Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Moloney GP et al. Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. 2008 Eur J Med Chem pmid:17582659
Snider NT et al. The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. 2008 J. Pharmacol. Exp. Ther. pmid:18698000
Shaladi AM et al. [Cannabinoids in the control of pain]. 2008 Recenti Prog Med pmid:19388223
Moreira FA et al. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. 2008 Neuropharmacology pmid:17709120
Roberts LA et al. Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. 2008 Neuropharmacology pmid:17631916
Ortar G et al. New tetrazole-based selective anandamide uptake inhibitors. 2008 Bioorg. Med. Chem. Lett. pmid:18424134
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Capasso R and Izzo AA Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. 2008 J. Neuroendocrinol. pmid:18426498
Ahn K et al. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. 2008 Chem. Rev. pmid:18429637
Rubio M et al. CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. 2008 Neuropharmacology pmid:18371990
Evans RM et al. Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. 2008 Br. J. Pharmacol. pmid:18376419
Di Marzo V and Maccarrone M FAAH and anandamide: is 2-AG really the odd one out? 2008 Trends Pharmacol. Sci. pmid:18394720
Kaufmann I et al. Anandamide and neutrophil function in patients with fibromyalgia. 2008 Psychoneuroendocrinology pmid:18395993
Hegde VL et al. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. 2008 Mol. Pharmacol. pmid:18388242
Solinas M et al. The endocannabinoid system in brain reward processes. 2008 Br. J. Pharmacol. pmid:18414385
Farrell EK and Merkler DJ Biosynthesis, degradation and pharmacological importance of the fatty acid amides. 2008 Drug Discov. Today pmid:18598910
Palmer JA et al. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. 2008 Neuroscience pmid:18541380
Yao F et al. Development of novel tail-modified anandamide analogs. 2008 Bioorg. Med. Chem. Lett. pmid:18723350
Kase Y et al. Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. 2008 Ther Apher Dial pmid:18937720
Waldeck-Weiermair M et al. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. 2008 J. Cell. Sci. pmid:18445684
Resstel LB et al. Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. 2008 Psychopharmacology (Berl.) pmid:18446325
Cippitelli A et al. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. 2008 Psychopharmacology (Berl.) pmid:18446329
Liu HY et al. [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18578993
Dembiński A et al. Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. 2008 Eur. J. Pharmacol. pmid:18593574
Stark K et al. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. 2008 FEBS J. pmid:18549450
Kamei J et al. [Sensitization of cough sensitivity through activation of C-and/or Adelta fibers]. 2008 Nippon Yakurigaku Zasshi pmid:18552444
Thors L et al. Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. 2008 Br. J. Pharmacol. pmid:18552875
Ellgren M et al. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. 2008 Eur Neuropsychopharmacol pmid:18674887
Fowler CJ and Ghafouri N Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? 2008 Pharmacol. Res. pmid:18675915
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289
Haller VL et al. Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. 2008 Eur. J. Pharmacol. pmid:18762181
da Veiga MA et al. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. 2008 J. Endocrinol. pmid:18755884
DeMorrow S et al. Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18096608
Scherma M et al. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. 2008 Neuropharmacology pmid:17904589
Rubino T et al. Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. 2008 Cereb. Cortex pmid:17921459
Sakamoto Y et al. Effectiveness of continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter after polymyxin B-immobilized fiber column therapy of septic shock. 2008 Jan-Feb ASAIO J. pmid:18204329
Lissoni P et al. The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. 2008 Nov-Dec Anticancer Res. pmid:19189659
Kurjak M et al. Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. 2008 Oct-Dec Neuropeptides pmid:18829105
Acone G et al. Low type I cannabinoid receptor levels characterize placental villous in labouring delivery. 2009 Placenta pmid:19097644
Wheal AJ and Randall MD Effects of hypertension on vasorelaxation to endocannabinoids in vitro. 2009 Eur. J. Pharmacol. pmid:19100733
Escartín-Pérez RE et al. Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. 2009 Physiol. Behav. pmid:19150453
Ozalp A and Barroso B Simultaneous quantitative analysis of N-acylethanolamides in clinical samples. 2009 Anal. Biochem. pmid:19665986
Eckardt K et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. 2009 Diabetologia pmid:19089403
Karbarz MJ et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. 2009 Anesth. Analg. pmid:19095868
Vignali M et al. The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. 2009 Glia pmid:19031444
Fernandez-Solari J et al. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. 2009 Braz. J. Med. Biol. Res. pmid:19448903
Ribeiro A et al. Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. 2009 Braz. J. Med. Biol. Res. pmid:19448906
Li D et al. Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. 2009 J. Hypertens. pmid:19462497
Mahmud A et al. Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. 2009 Neuroscience pmid:19463903
Vann RE et al. Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. 2009 Eur. J. Pharmacol. pmid:19470387
Vercelli CA et al. Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus. 2009 Reprod. Biomed. Online pmid:19490788
Aquila S et al. A new role of anandamide in human sperm: focus on metabolism. 2009 J. Cell. Physiol. pmid:19492411
Kingsley PJ and Marnett LJ Analysis of endocannabinoids, their congeners and COX-2 metabolites. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19505857
Dowie MJ et al. Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. 2009 Neuroscience pmid:19524019
Wise LE et al. Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. 2009 Neurobiol Learn Mem pmid:19524055
Grider JR et al. Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19589944
Batetta B et al. Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. 2009 J. Nutr. pmid:19549757
Catanzaro G et al. Anandamide increases swelling and reduces calcium sensitivity of mitochondria. 2009 Biochem. Biophys. Res. Commun. pmid:19679102
Fraga D et al. Endogenous cannabinoids induce fever through the activation of CB1 receptors. 2009 Br. J. Pharmacol. pmid:19681872
Lozovaya N et al. Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. 2009 Cell Calcium pmid:19682741
Okamoto Y et al. Enzymatic formation of anandamide. 2009 Vitam. Horm. pmid:19647106
Yates ML and Barker EL Organized trafficking of anandamide and related lipids. 2009 Vitam. Horm. pmid:19647107
Goodfellow CE and Glass M Anandamide receptor signal transduction. 2009 Vitam. Horm. pmid:19647109
Brown AJ and Robin Hiley C Is GPR55 an anandamide receptor? 2009 Vitam. Horm. pmid:19647110
Correa FG et al. The endocannabinoid anandamide from immunomodulation to neuroprotection. Implications for multiple sclerosis. 2009 Vitam. Horm. pmid:19647114
Tóth A et al. Anandamide and the vanilloid receptor (TRPV1). 2009 Vitam. Horm. pmid:19647120
Pasquariello N et al. Regulation of gene transcription and keratinocyte differentiation by anandamide. 2009 Vitam. Horm. pmid:19647122
Alpini G and Demorrow S Changes in the endocannabinoid system may give insight into new and effective treatments for cancer. 2009 Vitam. Horm. pmid:19647123
Astarita G et al. Targeted lipidomics as a tool to investigate endocannabinoid function. 2009 Int. Rev. Neurobiol. pmid:19607960
Pelorosso FG et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. 2009 Eur. J. Pharmacol. pmid:19022239
Guindon J and Hohmann AG The endocannabinoid system and pain. 2009 CNS Neurol Disord Drug Targets pmid:19839937
Järbe TU et al. Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. 2009 Psychopharmacology (Berl.) pmid:18521574
Marczylo TH et al. A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices. 2009 Anal. Biochem. pmid:18823934
Hong S et al. Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. 2009 Gut pmid:18936104
Correa F et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. 2009 Biochem. Pharmacol. pmid:18848818
McCue JM et al. In vitro synthesis of arachidonoyl amino acids by cytochrome c. 2009 Prostaglandins Other Lipid Mediat. pmid:19683594
Cottone E et al. Goldfish CB1 mRNA expression is affected by fasting and anandamide administration. 2009 Neuroreport pmid:19293731
Villanueva A et al. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. 2009 Shock pmid:19295473
Izzo AA et al. Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. 2009 Br. J. Pharmacol. pmid:19371345
Appendino G et al. Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. 2009 J. Med. Chem. pmid:19361197
El-Talatini MR et al. Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation. 2009 Hum. Reprod. pmid:19363040
Clapper JR et al. The endocannabinoid system as a target for the treatment of cannabis dependence. 2009 Neuropharmacology pmid:18691603
Brizzi A et al. New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo. 2009 J. Med. Chem. pmid:19331413
Catani MV et al. Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. 2009 J. Mol. Med. pmid:18820887
Shinohara Y et al. Cannabinoid in the nucleus accumbens enhances the intake of palatable solution. 2009 Neuroreport pmid:19734811
Campos AC and Guimarães FS Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:19735690
Wyffels L et al. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. 2009 J. Med. Chem. pmid:19719235
Di Marzo V et al. Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. 2009 Eur. J. Endocrinol. pmid:19745037
Cano C et al. Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. 2009 Eur J Med Chem pmid:19762126
Centonze D et al. Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. 2009 Neurol. Sci. pmid:19768368
Jean-Gilles L et al. Plasma endocannabinoid levels in multiple sclerosis. 2009 J. Neurol. Sci. pmid:19695579
Wyffels L et al. Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. 2009 Bioorg. Med. Chem. pmid:19054678
Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. 2009 Bone pmid:19059369
Jiang LS et al. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. 2009 Cardiovasc. Res. pmid:19074161
Aneetha H et al. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. 2009 Bioorg. Med. Chem. Lett. pmid:19013794
Panlilio LV et al. Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. 2009 Psychopharmacology (Berl.) pmid:19015836
De Petrocellis L et al. Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide. 2009 J. Lipid Res. pmid:19017617
Tuboly G et al. Antinociceptive interactions between anandamide and endomorphin-1 at the spinal level. 2009 Clin. Exp. Pharmacol. Physiol. pmid:19018802
Schacht JP et al. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. 2009 Psychopharmacology (Berl.) pmid:19002671
Mato S et al. CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. 2009 Glia pmid:18814177