| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oka S et al. | Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. | 2007 | J. Biochem. | pmid:17339228 |
| D'Argenio G et al. | Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. | 2007 | J. Mol. Med. | pmid:17396241 |
| Holt S et al. | Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. | 2007 | Eur. J. Pharmacol. | pmid:17397826 |
| Lam PM et al. | Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death. | 2007 | J. Neurochem. | pmid:17442052 |
| Richardson D et al. | Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry. | 2007 | Anal. Biochem. | pmid:17141174 |
| Köfalvi A et al. | Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. | 2007 | Br. J. Pharmacol. | pmid:17435795 |
| Cavuoto P et al. | Effects of cannabinoid receptors on skeletal muscle oxidative pathways. | 2007 | Mol. Cell. Endocrinol. | pmid:17270342 |
| Duarte CD et al. | Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. | 2007 | Bioorg. Med. Chem. | pmid:17275312 |
| Lam FF et al. | Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. | 2007 | Life Sci. | pmid:17275857 |
| Sharkey KA et al. | Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. | 2007 | Eur. J. Neurosci. | pmid:17459108 |
| Coopman K et al. | Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. | 2007 | Int. Immunopharmacol. | pmid:17276894 |
| Shivachar AC | Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes. | 2007 | Biochem. Pharmacol. | pmid:17445778 |
| Orliac ML et al. | Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. | 2007 | Eur. J. Pharmacol. | pmid:17482593 |
| Michalski CW et al. | Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. | 2007 | Gastroenterology | pmid:17484889 |
| Ghasemi M et al. | Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. | 2007 | Br. J. Pharmacol. | pmid:17486141 |
| Borsani E et al. | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. | 2007 | Brain Res. | pmid:17459353 |
| Thors L et al. | The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. | 2007 | Br. J. Pharmacol. | pmid:17325653 |
| Bátkai S et al. | Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. | 2007 | FASEB J. | pmid:17327359 |
| Cippitelli A et al. | The anandamide transport inhibitor AM404 reduces ethanol self-administration. | 2007 | Eur. J. Neurosci. | pmid:17650118 |
| Wang H et al. | Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259073 |
| Adermark L and Lovinger DM | Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077376 |
| Lemak MS et al. | Cannabinoid regulation in identified synapse of terrestrial snail. | 2007 | Eur. J. Neurosci. | pmid:18028114 |
| Béquet F et al. | CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. | 2007 | Eur. J. Neurosci. | pmid:18052990 |
| Chemin J et al. | Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. | 2007 | J. Biol. Chem. | pmid:17121818 |
| Vandevoorde S et al. | Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. | 2007 | Br. J. Pharmacol. | pmid:17143303 |
| Peroni RN et al. | Participation of CGRP and prostanoids in the sex-linked differences of vascular anandamide effects in mesenteric beds of Sprague-Dawley rats. | 2007 | Eur. J. Pharmacol. | pmid:17169358 |
| Moreira FA et al. | Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. | 2007 | Neuropharmacology | pmid:17156799 |
| Jin XH et al. | Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. | 2007 | J. Biol. Chem. | pmid:17158102 |
| Hanus LO | Discovery and isolation of anandamide and other endocannabinoids. | 2007 | Chem. Biodivers. | pmid:17712821 |
| Okamoto Y et al. | Biosynthetic pathways of the endocannabinoid anandamide. | 2007 | Chem. Biodivers. | pmid:17712822 |
| Rossi G et al. | Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. | 2007 | Endocrinology | pmid:17110429 |
| Yuece B et al. | Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex. | 2007 | Neurogastroenterol. Motil. | pmid:17727394 |
| Bourne C et al. | Novel, potent THC/anandamide (hybrid) analogs. | 2007 | Bioorg. Med. Chem. | pmid:17827022 |
| Russo R et al. | Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. | 2007 | Eur. J. Pharmacol. | pmid:17434479 |
| Bátkai S et al. | Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17434980 |
| Harada N and Okajima K | Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. | 2007 | Growth Horm. IGF Res. | pmid:17307377 |
| Romero FA et al. | Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17279740 |
| McCollum L et al. | Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17379772 |
| Wang Y et al. | Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17308041 |
| Murakami T et al. | Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. | 2007 | FEBS Lett. | pmid:17184778 |
| Gasperi V et al. | Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. | 2007 | Cell. Mol. Life Sci. | pmid:17187172 |
| Côté M et al. | Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. | 2007 | Int J Obes (Lond) | pmid:17224929 |
| Smita K et al. | Anandamide: an update. | 2007 | Fundam Clin Pharmacol | pmid:17227440 |
| Matas D et al. | Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. | 2007 | J. Biol. Chem. | pmid:17227767 |
| Wise LE et al. | Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. | 2007 | Eur. J. Pharmacol. | pmid:17217945 |
| Hsu SS et al. | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | 2007 | Toxicology | pmid:17222495 |
| Ade KK and Lovinger DM | Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. | 2007 | J. Neurosci. | pmid:17329438 |
| Harada N and Okajima K | Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats. | 2007 | Dig. Dis. Sci. | pmid:17211693 |
| Malfitano AM et al. | Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. | 2007 | Immunol. Lett. | pmid:17360047 |
| Blankman JL et al. | A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. | 2007 | Chem. Biol. | pmid:18096503 |
| Joshi SR | Endocannabinoid system--a novel target for cardiometabolic risk. | 2007 | J Assoc Physicians India | pmid:17879500 |
| Mitchell VA et al. | Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880375 |
| Soria-Gómez E et al. | Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. | 2007 | Br. J. Pharmacol. | pmid:17549045 |
| Hornig B | Endothelial vasodilatory cannabinoid receptor in the human pulmonary artery: a future option in the therapy of pulmonary hypertension? | 2007 | J. Hypertens. | pmid:17921811 |
| Kozłowska H et al. | Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. | 2007 | J. Hypertens. | pmid:17921818 |
| Kracke GR et al. | The cannabinoid receptor agonists, anandamide and WIN 55,212-2, do not directly affect mu opioid receptors expressed in Xenopus oocytes. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17960365 |
| Thomas KC et al. | Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17332266 |
| Battista N et al. | The endocannabinoid system in neurodegeneration. | 2006 Sep-Dec | Ital. J. Biochem. | pmid:17274532 |
| Lynch DL and Reggio PH | Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. | 2006 Jul-Aug | J. Comput. Aided Mol. Des. | pmid:17106765 |
| Dickason-Chesterfield AK et al. | Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. | 2006 Jul-Aug | Cell. Mol. Neurobiol. | pmid:16736384 |
| Kukushkin ML et al. | Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. | 2006 | Bull. Exp. Biol. Med. | pmid:17369898 |
| Szabo B et al. | Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. | 2006 | J. Physiol. (Lond.) | pmid:16973696 |
| Wiley JL et al. | Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. | 2006 | Life Sci. | pmid:16978656 |
| Thors L and Fowler CJ | Is there a temperature-dependent uptake of anandamide into cells? | 2006 | Br. J. Pharmacol. | pmid:16865094 |
| Nilsson O et al. | The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells. | 2006 | Eur. J. Pharmacol. | pmid:16928371 |
| Marx J | Drug development. Drugs inspired by a drug. | 2006 | Science | pmid:16424309 |
| Cupini LM et al. | Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. | 2006 | Cephalalgia | pmid:16472333 |
| GarcÃa Mdel C et al. | Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats. | 2006 | Eur. J. Pharmacol. | pmid:16472800 |
| Romano MR and Lograno MD | Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels. | 2006 | Br. J. Pharmacol. | pmid:16474412 |
| Tuccinardi T et al. | Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis. | 2006 | J. Med. Chem. | pmid:16451064 |
| Monterrubio S and Solowij N | Chronic stress and adaptation. | 2006 | Am J Psychiatry | pmid:16513893 |
| Bari M et al. | New insights into endocannabinoid degradation and its therapeutic potential. | 2006 | Mini Rev Med Chem | pmid:16515464 |
| Overton HA et al. | Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. | 2006 | Cell Metab. | pmid:16517404 |
| Matias I et al. | Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011761 |
| De Lago E et al. | Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. | 2006 | J. Neurochem. | pmid:16899063 |
| Laezza C et al. | Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. | 2006 | FEBS Lett. | pmid:17055492 |
| Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
| Migliarini B et al. | Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics. | 2006 | FEBS Lett. | pmid:16519888 |
| Wang J et al. | Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. | 2006 | J. Biol. Chem. | pmid:16527816 |
| Bortolato M et al. | Anxiolytic-like properties of the anandamide transport inhibitor AM404. | 2006 | Neuropsychopharmacology | pmid:16541083 |
| Maccarrone M et al. | Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. | 2006 | Thromb. Haemost. | pmid:16543970 |
| Siegmund SV et al. | Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. | 2006 | J. Biol. Chem. | pmid:16418162 |
| Salo OM et al. | 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data. | 2006 | J. Med. Chem. | pmid:16420041 |
| Kohro S et al. | Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. | 2006 | J Anesth | pmid:16421670 |
| Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
| Wei BQ et al. | A second fatty acid amide hydrolase with variable distribution among placental mammals. | 2006 | J. Biol. Chem. | pmid:17015445 |
| Rösch S et al. | R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16330497 |
| van der Stelt M et al. | Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. | 2006 | Cell. Mol. Life Sci. | pmid:16732431 |
| Sade H et al. | Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16107501 |
| Fisyunov A et al. | Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. | 2006 | J. Neurophysiol. | pmid:16738209 |
| Vogeser M et al. | Release of anandamide from blood cells. | 2006 | Clin. Chem. Lab. Med. | pmid:16599845 |
| Kopczyńska B and Szereda-Przestaszewska M | Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. | 2006 | Respir Physiol Neurobiol | pmid:16144778 |
| Wang H et al. | Fatty acid amide hydrolase deficiency limits early pregnancy events. | 2006 | J. Clin. Invest. | pmid:16886060 |
| Wiles AL et al. | N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. | 2006 | J. Neurochem. | pmid:16899062 |
| Lizanecz E et al. | Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1. | 2006 | Mol. Pharmacol. | pmid:16338989 |
| Moezi L et al. | Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. | 2006 | Br. J. Pharmacol. | pmid:17043671 |
| Grimaldi C et al. | Anandamide inhibits adhesion and migration of breast cancer cells. | 2006 | Exp. Cell Res. | pmid:16343481 |
| Eljaschewitsch E et al. | The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. | 2006 | Neuron | pmid:16387640 |
| Yang YY et al. | Roles of anandamide in the hepatic microcirculation in cirrhotic rats. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16407591 |
| Appendino G et al. | First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. | 2006 | FEBS Lett. | pmid:16406364 |