Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Sun X et al. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. 2016 J. Biol. Chem. pmid:26900150
Desarnaud F et al. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. 1995 J. Biol. Chem. pmid:7890734
Guo Y et al. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. 2005 J. Biol. Chem. pmid:15890658
Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. 1999 J. Biol. Chem. pmid:9915812
McFarland MJ et al. A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. 2004 J. Biol. Chem. pmid:15292270
Rueda D et al. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. 2002 J. Biol. Chem. pmid:12237305
Tian X et al. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. 2005 J. Biol. Chem. pmid:15964843
McAllister SD et al. Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. 2004 J. Biol. Chem. pmid:15326174
Jang Y et al. Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. 2012 J. Biol. Chem. pmid:22187434
Maccarrone M et al. Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. 2003 J. Biol. Chem. pmid:12799380
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Liu J et al. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. 2003 J. Biol. Chem. pmid:12949078
Pucci M et al. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. 2012 J. Biol. Chem. pmid:22431736
Simon GM and Cravatt BF Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. 2008 J. Biol. Chem. pmid:18227059
Paradisi A et al. Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. 2008 J. Biol. Chem. pmid:18165231
Kaczocha M et al. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. 2010 J. Biol. Chem. pmid:19926788
Jiang S et al. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. 2010 J. Biol. Chem. pmid:20826813
Silvestri C et al. Anandamide-derived prostamide F2α negatively regulates adipogenesis. 2013 J. Biol. Chem. pmid:23801328
Jin XH et al. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. 2007 J. Biol. Chem. pmid:17158102
Wang J et al. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. 2006 J. Biol. Chem. pmid:16527816
Siegmund SV et al. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. 2006 J. Biol. Chem. pmid:16418162
Kozak KR et al. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. 2002 J. Biol. Chem. pmid:12244105
Wei BQ et al. A second fatty acid amide hydrolase with variable distribution among placental mammals. 2006 J. Biol. Chem. pmid:17015445
Sugiura T et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. 2000 J. Biol. Chem. pmid:10617657
Ueda N et al. Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide. 1995 J. Biol. Chem. pmid:7559559
Deutsch DG et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. 2001 J. Biol. Chem. pmid:11118429
Walter L et al. Astrocytes in culture produce anandamide and other acylethanolamides. 2002 J. Biol. Chem. pmid:11916961
Matas D et al. Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. 2007 J. Biol. Chem. pmid:17227767
Huang SM et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. 2001 J. Biol. Chem. pmid:11518719
Yu M et al. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. 1997 J. Biol. Chem. pmid:9261124
De Petrocellis L et al. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. 2001 J. Biol. Chem. pmid:11278420
Olah Z et al. Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. 2001 J. Biol. Chem. pmid:11333266
Maccarrone M et al. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. 2000 J. Biol. Chem. pmid:10913156
Yu S et al. Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. 2014 J. Biol. Chem. pmid:24644281
Bisogno T et al. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. 1997 J. Biol. Chem. pmid:9013571
Brailoiu GC et al. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. 2011 J. Biol. Chem. pmid:21719698
Bari M et al. Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. 2005 J. Biol. Chem. pmid:15657045
Boldrup L et al. A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. 2004 J. Biochem. Biophys. Methods pmid:15262451
Sugiura T and Waku K Cannabinoid receptors and their endogenous ligands. 2002 J. Biochem. pmid:12097154
Oka S et al. Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. 2007 J. Biochem. pmid:17339228
Kishimoto S et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. 2004 J. Biochem. pmid:15115777
Wang J et al. Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. 2008 J. Biochem. pmid:18806270
Kobayashi Y et al. Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. 2001 J. Biochem. pmid:11328586
Li J et al. Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. 2004 J. Appl. Physiol. pmid:15220301
Roy A et al. Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat. 2012 J. Appl. Physiol. pmid:21903882
Lin YS et al. Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. 2009 J. Appl. Physiol. pmid:19131477
Artegoitia VM et al. Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. 2016 J. Anim. Sci. pmid:28046144
Koura Y et al. Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys. 2004 J. Am. Soc. Nephrol. pmid:15153559
Wagner JA et al. Endogenous cannabinoids mediate hypotension after experimental myocardial infarction. 2001 J. Am. Coll. Cardiol. pmid:11738314
Willibald J et al. Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells. 2012 J. Am. Chem. Soc. pmid:22812910
Kobayashi H et al. Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. 1999 J Toxicol Sci pmid:10073332
Canseco-Alba A and Rodríguez-Manzo G Anandamide transforms noncopulating rats into sexually active animals. 2013 J Sex Med pmid:22906359
Vural IM et al. Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: an in vitro study in rabbit corpus cavernosum. 2009 J Sex Med pmid:19175867
Li Q et al. Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart. 2013 J Physiol Sci pmid:23007622
Placzek EA et al. Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). 2010 J Pharm Biomed Anal pmid:20417049
Chen L et al. Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. 2009 J Pain pmid:19409856
Altinsoy A et al. A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. 2011 J Ocul Pharmacol Ther pmid:21848425
Mestre L et al. Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. 2011 J Neuroinflammation pmid:21851608
Rogers TJ The molecular basis for neuroimmune receptor signaling. 2012 J Neuroimmune Pharmacol pmid:22935971
Sharir H et al. The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. 2012 J Neuroimmune Pharmacol pmid:22454039
Carney ST et al. Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. 2009 J Neuroimmune Pharmacol pmid:19365734
Koethe D et al. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. 2009 J Neural Transm pmid:19137236
Kurtuncu M et al. Effects of cocaine in 5-lipoxygenase-deficient mice. 2008 J Neural Transm pmid:18327533
Hill MN et al. Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. 2008 J Neural Transm pmid:18974922
Latek D et al. Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR. 2011 J Mol Model pmid:21365223
Aberturas MR et al. Anandamide-loaded nanoparticles: preparation and characterization. 2011 J Microencapsul pmid:21425945
Sugiura T et al. N-arachidonoylethanolamine (anandamide), an endogenous cannabinoid receptor ligand, and related lipid molecules in the nervous tissues. 1996 J Lipid Mediat Cell Signal pmid:8906545
Ueda N et al. Enzymes for anandamide biosynthesis and metabolism. 1996 J Lipid Mediat Cell Signal pmid:8906546
Berdyshev EV et al. Anandamide--a new look on fatty acid ethanolamides. 1996 J Lipid Mediat Cell Signal pmid:9029374
Kurabayashi M et al. 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. 2005 Jan-Feb J Invest Surg pmid:15804949
Dux M et al. Endovanilloids are potential activators of the trigeminovascular nocisensor complex. 2016 J Headache Pain pmid:27189587
Greco R et al. Effects of anandamide in migraine: data from an animal model. 2011 J Headache Pain pmid:21331757
Camann DE et al. Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure. 2013 J Expo Sci Environ Epidemiol pmid:22805989
Fowler CJ et al. Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide. 2013 J Enzyme Inhib Med Chem pmid:22225576
Fowler CJ et al. Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. 2003 J Enzyme Inhib Med Chem pmid:12751821
Fowler CJ et al. Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin. 2003 J Enzyme Inhib Med Chem pmid:14506913
Miyashita K et al. Anandamide induces matrix metalloproteinase-2 production through cannabinoid-1 receptor and transient receptor potential vanilloid-1 in human dental pulp cells in culture. 2012 J Endod pmid:22595113
Stahl SM Getting stoned without inhaling: anandamide is the brain's natural marijuana. 1998 J Clin Psychiatry pmid:9862600
Joshi SR Endocannabinoid system--a novel target for cardiometabolic risk. 2007 J Assoc Physicians India pmid:17879500
Kohro S et al. Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. 2006 J Anesth pmid:16421670
Hashiguchi T et al. Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. 2008 J Anesth pmid:18685926
Stefano GB and Salamon EJ Nitric oxide and anandamide in OMT research. 2006 J Am Osteopath Assoc pmid:17122026
Degenhardt BF et al. Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. 2007 J Am Osteopath Assoc pmid:17908831
McPartland JM et al. Cannabimimetic effects of osteopathic manipulative treatment. 2005 J Am Osteopath Assoc pmid:16118355
Battista N et al. The endocannabinoid system in neurodegeneration. 2006 Sep-Dec Ital. J. Biochem. pmid:17274532
Laine K et al. Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12356827
Nucci C et al. Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17591864
Laine K et al. Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides. 2002 Invest. Ophthalmol. Vis. Sci. pmid:11818382
Njie YF et al. N-arachidonylethanolamide-induced increase in aqueous humor outflow facility. 2008 Invest. Ophthalmol. Vis. Sci. pmid:18539938
Romano MR and Lograno MD Evidence for the involvement of cannabinoid CB1 receptors in the bimatoprost-induced contractions on the human isolated ciliary muscle. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17652738
Cozzolino R et al. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. 2010 Invest New Drugs pmid:19189054
Astarita G et al. Targeted lipidomics as a tool to investigate endocannabinoid function. 2009 Int. Rev. Neurobiol. pmid:19607960
Patsos HA et al. The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. 2010 Int. J. Oncol. pmid:20514410
Lisboa SF et al. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. 2015 Int. J. Neuropsychopharmacol. pmid:25618404
Chauvet C et al. Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats. 2014 Int. J. Neuropsychopharmacol. pmid:25522382
Lisboa SF et al. Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning. 2010 Int. J. Neuropsychopharmacol. pmid:20587131
Giuliano M et al. Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. 2006 Int. J. Mol. Med. pmid:16596265
Tytgat J et al. Cannabinoid mimics in chocolate utilized as an argument in court. 2000 Int. J. Legal Med. pmid:10876983
Sun LJ et al. Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. 2014 Int. J. Infect. Dis. pmid:24704332
Stefano GB et al. Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications. 1998 Int. J. Cardiol. pmid:9687087