Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Wei D et al. | Endocannabinoid signaling mediates oxytocin-driven social reward. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26504214 |
Wang H et al. | Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14645706 |
Piomelli D et al. | Structural determinants for recognition and translocation by the anandamide transporter. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318965 |
Scorticati C et al. | The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280536 |
Grimaldi P et al. | The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19541620 |
Morena M et al. | Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25489086 |
Alger BE | Endocannabinoids: getting the message across. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15173576 |
Liu J et al. | A biosynthetic pathway for anandamide. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16938887 |
Járai Z et al. | Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570211 |
Boger DL et al. | Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10805767 |
De Petrocellis L et al. | The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9653194 |
Schuel H et al. | Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8052642 |
Facci L et al. | Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7724569 |
Skaper SD et al. | The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8633002 |
Devane WA and Axelrod J | Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022836 |
Cravatt BF et al. | Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11470906 |
Paria BC et al. | The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568154 |
Yoshida R et al. | Endocannabinoids selectively enhance sweet taste. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20080779 |
Mechoulam R and Deutsch DG | Toward an anandamide transporter. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16314567 |
Wenzel D et al. | Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24167249 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Fernández-Solari J et al. | Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14981261 |
Schmid PC et al. | Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9108127 |
Glaser ST et al. | Evidence against the presence of an anandamide transporter. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12655057 |
Kaczocha M et al. | Identification of intracellular carriers for the endocannabinoid anandamide. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19307565 |
Collin C et al. | Long-term synaptic transformation of hippocampal CA1 gamma-aminobutyric acid synapses and the effect of anandamide. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479747 |
Pertwee RG | Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. | 2014 | Proc Nutr Soc | pmid:24135210 |
Burston JJ and Woodhams SG | Endocannabinoid system and pain: an introduction. | 2014 | Proc Nutr Soc | pmid:24148358 |
Kwolek G et al. | [Influence of anandamide, the endogenous agonist of cannabinoid receptors on the circulatory system]. | 2005 | Postepy Hig Med Dosw (Online) | pmid:15928605 |
Bruijnzeel AW et al. | Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats. | 2016 | PLoS ONE | pmid:27065006 |
Vinod KY et al. | Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats. | 2012 | PLoS ONE | pmid:22606285 |
Martins CJ et al. | Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. | 2015 | PLoS ONE | pmid:26561012 |
Smith M et al. | The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. | 2015 | PLoS ONE | pmid:26414859 |
Gouveia-Figueira S et al. | Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor. | 2015 | PLoS ONE | pmid:26406890 |
Thörn Pérez C et al. | Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels. | 2015 | PLoS ONE | pmid:26197458 |
Chon SH et al. | Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. | 2012 | PLoS ONE | pmid:22937137 |
Woolcott OO et al. | High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. | 2015 | PLoS ONE | pmid:25855974 |
Nicholson J et al. | Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. | 2015 | PLoS ONE | pmid:25835291 |
De Angelis V et al. | Endocannabinoids control platelet activation and limit aggregate formation under flow. | 2014 | PLoS ONE | pmid:25264625 |
Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
Björklund E et al. | Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study. | 2014 | PLoS ONE | pmid:25078278 |
Dong W et al. | Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. | 2014 | PLoS ONE | pmid:24949851 |
Hama AT et al. | Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain. | 2014 | PLoS ONE | pmid:24788435 |
Kaczocha M et al. | Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia. | 2014 | PLoS ONE | pmid:24705380 |
Jackson AR et al. | Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction. | 2014 | PLoS ONE | pmid:24699635 |
Di Pasquale E et al. | The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. | 2009 | PLoS ONE | pmid:19330032 |
Gervasi MG et al. | Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. | 2013 | PLoS ONE | pmid:23977311 |
Leo LM et al. | Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. | 2014 | PLoS ONE | pmid:24416334 |
Li Q et al. | Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. | 2013 | PLoS ONE | pmid:23667607 |
Lobato NS et al. | Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. | 2013 | PLoS ONE | pmid:23667622 |
Gatta L et al. | Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. | 2012 | PLoS ONE | pmid:22363560 |
Berger WT et al. | Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. | 2012 | PLoS ONE | pmid:23236415 |
Compagnucci C et al. | Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. | 2013 | PLoS ONE | pmid:23372698 |
Bhaskaran MD and Smith BN | Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. | 2010 | PLoS ONE | pmid:20498848 |
Zschenderlein C et al. | Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. | 2011 | PLoS ONE | pmid:21249195 |
Starowicz K et al. | Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. | 2013 | PLoS ONE | pmid:23573230 |
Chadwick W et al. | Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. | 2010 | PLoS ONE | pmid:21179406 |
Cencioni MT et al. | Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. | 2010 | PLoS ONE | pmid:20098669 |
Sordelli MS et al. | The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. | 2011 | PLoS ONE | pmid:21559512 |
Derbenev AV and Smith BN | Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity. | 2013 | PLoS ONE | pmid:23936221 |
Ligresti A et al. | Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter. | 2010 | PLoS ONE | pmid:20422025 |
El-Talatini MR et al. | Localisation and function of the endocannabinoid system in the human ovary. | 2009 | PLoS ONE | pmid:19238202 |
Osycka-Salut C et al. | Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. | 2012 | PLoS ONE | pmid:22363468 |
Gervasi MG et al. | Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. | 2011 | PLoS ONE | pmid:21347292 |
Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
Hamtiaux L et al. | Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. | 2011 | PLoS ONE | pmid:22046372 |
Björklund E et al. | Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations. | 2014 | PLoS ONE | pmid:24466356 |
Leung K et al. | Role of FAAH-like anandamide transporter in anandamide inactivation. | 2013 | PLoS ONE | pmid:24223930 |
Karlsson J et al. | Effects of tumour necrosis factor α upon the metabolism of the endocannabinoid anandamide in prostate cancer cells. | 2017 | PLoS ONE | pmid:28910408 |
Murtaza G et al. | TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries. | 2017 | PLoS ONE | pmid:28301582 |
Palermo G et al. | Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets. | 2015 | PLoS Comput. Biol. | pmid:26111155 |
Brantl SA et al. | Mechanism of platelet activation induced by endocannabinoids in blood and plasma. | 2014 | Platelets | pmid:23789792 |
Gertsch J | Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system. | 2008 | Planta Med. | pmid:18275004 |
Acone G et al. | Low type I cannabinoid receptor levels characterize placental villous in labouring delivery. | 2009 | Placenta | pmid:19097644 |
Fonseca BM et al. | Anandamide-induced cell death: dual effects in primary rat decidual cell cultures. | 2009 | Placenta | pmid:19560819 |
Vercelli CA et al. | Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua. | 2009 | Placenta | pmid:19428101 |
Abán C et al. | Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. | 2013 | Placenta | pmid:23122699 |
Brocato B et al. | Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. | 2013 | Placenta | pmid:24008071 |
Cella M et al. | Dual effect of anandamide on rat placenta nitric oxide synthesis. | 2008 | Placenta | pmid:18561998 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Williams CM and Kirkham TC | Observational analysis of feeding induced by Delta9-THC and anandamide. | 2002 | Physiol. Behav. | pmid:12044596 |
EscartÃn-Pérez RE et al. | Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. | 2009 | Physiol. Behav. | pmid:19150453 |
Argueta DA and DiPatrizio NV | Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. | 2017 | Physiol. Behav. | pmid:28065722 |
Thompson Z et al. | Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. | 2017 | Physiol. Behav. | pmid:28017680 |
Parker LA et al. | The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). | 2009 | Physiol. Behav. | pmid:19239915 |
Skaper SD and Di Marzo V | Endocannabinoids in nervous system health and disease: the big picture in a nutshell. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108539 |
Di Marzo V and De Petrocellis L | Why do cannabinoid receptors have more than one endogenous ligand? | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108541 |
Puighermanal E et al. | Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108544 |
Starowicz K and Przewlocka B | Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108547 |
Rani Sagar D et al. | Dynamic changes to the endocannabinoid system in models of chronic pain. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108548 |
Campos AC et al. | Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108553 |
Schneider U et al. | Cannabinoid/anandamide system and schizophrenia: is there evidence for association? | 1998 | Pharmacopsychiatry | pmid:9754842 |
Hill MN et al. | Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. | 2008 | Pharmacopsychiatry | pmid:18311684 |
Ronco AM et al. | Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid. | 2007 | Pharmacology | pmid:17114903 |
Gonçalves P et al. | Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. | 2008 | Pharmacology | pmid:18431074 |
Araújo JR et al. | Effect of cannabinoids upon the uptake of folic acid by BeWo cells. | 2009 | Pharmacology | pmid:19145103 |
Fowler CJ et al. | Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide. | 1997 | Pharmacol. Toxicol. | pmid:9060042 |
Izzo AA and Sharkey KA | Cannabinoids and the gut: new developments and emerging concepts. | 2010 | Pharmacol. Ther. | pmid:20117132 |
Goutopoulos A and Makriyannis A | From cannabis to cannabinergics: new therapeutic opportunities. | 2002 | Pharmacol. Ther. | pmid:12182958 |