Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Maccarrone M et al. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. 2002 Blood pmid:12393387
González S et al. Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. 2002 Brain Res. pmid:12393235
Milton NG Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. 2002 Neurosci. Lett. pmid:12384227
Barthó L et al. Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle. 2002 Naunyn Schmiedebergs Arch. Pharmacol. pmid:12382081
Roberts LA et al. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. 2002 Br. J. Pharmacol. pmid:12359623
Wallace MJ et al. Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. 2002 Eur. J. Pharmacol. pmid:12359270
Laine K et al. Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12356827
Ralevic V et al. Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function. 2002 Life Sci. pmid:12354577
Oz M et al. Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. 2002 Synapse pmid:12325042
Kozak KR et al. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. 2002 J. Biol. Chem. pmid:12244105
Schuel H et al. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. 2002 Mol. Reprod. Dev. pmid:12237954
Rueda D et al. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. 2002 J. Biol. Chem. pmid:12237305
Anikwue R et al. Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. 2002 J. Pharmacol. Exp. Ther. pmid:12235269
Burstein SH et al. Regulation of anandamide tissue levels by N-arachidonylglycine. 2002 Biochem. Pharmacol. pmid:12234618
Plant LD et al. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. 2002 Stroke pmid:12215606
Someya A et al. Arachidonic acid release and prostaglandin F(2alpha) formation induced by anandamide and capsaicin in PC12 cells. 2002 Eur. J. Pharmacol. pmid:12206851
Kagaya M et al. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. 2002 Br. J. Pharmacol. pmid:12183329
Randall MD et al. Cardiovascular effects of cannabinoids. 2002 Pharmacol. Ther. pmid:12182966
Hansen HS et al. Putative neuroprotective actions of N-acyl-ethanolamines. 2002 Pharmacol. Ther. pmid:12182959
Goutopoulos A and Makriyannis A From cannabis to cannabinergics: new therapeutic opportunities. 2002 Pharmacol. Ther. pmid:12182958
Andersson DA et al. Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists. 2002 Mol. Pharmacol. pmid:12181448
Gubellini P et al. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. 2002 J. Neurosci. pmid:12177188
Chemin J et al. Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line. 2002 J. Neurosci. pmid:12177183
van der Stelt M et al. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. 2002 J. Med. Chem. pmid:12166944
Barnett-Norris J et al. Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor. 2002 J. Med. Chem. pmid:12166938
de Lago E et al. UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide. 2002 Eur. J. Pharmacol. pmid:12163112
Costa B et al. Chronic treatment with the endocannabinoid anandamide increases cytochrome P450 metabolizing system in the rat. 2002 Eur. J. Pharmacol. pmid:12163107
Schäbitz WR et al. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. 2002 Stroke pmid:12154273
Matias I et al. Presence and regulation of the endocannabinoid system in human dendritic cells. 2002 Eur. J. Biochem. pmid:12153574
Habayeb OM et al. Endogenous cannabinoids: metabolism and their role in reproduction. 2002 Life Sci. pmid:12148689
Di Marzo V et al. Endovanilloid signaling in pain. 2002 Curr. Opin. Neurobiol. pmid:12139983
Liu WM et al. Effects of anandamide on embryo implantation in the mouse. 2002 Life Sci. pmid:12137909
Dinh TP et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12136125
Szallasi A Vanilloid (capsaicin) receptors in health and disease. 2002 Am. J. Clin. Pathol. pmid:12109845
Sugiura T and Waku K Cannabinoid receptors and their endogenous ligands. 2002 J. Biochem. pmid:12097154
Vinklerová J et al. Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251. 2002 J. Psychopharmacol. (Oxford) pmid:12095072
Kirkham TC et al. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. 2002 Br. J. Pharmacol. pmid:12055133
Di Marzo V et al. Anandamide receptors. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052051
Högestätt ED and Zygmunt PM Cardiovascular pharmacology of anandamide. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052048
Pinto L et al. Endocannabinoids and the gut. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052047
Fride E Endocannabinoids in the central nervous system--an overview. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052038
Deutsch DG et al. The fatty acid amide hydrolase (FAAH). 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052036
Fowler CJ and Jacobsson SO Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052035
Sugiura T et al. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052034
Mechoulam R Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052029
Kreitzer AC and Regehr WG Retrograde signaling by endocannabinoids. 2002 Curr. Opin. Neurobiol. pmid:12049940
Williams CM and Kirkham TC Observational analysis of feeding induced by Delta9-THC and anandamide. 2002 Physiol. Behav. pmid:12044596
Farquhar-Smith WP et al. Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. 2002 Pain pmid:12031775
Smart D et al. 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. 2002 Br. J. Pharmacol. pmid:12023948
Porter AC et al. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. 2002 J. Pharmacol. Exp. Ther. pmid:12023533
Ross RA et al. Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide. 2002 J. Pharmacol. Exp. Ther. pmid:12023517
Maccarrone M et al. Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells. 2002 Biochem. J. pmid:12010121
Romero J et al. Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. 2002 Brain Res. Mol. Brain Res. pmid:12008024
Mukhopadhyay S et al. Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12003810
Maccarrone M et al. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. 2002 Eur. J. Neurosci. pmid:11982628
Gerdeman GL et al. Postsynaptic endocannabinoid release is critical to long-term depression in the striatum. 2002 Nat. Neurosci. pmid:11976704
Ishii I and Chun J Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. 2002 Neuroreport pmid:11973452
Gardiner SM et al. Complex regional haemodynamic effects of anandamide in conscious rats. 2002 Br. J. Pharmacol. pmid:11959791
Bisogno T et al. Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. 2002 Curr. Pharm. Des. pmid:11945157
Hansen HS et al. When and where are N-acylethanolamine phospholipids and anandamide formed? 2001 World Rev Nutr Diet pmid:11935960
Ueda N et al. Alkaline and acid amidases hydrolyzing anandamide and other N-acylethanolamines. 2001 World Rev Nutr Diet pmid:11935959
Valk P et al. Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2. 2000 Hematol. J. pmid:11920199
Walter L et al. Astrocytes in culture produce anandamide and other acylethanolamides. 2002 J. Biol. Chem. pmid:11916961
Lin YS and Lee LY Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. 2002 J. Physiol. (Lond.) pmid:11897863
Harris D et al. Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. 2002 J. Physiol. (Lond.) pmid:11897858
Molina-Holgado F et al. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. 2002 J. Neurosci. Res. pmid:11891798
Wenger T et al. The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats. 2002 Life Sci. pmid:11883716
Ford WR et al. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. 2002 Br. J. Pharmacol. pmid:11877326
Luo C et al. Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin. 2002 Neurosci. Lett. pmid:11872246
Di Marzo V et al. A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. 2002 J. Pharmacol. Exp. Ther. pmid:11861807
Hayase T et al. Protective effects of cannabinoid receptor ligands analogous to anandamide against cocaine toxicity. 2001 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:11828716
Maccarrone M et al. Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. 2002 Mol. Hum. Reprod. pmid:11818522
Laine K et al. Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides. 2002 Invest. Ophthalmol. Vis. Sci. pmid:11818382
Mechoulam R et al. Cannabinoids and brain injury: therapeutic implications. 2002 Trends Mol Med pmid:11815270
Martin BR et al. Assessment of structural commonality between tetrahydrocannabinol and anandamide. 2002 Eur. J. Pharmacol. pmid:11790376
Lever IJ and Malcangio M CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord. 2002 Br. J. Pharmacol. pmid:11786475
Ros J et al. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. 2002 Gastroenterology pmid:11781284
Izzo AA et al. The gastrointestinal pharmacology of cannabinoids. 2001 Curr Opin Pharmacol pmid:11757815
Begg M et al. Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum. 2002 Eur. J. Pharmacol. pmid:11755170
Darmani NA The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. 2002 J. Pharmacol. Exp. Ther. pmid:11752094
Al-Hayani A et al. The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. 2001 Neuropharmacology pmid:11747904
Chemin J et al. Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. 2001 EMBO J. pmid:11742980
López-Rodríguez ML et al. Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors. 2001 J. Med. Chem. pmid:11741470
Molderings GJ et al. Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. 2002 Neurochem. Int. pmid:11738482
Wagner JA et al. Endogenous cannabinoids mediate hypotension after experimental myocardial infarction. 2001 J. Am. Coll. Cardiol. pmid:11738314
Hayase T et al. Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms. 2001 J. Pharm. Pharmacol. pmid:11732755
Stamer WD et al. Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. 2001 Eur. J. Pharmacol. pmid:11730719
Karava V et al. Anandamide amidohydrolase activity, released in the medium by Tetrahymena pyriformis. Identification and partial characterization. 2001 FEBS Lett. pmid:11728445
Gurwitz D and Weizman A Fatty acid amide hydrolase inhibitors and the marijuana debate. 2001 Lancet pmid:11705595
Jamshidi N and Taylor DA Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. 2001 Br. J. Pharmacol. pmid:11704633
Rodríguez de Fonseca F et al. An anorexic lipid mediator regulated by feeding. 2001 Nature pmid:11700558
van der Stelt M et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. 2001 J. Neurosci. pmid:11698588
Bifulco M et al. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. 2001 FASEB J. pmid:11687506
Grainger J and Boachie-Ansah G Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. 2001 Br. J. Pharmacol. pmid:11682448
Nogueron MI et al. Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. 2001 J. Neurochem. pmid:11677265
Kurihara J et al. 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves. 2001 Jpn. J. Pharmacol. pmid:11676206
Ralevic V et al. Cannabinoid activation of recombinant and endogenous vanilloid receptors. 2001 Eur. J. Pharmacol. pmid:11672565
Berdyshev EV et al. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. 2001 FASEB J. pmid:11641243
White R et al. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. 2001 Br. J. Pharmacol. pmid:11606334
Bisogno T et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. 2001 Br. J. Pharmacol. pmid:11606325