Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Starowicz K et al. | Biochemistry and pharmacology of endovanilloids. | 2007 | Pharmacol. Ther. | pmid:17349697 |
Burstein SH | The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential. | 1999 | Pharmacol. Ther. | pmid:10341359 |
Izzo AA and Sharkey KA | Cannabinoids and the gut: new developments and emerging concepts. | 2010 | Pharmacol. Ther. | pmid:20117132 |
Woodward DF et al. | The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products. | 2008 | Pharmacol. Ther. | pmid:18700152 |
Goutopoulos A and Makriyannis A | From cannabis to cannabinergics: new therapeutic opportunities. | 2002 | Pharmacol. Ther. | pmid:12182958 |
Hansen HS et al. | Putative neuroprotective actions of N-acyl-ethanolamines. | 2002 | Pharmacol. Ther. | pmid:12182959 |
Randall MD et al. | Cardiovascular effects of cannabinoids. | 2002 | Pharmacol. Ther. | pmid:12182966 |
Snider NT et al. | Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. | 2010 | Pharmacol. Rev. | pmid:20133390 |
Blankman JL and Cravatt BF | Chemical probes of endocannabinoid metabolism. | 2013 | Pharmacol. Rev. | pmid:23512546 |
Mulè F et al. | Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon. | 2007 | Pharmacol. Res. | pmid:17574859 |
Khasabova IA et al. | JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | 2014 | Pharmacol. Res. | pmid:25304184 |
Mulè F et al. | Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations. | 2007 | Pharmacol. Res. | pmid:17656103 |
Navarria A et al. | The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. | 2014 | Pharmacol. Res. | pmid:24861565 |
Kerr DM et al. | Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid. | 2016 | Pharmacol. Res. | pmid:27592249 |
Yousif MH and Oriowo MA | Inhibitory effects of cannabinoid receptor ligands on electrically-evoked responses in rat isolated tracheal ring segments. | 1999 | Pharmacol. Res. | pmid:10527656 |
Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
Guindon J et al. | Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | 2013 | Pharmacol. Res. | pmid:23127915 |
De Petrocellis L et al. | N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. | 2011 | Pharmacol. Res. | pmid:21215315 |
Stefano GB et al. | 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. | 2000 | Pharmacol. Res. | pmid:10987990 |
Malek N et al. | The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. | 2016 | Pharmacol. Res. | pmid:27326920 |
Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
Nicolussi S et al. | Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. | 2014 | Pharmacol. Res. | pmid:24412246 |
Maione S et al. | Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. | 2013 | Pharmacol. Res. | pmid:23911581 |
Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
Baranowska-Kuczko M et al. | Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. | 2012 | Pharmacol. Res. | pmid:22627170 |
Fowler CJ et al. | The endocannabinoid signaling system: pharmacological and therapeutic aspects. | 2005 | Pharmacol. Biochem. Behav. | pmid:15935456 |
Smith FL et al. | Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats. | 1998 | Pharmacol. Biochem. Behav. | pmid:9610941 |
Wiley JL | Cannabis: discrimination of "internal bliss"? | 1999 | Pharmacol. Biochem. Behav. | pmid:10515300 |
Romero J et al. | Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol. | 1995 | Pharmacol. Biochem. Behav. | pmid:7675852 |
Wiley JL and Burston JJ | Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats. | 2010 | Pharmacol. Biochem. Behav. | pmid:19941884 |
Herrera-SolÃs A et al. | Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. | 2010 | Pharmacol. Biochem. Behav. | pmid:20056119 |
Rawls SM et al. | Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats. | 2006 | Pharmacol. Biochem. Behav. | pmid:16647109 |
Crawley JN et al. | Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. | 1993 | Pharmacol. Biochem. Behav. | pmid:7906042 |
Wiley JL et al. | Evaluation of cannabimimetic discriminative stimulus effects of anandamide and methylated fluoroanandamide in rhesus monkeys. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408225 |
Wenger T et al. | The effects of prenatally administered endogenous cannabinoid on rat offspring. | 1997 | Pharmacol. Biochem. Behav. | pmid:9300616 |
Reyes-Cabello C et al. | Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration. | 2012 | Pharmacol. Biochem. Behav. | pmid:22133635 |
Tuboly G et al. | The antinociceptive interaction of anandamide and adenosine at the spinal level. | 2009 | Pharmacol. Biochem. Behav. | pmid:18760296 |
Sulcova E et al. | Biphasic effects of anandamide. | 1998 | Pharmacol. Biochem. Behav. | pmid:9476980 |
Sadhasivam S et al. | Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. | 2015 | Pharmacogenomics J. | pmid:25558980 |
Laine K et al. | Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits. | 2001 | Pharm. Res. | pmid:11451037 |
Pate DW et al. | Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits. | 1997 | Pharm. Res. | pmid:9453062 |
Krishtal O et al. | The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids. | 2006 | Pflugers Arch. | pmid:16741755 |
Kenessey I et al. | Revisiting CB1 receptor as drug target in human melanoma. | 2012 | Pathol. Oncol. Res. | pmid:22447182 |
Farquhar-Smith WP et al. | Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. | 2002 | Pain | pmid:12031775 |
Horvath G et al. | The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level. | 2008 | Pain | pmid:17533116 |
Lichtman AH et al. | Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. | 2004 | Pain | pmid:15157693 |
Guindon J et al. | Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. | 2006 | Pain | pmid:16480822 |
Jaggar SI et al. | The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. | 1998 | Pain | pmid:9696473 |
Butler RK et al. | Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates. | 2008 | Pain | pmid:19004548 |
Richardson JD et al. | Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. | 1998 | Pain | pmid:9539680 |
Jia J et al. | Anandamide protects HT22 cells exposed to hydrogen peroxide by inhibiting CB1 receptor-mediated type 2 NADPH oxidase. | 2014 | Oxid Med Cell Longev | pmid:25136404 |
Palkovits M | [The brain and the pain: neurotransmitters and neuronal pathways of pain perception and response]. | 2000 | Orv Hetil | pmid:11184247 |
Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
Ravi J et al. | FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway. | 2014 | Oncotarget | pmid:24811863 |
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
Tong S et al. | Diagnostic accuracy of maternal serum macrophage inhibitory cytokine-1 and pregnancy-associated plasma protein-A at 6-10 weeks of gestation to predict miscarriage. | 2012 | Obstet Gynecol | pmid:22525911 |
Haas MJ et al. | Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. | 2012 | Obesity (Silver Spring) | pmid:22016100 |
Gonthier MP et al. | Identification of endocannabinoids and related compounds in human fat cells. | 2007 | Obesity (Silver Spring) | pmid:17426318 |
Engeli S et al. | Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects. | 2014 | Obesity (Silver Spring) | pmid:24616451 |
Starowicz KM et al. | Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. | 2008 | Obesity (Silver Spring) | pmid:18239598 |
Karaliota S et al. | Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation. | 2009 | Obesity (Silver Spring) | pmid:19543211 |
Zelber-Sagi S et al. | Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. | 2017 | Obesity (Silver Spring) | pmid:27863097 |
Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
Engeli S et al. | Peripheral endocannabinoid system activity in patients treated with sibutramine. | 2008 | Obesity (Silver Spring) | pmid:18356837 |
Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. | 2012 | Obesity (Silver Spring) | pmid:22334255 |
Romero TR et al. | The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs. | 2011 | Nitric Oxide | pmid:21875681 |
Kamei J et al. | [Sensitization of cough sensitivity through activation of C-and/or Adelta fibers]. | 2008 | Nippon Yakurigaku Zasshi | pmid:18552444 |
Yamaguchi Y et al. | [Surgical stress]. | 2005 | Nihon Geka Gakkai Zasshi | pmid:16045189 |
Kudo R and Hatake K | [Effect of ethanol on anandamide-induced sensory nerve dependent vasorelaxation]. | 2006 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:17313058 |
Hayase T et al. | Protective effects of cannabinoid receptor ligands analogous to anandamide against cocaine toxicity. | 2001 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:11828716 |
Kudo R and Hatake K | [Effect of ethanol on anandamide-induced sensory nerve dependent vasorelaxation (the second report)]. | 2008 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:18646646 |
Deutsch DG and Makriyannis A | Inhibitors of anandamide breakdown. | 1997 | NIDA Res. Monogr. | pmid:9260184 |
Liu J and Pope C | The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. | 2015 | Neurotoxicology | pmid:25447325 |
Harvey BS et al. | Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. | 2012 | Neurotoxicology | pmid:22233683 |
Carr RL et al. | Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. | 2017 | Neurotoxicology | pmid:26642910 |
Carr RL et al. | Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition. | 2014 | Neurotoxicology | pmid:24373905 |
Gasperi V et al. | Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. | 2005 | Neurotoxicology | pmid:16154199 |
Smaga I et al. | Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures. | 2014 | Neurotox Res | pmid:24652522 |
Smaga I et al. | Changes in the Brain Endocannabinoid System in Rat Models of Depression. | 2017 | Neurotox Res | pmid:28247204 |
Doroshenko P and Renaud LP | Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons. | 2009 | Neuroscience | pmid:19135504 |
Mahmud A et al. | Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. | 2009 | Neuroscience | pmid:19463903 |
Dowie MJ et al. | Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | 2009 | Neuroscience | pmid:19524019 |
Straiker A and Mackie K | Cannabinoid signaling in inhibitory autaptic hippocampal neurons. | 2009 | Neuroscience | pmid:19501632 |
De Petrocellis L et al. | Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response. | 1999 | Neuroscience | pmid:10392859 |
Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
Tree K et al. | Anandamide centrally depresses the respiratory rhythm generator of neonatal mice. | 2010 | Neuroscience | pmid:20800658 |
Szoke E et al. | Neonatal anandamide treatment results in prolonged mitochondrial damage in the vanilloid receptor type 1-immunoreactive B-type neurons of the rat trigeminal ganglion. | 2002 | Neuroscience | pmid:12435419 |
Veeraraghavan P et al. | A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. | 2016 | Neuroscience | pmid:27450568 |
Palkovits M et al. | Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. | 2008 | Neuroscience | pmid:18343585 |
Yang W et al. | Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. | 2016 | Neuroscience | pmid:26621126 |
Schmidt W et al. | Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia. | 2012 | Neuroscience | pmid:23069763 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Palmer JA et al. | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. | 2008 | Neuroscience | pmid:18541380 |
Murillo-RodrÃguez E et al. | The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain. | 2008 | Neuroscience | pmid:18822353 |
Singh Tahim A et al. | Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. | 2005 | Neuroscience | pmid:16198486 |
Muthian S et al. | Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. | 2004 | Neuroscience | pmid:15541895 |
de Oliveira Alvares L et al. | Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. | 2008 | Neuroscience | pmid:18554811 |
Raffa RB et al. | Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice. | 1999 | Neurosci. Lett. | pmid:10218903 |
Németh J et al. | Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. | 2003 | Neurosci. Lett. | pmid:12499047 |