Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schindler CW et al. | Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. | 2016 | Psychopharmacology (Berl.) | pmid:26803499 |
Naidu PS et al. | Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. | 2007 | Psychopharmacology (Berl.) | pmid:17279376 |
Egashira N et al. | Anandamide inhibits the DOI-induced head-twitch response in mice. | 2004 | Psychopharmacology (Berl.) | pmid:14586538 |
Fernandez-Espejo E and Galan-Rodriguez B | Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor. | 2004 | Psychopharmacology (Berl.) | pmid:15088080 |
Cassano T et al. | Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. | 2011 | Psychopharmacology (Berl.) | pmid:21042794 |
Higgs S et al. | Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. | 2003 | Psychopharmacology (Berl.) | pmid:12447606 |
Cross-Mellor SK et al. | Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. | 2007 | Psychopharmacology (Berl.) | pmid:17111174 |
Gorzalka BB et al. | Endocannabinoid modulation of male rat sexual behavior. | 2008 | Psychopharmacology (Berl.) | pmid:17694389 |
Rueda-Orozco PE et al. | A potential function of endocannabinoids in the selection of a navigation strategy by rats. | 2008 | Psychopharmacology (Berl.) | pmid:17805517 |
Sustkova-Fiserova M et al. | Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. | 2016 | Psychopharmacology (Berl.) | pmid:26507196 |
Solinas M et al. | Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide. | 2010 | Psychopharmacology (Berl.) | pmid:20179908 |
Fogaça MV et al. | Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats. | 2013 | Psychopharmacology (Berl.) | pmid:23183551 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Järbe TU et al. | Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. | 2009 | Psychopharmacology (Berl.) | pmid:18521574 |
Panlilio LV et al. | Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. | 2009 | Psychopharmacology (Berl.) | pmid:19015836 |
Schacht JP et al. | Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. | 2009 | Psychopharmacology (Berl.) | pmid:19002671 |
Dudášová A et al. | The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig. | 2013 | Pulm Pharmacol Ther | pmid:23428645 |
Qi M et al. | A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26411510 |
Shaladi AM et al. | [Cannabinoids in the control of pain]. | 2008 | Recenti Prog Med | pmid:19388223 |
Luce V et al. | The inhibitory effect of anandamide on oxytocin and vasopressin secretion from neurohypophysis is mediated by nitric oxide. | 2014 | Regul. Pept. | pmid:24342802 |
Nakata M and Yada T | Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. | 2008 | Regul. Pept. | pmid:17884194 |
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Fonseca BM et al. | Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. | 2009 | Reprod. Biol. Endocrinol. | pmid:19860893 |
Taylor AH et al. | Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. | 2011 | Reprod. Biol. Endocrinol. | pmid:22126420 |
Vercelli CA et al. | Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus. | 2009 | Reprod. Biomed. Online | pmid:19490788 |
Ribeiro ML et al. | 17beta-oestradiol and progesterone regulate anandamide synthesis in the rat uterus. | 2009 | Reprod. Biomed. Online | pmid:19192341 |
Bariani MV et al. | Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. | 2015 | Reproduction | pmid:26347521 |
Gervasi MG et al. | The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. | 2009 | Reproduction | pmid:19042982 |
Talevi R et al. | Is there a role for endocannabinoids in sperm-oviduct interaction? | 2010 | Reproduction | pmid:20511399 |
Almada M et al. | The endocannabinoid anandamide impairs in vitro decidualization of human cells. | 2016 | Reproduction | pmid:27568210 |
Langstein J et al. | cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. | 1996 Jul-Aug | Res. Immunol. | pmid:8903105 |
Kopczyńska B and Szereda-Przestaszewska M | Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. | 2006 | Respir Physiol Neurobiol | pmid:16144778 |
Brăiloiu C et al. | [Endothelium-derived hyperpolarizing factor]. | 1998 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:10756843 |
RodrÃguez de Fonseca F | [The endocannabinoid system and food intake control]. | 2004 Apr-Jun | Rev Med Univ Navarra | pmid:15382609 |
Hauer D et al. | Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. | 2012 | Rev Neurosci | pmid:23006898 |
Di Marzo V | Endocannabinoids: synthesis and degradation. | 2008 | Rev. Physiol. Biochem. Pharmacol. | pmid:18481028 |
Leweke FM et al. | Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. | 2007 | Schizophr. Res. | pmid:17566707 |
Song Y et al. | Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor. | 2015 | Sci Rep | pmid:26541090 |
Krishnan G and Chatterjee N | Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. | 2015 | Sci Rep | pmid:25943894 |
Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
Derkinderen P et al. | Regulation of a neuronal form of focal adhesion kinase by anandamide. | 1996 | Science | pmid:8781236 |
Karsak M et al. | Attenuation of allergic contact dermatitis through the endocannabinoid system. | 2007 | Science | pmid:17556587 |
Barinaga M | Pot, heroin unlock new areas for neuroscience. | 1992 | Science | pmid:1335165 |
Devane WA et al. | Isolation and structure of a brain constituent that binds to the cannabinoid receptor. | 1992 | Science | pmid:1470919 |
Marx J | Drug development. Drugs inspired by a drug. | 2006 | Science | pmid:16424309 |
Oliver D et al. | Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. | 2004 | Science | pmid:15031437 |
Mechoulam R and Lichtman AH | Neuroscience. Stout guards of the central nervous system. | 2003 | Science | pmid:14526067 |
Marsicano G et al. | CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | 2003 | Science | pmid:14526074 |
Van Sickle MD et al. | Identification and functional characterization of brainstem cannabinoid CB2 receptors. | 2005 | Science | pmid:16224028 |
Beltramo M et al. | Functional role of high-affinity anandamide transport, as revealed by selective inhibition. | 1997 | Science | pmid:9262477 |
Ueda N and Tsuboi K | [Enzymes involved in the biosynthesis and degradation of anandamide]. | 2005 | Seikagaku | pmid:16440755 |
Ueda N | [Anandamide: an endogenous cannabinoid receptor agonist]. | 1995 | Seikagaku | pmid:7594870 |
Yan MS et al. | [Cannabinoids, cannabinoid receptor and immune response]. | 2000 | Sheng Li Ke Xue Jin Zhan | pmid:12545719 |
Zhang J et al. | Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. | 2013 | Sheng Li Xue Bao | pmid:23598867 |
Villanueva A et al. | Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. | 2009 | Shock | pmid:19295473 |
Motobe T et al. | Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. | 2004 | Shock | pmid:14676677 |
Murillo-Rodriguez E et al. | Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. | 2003 | Sleep | pmid:14746372 |
Huitron-Resendiz S et al. | Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. | 2004 | Sleep | pmid:15453543 |
Malvindi MA et al. | Rod-shaped nanocrystals elicit neuronal activity in vivo. | 2008 | Small | pmid:18844306 |
Bari M et al. | Characterization of the endocannabinoid system in mouse embryonic stem cells. | 2011 | Stem Cells Dev. | pmid:20446814 |
Plant LD et al. | Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. | 2002 | Stroke | pmid:12215606 |
Mishima K et al. | Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. | 2005 | Stroke | pmid:15845890 |
Schäbitz WR et al. | Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. | 2002 | Stroke | pmid:12154273 |
Oz M et al. | Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. | 2002 | Synapse | pmid:12325042 |
Morera-Herreras T et al. | Regulation of subthalamic neuron activity by endocannabinoids. | 2010 | Synapse | pmid:20336631 |
Ishiguro H et al. | Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. | 2011 | Synapse | pmid:20506567 |
Lee TT et al. | Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. | 2013 | Synapse | pmid:22987804 |
Hohmann AG and Herkenham M | Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study. | 2000 | Synapse | pmid:10842353 |
Ueda N and Yamamoto S | [Anandamide: a marijuana-like compound produced in animal tissues]. | 1995 | Tanpakushitsu Kakusan Koso | pmid:8532892 |
Kase Y et al. | Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. | 2008 | Ther Apher Dial | pmid:18937720 |
Krumbholz A et al. | Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. | 2013 | Ther Drug Monit | pmid:23942543 |
Maccarrone M | The blissful state of endothelium. | 2003 | Thromb. Haemost. | pmid:12719771 |
Yamaji K et al. | Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. | 2003 | Thromb. Haemost. | pmid:12719786 |
Maccarrone M et al. | Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. | 2006 | Thromb. Haemost. | pmid:16543970 |
Harada N et al. | Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. | 2006 | Thromb. Haemost. | pmid:16732381 |
Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
Matsuda K et al. | The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. | 2005 | Tohoku J. Exp. Med. | pmid:16141678 |
Kaplan BL et al. | Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15893538 |
Kondakala S et al. | Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29097212 |
Quistad GB et al. | Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11350214 |
Vilela LR et al. | Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25933444 |
Kodani SD et al. | Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. | 2016 | Toxicol. Lett. | pmid:27659731 |
Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
Carr RL et al. | Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. | 2013 | Toxicol. Sci. | pmid:23761300 |
Hsu SS et al. | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | 2007 | Toxicology | pmid:17222495 |
Bluett RJ et al. | Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. | 2014 | Transl Psychiatry | pmid:25004388 |
Leweke FM et al. | Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. | 2012 | Transl Psychiatry | pmid:22832859 |
Maccarrone M et al. | Intracellular trafficking of anandamide: new concepts for signaling. | 2010 | Trends Biochem. Sci. | pmid:20570522 |
Alhouayek M and Muccioli GG | The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. | 2012 | Trends Mol Med | pmid:22917662 |
Gaetani S et al. | Anandamide hydrolysis: a new target for anti-anxiety drugs? | 2003 | Trends Mol Med | pmid:14604824 |
Maccarrone M | Inhibition of anandamide hydrolysis: cells also know how to do it. | 2004 | Trends Mol Med | pmid:14720580 |
Mechoulam R et al. | Cannabinoids and brain injury: therapeutic implications. | 2002 | Trends Mol Med | pmid:11815270 |
Szallasi A and Di Marzo V | New perspectives on enigmatic vanilloid receptors. | 2000 | Trends Neurosci. | pmid:11006466 |
Devane WA | New dawn of cannabinoid pharmacology. | 1994 | Trends Pharmacol. Sci. | pmid:8165721 |
Fowler CJ | Anandamide uptake explained? | 2012 | Trends Pharmacol. Sci. | pmid:22297258 |
Di Marzo V and Maccarrone M | FAAH and anandamide: is 2-AG really the odd one out? | 2008 | Trends Pharmacol. Sci. | pmid:18394720 |
Szolcsányi J | Anandamide and the question of its functional role for activation of capsaicin receptors. | 2000 | Trends Pharmacol. Sci. | pmid:10838604 |
Piomelli D et al. | The endocannabinoid system as a target for therapeutic drugs. | 2000 | Trends Pharmacol. Sci. | pmid:10838609 |
Randall MD and Kendall DA | Endocannabinoids: a new class of vasoactive substances. | 1998 | Trends Pharmacol. Sci. | pmid:9550942 |