Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
De Petrocellis L et al. Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. 2007 Exp. Cell Res. pmid:17428469
Starowicz K et al. Biochemistry and pharmacology of endovanilloids. 2007 Pharmacol. Ther. pmid:17349697
Bátkai S et al. Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17557913
Williams J et al. Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. 2007 Anal. Chem. pmid:17600384
Esposito G et al. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. 2007 J. Pharmacol. Exp. Ther. pmid:17545311
Karanian DA et al. Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage. 2007 J. Pharmacol. Exp. Ther. pmid:17545313
Velenovská M and Fisar Z Effect of cannabinoids on platelet serotonin uptake. 2007 Addict Biol pmid:17508987
Brizzi A et al. Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17561406
Hill MN et al. Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity. 2007 J. Neurochem. pmid:17561935
Leweke FM et al. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. 2007 Schizophr. Res. pmid:17566707
Ali AB Presynaptic Inhibition of GABAA receptor-mediated unitary IPSPs by cannabinoid receptors at synapses between CCK-positive interneurons in rat hippocampus. 2007 J. Neurophysiol. pmid:17567776
Fischbach T et al. Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats. 2007 J. Neurophysiol. pmid:17581853
Saitoh C et al. The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder. 2007 Eur. J. Pharmacol. pmid:17586490
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Jia Y and Lee LY Role of TRPV receptors in respiratory diseases. 2007 Biochim. Biophys. Acta pmid:17346945
Solinas M et al. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. 2007 J. Pharmacol. Exp. Ther. pmid:17351107
Centonze D et al. The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. 2007 Brain pmid:17626034
Spivak CE et al. The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors. 2007 Mol. Pharmacol. pmid:17628012
Thors L et al. Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake. 2007 Br. J. Pharmacol. pmid:17676056
Oz M et al. The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes. 2007 J. Pharmacol. Exp. Ther. pmid:17682128
Mulè F et al. Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations. 2007 Pharmacol. Res. pmid:17656103
Iuvone T et al. Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro. 2007 J. Mol. Med. pmid:17639288
Eisenstein TK et al. Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. 2007 J. Neuroimmunol. pmid:17640739
Pakdeechote P et al. Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed. 2007 Br. J. Pharmacol. pmid:17641668
Tanaka M et al. The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis. 2007 J. Endotoxin Res. pmid:17621544
Després JP The endocannabinoid system: a new target for the regulation of energy balance and metabolism. 2007 Crit Pathw Cardiol pmid:17667864
Akerman S et al. Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. 2007 J. Pharmacol. Exp. Ther. pmid:17018694
Shimozawa N et al. Estrogen and isoflavone attenuate stress-induced gastric mucosal injury by inhibiting decreases in gastric tissue levels of CGRP in ovariectomized rats. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17023553
Varvel SA et al. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. 2007 Neuropsychopharmacology pmid:17047668
Sarchielli P et al. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. 2007 Neuropsychopharmacology pmid:17119542
Yang YY et al. Role of Ca2+-dependent potassium channels in in vitro anandamide-mediated mesenteric vasorelaxation in rats with biliary cirrhosis. 2007 Liver Int. pmid:17845532
Ghasemi M et al. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. 2007 BJU Int. pmid:17850365
Cisneros JA et al. Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. 2007 J. Med. Chem. pmid:17764163
Evans RM et al. Chronic exposure of sensory neurones to increased levels of nerve growth factor modulates CB1/TRPV1 receptor crosstalk. 2007 Br. J. Pharmacol. pmid:17700720
Wheal AJ et al. Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats. 2007 Br. J. Pharmacol. pmid:17700721
Matias I et al. Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells. 2007 Br. J. Pharmacol. pmid:17704823
Herradón E et al. Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. 2007 Br. J. Pharmacol. pmid:17704831
Smid SD et al. The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. 2007 Eur. J. Pharmacol. pmid:17706636
Hiley CR and Hoi PM Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? 2007 Cardiovasc Drug Rev pmid:17445087
Nucci C et al. Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17591864
Braida D et al. 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. 2007 Eur. J. Pharmacol. pmid:17116299
Castelli MP et al. Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2. 2007 Eur. J. Pharmacol. pmid:17644084
DeMorrow S et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. 2007 J. Biol. Chem. pmid:17329257
Ortar G et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. 2007 J. Med. Chem. pmid:18027904
Degenhardt BF et al. Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. 2007 J Am Osteopath Assoc pmid:17908831
Xu H et al. Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene. 2007 Am. J. Physiol. Renal Physiol. pmid:17913835
Athanasiou A et al. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. 2007 Biochem. Biophys. Res. Commun. pmid:17931597
Imming P Fatty pain cures. 2007 Chem. Biol. pmid:18096498
Morgese MG et al. Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors. 2007 Exp. Neurol. pmid:17900568
King AR et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. 2007 Chem. Biol. pmid:18096504
Hillard CJ et al. Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. 2007 J. Mol. Neurosci. pmid:17901541
Opitz CA et al. Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. 2007 FEBS Lett. pmid:17904123
Romano MR and Lograno MD Evidence for the involvement of cannabinoid CB1 receptors in the bimatoprost-induced contractions on the human isolated ciliary muscle. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17652738
Bentzen PJ and Lang F Effect of anandamide on erythrocyte survival. 2007 Cell. Physiol. Biochem. pmid:17975305
Mukhopadhyay S and Tulis DA Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. 2007 Cardiovasc Hematol Agents Med Chem pmid:17979695
Dainese E et al. Modulation of the endocannabinoid system by lipid rafts. 2007 Curr. Med. Chem. pmid:17979719
Kim SR et al. Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity. 2007 Mol. Neurobiol. pmid:17917113
Battista N et al. The endocannabinoid system in neurodegeneration. 2006 Sep-Dec Ital. J. Biochem. pmid:17274532
Lynch DL and Reggio PH Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. 2006 Jul-Aug J. Comput. Aided Mol. Des. pmid:17106765
Dickason-Chesterfield AK et al. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. 2006 Jul-Aug Cell. Mol. Neurobiol. pmid:16736384
Waku K [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. 2006 Yakugaku Zasshi pmid:16462096
Petersen G et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. 2006 Biochim. Biophys. Acta pmid:16478679
Guindon J et al. Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. 2006 Pain pmid:16480822
Busch L et al. Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16487271
Schelling G et al. Effects of general anesthesia on anandamide blood levels in humans. 2006 Anesthesiology pmid:16436846
Guindon J and Beaulieu P Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. 2006 Neuropharmacology pmid:16442133
Bermúdez-Siva FJ et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. 2006 Eur. J. Pharmacol. pmid:16423347
Guagnini F et al. Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. 2006 Gut pmid:16423891
Stefano GB and Salamon EJ Nitric oxide and anandamide in OMT research. 2006 J Am Osteopath Assoc pmid:17122026
Lambert RC et al. Modulation of neuronal T-type calcium channels. 2006 CNS Neurol Disord Drug Targets pmid:17168746
Fowler CJ The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. 2006 Fundam Clin Pharmacol pmid:17109648
Wagner JA et al. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. 2006 J. Cardiovasc. Pharmacol. pmid:16775503
Bonechi C et al. Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. 2006 Eur J Med Chem pmid:16837109
Costa B et al. AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. 2006 Br. J. Pharmacol. pmid:16770320
Felder CC et al. Cannabinoids biology: the search for new therapeutic targets. 2006 Mol. Interv. pmid:16809476
Yeh JH et al. Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16623868
Laviolette SR and Grace AA The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. 2006 Cell. Mol. Life Sci. pmid:16699809
Balas L et al. Synthesis of a potential photoactivatable anandamide analog. 2006 Bioorg. Med. Chem. Lett. pmid:16682198
Shouman B et al. Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. 2006 Br. J. Pharmacol. pmid:16682966
Zaniewska M et al. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. 2006 Eur. J. Pharmacol. pmid:16730696
Harada N et al. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. 2006 Thromb. Haemost. pmid:16732381
Li J and Wang DH Differential mechanisms mediating depressor and diuretic effects of anandamide. 2006 J. Hypertens. pmid:17053550
Krishtal O et al. The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids. 2006 Pflugers Arch. pmid:16741755
Wang Y et al. A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening. 2006 Anal. Biochem. pmid:16707086
Bai X et al. TASK channel expression in human placenta and cytotrophoblast cells. 2006 J. Soc. Gynecol. Investig. pmid:16378911
Hejazi N et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. 2006 Mol. Pharmacol. pmid:16332990
Bojesen IN and Hansen HS Effect of an unstirred layer on the membrane permeability of anandamide. 2006 J. Lipid Res. pmid:16365480
Dembiński A et al. Cannabinoids in acute gastric damage and pancreatitis. 2006 J. Physiol. Pharmacol. pmid:17218765
D'Argenio G et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. 2006 FASEB J. pmid:16403786
Nakajima Y et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. 2006 FEBS Lett. pmid:16406050
Suplita RL et al. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. 2006 Neuropharmacology pmid:16316669
Avelino A and Cruz F TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16721555
Murillo-Rodriguez E et al. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. 2006 Life Sci. pmid:16434061
Juan-Picó P et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. 2006 Cell Calcium pmid:16321437
Cannizzaro C et al. Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. 2006 Neurochem. Int. pmid:16325966
de Lago E et al. UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. 2006 Eur Neuropsychopharmacol pmid:16006105
Ligresti A et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. 2006 Br. J. Pharmacol. pmid:16284631
Bir LS and Ercan S Effects of intrathecal anandamide on somatosensory evoked responses in rats. 2006 Exp. Neurol. pmid:16289169
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Malfitano AM et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. 2006 J. Neuroimmunol. pmid:16239036