| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Coopman K et al. | Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. | 2007 | Int. Immunopharmacol. | pmid:17276894 |
| Ribeiro A et al. | Anandamide prior to sensitization increases cell-mediated immunity in mice. | 2010 | Int. Immunopharmacol. | pmid:20093200 |
| Murakami T et al. | Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice. | 2009 | Int. Immunol. | pmid:19556302 |
| Yoshihara S et al. | Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways. | 2005 | Int. Arch. Allergy Immunol. | pmid:16103691 |
| Gatta-Cherifi B et al. | Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. | 2012 | Int J Obes (Lond) | pmid:21844878 |
| Mechoulam R et al. | Endocannabinoids, feeding and suckling--from our perspective. | 2006 | Int J Obes (Lond) | pmid:16570101 |
| Matias I et al. | Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. | 2006 | Int J Obes (Lond) | pmid:16570107 |
| Touriño C et al. | FAAH deficiency promotes energy storage and enhances the motivation for food. | 2010 | Int J Obes (Lond) | pmid:20029375 |
| Côté M et al. | Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. | 2007 | Int J Obes (Lond) | pmid:17224929 |
| Patsenker E et al. | Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. | 2015 | Int J Mol Sci | pmid:25826533 |
| Martinez-Vargas M et al. | Does the neuroprotective role of anandamide display diurnal variations? | 2013 | Int J Mol Sci | pmid:24287910 |
| Sexton M et al. | Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters. | 2014 | Inflammopharmacology | pmid:25135301 |
| Neelands TR et al. | Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons. | 2008 | Inflamm. Res. | pmid:18777111 |
| Malfitano AM et al. | Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. | 2007 | Immunol. Lett. | pmid:17360047 |
| Szendrei K | [A novel analgesics made from Cannabis]. | 2004 | Ideggyogy Sz | pmid:15042867 |
| Li J et al. | Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. | 2003 | Hypertension | pmid:12623992 |
| Wagner JA et al. | Mesenteric vasodilation mediated by endothelial anandamide receptors. | 1999 | Hypertension | pmid:9931142 |
| Wang Y et al. | VR1-mediated depressor effects during high-salt intake: role of anandamide. | 2005 | Hypertension | pmid:16144988 |
| Varga K et al. | Mechanism of the hypotensive action of anandamide in anesthetized rats. | 1996 | Hypertension | pmid:8843898 |
| Pulgar VM et al. | Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. | 2014 | Hypertension | pmid:24935942 |
| Lake KD et al. | Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats. | 1997 | Hypertension | pmid:9149688 |
| Taylor AH et al. | The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy. | 2007 Sep-Oct | Hum. Reprod. Update | pmid:17584820 |
| Rapino C et al. | Endocannabinoids as biomarkers of human reproduction. | 2014 Jul-Aug | Hum. Reprod. Update | pmid:24516083 |
| Amoako AA et al. | Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. | 2013 | Hum. Reprod. | pmid:23697839 |
| El-Talatini MR et al. | Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation. | 2009 | Hum. Reprod. | pmid:19363040 |
| Turco MY et al. | High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. | 2008 | Hum. Reprod. | pmid:18614613 |
| Ziegler CG et al. | Expression and function of endocannabinoid receptors in the human adrenal cortex. | 2010 | Horm. Metab. Res. | pmid:19862666 |
| Taylor AH et al. | Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. | 2010 | Histochem. Cell Biol. | pmid:20369362 |
| Basavarajappa BS et al. | Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. | 2014 | Hippocampus | pmid:24648181 |
| Hill MN et al. | Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. | 2008 | Hippocampus | pmid:18058925 |
| Yang K et al. | Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. | 2014 | Hippocampus | pmid:25087967 |
| Edwards JG et al. | A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. | 2012 | Hippocampus | pmid:21069781 |
| Siegmund SV et al. | Anandamide induces necrosis in primary hepatic stellate cells. | 2005 | Hepatology | pmid:15841466 |
| Biswas KK et al. | Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. | 2003 | Hepatology | pmid:14578855 |
| Valk P et al. | Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2. | 2000 | Hematol. J. | pmid:11920199 |
| Myrdal SE and Steyger PS | TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. | 2005 | Hear. Res. | pmid:15925202 |
| Park SW et al. | Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. | 2015 | Head Neck | pmid:24797795 |
| Sagie S et al. | [Short-and long-term effects of cannabinoids on memory, cognition and mental illness]. | 2013 | Harefuah | pmid:24483000 |
| Ho WS and Hillard CJ | Modulators of endocannabinoid enzymic hydrolysis and membrane transport. | 2005 | Handb Exp Pharmacol | pmid:16596775 |
| Elphick MR and Egertová M | The phylogenetic distribution and evolutionary origins of endocannabinoid signalling. | 2005 | Handb Exp Pharmacol | pmid:16596778 |
| Cascio MG and Marini P | Biosynthesis and Fate of Endocannabinoids. | 2015 | Handb Exp Pharmacol | pmid:26408157 |
| Contassot E et al. | Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. | 2004 | Gynecol. Oncol. | pmid:15047233 |
| Lazzarin N et al. | Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. | 2004 | Gynecol. Endocrinol. | pmid:15293893 |
| Guagnini F et al. | Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. | 2006 | Gut | pmid:16423891 |
| Domenicali M et al. | Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. | 2005 | Gut | pmid:15753538 |
| Hong S et al. | Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. | 2009 | Gut | pmid:18936104 |
| Patsos HA et al. | The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. | 2005 | Gut | pmid:16099783 |
| Harada N and Okajima K | Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. | 2007 | Growth Horm. IGF Res. | pmid:17307377 |
| Vignali M et al. | The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. | 2009 | Glia | pmid:19031444 |
| Ortega-Gutiérrez S et al. | Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. | 2005 | Glia | pmid:15920730 |
| Correa F et al. | Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB. | 2010 | Glia | pmid:19565660 |
| Krishnan G and Chatterjee N | Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. | 2012 | Glia | pmid:22807196 |
| Hernangómez M et al. | CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. | 2012 | Glia | pmid:22653796 |
| Facchinetti F et al. | Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. | 2003 | Glia | pmid:12509806 |
| Mato S et al. | CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. | 2009 | Glia | pmid:18814177 |
| Pastuhov SI et al. | Endocannabinoid signaling regulates regenerative axon navigation in Caenorhabditis elegans via the GPCRs NPR-19 and NPR-32. | 2016 | Genes Cells | pmid:27193416 |
| Ohsaka Y and Nishino H | 3T3-L1 adipocytes possess anandamide- and epinephrine-responsive machinery for MDM2 distribution to the plasma membrane. | 2013 | Gen. Physiol. Biophys. | pmid:23682023 |
| Piccinetti CC et al. | Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. | 2010 | Gen. Comp. Endocrinol. | pmid:19800340 |
| Chianese R et al. | Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. | 2014 | Gen. Comp. Endocrinol. | pmid:24566122 |
| Chianese R et al. | Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. | 2011 | Gen. Comp. Endocrinol. | pmid:21802420 |
| Liu J et al. | Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. | 2012 | Gastroenterology | pmid:22307032 |
| Michalski CW et al. | Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. | 2007 | Gastroenterology | pmid:17484889 |
| Ros J et al. | Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. | 2002 | Gastroenterology | pmid:11781284 |
| Maeda N et al. | Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. | 2009 | Fundam Clin Pharmacol | pmid:19527302 |
| Fowler CJ | The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. | 2006 | Fundam Clin Pharmacol | pmid:17109648 |
| Smita K et al. | Anandamide: an update. | 2007 | Fundam Clin Pharmacol | pmid:17227440 |
| Bari M et al. | The manifold actions of endocannabinoids on female and male reproductive events. | 2011 | Front Biosci (Landmark Ed) | pmid:21196184 |
| Bilmin K et al. | Influence of serum and albumin on the in vitro anandamide cytotoxicity toward C6 glioma cells assessed by the MTT cell viability assay: implications for the methodology of the MTT tests. | 2013 | Folia Neuropathol | pmid:23553136 |
| Juan CC et al. | Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. | 2015 | Fertil. Steril. | pmid:25935491 |
| El-Talatini MR et al. | The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle. | 2010 | Fertil. Steril. | pmid:19200965 |
| Wartmann M et al. | The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide. | 1995 | FEBS Lett. | pmid:7867785 |
| Molina-Holgado F et al. | The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. | 1998 | FEBS Lett. | pmid:9738948 |
| Kiss Z | Anandamide stimulates phospholipase D activity in PC12 cells but not in NIH 3T3 fibroblasts. | 1999 | FEBS Lett. | pmid:10214947 |
| Maccarrone M et al. | Anandamide activates human platelets through a pathway independent of the arachidonate cascade. | 1999 | FEBS Lett. | pmid:10214961 |
| Murillo-RodrÃguez E et al. | Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. | 2006 | FEBS Lett. | pmid:16844117 |
| Ueda N et al. | An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. | 1999 | FEBS Lett. | pmid:10431820 |
| Migliarini B et al. | Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics. | 2006 | FEBS Lett. | pmid:16519888 |
| Felder CC et al. | Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. | 1996 | FEBS Lett. | pmid:8814296 |
| Maurelli S et al. | Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'. | 1995 | FEBS Lett. | pmid:8543025 |
| Karava V et al. | Anandamide amidohydrolase activity, released in the medium by Tetrahymena pyriformis. Identification and partial characterization. | 2001 | FEBS Lett. | pmid:11728445 |
| Schmid PC et al. | Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. | 1995 | FEBS Lett. | pmid:7498458 |
| Sarker KP et al. | Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. | 2000 | FEBS Lett. | pmid:10781801 |
| Braud S et al. | Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid. | 2000 | FEBS Lett. | pmid:10760504 |
| Zaccagnino P et al. | Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. | 2011 | FEBS Lett. | pmid:21187088 |
| Derocq JM et al. | The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. | 1998 | FEBS Lett. | pmid:9563506 |
| Murakami T et al. | Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. | 2007 | FEBS Lett. | pmid:17184778 |
| Flygare J et al. | Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. | 2005 | FEBS Lett. | pmid:16337199 |
| Nakajima Y et al. | Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. | 2006 | FEBS Lett. | pmid:16406050 |
| De Petrocellis L et al. | Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. | 2001 | FEBS Lett. | pmid:11602256 |
| van der Stelt M et al. | Dioxygenation of N-linoleoyl amides by soybean lipoxygenase-1. | 1997 | FEBS Lett. | pmid:9271222 |
| Maccarrone M et al. | Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors. | 2000 | FEBS Lett. | pmid:10692582 |
| Sarnataro D et al. | Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. | 2005 | FEBS Lett. | pmid:16263116 |
| De Petrocellis L et al. | Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. | 2000 | FEBS Lett. | pmid:11033355 |
| Wang Y et al. | Polymyxin B binds to anandamide and inhibits its cytotoxic effect. | 2000 | FEBS Lett. | pmid:10734225 |
| Appendino G et al. | First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. | 2006 | FEBS Lett. | pmid:16406364 |
| Di Marzo V et al. | Interactions between synthetic vanilloids and the endogenous cannabinoid system. | 1998 | FEBS Lett. | pmid:9801167 |
| Maccarrone M and Finazzi-Agró A | Platelet activation: a new vascular activity of anandamide. | 2000 | FEBS Lett. | pmid:11184253 |
| Giuffrida A and Piomelli D | Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma. | 1998 | FEBS Lett. | pmid:9498819 |
| Goparaju SK et al. | Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. | 1998 | FEBS Lett. | pmid:9475172 |
| Opitz CA et al. | Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. | 2007 | FEBS Lett. | pmid:17904123 |