| MeSH term | MeSH ID | Detail |
|---|---|---|
| Overweight | D050177 | 11 associated lipids |
| Headache Disorders, Secondary | D051271 | 1 associated lipids |
| Orthostatic Intolerance | D054971 | 1 associated lipids |
| Vascular System Injuries | D057772 | 2 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smart D et al. | 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. | 2002 | Br. J. Pharmacol. | pmid:12023948 |
| Grainger J and Boachie-Ansah G | Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. | 2001 | Br. J. Pharmacol. | pmid:11682448 |
| Kirkham TC et al. | Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. | 2002 | Br. J. Pharmacol. | pmid:12055133 |
| Köfalvi A et al. | Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. | 2007 | Br. J. Pharmacol. | pmid:17435795 |
| Zoratti C et al. | Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. | 2003 | Br. J. Pharmacol. | pmid:14645143 |
| Taddei S | Evolving the concept of regulation of vascular tone in humans. | 2005 | Br. J. Pharmacol. | pmid:15997231 |
| Izzo AA et al. | Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. | 2012 | Br. J. Pharmacol. | pmid:22300105 |
| White R et al. | Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. | 2001 | Br. J. Pharmacol. | pmid:11606334 |
| Ameri A et al. | Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. | 1999 | Br. J. Pharmacol. | pmid:10372827 |
| Klegeris A et al. | Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | 2003 | Br. J. Pharmacol. | pmid:12813001 |
| Thors L et al. | The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. | 2007 | Br. J. Pharmacol. | pmid:17325653 |
| Fleming I et al. | Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists. | 1999 | Br. J. Pharmacol. | pmid:10193775 |
| Ruiz-Llorente L et al. | Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. | 2004 | Br. J. Pharmacol. | pmid:14718261 |
| Vandevoorde S et al. | Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. | 2007 | Br. J. Pharmacol. | pmid:17143303 |
| Izzo AA et al. | Effect of vanilloid drugs on gastrointestinal transit in mice. | 2001 | Br. J. Pharmacol. | pmid:11264233 |
| Gauldie SD et al. | Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. | 2001 | Br. J. Pharmacol. | pmid:11159713 |
| Stewart JL and McMahon LR | The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. | 2011 | Br. J. Pharmacol. | pmid:21449917 |
| Costa B et al. | AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. | 2006 | Br. J. Pharmacol. | pmid:16770320 |
| Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
| Shouman B et al. | Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. | 2006 | Br. J. Pharmacol. | pmid:16682966 |
| O'Sullivan SE et al. | The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. | 2005 | Br. J. Pharmacol. | pmid:15821751 |
| Kawahara H et al. | Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. | 2011 | Br. J. Pharmacol. | pmid:21175570 |
| De Petrocellis L et al. | Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. | 2011 | Br. J. Pharmacol. | pmid:21175579 |
| Stanford SJ et al. | Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. | 2001 | Br. J. Pharmacol. | pmid:11454655 |
| Mang CF et al. | Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. | 2001 | Br. J. Pharmacol. | pmid:11522608 |
| Jonsson KO et al. | Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. | 2001 | Br. J. Pharmacol. | pmid:11498512 |
| Craib SJ et al. | A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. | 2001 | Br. J. Pharmacol. | pmid:11522594 |
| Andrag E and Curtis MJ | Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids. | 2013 | Br. J. Pharmacol. | pmid:23713981 |
| Ford WR et al. | Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. | 2002 | Br. J. Pharmacol. | pmid:11877326 |
| Mair KM et al. | Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | 2010 | Br. J. Pharmacol. | pmid:20718749 |
| Jacobsson SO and Fowler CJ | Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. | 2001 | Br. J. Pharmacol. | pmid:11309246 |
| Spicuzza L et al. | Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves. | 2000 | Br. J. Pharmacol. | pmid:10928980 |
| Thors L et al. | Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. | 2008 | Br. J. Pharmacol. | pmid:18552875 |
| Ligresti A et al. | New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. | 2006 | Br. J. Pharmacol. | pmid:16284631 |
| Plane F et al. | Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. | 1997 | Br. J. Pharmacol. | pmid:9283682 |
| Soria-Gómez E et al. | Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. | 2007 | Br. J. Pharmacol. | pmid:17549045 |
| Bittner S et al. | TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. | 2009 | Brain | pmid:19570851 |
| Centonze D et al. | The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. | 2007 | Brain | pmid:17626034 |
| Butti E et al. | Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. | 2012 | Brain | pmid:23008234 |
| Patel RR et al. | Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. | 2016 | Brain | pmid:27267376 |
| Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
| Rossi S et al. | Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:21473912 |
| Mecha M et al. | Endocannabinoids drive the acquisition of an alternative phenotype in microglia. | 2015 | Brain Behav. Immun. | pmid:26086345 |
| Correa F et al. | The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. | 2011 | Brain Behav. Immun. | pmid:21310228 |
| Borsani E et al. | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. | 2007 | Brain Res. | pmid:17459353 |
| Patel NA et al. | Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. | 1998 | Brain Res. | pmid:9666136 |
| Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
| Minowa S et al. | Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. | 2005 | Brain Res. | pmid:15781048 |
| de Lago E et al. | Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. | 2004 | Brain Res. | pmid:15064146 |
| Houser SJ et al. | Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide. | 2000 | Brain Res. | pmid:10700588 |