Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Sun X et al. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. 2016 J. Biol. Chem. pmid:26900150
Desarnaud F et al. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. 1995 J. Biol. Chem. pmid:7890734
Guo Y et al. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. 2005 J. Biol. Chem. pmid:15890658
Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. 1999 J. Biol. Chem. pmid:9915812
McFarland MJ et al. A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. 2004 J. Biol. Chem. pmid:15292270
Rueda D et al. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. 2002 J. Biol. Chem. pmid:12237305
Tian X et al. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. 2005 J. Biol. Chem. pmid:15964843
McAllister SD et al. Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. 2004 J. Biol. Chem. pmid:15326174
Jang Y et al. Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. 2012 J. Biol. Chem. pmid:22187434
Maccarrone M et al. The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. 2003 J. Biol. Chem. pmid:12815050
Maccarrone M et al. Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. 2003 J. Biol. Chem. pmid:12799380
Kaczocha M et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. 2006 J. Biol. Chem. pmid:16461355
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Liu J et al. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. 2003 J. Biol. Chem. pmid:12949078
Pucci M et al. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. 2012 J. Biol. Chem. pmid:22431736
Ahern GP Activation of TRPV1 by the satiety factor oleoylethanolamide. 2003 J. Biol. Chem. pmid:12761211
Simon GM and Cravatt BF Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. 2008 J. Biol. Chem. pmid:18227059
Paradisi A et al. Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. 2008 J. Biol. Chem. pmid:18165231
Chemin J et al. Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. 2007 J. Biol. Chem. pmid:17121818
Jiang S et al. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. 2010 J. Biol. Chem. pmid:20826813
Silvestri C et al. Anandamide-derived prostamide F2α negatively regulates adipogenesis. 2013 J. Biol. Chem. pmid:23801328
Jin XH et al. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. 2007 J. Biol. Chem. pmid:17158102
Maccarrone M et al. Anandamide hydrolysis by human cells in culture and brain. 1998 J. Biol. Chem. pmid:9822713
Wang J et al. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. 2006 J. Biol. Chem. pmid:16527816
Kozak KR et al. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. 2002 J. Biol. Chem. pmid:12244105
Wei BQ et al. A second fatty acid amide hydrolase with variable distribution among placental mammals. 2006 J. Biol. Chem. pmid:17015445
Sugiura T et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. 2000 J. Biol. Chem. pmid:10617657
Ueda N et al. Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide. 1995 J. Biol. Chem. pmid:7559559
Deutsch DG et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. 2001 J. Biol. Chem. pmid:11118429
Walter L et al. Astrocytes in culture produce anandamide and other acylethanolamides. 2002 J. Biol. Chem. pmid:11916961
Matas D et al. Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. 2007 J. Biol. Chem. pmid:17227767
Huang SM et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. 2001 J. Biol. Chem. pmid:11518719
DeMorrow S et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. 2007 J. Biol. Chem. pmid:17329257
Yu M et al. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. 1997 J. Biol. Chem. pmid:9261124
De Petrocellis L et al. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. 2001 J. Biol. Chem. pmid:11278420
Olah Z et al. Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. 2001 J. Biol. Chem. pmid:11333266
Maccarrone M et al. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. 2000 J. Biol. Chem. pmid:10913156
Yu S et al. Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. 2014 J. Biol. Chem. pmid:24644281
Bisogno T et al. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. 1997 J. Biol. Chem. pmid:9013571
Brailoiu GC et al. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. 2011 J. Biol. Chem. pmid:21719698
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951
Chu CJ et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. 2003 J. Biol. Chem. pmid:12569099
Bari M et al. Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. 2005 J. Biol. Chem. pmid:15657045
Stefano GB et al. Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. 1998 J. Cardiovasc. Pharmacol. pmid:9641464
Stefano GB et al. Long-term exposure of human blood vessels to HIV gp120, morphine, and anandamide increases endothelial adhesion of monocytes: uncoupling of nitric oxide release. 1998 J. Cardiovasc. Pharmacol. pmid:9641470
Wagner JA et al. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. 2006 J. Cardiovasc. Pharmacol. pmid:16775503
Hiley CR Endocannabinoids and the heart. 2009 J. Cardiovasc. Pharmacol. pmid:19276990
Wagner JA et al. Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. 2005 J. Cardiovasc. Pharmacol. pmid:16116341
Hydock DS et al. Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. 2009 J. Cardiovasc. Pharmacol. Ther. pmid:19129423
Signorello MG et al. The anandamide effect on NO/cGMP pathway in human platelets. 2011 J. Cell. Biochem. pmid:21328466
Chang YH et al. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. 2001 J. Cell. Biochem. pmid:11329626
Aquila S et al. A new role of anandamide in human sperm: focus on metabolism. 2009 J. Cell. Physiol. pmid:19492411
Proto MC et al. Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. 2012 J. Cell. Physiol. pmid:21412772
Pisanti S et al. Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. 2015 J. Cell. Physiol. pmid:25684344
Pisanti S et al. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. 2007 J. Cell. Physiol. pmid:17192847
Lin GC et al. Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. 2004 J. Cell. Sci. pmid:14762115
Maccarrone M et al. Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. 2005 J. Cell. Sci. pmid:16144868
Waldeck-Weiermair M et al. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. 2008 J. Cell. Sci. pmid:18445684
Cernak I et al. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. 2004 J. Cereb. Blood Flow Metab. pmid:15129189
Kingsley PJ and Marnett LJ Analysis of endocannabinoids, their congeners and COX-2 metabolites. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19505857
Palandra J et al. Endogenous ethanolamide analysis in human plasma using HPLC tandem MS with electrospray ionization. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19535304
Obata T et al. Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. 2003 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12829006
Zoerner AA et al. Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19414283
Amoako AA et al. Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21056015
Zoerner AA et al. Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21752730
Yagen B and Burstein S Novel and sensitive method for the detection of anandamide by the use of its dansyl derivative. 2000 J. Chromatogr. B Biomed. Sci. Appl. pmid:10798298
Koga D et al. Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogs in rat brain and peripheral tissues. 1997 J. Chromatogr. B Biomed. Sci. Appl. pmid:9106024
Monteleone P et al. Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. 2012 J. Clin. Endocrinol. Metab. pmid:22442280
Gebeh AK et al. Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. 2012 J. Clin. Endocrinol. Metab. pmid:22701012
Gebeh AK et al. Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity. 2013 J. Clin. Endocrinol. Metab. pmid:23372171
Jumpertz R et al. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. 2011 J. Clin. Endocrinol. Metab. pmid:21177788
Rossato M et al. Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. 2005 J. Clin. Endocrinol. Metab. pmid:15562018
Habayeb OM et al. Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? 2004 J. Clin. Endocrinol. Metab. pmid:15531501
Osei-Hyiaman D et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. 2005 J. Clin. Invest. pmid:15864349
Schuel H Tuning the oviduct to the anandamide tone. 2006 J. Clin. Invest. pmid:16886056
Wang H et al. Fatty acid amide hydrolase deficiency limits early pregnancy events. 2006 J. Clin. Invest. pmid:16886060
Deutsch DG et al. Production and physiological actions of anandamide in the vasculature of the rat kidney. 1997 J. Clin. Invest. pmid:9294122
Jiang W et al. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. 2005 J. Clin. Invest. pmid:16224541
Egertová M et al. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. 2008 J. Comp. Neurol. pmid:18067139
Suárez J et al. Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. 2010 J. Comp. Neurol. pmid:20533360
Lynch DL and Reggio PH Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. 2006 Jul-Aug J. Comput. Aided Mol. Des. pmid:17106765
da Veiga MA et al. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. 2008 J. Endocrinol. pmid:18755884
Tanaka M et al. The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis. 2007 J. Endotoxin Res. pmid:17621544
Yang Q et al. Anandamide induces cell death through lipid rafts in hepatic stellate cells. 2010 J. Gastroenterol. Hepatol. pmid:20059638
Gaskari SA et al. Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. 2015 J. Hepatol. pmid:25640062
Yang YY et al. Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids. 2010 J. Hepatol. pmid:20626112
Liu H et al. Endocannabinoids anandamide and its cannabinoid receptors in liver fibrosis after murine schistosomiasis. 2009 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:19399401
Li D et al. Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. 2009 J. Hypertens. pmid:19462497
Engeli S et al. Circulating anandamide and blood pressure in patients with obstructive sleep apnea. 2012 J. Hypertens. pmid:23032139
Li J and Wang DH Differential mechanisms mediating depressor and diuretic effects of anandamide. 2006 J. Hypertens. pmid:17053550
Hornig B Endothelial vasodilatory cannabinoid receptor in the human pulmonary artery: a future option in the therapy of pulmonary hypertension? 2007 J. Hypertens. pmid:17921811
Kozłowska H et al. Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. 2007 J. Hypertens. pmid:17921818
Sancho R et al. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. 2005 J. Immunol. pmid:16148147
Do Y et al. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. 2004 J. Immunol. pmid:15294950
Bari M et al. Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. 2006 J. Immunol. pmid:17015679
Qi J et al. Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. 2011 J. Immunol. pmid:21515789
Maccarrone M et al. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. 2001 J. Immunol. pmid:11390466
Salzet M et al. Leech immunocytes contain proopiomelanocortin: nitric oxide mediates hemolymph proopiomelanocortin processing. 1997 J. Immunol. pmid:9548480
Chiurchiù V et al. Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor-Mediated mTOR Inhibition in Human Keratinocytes. 2016 J. Immunol. pmid:27694494
Basta PV et al. Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide. 2004 J. Immunol. Methods pmid:14980433