Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Migraine Disorders D008881 11 associated lipids
Morphine Dependence D009021 9 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Muscle Spasticity D009128 5 associated lipids
Mycoses D009181 18 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms D009369 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Obesity D009765 29 associated lipids
Pain D010146 64 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Peptic Ulcer D010437 19 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Pregnancy, Ectopic D011271 5 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Schistosomiasis japonica D012554 3 associated lipids
Seizures D012640 87 associated lipids
Shock, Septic D012772 11 associated lipids
Sleep Deprivation D012892 5 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Stomach Ulcer D013276 75 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Urinary Incontinence D014549 4 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Ocular Hypotension D015814 2 associated lipids
Alveolar Bone Loss D016301 10 associated lipids
Cardiovirus Infections D018188 3 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Impotence, Vasculogenic D018783 4 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Sleep Apnea, Obstructive D020181 9 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Somatosensory Disorders D020886 1 associated lipids
Sleep Disorders, Intrinsic D020919 1 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Okine BN et al. Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. 2012 Br. J. Pharmacol. pmid:22595021
Grainger J and Boachie-Ansah G Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. 2001 Br. J. Pharmacol. pmid:11682448
Sun Y et al. Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. 2007 Br. J. Pharmacol. pmid:17906680
Ross RA et al. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. 2001 Br. J. Pharmacol. pmid:11159715
Köfalvi A et al. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. 2007 Br. J. Pharmacol. pmid:17435795
Roberts LA et al. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. 2002 Br. J. Pharmacol. pmid:12359623
White R et al. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. 2001 Br. J. Pharmacol. pmid:11606334
Tucker RC et al. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. 2001 Br. J. Pharmacol. pmid:11226144
Woodhams SG et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. 2012 Br. J. Pharmacol. pmid:22924700
Ghasemi M et al. Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. 2007 Br. J. Pharmacol. pmid:17486141
Fraga D et al. Endogenous cannabinoids induce fever through the activation of CB1 receptors. 2009 Br. J. Pharmacol. pmid:19681872
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Hillard CJ and Jarrahian A Cellular accumulation of anandamide: consensus and controversy. 2003 Br. J. Pharmacol. pmid:12970089
O'Sullivan SE et al. Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries. 2004 Br. J. Pharmacol. pmid:15148250
Randall MD et al. The complexities of the cardiovascular actions of cannabinoids. 2004 Br. J. Pharmacol. pmid:15131000
Di Marzo V et al. The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. 2008 Br. J. Pharmacol. pmid:18223666
De Petrocellis L et al. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. 2012 Br. J. Pharmacol. pmid:22861649
Wheal AJ et al. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. 2007 Br. J. Pharmacol. pmid:17245361
Gamaleddin I et al. The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. 2011 Br. J. Pharmacol. pmid:21501143
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Booker L et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. 2012 Br. J. Pharmacol. pmid:21506952
Jamshidi N and Taylor DA Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. 2001 Br. J. Pharmacol. pmid:11704633
Shouman B et al. Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. 2006 Br. J. Pharmacol. pmid:16682966
McHugh D et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. 2012 Br. J. Pharmacol. pmid:21595653
O'Sullivan SE et al. The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. 2005 Br. J. Pharmacol. pmid:15821751
Guindon J et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. 2011 Br. J. Pharmacol. pmid:21198549
Craib SJ et al. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. 2001 Br. J. Pharmacol. pmid:11522594
White R and Hiley CR A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. 1997 Br. J. Pharmacol. pmid:9422801
Zygmunt PM et al. Studies on the effects of anandamide in rat hepatic artery. 1997 Br. J. Pharmacol. pmid:9422814
Ford WR et al. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. 2002 Br. J. Pharmacol. pmid:11877326
Scherma M et al. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. 2012 Br. J. Pharmacol. pmid:21557729
Jacobsson SO and Fowler CJ Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. 2001 Br. J. Pharmacol. pmid:11309246
Maione S et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. 2008 Br. J. Pharmacol. pmid:18660824
Gardiner SM et al. Complex regional haemodynamic effects of anandamide in conscious rats. 2002 Br. J. Pharmacol. pmid:11959791
Jia Y et al. Anandamide induces cough in conscious guinea-pigs through VR1 receptors. 2002 Br. J. Pharmacol. pmid:12411414
Geraghty DP and Mazzone SB Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide. 2002 Br. J. Pharmacol. pmid:12411424
Bittner S et al. TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. 2009 Brain pmid:19570851
Centonze D et al. The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. 2007 Brain pmid:17626034
Butti E et al. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. 2012 Brain pmid:23008234
Patel RR et al. Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. 2016 Brain pmid:27267376
Doenni VM et al. Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. 2016 Brain Behav. Immun. pmid:27453335
Rossi S et al. Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. 2011 Brain Behav. Immun. pmid:21473912
Mecha M et al. Endocannabinoids drive the acquisition of an alternative phenotype in microglia. 2015 Brain Behav. Immun. pmid:26086345
Correa F et al. The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. 2011 Brain Behav. Immun. pmid:21310228
Marco EM et al. Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. 2009 Brain Res. pmid:19133243
McGregor IS et al. A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. 1998 Brain Res. pmid:9748483
Murillo-Rodríguez E et al. Anandamide modulates sleep and memory in rats. 1998 Brain Res. pmid:9813364
Christopoulos A and Wilson K Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. 2001 Brain Res. pmid:11578621
González S et al. Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. 2002 Brain Res. pmid:12393235
Yue HY et al. AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. 2004 Brain Res. pmid:15276889
Borsani E et al. AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. 2007 Brain Res. pmid:17459353
Barros DM et al. Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems. 2004 Brain Res. pmid:15234253
Patel NA et al. Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. 1998 Brain Res. pmid:9666136
Nicholson RA et al. Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. 2003 Brain Res. pmid:12834914
Prevot V et al. Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation. 1998 Brain Res. pmid:9593913
Stefano GB et al. Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues. 1998 Brain Res. pmid:9630717
Van der Kloot W Anandamide, a naturally-occurring agonist of the cannabinoid receptor, blocks adenylate cyclase at the frog neuromuscular junction. 1994 Brain Res. pmid:7953630
Hohmann AG et al. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. 1999 Brain Res. pmid:10082879
Lees G and Dougalis A Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. 2004 Brain Res. pmid:14715144
Soni N et al. Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal. 2017 Brain Res. pmid:28404451
Lara-Celador I et al. Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. 2012 Brain Res. pmid:22841538
Hoot MR et al. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. 2010 Brain Res. pmid:20380816
Fride E Anandamides: tolerance and cross-tolerance to delta 9-tetrahydrocannabinol. 1995 Brain Res. pmid:8593598
Minowa S et al. Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. 2005 Brain Res. pmid:15781048
de Lago E et al. Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. 2004 Brain Res. pmid:15064146
Stefano GB et al. Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release. 1997 Brain Res. pmid:9272829
Houser SJ et al. Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide. 2000 Brain Res. pmid:10700588
Stefano GB et al. Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release. 1997 Brain Res. pmid:9125406
Potenzieri C et al. Excitation of cutaneous C nociceptors by intraplantar administration of anandamide. 2009 Brain Res. pmid:19285051
Kim HI et al. Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. 2005 Brain Res. pmid:16256960
Romero J et al. Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function. 1995 Brain Res. pmid:8974649
Chakrabarti A et al. Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. 1998 Brain Res. Bull. pmid:9434204
Lin QS et al. Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. 2011 Brain Res. Bull. pmid:21801815
Fride E and Mechoulam R Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. 1996 Brain Res. Dev. Brain Res. pmid:8873985
Matias I et al. Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis. 2001 Brain Res. Mol. Brain Res. pmid:11245916
Golech SA et al. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. 2004 Brain Res. Mol. Brain Res. pmid:15548432
Romero J et al. Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. 2002 Brain Res. Mol. Brain Res. pmid:12008024
Yusifzade K et al. The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig. 2009 Bratisl Lek Listy pmid:19711821
Fernandez-Solari J et al. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. 2009 Braz. J. Med. Biol. Res. pmid:19448903
Ribeiro A et al. Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. 2009 Braz. J. Med. Biol. Res. pmid:19448906
Fogaça MV et al. Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. 2012 Braz. J. Med. Biol. Res. pmid:22392189
Kukushkin ML et al. Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. 2006 Bull. Exp. Biol. Med. pmid:17369898
Krylatov AV et al. Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. 2002 Bull. Exp. Biol. Med. pmid:12428277
Andrianova EL et al. In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. 2011 Bull. Exp. Biol. Med. pmid:22442796
Ugdyzhekova DS et al. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. 2001 Bull. Exp. Biol. Med. pmid:11427912
Vavilin VA et al. Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis. 2013 Bull. Exp. Biol. Med. pmid:24319743
Vásquez C et al. Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. 2003 Can. J. Physiol. Pharmacol. pmid:12774849
Joseph J et al. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. 2004 Cancer Immunol. Immunother. pmid:15034673
Blázquez C et al. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. 2004 Cancer Res. pmid:15313899
Hiley CR and Hoi PM Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? 2007 Cardiovasc Drug Rev pmid:17445087
Mukhopadhyay S and Tulis DA Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. 2007 Cardiovasc Hematol Agents Med Chem pmid:17979695
Wang Y and Wang DH Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. 2007 Cardiovasc Hematol Disord Drug Targets pmid:17346127
Mukhopadhyay P et al. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. 2010 Cardiovasc. Res. pmid:19942623
Barana A et al. Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. 2010 Cardiovasc. Res. pmid:19689982
Jiang LS et al. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. 2009 Cardiovasc. Res. pmid:19074161
Kvasnicka T [Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. 2005 Cas. Lek. Cesk. pmid:15807291
Lozovaya N et al. Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. 2009 Cell Calcium pmid:19682741
Tsumura M et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. 2012 Cell Calcium pmid:22656960
Juan-Picó P et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. 2006 Cell Calcium pmid:16321437
Al Kury LT et al. Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes. 2014 Cell Calcium pmid:24472666