Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

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What functions are associated with Anandamide?


Related references are published most in these journals:

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What lipids are associated with Anandamide?

Related references are published most in these journals:

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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Romano MR and Lograno MD Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels. 2006 Br. J. Pharmacol. pmid:16474412
García Mdel C et al. Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats. 2006 Eur. J. Pharmacol. pmid:16472800
Cupini LM et al. Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. 2006 Cephalalgia pmid:16472333
Glaser ST et al. Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. 2005 Nov-Dec Vis. Neurosci. pmid:16469181
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Waku K [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. 2006 Yakugaku Zasshi pmid:16462096
Kaczocha M et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. 2006 J. Biol. Chem. pmid:16461355
Tuccinardi T et al. Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis. 2006 J. Med. Chem. pmid:16451064
Guindon J and Beaulieu P Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. 2006 Neuropharmacology pmid:16442133
Ueda N and Tsuboi K [Enzymes involved in the biosynthesis and degradation of anandamide]. 2005 Seikagaku pmid:16440755
Schelling G et al. Effects of general anesthesia on anandamide blood levels in humans. 2006 Anesthesiology pmid:16436846
Murillo-Rodriguez E et al. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. 2006 Life Sci. pmid:16434061
Marx J Drug development. Drugs inspired by a drug. 2006 Science pmid:16424309
Meuth SG et al. The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. 2006 Mol. Pharmacol. pmid:16424077
Guagnini F et al. Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. 2006 Gut pmid:16423891
Bermúdez-Siva FJ et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. 2006 Eur. J. Pharmacol. pmid:16423347
Kohro S et al. Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. 2006 J Anesth pmid:16421670
Salo OM et al. 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data. 2006 J. Med. Chem. pmid:16420041
Siegmund SV et al. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. 2006 J. Biol. Chem. pmid:16418162
Voets T et al. Sensing with TRP channels. 2005 Nat. Chem. Biol. pmid:16408004
Yang YY et al. Roles of anandamide in the hepatic microcirculation in cirrhotic rats. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16407591
Appendino G et al. First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. 2006 FEBS Lett. pmid:16406364
Nakajima Y et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. 2006 FEBS Lett. pmid:16406050
D'Argenio G et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. 2006 FASEB J. pmid:16403786
Eljaschewitsch E et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. 2006 Neuron pmid:16387640
Bai X et al. TASK channel expression in human placenta and cytotrophoblast cells. 2006 J. Soc. Gynecol. Investig. pmid:16378911
Ligresti A et al. Endocannabinoid metabolic pathways and enzymes. 2005 Curr Drug Targets CNS Neurol Disord pmid:16375679
Bojesen IN and Hansen HS Effect of an unstirred layer on the membrane permeability of anandamide. 2006 J. Lipid Res. pmid:16365480
Gobbi G et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16352709
Varvel SA et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. 2006 J. Pharmacol. Exp. Ther. pmid:16352706
Siegmund SV and Brenner DA Molecular pathogenesis of alcohol-induced hepatic fibrosis. 2005 Alcohol. Clin. Exp. Res. pmid:16344593
Grimaldi C et al. Anandamide inhibits adhesion and migration of breast cancer cells. 2006 Exp. Cell Res. pmid:16343481
Lizanecz E et al. Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1. 2006 Mol. Pharmacol. pmid:16338989
Flygare J et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. 2005 FEBS Lett. pmid:16337199
Hejazi N et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. 2006 Mol. Pharmacol. pmid:16332990
Rösch S et al. R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. 2006 J. Pharmacol. Exp. Ther. pmid:16330497
Cannizzaro C et al. Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. 2006 Neurochem. Int. pmid:16325966
Juan-Picó P et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. 2006 Cell Calcium pmid:16321437
Suplita RL et al. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. 2006 Neuropharmacology pmid:16316669
Mechoulam R and Deutsch DG Toward an anandamide transporter. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16314567
Bir LS and Ercan S Effects of intrathecal anandamide on somatosensory evoked responses in rats. 2006 Exp. Neurol. pmid:16289169
Ligresti A et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. 2006 Br. J. Pharmacol. pmid:16284631
Brizzi A et al. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. 2005 J. Med. Chem. pmid:16279794
Glaser ST et al. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. 2006 J. Pharmacol. Exp. Ther. pmid:16278311
Kadoi Y et al. Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. 2005 Crit. Care Med. pmid:16276190
Sarnataro D et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. 2005 FEBS Lett. pmid:16263116
Kim HI et al. Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. 2005 Brain Res. pmid:16256960
Cabranes A et al. Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. 2005 Neurobiol. Dis. pmid:16242629
Di S et al. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. 2005 J. Physiol. (Lond.) pmid:16239276
Malfitano AM et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. 2006 J. Neuroimmunol. pmid:16239036
Jiang W et al. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. 2005 J. Clin. Invest. pmid:16224541
Van Sickle MD et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. 2005 Science pmid:16224028
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Thomas A et al. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. 2005 Br. J. Pharmacol. pmid:16205722
Mechoulam R Plant cannabinoids: a neglected pharmacological treasure trove. 2005 Br. J. Pharmacol. pmid:16205721
Tzavara ET et al. Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications. 2006 Biol. Psychiatry pmid:16199010
Singh Tahim A et al. Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. 2005 Neuroscience pmid:16198486
Li C et al. High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor. 2005 J. Med. Chem. pmid:16190768
Schmidt A et al. Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. 2006 Biomed. Chromatogr. pmid:16189813
Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. 2005 Diabetes pmid:16186383
Battista N et al. Endocannabinoids and their involvement in the neurovascular system. 2004 Curr Neurovasc Res pmid:16185189
Straiker A and Mackie K Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. 2005 J. Physiol. (Lond.) pmid:16179366
Bazinet RP et al. Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. 2005 Neurochem. Res. pmid:16176062
Barun S et al. Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16173925
Underdown NJ et al. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. 2005 Br. J. Pharmacol. pmid:16158067
Sun YX et al. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. 2005 Biochim. Biophys. Acta pmid:16154384
Gasperi V et al. Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. 2005 Neurotoxicology pmid:16154199
Yang W et al. Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. 2005 J. Lipid Res. pmid:16150817
Hayase T et al. Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands. 2005 Behav Pharmacol pmid:16148444
Sancho R et al. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. 2005 J. Immunol. pmid:16148147
Wang Y et al. VR1-mediated depressor effects during high-salt intake: role of anandamide. 2005 Hypertension pmid:16144988
Maccarrone M et al. Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. 2005 J. Cell. Sci. pmid:16144868
Kopczyńska B and Szereda-Przestaszewska M Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. 2006 Respir Physiol Neurobiol pmid:16144778
Matsuda K et al. The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. 2005 Tohoku J. Exp. Med. pmid:16141678
Valenti M et al. The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake. 2005 J. Neurochem. pmid:16135090
Osei-Hyiaman D et al. Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. 2005 Neuroendocrinology pmid:16131814
Suplita RL et al. Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. 2005 Neuropharmacology pmid:16129456
Schuel H and Burkman LJ A tale of two cells: endocannabinoid-signaling regulates functions of neurons and sperm. 2005 Biol. Reprod. pmid:16120829
McPartland JM et al. Cannabimimetic effects of osteopathic manipulative treatment. 2005 J Am Osteopath Assoc pmid:16118355
Wagner JA et al. Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. 2005 J. Cardiovasc. Pharmacol. pmid:16116341
van der Stelt M et al. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. 2005 EMBO J. pmid:16107881
Sade H et al. Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids. 2006 Am. J. Physiol., Cell Physiol. pmid:16107501
Yoshihara S et al. Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways. 2005 Int. Arch. Allergy Immunol. pmid:16103691
Patsos HA et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. 2005 Gut pmid:16099783
van der Stelt M and Di Marzo V Anandamide as an intracellular messenger regulating ion channel activity. 2005 Prostaglandins Other Lipid Mediat. pmid:16099396
Besana A et al. Lipids and two-pore domain K+ channels in excitable cells. 2005 Prostaglandins Other Lipid Mediat. pmid:16099395
Poblete IM et al. Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. 2005 J. Physiol. (Lond.) pmid:16081483
Movahed P et al. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. 2005 J. Biol. Chem. pmid:16081411
Lambert DM and Fowler CJ The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. 2005 J. Med. Chem. pmid:16078824
Lee MG et al. Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. 2005 Br. J. Pharmacol. pmid:16056239
Kraft B and Kress HG Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. 2005 J. Pharmacol. Exp. Ther. pmid:16055676
Wahn H et al. The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:16055511
Yamaguchi Y et al. [Surgical stress]. 2005 Nihon Geka Gakkai Zasshi pmid:16045189
Lynch DL and Reggio PH Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics. 2005 J. Med. Chem. pmid:16033262
Gaskari SA et al. Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. 2005 Br. J. Pharmacol. pmid:16025138
Solbrig MV et al. A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. 2005 Exp. Neurol. pmid:16022863
Awumey EM et al. Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:16014613
de Lago E et al. UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. 2006 Eur Neuropsychopharmacol pmid:16006105
Movahed P et al. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. 2005 Br. J. Pharmacol. pmid:15997233
Taddei S Evolving the concept of regulation of vascular tone in humans. 2005 Br. J. Pharmacol. pmid:15997231