Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Edgemond WS et al. | The binding of novel phenolic derivatives of anandamide to brain cannabinoid receptors. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784462 |
Mechoulam R | Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052029 |
Sugiura T et al. | Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052034 |
Fowler CJ and Jacobsson SO | Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052035 |
Deutsch DG et al. | The fatty acid amide hydrolase (FAAH). | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052036 |
Fride E | Endocannabinoids in the central nervous system--an overview. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052038 |
Pinto L et al. | Endocannabinoids and the gut. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052047 |
Högestätt ED and Zygmunt PM | Cardiovascular pharmacology of anandamide. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052048 |
Di Marzo V et al. | Anandamide receptors. | 2002 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12052051 |
Johnson DE et al. | Isolation, identification and synthesis of an endogenous arachidonic amide that inhibits calcium channel antagonist 1,4-dihydropyridine binding. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8341720 |
Di Marzo V and Fontana A | Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone'. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7675818 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Iannotti FA et al. | Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23830028 |
Johannesson M et al. | Cloning, purification and characterization of non-human primate 12/15-lipoxygenases. | 2010 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20106647 |
Boring DL et al. | Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931121 |
Chen P et al. | Metabolism of anandamide in cerebral microvascular endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165032 |
Wang J and Ueda N | Biology of endocannabinoid synthesis system. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19126434 |
Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Wang H et al. | Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259073 |
Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
Hillard CJ | Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785538 |
Burstein SH et al. | Oxidative metabolism of anandamide. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785540 |
Di Marzo V et al. | Cannabimimetic fatty acid derivatives in cancer and inflammation. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785541 |
Kunos G et al. | Cardiovascular effects of endocannabinoids--the plot thickens. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785543 |
McCue JM et al. | In vitro synthesis of arachidonoyl amino acids by cytochrome c. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19683594 |
Nicotra LL et al. | Prostaglandin ethanolamides attenuate damage in a human explant colitis model. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23380599 |
Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |
van der Stelt M and Di Marzo V | Anandamide as an intracellular messenger regulating ion channel activity. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099396 |
Mimeault M et al. | Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. | 2003 | Prostate | pmid:12746841 |
Basavarajappa BS | Critical enzymes involved in endocannabinoid metabolism. | 2007 | Protein Pept. Lett. | pmid:17346227 |
Heyman E et al. | Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | 2012 | Psychoneuroendocrinology | pmid:22029953 |
Hill MN et al. | Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. | 2009 | Psychoneuroendocrinology | pmid:19394765 |
Gray JM et al. | Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. | 2016 | Psychoneuroendocrinology | pmid:26821211 |
Marco EM et al. | Emotional, endocrine and brain anandamide response to social challenge in infant male rats. | 2013 | Psychoneuroendocrinology | pmid:23660109 |
Fride E and Mechoulam R | Developmental aspects of anandamide: ontogeny of response and prenatal exposure. | 1996 | Psychoneuroendocrinology | pmid:8774060 |
Kaufmann I et al. | Anandamide and neutrophil function in patients with fibromyalgia. | 2008 | Psychoneuroendocrinology | pmid:18395993 |
Hill MN et al. | Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. | 2013 | Psychoneuroendocrinology | pmid:24035186 |
Schindler CW et al. | Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. | 2016 | Psychopharmacology (Berl.) | pmid:26803499 |
Naidu PS et al. | Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. | 2007 | Psychopharmacology (Berl.) | pmid:17279376 |
Panlilio LV et al. | Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. | 2016 | Psychopharmacology (Berl.) | pmid:26558620 |
Fernandez-Espejo E and Galan-Rodriguez B | Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor. | 2004 | Psychopharmacology (Berl.) | pmid:15088080 |
Mallet PE and Beninger RJ | The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. | 1998 | Psychopharmacology (Berl.) | pmid:9862397 |
Cassano T et al. | Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. | 2011 | Psychopharmacology (Berl.) | pmid:21042794 |
Higgs S et al. | Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. | 2003 | Psychopharmacology (Berl.) | pmid:12447606 |
Cross-Mellor SK et al. | Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. | 2007 | Psychopharmacology (Berl.) | pmid:17111174 |
Morera-Herreras T et al. | Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats. | 2011 | Psychopharmacology (Berl.) | pmid:20959968 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Mangieri RA et al. | An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. | 2009 | Psychopharmacology (Berl.) | pmid:19343330 |
Panlilio LV et al. | Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. | 2009 | Psychopharmacology (Berl.) | pmid:19015836 |
Schacht JP et al. | Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. | 2009 | Psychopharmacology (Berl.) | pmid:19002671 |