| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Gain | D015430 | 101 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Urinary Bladder Diseases | D001745 | 4 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Glass M et al. | Misidentification of prostamides as prostaglandins. | 2005 | J. Lipid Res. | pmid:15863842 |
| Newberry EP et al. | Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. | 2012 | J. Lipid Res. | pmid:22327204 |
| Ambrosi S et al. | On the importance of anandamide structural features for its interactions with DPPC bilayers: effects on PLA2 activity. | 2005 | J. Lipid Res. | pmid:15961786 |
| Bojesen IN and Hansen HS | Membrane transport of anandamide through resealed human red blood cell membranes. | 2005 | J. Lipid Res. | pmid:15930521 |
| Weber A et al. | Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729864 |
| Kantae V et al. | Quantitative profiling of endocannabinoids and related -acylethanolamines in human CSF using nano LC-MS/MS. | 2017 | J. Lipid Res. | pmid:27999147 |
| Long JZ et al. | An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase. | 2011 | J. Lipid Res. | pmid:21097653 |
| Oddi S et al. | Pitfalls and solutions in assaying anandamide transport in cells. | 2010 | J. Lipid Res. | pmid:20447929 |
| Fezza F et al. | Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation. | 2008 | J. Lipid Res. | pmid:18316795 |
| Jacome-Sosa M et al. | Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat. | 2016 | J. Lipid Res. | pmid:26891736 |
| Yang W et al. | Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. | 2005 | J. Lipid Res. | pmid:16150817 |
| Patel S et al. | The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. | 2005 | J. Lipid Res. | pmid:15576840 |
| Bojesen IN and Hansen HS | Effect of an unstirred layer on the membrane permeability of anandamide. | 2006 | J. Lipid Res. | pmid:16365480 |
| Clugston RD et al. | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | J. Lipid Res. | pmid:21856784 |
| Markey SP et al. | Base- and acid-catalyzed interconversions of O-acyl- and N-acyl-ethanolamines: a cautionary note for lipid analyses. | 2000 | J. Lipid Res. | pmid:10744787 |
| Hillard CJ and Campbell WB | Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid. | 1997 | J. Lipid Res. | pmid:9458263 |
| Astarita G et al. | Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. | 2008 | J. Lipid Res. | pmid:17957091 |
| De Petrocellis L et al. | Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide. | 2009 | J. Lipid Res. | pmid:19017617 |
| Turcotte C et al. | Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. | 2015 | J. Leukoc. Biol. | pmid:25877930 |
| Oka S et al. | 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. | 2004 | J. Leukoc. Biol. | pmid:15316028 |
| Jackson AR et al. | Characterization of endocannabinoid-mediated induction of myeloid-derived suppressor cells involving mast cells and MCP-1. | 2014 | J. Leukoc. Biol. | pmid:24319288 |
| Czifra G et al. | Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. | 2012 | J. Invest. Dermatol. | pmid:22513781 |
| Basta PV et al. | Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide. | 2004 | J. Immunol. Methods | pmid:14980433 |
| Sancho R et al. | Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. | 2005 | J. Immunol. | pmid:16148147 |
| Do Y et al. | Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. | 2004 | J. Immunol. | pmid:15294950 |
| Bari M et al. | Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. | 2006 | J. Immunol. | pmid:17015679 |
| Qi J et al. | Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. | 2011 | J. Immunol. | pmid:21515789 |
| Maccarrone M et al. | Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. | 2001 | J. Immunol. | pmid:11390466 |
| Salzet M et al. | Leech immunocytes contain proopiomelanocortin: nitric oxide mediates hemolymph proopiomelanocortin processing. | 1997 | J. Immunol. | pmid:9548480 |
| Chiurchiù V et al. | Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor-Mediated mTOR Inhibition in Human Keratinocytes. | 2016 | J. Immunol. | pmid:27694494 |
| Li D et al. | Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. | 2009 | J. Hypertens. | pmid:19462497 |
| Engeli S et al. | Circulating anandamide and blood pressure in patients with obstructive sleep apnea. | 2012 | J. Hypertens. | pmid:23032139 |
| Li J and Wang DH | Differential mechanisms mediating depressor and diuretic effects of anandamide. | 2006 | J. Hypertens. | pmid:17053550 |
| Hornig B | Endothelial vasodilatory cannabinoid receptor in the human pulmonary artery: a future option in the therapy of pulmonary hypertension? | 2007 | J. Hypertens. | pmid:17921811 |
| Kozłowska H et al. | Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. | 2007 | J. Hypertens. | pmid:17921818 |
| Liu H et al. | Endocannabinoids anandamide and its cannabinoid receptors in liver fibrosis after murine schistosomiasis. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19399401 |
| Gaskari SA et al. | Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. | 2015 | J. Hepatol. | pmid:25640062 |
| Yang YY et al. | Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids. | 2010 | J. Hepatol. | pmid:20626112 |
| Yang Q et al. | Anandamide induces cell death through lipid rafts in hepatic stellate cells. | 2010 | J. Gastroenterol. Hepatol. | pmid:20059638 |
| Tanaka M et al. | The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis. | 2007 | J. Endotoxin Res. | pmid:17621544 |
| da Veiga MA et al. | Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. | 2008 | J. Endocrinol. | pmid:18755884 |
| Lynch DL and Reggio PH | Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. | 2006 Jul-Aug | J. Comput. Aided Mol. Des. | pmid:17106765 |
| Egertová M et al. | Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. | 2008 | J. Comp. Neurol. | pmid:18067139 |
| Suárez J et al. | Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. | 2010 | J. Comp. Neurol. | pmid:20533360 |
| Osei-Hyiaman D et al. | Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. | 2005 | J. Clin. Invest. | pmid:15864349 |
| Schuel H | Tuning the oviduct to the anandamide tone. | 2006 | J. Clin. Invest. | pmid:16886056 |
| Wang H et al. | Fatty acid amide hydrolase deficiency limits early pregnancy events. | 2006 | J. Clin. Invest. | pmid:16886060 |
| Deutsch DG et al. | Production and physiological actions of anandamide in the vasculature of the rat kidney. | 1997 | J. Clin. Invest. | pmid:9294122 |
| Jiang W et al. | Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. | 2005 | J. Clin. Invest. | pmid:16224541 |
| Monteleone P et al. | Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22442280 |
| Gebeh AK et al. | Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22701012 |
| Gebeh AK et al. | Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity. | 2013 | J. Clin. Endocrinol. Metab. | pmid:23372171 |
| Jumpertz R et al. | Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21177788 |
| Rossato M et al. | Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15562018 |
| Habayeb OM et al. | Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? | 2004 | J. Clin. Endocrinol. Metab. | pmid:15531501 |
| Yagen B and Burstein S | Novel and sensitive method for the detection of anandamide by the use of its dansyl derivative. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10798298 |
| Koga D et al. | Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogs in rat brain and peripheral tissues. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9106024 |
| Kingsley PJ and Marnett LJ | Analysis of endocannabinoids, their congeners and COX-2 metabolites. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19505857 |
| Palandra J et al. | Endogenous ethanolamide analysis in human plasma using HPLC tandem MS with electrospray ionization. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19535304 |
| Obata T et al. | Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12829006 |
| Zoerner AA et al. | Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19414283 |
| Amoako AA et al. | Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21056015 |
| Zoerner AA et al. | Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21752730 |
| Cernak I et al. | The "dark side" of endocannabinoids: a neurotoxic role for anandamide. | 2004 | J. Cereb. Blood Flow Metab. | pmid:15129189 |
| Lin GC et al. | Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. | 2004 | J. Cell. Sci. | pmid:14762115 |
| Maccarrone M et al. | Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. | 2005 | J. Cell. Sci. | pmid:16144868 |
| Waldeck-Weiermair M et al. | Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. | 2008 | J. Cell. Sci. | pmid:18445684 |
| Aquila S et al. | A new role of anandamide in human sperm: focus on metabolism. | 2009 | J. Cell. Physiol. | pmid:19492411 |
| Proto MC et al. | Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. | 2012 | J. Cell. Physiol. | pmid:21412772 |
| Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
| Pisanti S et al. | Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. | 2007 | J. Cell. Physiol. | pmid:17192847 |
| Signorello MG et al. | The anandamide effect on NO/cGMP pathway in human platelets. | 2011 | J. Cell. Biochem. | pmid:21328466 |
| Chang YH et al. | Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. | 2001 | J. Cell. Biochem. | pmid:11329626 |
| Hydock DS et al. | Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. | 2009 | J. Cardiovasc. Pharmacol. Ther. | pmid:19129423 |
| Stefano GB et al. | Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9641464 |
| Stefano GB et al. | Long-term exposure of human blood vessels to HIV gp120, morphine, and anandamide increases endothelial adhesion of monocytes: uncoupling of nitric oxide release. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9641470 |
| Wagner JA et al. | 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16775503 |
| Hiley CR | Endocannabinoids and the heart. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19276990 |
| Wagner JA et al. | Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. | 2005 | J. Cardiovasc. Pharmacol. | pmid:16116341 |
| Tian X et al. | The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. | 2005 | J. Biol. Chem. | pmid:15964843 |
| Maccarrone M et al. | The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. | 2003 | J. Biol. Chem. | pmid:12815050 |
| Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
| Kaczocha M et al. | Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. | 2006 | J. Biol. Chem. | pmid:16461355 |
| Koutek B et al. | Inhibitors of arachidonoyl ethanolamide hydrolysis. | 1994 | J. Biol. Chem. | pmid:8083191 |
| Kruszka KK and Gross RW | The ATP- and CoA-independent synthesis of arachidonoylethanolamide. A novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptor. | 1994 | J. Biol. Chem. | pmid:8182035 |
| Chemin J et al. | Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. | 2007 | J. Biol. Chem. | pmid:17121818 |
| Silvestri C et al. | Anandamide-derived prostamide F2α negatively regulates adipogenesis. | 2013 | J. Biol. Chem. | pmid:23801328 |
| Jin XH et al. | Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. | 2007 | J. Biol. Chem. | pmid:17158102 |
| Maccarrone M et al. | Anandamide hydrolysis by human cells in culture and brain. | 1998 | J. Biol. Chem. | pmid:9822713 |
| Kozak KR et al. | Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. | 2002 | J. Biol. Chem. | pmid:12244105 |
| Kempe K et al. | Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue. | 1996 | J. Biol. Chem. | pmid:8663381 |
| Stefano GB et al. | Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes. | 1996 | J. Biol. Chem. | pmid:8702604 |
| Sugiura T et al. | Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. | 2000 | J. Biol. Chem. | pmid:10617657 |
| Deutsch DG et al. | The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. | 2001 | J. Biol. Chem. | pmid:11118429 |
| Matas D et al. | Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. | 2007 | J. Biol. Chem. | pmid:17227767 |
| DeMorrow S et al. | Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. | 2007 | J. Biol. Chem. | pmid:17329257 |
| De Petrocellis L et al. | The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. | 2001 | J. Biol. Chem. | pmid:11278420 |
| Manna JD et al. | Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. | 2014 | J. Biol. Chem. | pmid:25301951 |
| Chu CJ et al. | N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. | 2003 | J. Biol. Chem. | pmid:12569099 |
| Bari M et al. | Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. | 2005 | J. Biol. Chem. | pmid:15657045 |