Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Moloney GP et al. | Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. | 2008 | Eur J Med Chem | pmid:17582659 |
Snider NT et al. | The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18698000 |
Shaladi AM et al. | [Cannabinoids in the control of pain]. | 2008 | Recenti Prog Med | pmid:19388223 |
Moreira FA et al. | Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. | 2008 | Neuropharmacology | pmid:17709120 |
Roberts LA et al. | Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. | 2008 | Neuropharmacology | pmid:17631916 |
Ortar G et al. | New tetrazole-based selective anandamide uptake inhibitors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18424134 |
Bisogno T | Endogenous cannabinoids: structure and metabolism. | 2008 | J. Neuroendocrinol. | pmid:18426492 |
Capasso R and Izzo AA | Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. | 2008 | J. Neuroendocrinol. | pmid:18426498 |
Ahn K et al. | Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. | 2008 | Chem. Rev. | pmid:18429637 |
Rubio M et al. | CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | 2008 | Neuropharmacology | pmid:18371990 |
Evans RM et al. | Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. | 2008 | Br. J. Pharmacol. | pmid:18376419 |
Di Marzo V and Maccarrone M | FAAH and anandamide: is 2-AG really the odd one out? | 2008 | Trends Pharmacol. Sci. | pmid:18394720 |
Kaufmann I et al. | Anandamide and neutrophil function in patients with fibromyalgia. | 2008 | Psychoneuroendocrinology | pmid:18395993 |
Hegde VL et al. | Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. | 2008 | Mol. Pharmacol. | pmid:18388242 |
Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
Farrell EK and Merkler DJ | Biosynthesis, degradation and pharmacological importance of the fatty acid amides. | 2008 | Drug Discov. Today | pmid:18598910 |
Palmer JA et al. | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. | 2008 | Neuroscience | pmid:18541380 |
Yao F et al. | Development of novel tail-modified anandamide analogs. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18723350 |
Kase Y et al. | Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. | 2008 | Ther Apher Dial | pmid:18937720 |
Waldeck-Weiermair M et al. | Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. | 2008 | J. Cell. Sci. | pmid:18445684 |
Resstel LB et al. | Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. | 2008 | Psychopharmacology (Berl.) | pmid:18446325 |
Cippitelli A et al. | Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. | 2008 | Psychopharmacology (Berl.) | pmid:18446329 |
Liu HY et al. | [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18578993 |
Dembiński A et al. | Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. | 2008 | Eur. J. Pharmacol. | pmid:18593574 |
Stark K et al. | Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. | 2008 | FEBS J. | pmid:18549450 |
Kamei J et al. | [Sensitization of cough sensitivity through activation of C-and/or Adelta fibers]. | 2008 | Nippon Yakurigaku Zasshi | pmid:18552444 |
Thors L et al. | Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. | 2008 | Br. J. Pharmacol. | pmid:18552875 |
Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
Haller VL et al. | Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. | 2008 | Eur. J. Pharmacol. | pmid:18762181 |
da Veiga MA et al. | Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. | 2008 | J. Endocrinol. | pmid:18755884 |
DeMorrow S et al. | Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18096608 |
Scherma M et al. | The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. | 2008 | Neuropharmacology | pmid:17904589 |
Rubino T et al. | Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. | 2008 | Cereb. Cortex | pmid:17921459 |
Sakamoto Y et al. | Effectiveness of continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter after polymyxin B-immobilized fiber column therapy of septic shock. | 2008 Jan-Feb | ASAIO J. | pmid:18204329 |
Lissoni P et al. | The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. | 2008 Nov-Dec | Anticancer Res. | pmid:19189659 |
Kurjak M et al. | Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. | 2008 Oct-Dec | Neuropeptides | pmid:18829105 |
Acone G et al. | Low type I cannabinoid receptor levels characterize placental villous in labouring delivery. | 2009 | Placenta | pmid:19097644 |
Wheal AJ and Randall MD | Effects of hypertension on vasorelaxation to endocannabinoids in vitro. | 2009 | Eur. J. Pharmacol. | pmid:19100733 |
EscartÃn-Pérez RE et al. | Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. | 2009 | Physiol. Behav. | pmid:19150453 |
Ozalp A and Barroso B | Simultaneous quantitative analysis of N-acylethanolamides in clinical samples. | 2009 | Anal. Biochem. | pmid:19665986 |
Eckardt K et al. | Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. | 2009 | Diabetologia | pmid:19089403 |
Karbarz MJ et al. | Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. | 2009 | Anesth. Analg. | pmid:19095868 |
Vignali M et al. | The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. | 2009 | Glia | pmid:19031444 |
Fernandez-Solari J et al. | Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448903 |
Ribeiro A et al. | Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448906 |
Li D et al. | Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. | 2009 | J. Hypertens. | pmid:19462497 |
Mahmud A et al. | Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. | 2009 | Neuroscience | pmid:19463903 |
Vann RE et al. | Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. | 2009 | Eur. J. Pharmacol. | pmid:19470387 |
Vercelli CA et al. | Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus. | 2009 | Reprod. Biomed. Online | pmid:19490788 |
Aquila S et al. | A new role of anandamide in human sperm: focus on metabolism. | 2009 | J. Cell. Physiol. | pmid:19492411 |
Kingsley PJ and Marnett LJ | Analysis of endocannabinoids, their congeners and COX-2 metabolites. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19505857 |
Dowie MJ et al. | Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | 2009 | Neuroscience | pmid:19524019 |
Wise LE et al. | Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. | 2009 | Neurobiol Learn Mem | pmid:19524055 |
Grider JR et al. | Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19589944 |
Batetta B et al. | Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. | 2009 | J. Nutr. | pmid:19549757 |
Catanzaro G et al. | Anandamide increases swelling and reduces calcium sensitivity of mitochondria. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19679102 |
Fraga D et al. | Endogenous cannabinoids induce fever through the activation of CB1 receptors. | 2009 | Br. J. Pharmacol. | pmid:19681872 |
Lozovaya N et al. | Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. | 2009 | Cell Calcium | pmid:19682741 |
Okamoto Y et al. | Enzymatic formation of anandamide. | 2009 | Vitam. Horm. | pmid:19647106 |
Yates ML and Barker EL | Organized trafficking of anandamide and related lipids. | 2009 | Vitam. Horm. | pmid:19647107 |
Goodfellow CE and Glass M | Anandamide receptor signal transduction. | 2009 | Vitam. Horm. | pmid:19647109 |
Brown AJ and Robin Hiley C | Is GPR55 an anandamide receptor? | 2009 | Vitam. Horm. | pmid:19647110 |
Correa FG et al. | The endocannabinoid anandamide from immunomodulation to neuroprotection. Implications for multiple sclerosis. | 2009 | Vitam. Horm. | pmid:19647114 |
Tóth A et al. | Anandamide and the vanilloid receptor (TRPV1). | 2009 | Vitam. Horm. | pmid:19647120 |
Pasquariello N et al. | Regulation of gene transcription and keratinocyte differentiation by anandamide. | 2009 | Vitam. Horm. | pmid:19647122 |
Alpini G and Demorrow S | Changes in the endocannabinoid system may give insight into new and effective treatments for cancer. | 2009 | Vitam. Horm. | pmid:19647123 |
Astarita G et al. | Targeted lipidomics as a tool to investigate endocannabinoid function. | 2009 | Int. Rev. Neurobiol. | pmid:19607960 |
Pelorosso FG et al. | The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. | 2009 | Eur. J. Pharmacol. | pmid:19022239 |
Guindon J and Hohmann AG | The endocannabinoid system and pain. | 2009 | CNS Neurol Disord Drug Targets | pmid:19839937 |
Järbe TU et al. | Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. | 2009 | Psychopharmacology (Berl.) | pmid:18521574 |
Marczylo TH et al. | A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices. | 2009 | Anal. Biochem. | pmid:18823934 |
Hong S et al. | Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. | 2009 | Gut | pmid:18936104 |
Correa F et al. | A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. | 2009 | Biochem. Pharmacol. | pmid:18848818 |
McCue JM et al. | In vitro synthesis of arachidonoyl amino acids by cytochrome c. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19683594 |
Cottone E et al. | Goldfish CB1 mRNA expression is affected by fasting and anandamide administration. | 2009 | Neuroreport | pmid:19293731 |
Villanueva A et al. | Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. | 2009 | Shock | pmid:19295473 |
Izzo AA et al. | Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. | 2009 | Br. J. Pharmacol. | pmid:19371345 |
Appendino G et al. | Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. | 2009 | J. Med. Chem. | pmid:19361197 |
El-Talatini MR et al. | Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation. | 2009 | Hum. Reprod. | pmid:19363040 |
Clapper JR et al. | The endocannabinoid system as a target for the treatment of cannabis dependence. | 2009 | Neuropharmacology | pmid:18691603 |
Brizzi A et al. | New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo. | 2009 | J. Med. Chem. | pmid:19331413 |
Catani MV et al. | Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | 2009 | J. Mol. Med. | pmid:18820887 |
Shinohara Y et al. | Cannabinoid in the nucleus accumbens enhances the intake of palatable solution. | 2009 | Neuroreport | pmid:19734811 |
Campos AC and Guimarães FS | Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. | 2009 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:19735690 |
Wyffels L et al. | Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. | 2009 | J. Med. Chem. | pmid:19719235 |
Di Marzo V et al. | Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. | 2009 | Eur. J. Endocrinol. | pmid:19745037 |
Cano C et al. | Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. | 2009 | Eur J Med Chem | pmid:19762126 |
Centonze D et al. | Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. | 2009 | Neurol. Sci. | pmid:19768368 |
Jean-Gilles L et al. | Plasma endocannabinoid levels in multiple sclerosis. | 2009 | J. Neurol. Sci. | pmid:19695579 |
Wyffels L et al. | Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. | 2009 | Bioorg. Med. Chem. | pmid:19054678 |
Rossi F et al. | The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. | 2009 | Bone | pmid:19059369 |
Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
Aneetha H et al. | Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19013794 |
Panlilio LV et al. | Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. | 2009 | Psychopharmacology (Berl.) | pmid:19015836 |
De Petrocellis L et al. | Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide. | 2009 | J. Lipid Res. | pmid:19017617 |
Tuboly G et al. | Antinociceptive interactions between anandamide and endomorphin-1 at the spinal level. | 2009 | Clin. Exp. Pharmacol. Physiol. | pmid:19018802 |
Schacht JP et al. | Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. | 2009 | Psychopharmacology (Berl.) | pmid:19002671 |
Mato S et al. | CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. | 2009 | Glia | pmid:18814177 |