Abalo R et al. | Evaluation of the effect of age on cannabinoid receptor functionality and expression in guinea-pig ileum longitudinal muscle-myenteric plexus preparations. | 2005 Jul 22-29 | Neurosci. Lett. | pmid:15936532 |
Kurabayashi M et al. | 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. | 2005 Jan-Feb | J Invest Surg | pmid:15804949 |
Basavarajappa BS and Hungund BL | Role of the endocannabinoid system in the development of tolerance to alcohol. | 2005 Jan-Feb | Alcohol Alcohol. | pmid:15550443 |
RodrÃguez de Fonseca F et al. | The endocannabinoid system: physiology and pharmacology. | 2005 Jan-Feb | Alcohol Alcohol. | pmid:15550444 |
Ahern GP et al. | Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. | 2005 | J. Neurosci. | pmid:15917451 |
Glass M et al. | Misidentification of prostamides as prostaglandins. | 2005 | J. Lipid Res. | pmid:15863842 |
Osei-Hyiaman D et al. | Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. | 2005 | J. Clin. Invest. | pmid:15864349 |
Siegmund SV et al. | Anandamide induces necrosis in primary hepatic stellate cells. | 2005 | Hepatology | pmid:15841466 |
Ortega-Gutiérrez S et al. | Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. | 2005 | Glia | pmid:15920730 |
Gavva NR et al. | AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15615864 |
Sancho R et al. | Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. | 2005 | J. Immunol. | pmid:16148147 |
Kraft B and Kress HG | Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16055676 |
Poblete IM et al. | Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. | 2005 | J. Physiol. (Lond.) | pmid:16081483 |
Justinova Z et al. | The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. | 2005 | J. Neurosci. | pmid:15944392 |
Bazinet RP et al. | Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. | 2005 | Neurochem. Res. | pmid:16176062 |
Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
Engeli S et al. | Activation of the peripheral endocannabinoid system in human obesity. | 2005 | Diabetes | pmid:16186383 |
Maccarrone M et al. | Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | 2005 | Mol. Hum. Reprod. | pmid:15563449 |
Patel S et al. | The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. | 2005 | J. Lipid Res. | pmid:15576840 |
Fegley D et al. | Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15579492 |
Lee MG et al. | Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. | 2005 | Br. J. Pharmacol. | pmid:16056239 |
Movahed P et al. | Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. | 2005 | Br. J. Pharmacol. | pmid:15997233 |
Movahed P et al. | Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. | 2005 | J. Biol. Chem. | pmid:16081411 |
Awumey EM et al. | Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16014613 |
Solbrig MV et al. | A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. | 2005 | Exp. Neurol. | pmid:16022863 |