Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Derkinderen P et al. | Regulation of a neuronal form of focal adhesion kinase by anandamide. | 1996 | Science | pmid:8781236 |
Shimasue K et al. | Effects of anandamide and arachidonic acid on specific binding of (+) -PN200-110, diltiazem and (-) -desmethoxyverapamil to L-type Ca2+ channel. | 1996 | Eur. J. Pharmacol. | pmid:8904088 |
Sugiura T et al. | Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8573114 |
Jarho P et al. | Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide. | 1996 | Life Sci. | pmid:8602110 |
Skaper SD et al. | The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8633002 |
Shivachar AC et al. | Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride]. | 1996 | Biochem. Pharmacol. | pmid:8615904 |
Varga K et al. | Mechanism of the hypotensive action of anandamide in anesthetized rats. | 1996 | Hypertension | pmid:8843898 |
Poling JS et al. | Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels. | 1996 | Neuropharmacology | pmid:8938728 |
Di Marzo V et al. | Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8858137 |
Ishac EJ et al. | Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. | 1996 | Br. J. Pharmacol. | pmid:8864538 |
Fride E and Mechoulam R | Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. | 1996 | Brain Res. Dev. Brain Res. | pmid:8873985 |
Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
James JS | Marijuana and chocolate. | 1996 | AIDS Treat News | pmid:11363932 |
Thomas BF et al. | Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore. | 1996 | J. Med. Chem. | pmid:8558515 |
Boring DL et al. | Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931121 |
Berdyshev EV et al. | Anandamide--a new look on fatty acid ethanolamides. | 1996 | J Lipid Mediat Cell Signal | pmid:9029374 |
Randall MD et al. | An endogenous cannabinoid as an endothelium-derived vasorelaxant. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954092 |
Paria BC et al. | The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period. | 1996 | Mol. Reprod. Dev. | pmid:8914076 |
Khanolkar AD et al. | Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. | 1996 | J. Med. Chem. | pmid:8893848 |
Langstein J et al. | cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. | 1996 Jul-Aug | Res. Immunol. | pmid:8903105 |
Thomas EA et al. | Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. | 1997 | J. Neurosci. Res. | pmid:9452020 |
Hunter SA and Burstein SH | Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis. | 1997 | Life Sci. | pmid:9126878 |
Bisogno T et al. | The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9344854 |
Mechoulam R et al. | Anandamide may mediate sleep induction. | 1997 | Nature | pmid:9288961 |
Hansen HS et al. | Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons. | 1997 | J. Neurochem. | pmid:9231736 |
Castellano C et al. | The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors. | 1997 | Behav Pharmacol | pmid:9832956 |
Wiley JL et al. | Evaluation of cannabimimetic discriminative stimulus effects of anandamide and methylated fluoroanandamide in rhesus monkeys. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408225 |
Randall MD et al. | Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. | 1997 | Eur. J. Pharmacol. | pmid:9314035 |
Di Tomaso E et al. | Endogenous lipids that activate cannabinoid receptors. Formation and inactivation. | 1997 | Adv. Exp. Med. Biol. | pmid:9321973 |
White R and Hiley CR | A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. | 1997 | Br. J. Pharmacol. | pmid:9422801 |
Zygmunt PM et al. | Studies on the effects of anandamide in rat hepatic artery. | 1997 | Br. J. Pharmacol. | pmid:9422814 |
Jarrahian A and Hillard CJ | Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431821 |
Sasaki T and Chang MC | N-arachidonylethanolamine (anandamide) formation from N-arachidonylphosphatidylethanolamine in rat brain membranes. | 1997 | Life Sci. | pmid:9365227 |
Randall MD and Kendall DA | Involvement of a cannabinoid in endothelium-derived hyperpolarizing factor-mediated coronary vasorelaxation. | 1997 | Eur. J. Pharmacol. | pmid:9369375 |
Burkey TH et al. | Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain. | 1997 | Eur. J. Pharmacol. | pmid:9384246 |
Calignano A et al. | Potentiation of anandamide hypotension by the transport inhibitor, AM404. | 1997 | Eur. J. Pharmacol. | pmid:9389389 |
Bloom AS et al. | Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes. | 1997 | Neurochem. Res. | pmid:9131634 |
Deutsch DG and Makriyannis A | Inhibitors of anandamide breakdown. | 1997 | NIDA Res. Monogr. | pmid:9260184 |
Yu M et al. | Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. | 1997 | J. Biol. Chem. | pmid:9261124 |
Welch SP | Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. | 1997 | Drug Alcohol Depend | pmid:9179505 |
van der Stelt M et al. | Dioxygenation of N-linoleoyl amides by soybean lipoxygenase-1. | 1997 | FEBS Lett. | pmid:9271222 |
Stefano GB et al. | Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release. | 1997 | Brain Res. | pmid:9272829 |
Schmid PC et al. | Anandamide and other N-acylethanolamines in mouse peritoneal macrophages. | 1997 | Chem. Phys. Lipids | pmid:9275307 |
Seltzman HH et al. | Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide. | 1997 | J. Med. Chem. | pmid:9357529 |
Cadogan AK et al. | Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum. | 1997 | J. Neurochem. | pmid:9282935 |
Deutsch DG et al. | Production and physiological actions of anandamide in the vasculature of the rat kidney. | 1997 | J. Clin. Invest. | pmid:9294122 |
Kurahashi Y et al. | Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299394 |
Wenger T et al. | Arachidonyl ethanolamide (anandamide) activates the parvocellular part of hypothalamic paraventricular nucleus. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299434 |
Wenger T et al. | The effects of prenatally administered endogenous cannabinoid on rat offspring. | 1997 | Pharmacol. Biochem. Behav. | pmid:9300616 |
Hillard CJ et al. | Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. | 1997 | J. Neurochem. | pmid:9231721 |
Lake KD et al. | Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190833 |
Wenger T et al. | Effects of anandamide on gestation in pregnant rats. | 1997 | Life Sci. | pmid:9199480 |
Molina-Holgado F et al. | Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes. | 1997 | Neuroreport | pmid:9223079 |
Willoughby KA et al. | The biodisposition and metabolism of anandamide in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9223560 |
Beltramo M et al. | Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one. | 1997 | FEBS Lett. | pmid:9091314 |
Thumser AE et al. | A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis. | 1997 | Biochem. Pharmacol. | pmid:9065749 |
Ryan WJ et al. | Potent anandamide analogs: the effect of changing the length and branching of the end pentyl chain. | 1997 | J. Med. Chem. | pmid:9357528 |
Bisogno T et al. | Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells. | 1997 | Biochem. J. | pmid:9065792 |
De Petrocellis L et al. | Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070224 |
Deutsch DG et al. | Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070252 |
Lake KD et al. | Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats. | 1997 | Hypertension | pmid:9149688 |
Bisogno T et al. | Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus. | 1997 | Biochim. Biophys. Acta | pmid:9150253 |
Stefano GB et al. | Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release. | 1997 | Brain Res. | pmid:9125406 |
Mechoulam R | Todd's achievement. | 1997 | Nature | pmid:9126725 |
Koga D et al. | Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogs in rat brain and peripheral tissues. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9106024 |
Schmid PC et al. | Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9108127 |
Cadas H et al. | Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. | 1997 | J. Neurosci. | pmid:9006968 |
Sheskin T et al. | Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. | 1997 | J. Med. Chem. | pmid:9057852 |
Bisogno T et al. | Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. | 1997 | J. Biol. Chem. | pmid:9013571 |
Fowler CJ et al. | Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide. | 1997 | Pharmacol. Toxicol. | pmid:9060042 |
Salzet M et al. | Leech immunocytes contain proopiomelanocortin: nitric oxide mediates hemolymph proopiomelanocortin processing. | 1997 | J. Immunol. | pmid:9548480 |
Calignano A et al. | Inhibition of intestinal motility by anandamide, an endogenous cannabinoid. | 1997 | Eur. J. Pharmacol. | pmid:9537804 |
Pate DW et al. | Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits. | 1997 | Pharm. Res. | pmid:9453062 |
Hillard CJ and Campbell WB | Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid. | 1997 | J. Lipid Res. | pmid:9458263 |
Berdyshev EV et al. | Influence of fatty acid ethanolamides and delta9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells. | 1997 | Eur. J. Pharmacol. | pmid:9253958 |
Soderstrom K et al. | Discovery of novel cannabinoid receptor ligands from diverse marine organisms. | 1997 | Adv. Exp. Med. Biol. | pmid:9561107 |
Plane F et al. | Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. | 1997 | Br. J. Pharmacol. | pmid:9283682 |
Fowler CJ et al. | Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9353392 |
Stark S et al. | Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells. | 1997 | Cell. Mol. Neurobiol. | pmid:9353590 |
van der Stelt M et al. | The effect of hydroxylation of linoleoyl amides on their cannabinomimetic properties. | 1997 | FEBS Lett. | pmid:9357990 |
Beltramo M et al. | Functional role of high-affinity anandamide transport, as revealed by selective inhibition. | 1997 | Science | pmid:9262477 |
Valk P et al. | Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. | 1997 | Blood | pmid:9269762 |
Brodkin J and Moerschbaecher JM | SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9316868 |
Twitchell W et al. | Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. | 1997 | J. Neurophysiol. | pmid:9242259 |
Matsuda S et al. | Metabolism of anandamide, an endogenous cannabinoid receptor ligand, in porcine ocular tissues. | 1997 | Exp. Eye Res. | pmid:9245900 |
Fernández-Ruiz JJ et al. | Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. | 1997 | Biochem. Pharmacol. | pmid:9256167 |
Wagner JA et al. | Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. | 1997 | Nature | pmid:9394002 |
Burkey RT and Nation JR | (R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure. | 1997 | Exp Clin Psychopharmacol | pmid:9260067 |
Compton DR and Martin BR | The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9399986 |
Stella N et al. | A second endogenous cannabinoid that modulates long-term potentiation. | 1997 | Nature | pmid:9285589 |
Mikawa Y et al. | Ocular activity of topically administered anandamide in the rabbit. | 1997 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9304433 |
Bisogno T et al. | Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation. | 1998 | Eur. J. Biochem. | pmid:9688276 |
Fulton D and Quilley J | Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9732371 |
Welch SP et al. | Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9732392 |
Stefano GB et al. | Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues. | 1998 | Brain Res. | pmid:9630717 |
Qin C et al. | Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography. | 1998 | Anal. Biochem. | pmid:9683506 |
van Zadelhoff G et al. | With anandamide as substrate plant 5-lipoxygenases behave like 11-lipoxygenases. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9675081 |
Stein EA et al. | Selective effects of the endogenous cannabinoid arachidonylethanolamide (anandamide) on regional cerebral blood flow in the rat. | 1998 | Neuropsychopharmacology | pmid:9803424 |
Randall MD and Kendall DA | Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery. | 1998 | Eur. J. Pharmacol. | pmid:9617751 |
Qureshi J et al. | Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol. | 1998 | Mol. Cell. Biochem. | pmid:9562238 |