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The promise of advances in the field of endocannabinoids. |
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Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? |
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Metabolism of anandamide in cerebral microvascular endothelial cells. |
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Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. |
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Neuropharmacology |
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Proc. Natl. Acad. Sci. U.S.A. |
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Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. |
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Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. |
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Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. |
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A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. |
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AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. |
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Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors. |
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The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. |
2004 |
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A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. |
2004 |
J. Pharmacol. Exp. Ther. |
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Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors. |
2004 |
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A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. |
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Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. |
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Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. |
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A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats. |
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Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. |
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2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. |
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Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. |
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The anandamide membrane transporter. Structure-activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region. |
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Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. |
2004 |
Neuropsychopharmacology |
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Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. |
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Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. |
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[The endocannabinoid system and food intake control]. |
2004 Apr-Jun |
Rev Med Univ Navarra |
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Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. |
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Circulation |
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Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. |
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J. Neuropathol. Exp. Neurol. |
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Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. |
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Sleep |
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The endogenous cannabinoid system and the treatment of marijuana dependence. |
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Neuropharmacology |
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Effects of anandamide on the binding and signaling properties of M1 muscarinic acetylcholine receptors. |
2004 |
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The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. |
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Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase. |
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Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? |
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Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. |
2004 |
Neuroscience |
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Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. |
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Role of the endocannabinoid system in the development of tolerance to alcohol. |
2005 Jan-Feb |
Alcohol Alcohol. |
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The endocannabinoid system: physiology and pharmacology. |
2005 Jan-Feb |
Alcohol Alcohol. |
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Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. |
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Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. |
2005 |
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Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. |
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The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. |
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Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. |
2005 |
J. Pharmacol. Exp. Ther. |
pmid:15579492
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Braun M and Kietzmann M |
Ischaemia-reperfusion injury in the isolated haemoperfused bovine uterus: an in vitro model of acute inflammation. |
2004 |
Altern Lab Anim |
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Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. |
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AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. |
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J. Pharmacol. Exp. Ther. |
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Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes. |
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Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. |
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Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. |
2005 |
Eur. J. Pharmacol. |
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Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. |
2005 |
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Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. |
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Biochem. Pharmacol. |
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Reductions in levels of bacterial superantigens/cannabinoids by plasma exchange in a patient with severe toxic shock syndrome. |
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AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation. |
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Additive effects of endogenous cannabinoid anandamide and ethanol on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. |
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J. Pharmacol. Exp. Ther. |
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Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. |
2005 |
Br J Anaesth |
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Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes. |
2005 |
Cell. Mol. Life Sci. |
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Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice. |
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Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis. |
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Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. |
2005 |
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A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity. |
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Anal. Biochem. |
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Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. |
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Brain Res. |
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Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin. |
2005 |
Chem. Phys. Lipids |
pmid:15784231
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A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. |
2005 |
Biochem. Pharmacol. |
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Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. |
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Biochem. Pharmacol. |
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Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. |
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2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. |
2005 Jan-Feb |
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[Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. |
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Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. |
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Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. |
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Am. J. Physiol. Heart Circ. Physiol. |
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The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. |
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Br. J. Pharmacol. |
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Finding of endocannabinoids in human eye tissues: implications for glaucoma. |
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The cardiovascular actions of anandamide: more targets? |
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Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. |
2005 |
Neuropsychopharmacology |
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Anandamide induces necrosis in primary hepatic stellate cells. |
2005 |
Hepatology |
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Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. |
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Stroke |
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High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients. |
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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. |
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Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. |
2005 |
J. Psychopharmacol. (Oxford) |
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N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. |
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Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. |
2005 |
Toxicol. Appl. Pharmacol. |
pmid:15893538
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A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. |
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FASEB J. |
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Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. |
2005 |
Br. J. Pharmacol. |
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Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus. |
2005 |
Exp. Neurol. |
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