| MeSH term | MeSH ID | Detail |
|---|---|---|
| Overweight | D050177 | 11 associated lipids |
| Headache Disorders, Secondary | D051271 | 1 associated lipids |
| Orthostatic Intolerance | D054971 | 1 associated lipids |
| Vascular System Injuries | D057772 | 2 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smart D et al. | 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. | 2002 | Br. J. Pharmacol. | pmid:12023948 |
| Ross RA | Anandamide and vanilloid TRPV1 receptors. | 2003 | Br. J. Pharmacol. | pmid:14517174 |
| Vandevoorde S and Fowler CJ | Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. | 2005 | Br. J. Pharmacol. | pmid:15895107 |
| Malinowska B et al. | Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? | 2012 | Br. J. Pharmacol. | pmid:22022923 |
| Mombouli JV et al. | Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. | 1999 | Br. J. Pharmacol. | pmid:10323591 |
| Hind WH et al. | Endocannabinoids modulate human blood-brain barrier permeability in vitro. | 2015 | Br. J. Pharmacol. | pmid:25651941 |
| Akerman S et al. | Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors. | 2004 | Br. J. Pharmacol. | pmid:15277315 |
| Thors L and Fowler CJ | Is there a temperature-dependent uptake of anandamide into cells? | 2006 | Br. J. Pharmacol. | pmid:16865094 |
| Van den Bossche I and Vanheel B | Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta. | 2000 | Br. J. Pharmacol. | pmid:10960073 |
| Al Kury LT et al. | Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes. | 2014 | Br. J. Pharmacol. | pmid:24758718 |
| Gardener MJ et al. | Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries. | 2004 | Br. J. Pharmacol. | pmid:15066906 |
| Chicca A et al. | The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. | 2012 | Br. J. Pharmacol. | pmid:22646533 |
| Brighton PJ et al. | Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. | 2011 | Br. J. Pharmacol. | pmid:21486283 |
| Gardiner SM et al. | Factors influencing the regional haemodynamic responses to methanandamide and anandamide in conscious rats. | 2009 | Br. J. Pharmacol. | pmid:19702785 |
| Pertwee RG et al. | Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide. | 1993 | Br. J. Pharmacol. | pmid:8306090 |
| Zakrzeska A et al. | A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. | 2010 | Br. J. Pharmacol. | pmid:20105178 |
| Ho WS and Randall MD | Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. | 2007 | Br. J. Pharmacol. | pmid:17245358 |
| Thors L et al. | Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. | 2010 | Br. J. Pharmacol. | pmid:20590565 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
| Rajesh M et al. | Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. | 2010 | Br. J. Pharmacol. | pmid:20590572 |
| Wheal AJ et al. | Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity. | 2010 | Br. J. Pharmacol. | pmid:20590573 |
| Gutierrez-Lopez MD et al. | Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. | 2010 | Br. J. Pharmacol. | pmid:20590579 |
| Smith PJ and McQueen DS | Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat. | 2001 | Br. J. Pharmacol. | pmid:11588121 |
| Randall MD | The cardiovascular actions of anandamide: more targets? | 2005 | Br. J. Pharmacol. | pmid:15834438 |
| Kwolek G et al. | Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats. | 2005 | Br. J. Pharmacol. | pmid:15834445 |
| Li Q et al. | Electrophysiological effects of anandamide on rat myocardium. | 2009 | Br. J. Pharmacol. | pmid:20050190 |
| Underdown NJ et al. | Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. | 2005 | Br. J. Pharmacol. | pmid:16158067 |
| Aquila S et al. | Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. | 2010 | Br. J. Pharmacol. | pmid:20067470 |
| Lever IJ and Malcangio M | CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord. | 2002 | Br. J. Pharmacol. | pmid:11786475 |
| Oliveira L et al. | Effects of some isoprostanes on the human umbilical artery in vitro. | 2000 | Br. J. Pharmacol. | pmid:10711349 |
| Steffens M et al. | Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex. | 2004 | Br. J. Pharmacol. | pmid:14993102 |
| Holt S et al. | Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen. | 2001 | Br. J. Pharmacol. | pmid:11399668 |
| Ho WS et al. | 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. | 2008 | Br. J. Pharmacol. | pmid:18695637 |
| Ghafouri N et al. | Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. | 2004 | Br. J. Pharmacol. | pmid:15492019 |
| Lee MG et al. | Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. | 2005 | Br. J. Pharmacol. | pmid:16056239 |
| Movahed P et al. | Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. | 2005 | Br. J. Pharmacol. | pmid:15997233 |
| Bittner S et al. | TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. | 2009 | Brain | pmid:19570851 |
| Centonze D et al. | The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. | 2007 | Brain | pmid:17626034 |
| Butti E et al. | Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. | 2012 | Brain | pmid:23008234 |
| Patel RR et al. | Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. | 2016 | Brain | pmid:27267376 |
| Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
| Rossi S et al. | Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:21473912 |
| Mecha M et al. | Endocannabinoids drive the acquisition of an alternative phenotype in microglia. | 2015 | Brain Behav. Immun. | pmid:26086345 |
| Correa F et al. | The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. | 2011 | Brain Behav. Immun. | pmid:21310228 |
| Marco EM et al. | Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. | 2009 | Brain Res. | pmid:19133243 |
| McGregor IS et al. | A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. | 1998 | Brain Res. | pmid:9748483 |
| Murillo-RodrÃguez E et al. | Anandamide modulates sleep and memory in rats. | 1998 | Brain Res. | pmid:9813364 |
| Christopoulos A and Wilson K | Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. | 2001 | Brain Res. | pmid:11578621 |
| González S et al. | Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. | 2002 | Brain Res. | pmid:12393235 |
| Yue HY et al. | AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. | 2004 | Brain Res. | pmid:15276889 |
| Borsani E et al. | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. | 2007 | Brain Res. | pmid:17459353 |
| Barros DM et al. | Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems. | 2004 | Brain Res. | pmid:15234253 |
| Patel NA et al. | Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. | 1998 | Brain Res. | pmid:9666136 |
| Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
| Prevot V et al. | Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation. | 1998 | Brain Res. | pmid:9593913 |
| Stefano GB et al. | Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues. | 1998 | Brain Res. | pmid:9630717 |
| Van der Kloot W | Anandamide, a naturally-occurring agonist of the cannabinoid receptor, blocks adenylate cyclase at the frog neuromuscular junction. | 1994 | Brain Res. | pmid:7953630 |
| Hohmann AG et al. | Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. | 1999 | Brain Res. | pmid:10082879 |
| Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
| Soni N et al. | Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal. | 2017 | Brain Res. | pmid:28404451 |
| Lara-Celador I et al. | Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. | 2012 | Brain Res. | pmid:22841538 |
| Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
| Fride E | Anandamides: tolerance and cross-tolerance to delta 9-tetrahydrocannabinol. | 1995 | Brain Res. | pmid:8593598 |
| Minowa S et al. | Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. | 2005 | Brain Res. | pmid:15781048 |
| de Lago E et al. | Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. | 2004 | Brain Res. | pmid:15064146 |
| Stefano GB et al. | Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release. | 1997 | Brain Res. | pmid:9272829 |
| Houser SJ et al. | Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide. | 2000 | Brain Res. | pmid:10700588 |
| Stefano GB et al. | Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release. | 1997 | Brain Res. | pmid:9125406 |
| Potenzieri C et al. | Excitation of cutaneous C nociceptors by intraplantar administration of anandamide. | 2009 | Brain Res. | pmid:19285051 |
| Kim HI et al. | Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. | 2005 | Brain Res. | pmid:16256960 |
| Romero J et al. | Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function. | 1995 | Brain Res. | pmid:8974649 |
| Chakrabarti A et al. | Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. | 1998 | Brain Res. Bull. | pmid:9434204 |
| Lin QS et al. | Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. | 2011 | Brain Res. Bull. | pmid:21801815 |
| Fride E and Mechoulam R | Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. | 1996 | Brain Res. Dev. Brain Res. | pmid:8873985 |
| Matias I et al. | Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis. | 2001 | Brain Res. Mol. Brain Res. | pmid:11245916 |
| Golech SA et al. | Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. | 2004 | Brain Res. Mol. Brain Res. | pmid:15548432 |
| Romero J et al. | Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. | 2002 | Brain Res. Mol. Brain Res. | pmid:12008024 |
| Yusifzade K et al. | The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig. | 2009 | Bratisl Lek Listy | pmid:19711821 |
| Fernandez-Solari J et al. | Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448903 |
| Ribeiro A et al. | Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448906 |
| Fogaça MV et al. | Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. | 2012 | Braz. J. Med. Biol. Res. | pmid:22392189 |
| Kukushkin ML et al. | Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. | 2006 | Bull. Exp. Biol. Med. | pmid:17369898 |
| Krylatov AV et al. | Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. | 2002 | Bull. Exp. Biol. Med. | pmid:12428277 |
| Andrianova EL et al. | In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. | 2011 | Bull. Exp. Biol. Med. | pmid:22442796 |
| Ugdyzhekova DS et al. | Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. | 2001 | Bull. Exp. Biol. Med. | pmid:11427912 |
| Vavilin VA et al. | Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis. | 2013 | Bull. Exp. Biol. Med. | pmid:24319743 |
| Vásquez C et al. | Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774849 |
| Joseph J et al. | Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. | 2004 | Cancer Immunol. Immunother. | pmid:15034673 |
| Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
| Hiley CR and Hoi PM | Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? | 2007 | Cardiovasc Drug Rev | pmid:17445087 |
| Mukhopadhyay S and Tulis DA | Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. | 2007 | Cardiovasc Hematol Agents Med Chem | pmid:17979695 |
| Wang Y and Wang DH | Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. | 2007 | Cardiovasc Hematol Disord Drug Targets | pmid:17346127 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. | 2010 | Cardiovasc. Res. | pmid:19942623 |
| Barana A et al. | Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. | 2010 | Cardiovasc. Res. | pmid:19689982 |
| Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
| Kvasnicka T | [Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. | 2005 | Cas. Lek. Cesk. | pmid:15807291 |
| Lozovaya N et al. | Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. | 2009 | Cell Calcium | pmid:19682741 |
| Tsumura M et al. | TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. | 2012 | Cell Calcium | pmid:22656960 |
| Juan-Picó P et al. | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. | 2006 | Cell Calcium | pmid:16321437 |
| Al Kury LT et al. | Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes. | 2014 | Cell Calcium | pmid:24472666 |