Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

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What functions are associated with Anandamide?


Related references are published most in these journals:

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What lipids are associated with Anandamide?

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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Kelley BG and Thayer SA Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors. 2004 Eur. J. Pharmacol. pmid:15288572
Rockwell CE and Kaminski NE A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. 2004 J. Pharmacol. Exp. Ther. pmid:15284281
Scorticati C et al. The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15280536
Akerman S et al. Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors. 2004 Br. J. Pharmacol. pmid:15277315
Yue HY et al. AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. 2004 Brain Res. pmid:15276889
Boldrup L et al. A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. 2004 J. Biochem. Biophys. Methods pmid:15262451
D'Amico M et al. Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus. 2004 Neurochem. Res. pmid:15260134
Barros DM et al. Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems. 2004 Brain Res. pmid:15234253
Lichtman AH et al. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. 2004 J. Pharmacol. Exp. Ther. pmid:15229230
Li J et al. Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. 2004 J. Appl. Physiol. pmid:15220301
Ortega-Gutiérrez S et al. Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. 2004 Biochemistry pmid:15209515
Kraft B et al. Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide. 2004 Life Sci. pmid:15193957
Martínez-González D et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. 2004 Neurosci. Lett. pmid:15193744
Peroni RN et al. Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens. 2004 Eur. J. Pharmacol. pmid:15189776
Witting A et al. Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice. 2004 J. Neurochem. pmid:15189359
Kim J and Alger BE Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. 2004 Nat. Neurosci. pmid:15184902
Alger BE Endocannabinoids: getting the message across. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15173576
Breivogel CS et al. Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. 2004 Neuropharmacology pmid:15165836
Chen P et al. Metabolism of anandamide in cerebral microvascular endothelial cells. 2004 Prostaglandins Other Lipid Mediat. pmid:15165032
Russo EB Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159679
Fride E The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159678
Mechoulam R The promise of advances in the field of endocannabinoids. 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159675
Karlsson M et al. Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments. 2004 Eur J Pharm Sci pmid:15158903
Mendiguren A and Pineda J Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices. 2004 Neurosci. Lett. pmid:15157983
Lichtman AH et al. Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. 2004 Pain pmid:15157693
Koura Y et al. Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys. 2004 J. Am. Soc. Nephrol. pmid:15153559
Parkkari T et al. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives. 2004 Bioorg. Med. Chem. Lett. pmid:15149681
O'Sullivan SE et al. Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries. 2004 Br. J. Pharmacol. pmid:15148250
Maccarrone M et al. Enhanced anandamide degradation is associated with neuronal apoptosis induced by the HIV-1 coat glycoprotein gp120 in the rat neocortex. 2004 J. Neurochem. pmid:15147522
Fowler CJ et al. Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle. 2004 Eur. J. Pharmacol. pmid:15145699
McQueen DS et al. Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats. 2004 Eur. J. Pharmacol. pmid:15140635
Fegley D et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15138300
Randall MD et al. The complexities of the cardiovascular actions of cannabinoids. 2004 Br. J. Pharmacol. pmid:15131000
Cernak I et al. The "dark side" of endocannabinoids: a neurotoxic role for anandamide. 2004 J. Cereb. Blood Flow Metab. pmid:15129189
Van Der Stelt M and Di Marzo V Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. 2004 Eur. J. Biochem. pmid:15128293
Pacher P et al. Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. 2004 J. Physiol. (Lond.) pmid:15121805
Kishimoto S et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. 2004 J. Biochem. pmid:15115777
Centonze D et al. A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission. 2004 Neuropsychopharmacology pmid:15100701
González S et al. Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. 2004 Drug Alcohol Depend pmid:15099659
Valenti M et al. Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. 2004 Cell. Mol. Life Sci. pmid:15095014
Fernandez-Espejo E and Galan-Rodriguez B Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor. 2004 Psychopharmacology (Berl.) pmid:15088080
Gardener MJ et al. Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries. 2004 Br. J. Pharmacol. pmid:15066906
de Lago E et al. Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. 2004 Brain Res. pmid:15064146
Contassot E et al. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. 2004 Gynecol. Oncol. pmid:15047233
Szendrei K [A novel analgesics made from Cannabis]. 2004 Ideggyogy Sz pmid:15042867
Joseph J et al. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. 2004 Cancer Immunol. Immunother. pmid:15034673
Oliver D et al. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. 2004 Science pmid:15031437
Evans RM et al. Multiple actions of anandamide on neonatal rat cultured sensory neurones. 2004 Br. J. Pharmacol. pmid:15023857
Cruz F Mechanisms involved in new therapies for overactive bladder. 2004 Urology pmid:15013655
Fernandez-Espejo E et al. Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function. 2004 Neuropsychopharmacology pmid:15010694
Berger C et al. Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia? 2004 J. Neurochem. pmid:15009671
Price TJ et al. Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. 2004 Br. J. Pharmacol. pmid:15006899
Sun YX et al. Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. 2004 Biochem. J. pmid:14998370
Steffens M et al. Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex. 2004 Br. J. Pharmacol. pmid:14993102
Costanzi M et al. Effects of anandamide and morphine combinations on memory consolidation in cd1 mice: involvement of dopaminergic mechanisms. 2004 Neurobiol Learn Mem pmid:14990234
Fernández-Solari J et al. Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14981261
Basta PV et al. Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide. 2004 J. Immunol. Methods pmid:14980433
Guo J and Ikeda SR Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. 2004 Mol. Pharmacol. pmid:14978245
Ligresti A et al. Further evidence for the existence of a specific process for the membrane transport of anandamide. 2004 Biochem. J. pmid:14969584
Lin GC et al. Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. 2004 J. Cell. Sci. pmid:14762115
Matias I et al. Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism. 2004 J. Pharmacol. Exp. Ther. pmid:14757851
Moezi L et al. Potentiation of anandamide effects in mesenteric beds isolated from bile duct-ligated rats: role of nitric oxide. 2004 Eur. J. Pharmacol. pmid:14751408
Dennedy MC et al. Cannabinoids and the human uterus during pregnancy. 2004 Am. J. Obstet. Gynecol. pmid:14749627
Murillo-Rodriguez E et al. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. 2003 Sleep pmid:14746372
de Lago E et al. In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. 2004 Eur. J. Pharmacol. pmid:14744610
Weber A et al. Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. 2004 J. Lipid Res. pmid:14729864
Maccarrone M Inhibition of anandamide hydrolysis: cells also know how to do it. 2004 Trends Mol Med pmid:14720580
Akerman S et al. Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. 2004 J. Pharmacol. Exp. Ther. pmid:14718591
Ruiz-Llorente L et al. Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. 2004 Br. J. Pharmacol. pmid:14718261
Lees G and Dougalis A Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. 2004 Brain Res. pmid:14715144
Devane WA et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. 1992 Science pmid:1470919
Piomelli D THC: moderation during implantation. 2004 Nat. Med. pmid:14702623
Kasai HF et al. Analyses of anandamide and endocannabinoid-like compounds using collision-induced dissociation in fast atom bombardment ionization-mass spectrometry and gas chromatography/chemical ionization-mass spectrometry. 2003 Anal Sci pmid:14696920
Wenger T et al. The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice. 2003 Neuroendocrinology pmid:14688442
Motobe T et al. Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. 2004 Shock pmid:14676677
Arizzi MN et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. 2004 Life Sci. pmid:14672756
Nilsson O et al. Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures. 2003 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:14659458
Wang H et al. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14645706
Zoratti C et al. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. 2003 Br. J. Pharmacol. pmid:14645143
Jones S and Howl J Cannabinoid receptor systems: therapeutic targets for tumour intervention. 2003 Expert Opin. Ther. Targets pmid:14640910
Farquhar-Smith WP and Rice AS A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia. 2003 Anesthesiology pmid:14639155
Kollarik M and Undem BJ Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice. 2004 J. Physiol. (Lond.) pmid:14634201
Okamoto Y et al. Molecular characterization of a phospholipase D generating anandamide and its congeners. 2004 J. Biol. Chem. pmid:14634025
Sparling PB et al. Exercise activates the endocannabinoid system. 2003 Neuroreport pmid:14625449
Seagard JL et al. Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14615281
McAllister SD et al. An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. 2003 J. Med. Chem. pmid:14613317
Gaetani S et al. Anandamide hydrolysis: a new target for anti-anxiety drugs? 2003 Trends Mol Med pmid:14604824
Egashira N et al. Anandamide inhibits the DOI-induced head-twitch response in mice. 2004 Psychopharmacology (Berl.) pmid:14586538
Biswas KK et al. Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. 2003 Hepatology pmid:14578855
Johnson RP et al. System-specific O2 sensitivity of the tandem pore domain K+ channel TASK-1. 2004 Am. J. Physiol., Cell Physiol. pmid:14576090
Chen N et al. Inhibition by arachidonic acid and other fatty acids of dopamine uptake at the human dopamine transporter. 2003 Eur. J. Pharmacol. pmid:14575792
Han B et al. Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. 2003 J. Nat. Prod. pmid:14575438
Steffens M et al. Quantitative measurement of depolarization-induced anandamide release in human and rat neocortex. 2003 Naunyn Schmiedebergs Arch. Pharmacol. pmid:14566450
Maccarrone M et al. Endocannabinoid degradation, endotoxic shock and inflammation. 2002 Curr Drug Targets Inflamm Allergy pmid:14561206
Gurney AM et al. Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. 2003 Circ. Res. pmid:14551239
Marsicano G et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. 2003 Science pmid:14526074
Mechoulam R and Lichtman AH Neuroscience. Stout guards of the central nervous system. 2003 Science pmid:14526067
Vandevoorde S et al. Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. 2003 J. Med. Chem. pmid:14521402
Ross RA Anandamide and vanilloid TRPV1 receptors. 2003 Br. J. Pharmacol. pmid:14517174
Fowler CJ et al. Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin. 2003 J Enzyme Inhib Med Chem pmid:14506913