Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Stefano GB Endocannabinoid immune and vascular signaling. 2000 Acta Pharmacol. Sin. pmid:11603279
De Petrocellis L et al. Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. 2001 FEBS Lett. pmid:11602256
Smith PJ and McQueen DS Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat. 2001 Br. J. Pharmacol. pmid:11588121
Fowler CJ et al. Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. 2001 Biochem. Pharmacol. pmid:11585048
Hansen HH et al. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. 2001 J. Neurochem. pmid:11579150
Christopoulos A and Wilson K Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. 2001 Brain Res. pmid:11578621
Rice AS Cannabinoids and pain. 2001 Curr Opin Investig Drugs pmid:11575713
Mendizábal VE et al. Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed. 2001 Eur. J. Pharmacol. pmid:11567656
Maccarrone M et al. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. 2001 Arch. Biochem. Biophys. pmid:11556820
Mang CF et al. Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. 2001 Br. J. Pharmacol. pmid:11522608
Craib SJ et al. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. 2001 Br. J. Pharmacol. pmid:11522594
Huang SM et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. 2001 J. Biol. Chem. pmid:11518719
Stella N and Piomelli D Receptor-dependent formation of endogenous cannabinoids in cortical neurons. 2001 Eur. J. Pharmacol. pmid:11513837
Crozier Willi G et al. Lipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods. 2001 Nestle Nutr Workshop Ser Clin Perform Programme pmid:11510437
Jonsson KO et al. Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. 2001 Br. J. Pharmacol. pmid:11498512
Bradbury J Small part of cannabis puzzle solved by animal studies. 2001 Lancet pmid:11498223
Di Marzo V et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. 2001 Biochem. J. pmid:11485574
Vellani V et al. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. 2001 J. Physiol. (Lond.) pmid:11483711
Cravatt BF et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11470906
Ueda N et al. Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. 2001 J. Biol. Chem. pmid:11463796
Maccarrone M et al. Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. 2001 J. Neurochem. pmid:11461969
Möhle R et al. Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. 2001 Ann. N. Y. Acad. Sci. pmid:11458515
Stanford SJ et al. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. 2001 Br. J. Pharmacol. pmid:11454655
Senior K Endogenously produced cannabinoids and liver cirrhosis. 2001 Lancet pmid:11454385
Laine K et al. Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits. 2001 Pharm. Res. pmid:11451037
Porter AC and Felder CC The endocannabinoid nervous system: unique opportunities for therapeutic intervention. 2001 Pharmacol. Ther. pmid:11448725
Wagner JA et al. Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors. 2001 Eur. J. Pharmacol. pmid:11448486
Sprague J et al. Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide. 2001 Eur. J. Pharmacol. pmid:11448475
Murillo-Rodríguez E et al. Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor. 2001 Neuroreport pmid:11447321
Bátkai S et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. 2001 Nat. Med. pmid:11433348
Morisset V and Urban L Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. 2001 J. Neurophysiol. pmid:11431486
Di Marzo V et al. Anandamide: some like it hot. 2001 Trends Pharmacol. Sci. pmid:11431028
Ugdyzhekova DS et al. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. 2001 Bull. Exp. Biol. Med. pmid:11427912
Fride E et al. Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. 2001 Eur. J. Pharmacol. pmid:11426843
Calignano A et al. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. 2001 Eur. J. Pharmacol. pmid:11426841
De Petrocellis L et al. The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. 2001 J. Neurochem. pmid:11413249
Boger DL et al. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. 2001 Bioorg. Med. Chem. Lett. pmid:11412972
Wang Y et al. Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. 2001 Anal. Biochem. pmid:11412008
Breivogel CS et al. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. 2001 Mol. Pharmacol. pmid:11408610
Di Marzo V et al. Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. 2001 Eur. J. Pharmacol. pmid:11408034
Holt S et al. Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen. 2001 Br. J. Pharmacol. pmid:11399668
Wenger T et al. The central cannabinoid receptor inactivation suppresses endocrine reproductive functions. 2001 Biochem. Biophys. Res. Commun. pmid:11394887
Maccarrone M et al. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. 2001 J. Immunol. pmid:11390466
Farquhar-Smith WP and Rice AS Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder. 2001 Anesthesiology pmid:11374613
James JS Marijuana and chocolate. 1996 AIDS Treat News pmid:11363932
Berger A et al. Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353819
Day TA et al. Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. 2001 Mol. Pharmacol. pmid:11353795
Quistad GB et al. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. 2001 Toxicol. Appl. Pharmacol. pmid:11350214
Bueb JL et al. Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. 2001 Biochim. Biophys. Acta pmid:11336796
Olah Z et al. Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. 2001 J. Biol. Chem. pmid:11333266
Chang YH et al. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. 2001 J. Cell. Biochem. pmid:11329626
Kobayashi Y et al. Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. 2001 J. Biochem. pmid:11328586
Fimiani C et al. Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. 2000 Acta Pharmacol. Sin. pmid:11324436
Kim D and Thayer SA Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. 2001 J. Neurosci. pmid:11319244
Jacobsson SO and Fowler CJ Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. 2001 Br. J. Pharmacol. pmid:11309246
Smart D et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. 2001 Eur. J. Pharmacol. pmid:11301059
Mechoulam R and Fride E Physiology. A hunger for cannabinoids. 2001 Nature pmid:11298428
D'Souza DC and Kosten TR Cannabinoid antagonists: a treatment in search of an illness. 2001 Arch. Gen. Psychiatry pmid:11296092
De Petrocellis L et al. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. 2001 J. Biol. Chem. pmid:11278420
Bisogno T et al. The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. 2001 Eur. J. Biochem. pmid:11277920
Kagota S et al. 2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor. 2001 Eur. J. Pharmacol. pmid:11275004
Izzo AA et al. Effect of vanilloid drugs on gastrointestinal transit in mice. 2001 Br. J. Pharmacol. pmid:11264233
Matias I et al. Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis. 2001 Brain Res. Mol. Brain Res. pmid:11245916
Maingret F et al. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. 2001 EMBO J. pmid:11226154
Tucker RC et al. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. 2001 Br. J. Pharmacol. pmid:11226144
Morefield SI et al. Drug evaluations using neuronal networks cultured on microelectrode arrays. 2000 Biosens Bioelectron pmid:11219752
Maccarrone M et al. Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture. 2001 J. Neurochem. pmid:11208922
Maccarrone M and Finazzi-Agró A Platelet activation: a new vascular activity of anandamide. 2000 FEBS Lett. pmid:11184253
Palkovits M [The brain and the pain: neurotransmitters and neuronal pathways of pain perception and response]. 2000 Orv Hetil pmid:11184247
Di Marzo V et al. Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands. 2001 Biochem. Biophys. Res. Commun. pmid:11181068
MacCarrone M et al. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. 2001 Eur. J. Biochem. pmid:11168423
Vanheel B and Van de Voorde J Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries. 2001 J. Pharmacol. Exp. Ther. pmid:11160613
Tognetto M et al. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. 2001 J. Neurosci. pmid:11160380
Ross RA et al. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. 2001 Br. J. Pharmacol. pmid:11159715
Gauldie SD et al. Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. 2001 Br. J. Pharmacol. pmid:11159713
Baker D et al. Endocannabinoids control spasticity in a multiple sclerosis model. 2001 FASEB J. pmid:11156943
Hansen HH et al. Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. 2001 J. Neurochem. pmid:11145976
Premkumar LS and Ahern GP Induction of vanilloid receptor channel activity by protein kinase C. 2000 Dec 21-28 Nature pmid:11140687
Garcia N et al. Systemic and portal hemodynamic effects of anandamide. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11123193
Deutsch DG et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. 2001 J. Biol. Chem. pmid:11118429
Kunos G et al. Endocannabinoids as cardiovascular modulators. 2000 Chem. Phys. Lipids pmid:11106789
Hillard CJ and Jarrahian A The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. 2000 Chem. Phys. Lipids pmid:11106786
Schmid HH Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? 2000 Chem. Phys. Lipids pmid:11106783
Howlett AC and Mukhopadhyay S Cellular signal transduction by anandamide and 2-arachidonoylglycerol. 2000 Chem. Phys. Lipids pmid:11106782
Reggio PH and Traore H Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. 2000 Chem. Phys. Lipids pmid:11106780
Calignano A et al. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. 2000 Prog. Brain Res. pmid:11098711
Maccarrone M et al. Anandamide and 2-arachidonoylglycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the arachidonate cascade. 2000 Biochem. Biophys. Res. Commun. pmid:11095952
Calignano A et al. Bidirectional control of airway responsiveness by endogenous cannabinoids. 2000 Nature pmid:11081515
Giuffrida A et al. Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404. 2000 Eur. J. Pharmacol. pmid:11080522
Rubino T et al. Loss of cannabinoid-stimulated guanosine 5'-O-(3-[(35)S]Thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats. 2000 J. Neurochem. pmid:11080200
Di Marzo V et al. Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. 2000 J. Neurochem. pmid:11080195
Bisogno T et al. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. 2000 Biochem. J. pmid:11042139
Di Marzo V et al. Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. 2000 Eur. J. Pharmacol. pmid:11040343
De Petrocellis L et al. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. 2000 FEBS Lett. pmid:11033355
Fernandez-Patron C et al. Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. 2000 Circ. Res. pmid:11029402
Szallasi A and Di Marzo V New perspectives on enigmatic vanilloid receptors. 2000 Trends Neurosci. pmid:11006466
Klein TW et al. The cannabinoid system and cytokine network. 2000 Proc. Soc. Exp. Biol. Med. pmid:10998193
Stefano GB et al. 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. 2000 Pharmacol. Res. pmid:10987990
Wiley JL et al. Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects. 2000 Life Sci. pmid:10983852
Oz M et al. Endogenous cannabinoid anandamide directly inhibits voltage-dependent Ca(2+) fluxes in rabbit T-tubule membranes. 2000 Eur. J. Pharmacol. pmid:10980258