Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Moloney GP et al. Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. 2008 Eur J Med Chem pmid:17582659
Moreira FA et al. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. 2008 Neuropharmacology pmid:17709120
Evans RM et al. Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. 2008 Br. J. Pharmacol. pmid:18376419
Di Marzo V and Maccarrone M FAAH and anandamide: is 2-AG really the odd one out? 2008 Trends Pharmacol. Sci. pmid:18394720
Kaufmann I et al. Anandamide and neutrophil function in patients with fibromyalgia. 2008 Psychoneuroendocrinology pmid:18395993
Yao F et al. Development of novel tail-modified anandamide analogs. 2008 Bioorg. Med. Chem. Lett. pmid:18723350
Dembiński A et al. Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. 2008 Eur. J. Pharmacol. pmid:18593574
Stark K et al. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. 2008 FEBS J. pmid:18549450
Kamei J et al. [Sensitization of cough sensitivity through activation of C-and/or Adelta fibers]. 2008 Nippon Yakurigaku Zasshi pmid:18552444
Thors L et al. Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. 2008 Br. J. Pharmacol. pmid:18552875
da Veiga MA et al. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. 2008 J. Endocrinol. pmid:18755884
DeMorrow S et al. Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18096608
Rubino T et al. Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. 2008 Cereb. Cortex pmid:17921459
Taylor AH et al. The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy. 2007 Sep-Oct Hum. Reprod. Update pmid:17584820
Sakamoto Y et al. Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. 2007 Sep-Oct ASAIO J. pmid:17885340
Oka S et al. Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. 2007 J. Biochem. pmid:17339228
D'Argenio G et al. Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. 2007 J. Mol. Med. pmid:17396241
Holt S et al. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. 2007 Eur. J. Pharmacol. pmid:17397826
Mahler SV et al. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. 2007 Neuropsychopharmacology pmid:17406653
Kopczyńska B The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats. 2007 Life Sci. pmid:17379256
Ferrer B et al. Regulation of brain anandamide by acute administration of ethanol. 2007 Biochem. J. pmid:17302558
Naidu PS et al. Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. 2007 Psychopharmacology (Berl.) pmid:17279376
Sun Y et al. Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. 2007 Br. J. Pharmacol. pmid:17906680
Rubio M et al. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. 2007 Neurosci. Lett. pmid:17574742
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. 2007 Br. J. Pharmacol. pmid:17876302
Lam PM et al. Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death. 2007 J. Neurochem. pmid:17442052
Mulè F et al. Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon. 2007 Pharmacol. Res. pmid:17574859
Richardson D et al. Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry. 2007 Anal. Biochem. pmid:17141174
Köfalvi A et al. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. 2007 Br. J. Pharmacol. pmid:17435795
Cavuoto P et al. Effects of cannabinoid receptors on skeletal muscle oxidative pathways. 2007 Mol. Cell. Endocrinol. pmid:17270342
Duarte CD et al. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17275312
Lam FF et al. Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. 2007 Life Sci. pmid:17275857
Sharkey KA et al. Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. 2007 Eur. J. Neurosci. pmid:17459108
Coopman K et al. Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. 2007 Int. Immunopharmacol. pmid:17276894
Shivachar AC Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes. 2007 Biochem. Pharmacol. pmid:17445778
Orliac ML et al. Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. 2007 Eur. J. Pharmacol. pmid:17482593
Michalski CW et al. Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. 2007 Gastroenterology pmid:17484889
Ghasemi M et al. Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. 2007 Br. J. Pharmacol. pmid:17486141
Borsani E et al. AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. 2007 Brain Res. pmid:17459353
Sit SY et al. Novel inhibitors of fatty acid amide hydrolase. 2007 Bioorg. Med. Chem. Lett. pmid:17459705
Lory P and Chemin J Towards the discovery of novel T-type calcium channel blockers. 2007 Expert Opin. Ther. Targets pmid:17465728
Ryan D et al. Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. 2007 Eur. J. Neurosci. pmid:17419758
Gonthier MP et al. Identification of endocannabinoids and related compounds in human fat cells. 2007 Obesity (Silver Spring) pmid:17426318
Raduner S et al. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. 2007 J. Nat. Prod. pmid:17497806
Wang Y and Wang DH Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. 2007 Cardiovasc Hematol Disord Drug Targets pmid:17346127
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Thors L et al. The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. 2007 Br. J. Pharmacol. pmid:17325653
Bátkai S et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. 2007 FASEB J. pmid:17327359
Cippitelli A et al. The anandamide transport inhibitor AM404 reduces ethanol self-administration. 2007 Eur. J. Neurosci. pmid:17650118
Wang H et al. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. 2007 Prostaglandins Other Lipid Mediat. pmid:17259073
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Lemak MS et al. Cannabinoid regulation in identified synapse of terrestrial snail. 2007 Eur. J. Neurosci. pmid:18028114
Béquet F et al. CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. 2007 Eur. J. Neurosci. pmid:18052990
Rettori V et al. Endocannabinoids in TNF-alpha and ethanol actions. 2007 Neuroimmunomodulation pmid:18073513
Chemin J et al. Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. 2007 J. Biol. Chem. pmid:17121818
Vandevoorde S et al. Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. 2007 Br. J. Pharmacol. pmid:17143303
Peroni RN et al. Participation of CGRP and prostanoids in the sex-linked differences of vascular anandamide effects in mesenteric beds of Sprague-Dawley rats. 2007 Eur. J. Pharmacol. pmid:17169358
Moreira FA et al. Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. 2007 Neuropharmacology pmid:17156799
Jin XH et al. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. 2007 J. Biol. Chem. pmid:17158102
Hanus LO Discovery and isolation of anandamide and other endocannabinoids. 2007 Chem. Biodivers. pmid:17712821
Okamoto Y et al. Biosynthetic pathways of the endocannabinoid anandamide. 2007 Chem. Biodivers. pmid:17712822
Rossi G et al. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. 2007 Endocrinology pmid:17110429
Yuece B et al. Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex. 2007 Neurogastroenterol. Motil. pmid:17727394
Cross-Mellor SK et al. Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. 2007 Psychopharmacology (Berl.) pmid:17111174
Ronco AM et al. Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid. 2007 Pharmacology pmid:17114903
Bourne C et al. Novel, potent THC/anandamide (hybrid) analogs. 2007 Bioorg. Med. Chem. pmid:17827022
Ho WS and Randall MD Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. 2007 Br. J. Pharmacol. pmid:17245358
Russo R et al. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. 2007 Eur. J. Pharmacol. pmid:17434479
Wheal AJ et al. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. 2007 Br. J. Pharmacol. pmid:17245361
Bátkai S et al. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17434980
Harada N and Okajima K Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. 2007 Growth Horm. IGF Res. pmid:17307377
Romero FA et al. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. 2007 J. Med. Chem. pmid:17279740
McCollum L et al. Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. 2007 J. Pharmacol. Exp. Ther. pmid:17379772
Wang Y et al. Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. 2007 J. Pharmacol. Exp. Ther. pmid:17308041
Snider NT et al. Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. 2007 J. Pharmacol. Exp. Ther. pmid:17272674
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Solinas M et al. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. 2007 J. Pharmacol. Exp. Ther. pmid:17210800
Murakami T et al. Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. 2007 FEBS Lett. pmid:17184778
Gasperi V et al. Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. 2007 Cell. Mol. Life Sci. pmid:17187172
Côté M et al. Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. 2007 Int J Obes (Lond) pmid:17224929
Smita K et al. Anandamide: an update. 2007 Fundam Clin Pharmacol pmid:17227440
Matas D et al. Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. 2007 J. Biol. Chem. pmid:17227767
Wise LE et al. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. 2007 Eur. J. Pharmacol. pmid:17217945
Hsu SS et al. Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. 2007 Toxicology pmid:17222495
Ade KK and Lovinger DM Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. 2007 J. Neurosci. pmid:17329438
Harada N and Okajima K Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats. 2007 Dig. Dis. Sci. pmid:17211693
Pisanti S et al. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. 2007 J. Cell. Physiol. pmid:17192847
Ekins S et al. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. 2007 Drug Metab. Dispos. pmid:17194716
Schreiber D et al. Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. 2007 Anal. Biochem. pmid:17196922
Kreutz S et al. Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. 2007 Exp. Neurol. pmid:17010339
Malfitano AM et al. Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. 2007 Immunol. Lett. pmid:17360047
Blankman JL et al. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. 2007 Chem. Biol. pmid:18096503
Stengel PW et al. Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs. 2007 Eur. J. Pharmacol. pmid:17166495
Joshi SR Endocannabinoid system--a novel target for cardiometabolic risk. 2007 J Assoc Physicians India pmid:17879500
Mitchell VA et al. Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17880375
Soria-Gómez E et al. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. 2007 Br. J. Pharmacol. pmid:17549045
Hornig B Endothelial vasodilatory cannabinoid receptor in the human pulmonary artery: a future option in the therapy of pulmonary hypertension? 2007 J. Hypertens. pmid:17921811
Kozłowska H et al. Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. 2007 J. Hypertens. pmid:17921818
Kracke GR et al. The cannabinoid receptor agonists, anandamide and WIN 55,212-2, do not directly affect mu opioid receptors expressed in Xenopus oocytes. 2007 Naunyn Schmiedebergs Arch. Pharmacol. pmid:17960365
Thomas KC et al. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. 2007 J. Pharmacol. Exp. Ther. pmid:17332266