Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Orthostatic Intolerance D054971 1 associated lipids
Schistosomiasis japonica D012554 3 associated lipids
Sleep Disorders, Intrinsic D020919 1 associated lipids
Headache Disorders, Secondary D051271 1 associated lipids
Acute Pain D059787 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Movsesyan VA et al. Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. 2004 Cell Death Differ. pmid:15375383
Maccarrone M and Finazzi-Agró A The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. 2003 Cell Death Differ. pmid:12934069
Overton HA et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. 2006 Cell Metab. pmid:16517404
Oddi S et al. Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes. 2005 Cell. Mol. Life Sci. pmid:15723173
Valenti M et al. Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. 2004 Cell. Mol. Life Sci. pmid:15095014
Hermann H et al. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. 2003 Cell. Mol. Life Sci. pmid:12737320
Oddi S et al. Evidence for the intracellular accumulation of anandamide in adiposomes. 2008 Cell. Mol. Life Sci. pmid:18213445
Catani MV et al. Anandamide extends platelets survival through CB(1)-dependent Akt signaling. 2010 Cell. Mol. Life Sci. pmid:19936621
Sarker KP and Maruyama I Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. 2003 Cell. Mol. Life Sci. pmid:12861385
Laviolette SR and Grace AA The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. 2006 Cell. Mol. Life Sci. pmid:16699809
van der Stelt M et al. Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. 2006 Cell. Mol. Life Sci. pmid:16732431
Gasperi V et al. Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. 2007 Cell. Mol. Life Sci. pmid:17187172
Dickason-Chesterfield AK et al. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. 2006 Jul-Aug Cell. Mol. Neurobiol. pmid:16736384
Stark S et al. Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells. 1997 Cell. Mol. Neurobiol. pmid:9353590
Bobbala D et al. Effect of anandamide in Plasmodium Berghei-infected mice. 2010 Cell. Physiol. Biochem. pmid:20798520
Jenkin KA et al. Role for cannabinoid receptors in human proximal tubular hypertrophy. 2010 Cell. Physiol. Biochem. pmid:21220919
Bentzen PJ and Lang F Effect of anandamide on erythrocyte survival. 2007 Cell. Physiol. Biochem. pmid:17975305
Fimiani C et al. Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release. 1999 Cell. Signal. pmid:10353693
Greco R et al. Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. 2010 Cephalalgia pmid:19515121
Cupini LM et al. Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. 2006 Cephalalgia pmid:16472333
Rubino T et al. Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. 2008 Cereb. Cortex pmid:17921459
Hanus LO Discovery and isolation of anandamide and other endocannabinoids. 2007 Chem. Biodivers. pmid:17712821
Okamoto Y et al. Biosynthetic pathways of the endocannabinoid anandamide. 2007 Chem. Biodivers. pmid:17712822
Lehtonen M et al. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. 2008 Chem. Biodivers. pmid:19035572
Oddi S et al. Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins. 2009 Chem. Biol. pmid:19481477
Ahn K et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. 2009 Chem. Biol. pmid:19389627
Godlewski G et al. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. 2010 Chem. Biol. pmid:21095576
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Blankman JL et al. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. 2007 Chem. Biol. pmid:18096503
Imming P Fatty pain cures. 2007 Chem. Biol. pmid:18096498
King AR et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. 2007 Chem. Biol. pmid:18096504
Schmid PC et al. Alternative pathways of anandamide biosynthesis in rat testes. 1998 Chem. Phys. Lipids pmid:9631536
Di Scala C et al. Ceramide binding to anandamide increases its half-life and potentiates its cytotoxicity in human neuroblastoma cells. 2017 Chem. Phys. Lipids pmid:28389107
Palmer SL et al. Cannabinergic ligands. 2002 Chem. Phys. Lipids pmid:12505686
Razdan RK and Mahadevan A Recent advances in the synthesis of endocannabinoid related ligands. 2002 Chem. Phys. Lipids pmid:12505687
Kunos G et al. The quest for a vascular endothelial cannabinoid receptor. 2002 Chem. Phys. Lipids pmid:12505689
Wiley JL and Martin BR Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. 2002 Chem. Phys. Lipids pmid:12505690
Schmid HH et al. Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges. 2002 Chem. Phys. Lipids pmid:12505695
Cravatt BF and Lichtman AH The enzymatic inactivation of the fatty acid amide class of signaling lipids. 2002 Chem. Phys. Lipids pmid:12505696
Paria BC et al. Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation. 2002 Chem. Phys. Lipids pmid:12505701
Sandberg A and Fowler CJ Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin. 2005 Chem. Phys. Lipids pmid:15784231
Kotsikorou E et al. Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55. 2011 Chem. Phys. Lipids pmid:21185816
Reggio PH and Traore H Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. 2000 Chem. Phys. Lipids pmid:11106780
Howlett AC and Mukhopadhyay S Cellular signal transduction by anandamide and 2-arachidonoylglycerol. 2000 Chem. Phys. Lipids pmid:11106782
Schmid HH Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? 2000 Chem. Phys. Lipids pmid:11106783
Hillard CJ and Jarrahian A The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. 2000 Chem. Phys. Lipids pmid:11106786
Kunos G et al. Endocannabinoids as cardiovascular modulators. 2000 Chem. Phys. Lipids pmid:11106789
Schmid PC et al. Anandamide and other N-acylethanolamines in mouse peritoneal macrophages. 1997 Chem. Phys. Lipids pmid:9275307
Schmid PC et al. A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. 2000 Chem. Phys. Lipids pmid:10669310
Xie S et al. Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. 2010 Chem. Res. Toxicol. pmid:21049984