Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Parkinson Disease, Secondary D010302 17 associated lipids
Pain D010146 64 associated lipids
Obesity D009765 29 associated lipids
Neuroblastoma D009447 66 associated lipids
Neuralgia D009437 28 associated lipids
Nervous System Diseases D009422 37 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neoplasms D009369 13 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Mycoses D009181 18 associated lipids
Muscle Spasticity D009128 5 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Morphine Dependence D009021 9 associated lipids
Migraine Disorders D008881 11 associated lipids
Memory Disorders D008569 33 associated lipids
Melanoma D008545 69 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Learning Disorders D007859 11 associated lipids
Intestinal Pseudo-Obstruction D007418 5 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Kukushkin ML et al. Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. 2006 Bull. Exp. Biol. Med. pmid:17369898
Szabo B et al. Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. 2006 J. Physiol. (Lond.) pmid:16973696
Wiley JL et al. Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. 2006 Life Sci. pmid:16978656
Thors L and Fowler CJ Is there a temperature-dependent uptake of anandamide into cells? 2006 Br. J. Pharmacol. pmid:16865094
Kaczocha M et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. 2006 J. Biol. Chem. pmid:16461355
Waku K [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. 2006 Yakugaku Zasshi pmid:16462096
Petersen G et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. 2006 Biochim. Biophys. Acta pmid:16478679
Guindon J et al. Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. 2006 Pain pmid:16480822
Busch L et al. Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16487271
Schelling G et al. Effects of general anesthesia on anandamide blood levels in humans. 2006 Anesthesiology pmid:16436846
Guindon J and Beaulieu P Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. 2006 Neuropharmacology pmid:16442133
Bermúdez-Siva FJ et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. 2006 Eur. J. Pharmacol. pmid:16423347
Guagnini F et al. Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. 2006 Gut pmid:16423891
Meuth SG et al. The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. 2006 Mol. Pharmacol. pmid:16424077
Marx J Drug development. Drugs inspired by a drug. 2006 Science pmid:16424309
Cupini LM et al. Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. 2006 Cephalalgia pmid:16472333
García Mdel C et al. Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats. 2006 Eur. J. Pharmacol. pmid:16472800
Romano MR and Lograno MD Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels. 2006 Br. J. Pharmacol. pmid:16474412
Tuccinardi T et al. Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis. 2006 J. Med. Chem. pmid:16451064
Monterrubio S and Solowij N Chronic stress and adaptation. 2006 Am J Psychiatry pmid:16513893
Bari M et al. New insights into endocannabinoid degradation and its therapeutic potential. 2006 Mini Rev Med Chem pmid:16515464
Stefano GB and Salamon EJ Nitric oxide and anandamide in OMT research. 2006 J Am Osteopath Assoc pmid:17122026
Lambert RC et al. Modulation of neuronal T-type calcium channels. 2006 CNS Neurol Disord Drug Targets pmid:17168746
Fowler CJ The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. 2006 Fundam Clin Pharmacol pmid:17109648
De Lago E et al. Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. 2006 J. Neurochem. pmid:16899063
Laezza C et al. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. 2006 FEBS Lett. pmid:17055492
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Migliarini B et al. Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics. 2006 FEBS Lett. pmid:16519888
Wang J et al. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. 2006 J. Biol. Chem. pmid:16527816
Bortolato M et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. 2006 Neuropsychopharmacology pmid:16541083
Maccarrone M et al. Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. 2006 Thromb. Haemost. pmid:16543970
Varvel SA et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. 2006 J. Pharmacol. Exp. Ther. pmid:16352706
Wei BQ et al. A second fatty acid amide hydrolase with variable distribution among placental mammals. 2006 J. Biol. Chem. pmid:17015445
Wagner JA et al. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. 2006 J. Cardiovasc. Pharmacol. pmid:16775503
Bonechi C et al. Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. 2006 Eur J Med Chem pmid:16837109
Costa B et al. AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. 2006 Br. J. Pharmacol. pmid:16770320
Felder CC et al. Cannabinoids biology: the search for new therapeutic targets. 2006 Mol. Interv. pmid:16809476
Yeh JH et al. Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16623868
Laviolette SR and Grace AA The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. 2006 Cell. Mol. Life Sci. pmid:16699809
Balas L et al. Synthesis of a potential photoactivatable anandamide analog. 2006 Bioorg. Med. Chem. Lett. pmid:16682198
Shouman B et al. Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. 2006 Br. J. Pharmacol. pmid:16682966
Zaniewska M et al. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. 2006 Eur. J. Pharmacol. pmid:16730696
Harada N et al. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. 2006 Thromb. Haemost. pmid:16732381
van der Stelt M et al. Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. 2006 Cell. Mol. Life Sci. pmid:16732431
Fisyunov A et al. Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. 2006 J. Neurophysiol. pmid:16738209
Vogeser M et al. Release of anandamide from blood cells. 2006 Clin. Chem. Lab. Med. pmid:16599845
Kopczyńska B and Szereda-Przestaszewska M Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. 2006 Respir Physiol Neurobiol pmid:16144778
Li J and Wang DH Differential mechanisms mediating depressor and diuretic effects of anandamide. 2006 J. Hypertens. pmid:17053550
Krishtal O et al. The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids. 2006 Pflugers Arch. pmid:16741755
Wang Y et al. A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening. 2006 Anal. Biochem. pmid:16707086
Wiles AL et al. N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. 2006 J. Neurochem. pmid:16899062
Bai X et al. TASK channel expression in human placenta and cytotrophoblast cells. 2006 J. Soc. Gynecol. Investig. pmid:16378911
Hejazi N et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. 2006 Mol. Pharmacol. pmid:16332990
Bojesen IN and Hansen HS Effect of an unstirred layer on the membrane permeability of anandamide. 2006 J. Lipid Res. pmid:16365480
Dembiński A et al. Cannabinoids in acute gastric damage and pancreatitis. 2006 J. Physiol. Pharmacol. pmid:17218765
D'Argenio G et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. 2006 FASEB J. pmid:16403786
Nakajima Y et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. 2006 FEBS Lett. pmid:16406050
Suplita RL et al. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. 2006 Neuropharmacology pmid:16316669
Avelino A and Cruz F TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16721555
Murillo-Rodriguez E et al. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. 2006 Life Sci. pmid:16434061
Juan-Picó P et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. 2006 Cell Calcium pmid:16321437
Cannizzaro C et al. Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. 2006 Neurochem. Int. pmid:16325966
Lizanecz E et al. Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1. 2006 Mol. Pharmacol. pmid:16338989
Moezi L et al. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. 2006 Br. J. Pharmacol. pmid:17043671
Grimaldi C et al. Anandamide inhibits adhesion and migration of breast cancer cells. 2006 Exp. Cell Res. pmid:16343481
Eljaschewitsch E et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. 2006 Neuron pmid:16387640
de Lago E et al. UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. 2006 Eur Neuropsychopharmacol pmid:16006105
Ligresti A et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. 2006 Br. J. Pharmacol. pmid:16284631
Bir LS and Ercan S Effects of intrathecal anandamide on somatosensory evoked responses in rats. 2006 Exp. Neurol. pmid:16289169
Yang YY et al. Roles of anandamide in the hepatic microcirculation in cirrhotic rats. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16407591
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Glaser ST et al. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. 2006 J. Pharmacol. Exp. Ther. pmid:16278311
Appendino G et al. First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. 2006 FEBS Lett. pmid:16406364
Malfitano AM et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. 2006 J. Neuroimmunol. pmid:16239036
Glaser ST et al. Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. 2005 Nov-Dec Vis. Neurosci. pmid:16469181
Abalo R et al. Evaluation of the effect of age on cannabinoid receptor functionality and expression in guinea-pig ileum longitudinal muscle-myenteric plexus preparations. 2005 Jul 22-29 Neurosci. Lett. pmid:15936532
Kurabayashi M et al. 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. 2005 Jan-Feb J Invest Surg pmid:15804949
Basavarajappa BS and Hungund BL Role of the endocannabinoid system in the development of tolerance to alcohol. 2005 Jan-Feb Alcohol Alcohol. pmid:15550443
Rodríguez de Fonseca F et al. The endocannabinoid system: physiology and pharmacology. 2005 Jan-Feb Alcohol Alcohol. pmid:15550444
Hillard CJ and Jarrahian A Accumulation of anandamide: evidence for cellular diversity. 2005 Neuropharmacology pmid:15910883
Jia Y et al. TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence. 2005 Drug News Perspect. pmid:15915217
Ahern GP et al. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. 2005 J. Neurosci. pmid:15917451
Glass M et al. Misidentification of prostamides as prostaglandins. 2005 J. Lipid Res. pmid:15863842
Osei-Hyiaman D et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. 2005 J. Clin. Invest. pmid:15864349
Siegmund SV et al. Anandamide induces necrosis in primary hepatic stellate cells. 2005 Hepatology pmid:15841466
Gavva NR et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. 2005 J. Pharmacol. Exp. Ther. pmid:15615864
Sancho R et al. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. 2005 J. Immunol. pmid:16148147
Kraft B and Kress HG Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. 2005 J. Pharmacol. Exp. Ther. pmid:16055676
Poblete IM et al. Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. 2005 J. Physiol. (Lond.) pmid:16081483
Sun YX et al. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. 2005 Biochim. Biophys. Acta pmid:16154384
Domenicali M et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. 2005 Gut pmid:15753538
Barun S et al. Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16173925
Bazinet RP et al. Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. 2005 Neurochem. Res. pmid:16176062
Oz M et al. Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes. 2005 Arch. Biochem. Biophys. pmid:15639235
Straiker A and Mackie K Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. 2005 J. Physiol. (Lond.) pmid:16179366
Underdown NJ et al. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. 2005 Br. J. Pharmacol. pmid:16158067
Wang Y et al. VR1-mediated depressor effects during high-salt intake: role of anandamide. 2005 Hypertension pmid:16144988
Lee MG et al. Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. 2005 Br. J. Pharmacol. pmid:16056239
Movahed P et al. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. 2005 Br. J. Pharmacol. pmid:15997233
Movahed P et al. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. 2005 J. Biol. Chem. pmid:16081411