Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Palermo G et al. Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets. 2015 PLoS Comput. Biol. pmid:26111155
Bruijnzeel AW et al. Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats. 2016 PLoS ONE pmid:27065006
Vinod KY et al. Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats. 2012 PLoS ONE pmid:22606285
Martins CJ et al. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 PLoS ONE pmid:26561012
Smith M et al. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. 2015 PLoS ONE pmid:26414859
Gouveia-Figueira S et al. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor. 2015 PLoS ONE pmid:26406890
Thörn Pérez C et al. Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels. 2015 PLoS ONE pmid:26197458
Chon SH et al. Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. 2012 PLoS ONE pmid:22937137
Woolcott OO et al. High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. 2015 PLoS ONE pmid:25855974
Nicholson J et al. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. 2015 PLoS ONE pmid:25835291
De Angelis V et al. Endocannabinoids control platelet activation and limit aggregate formation under flow. 2014 PLoS ONE pmid:25264625
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Björklund E et al. Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study. 2014 PLoS ONE pmid:25078278
Dong W et al. Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. 2014 PLoS ONE pmid:24949851
Hama AT et al. Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain. 2014 PLoS ONE pmid:24788435
Kaczocha M et al. Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia. 2014 PLoS ONE pmid:24705380
Jackson AR et al. Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction. 2014 PLoS ONE pmid:24699635
Di Pasquale E et al. The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. 2009 PLoS ONE pmid:19330032
Gervasi MG et al. Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. 2013 PLoS ONE pmid:23977311
Leo LM et al. Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. 2014 PLoS ONE pmid:24416334
Li Q et al. Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. 2013 PLoS ONE pmid:23667607
Lobato NS et al. Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. 2013 PLoS ONE pmid:23667622
Gatta L et al. Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. 2012 PLoS ONE pmid:22363560
Berger WT et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. 2012 PLoS ONE pmid:23236415
Compagnucci C et al. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. 2013 PLoS ONE pmid:23372698
Bhaskaran MD and Smith BN Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. 2010 PLoS ONE pmid:20498848
Zschenderlein C et al. Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. 2011 PLoS ONE pmid:21249195
Starowicz K et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. 2013 PLoS ONE pmid:23573230
Chadwick W et al. Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. 2010 PLoS ONE pmid:21179406
Cencioni MT et al. Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. 2010 PLoS ONE pmid:20098669
Sordelli MS et al. The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. 2011 PLoS ONE pmid:21559512
Derbenev AV and Smith BN Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity. 2013 PLoS ONE pmid:23936221
Ligresti A et al. Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter. 2010 PLoS ONE pmid:20422025
El-Talatini MR et al. Localisation and function of the endocannabinoid system in the human ovary. 2009 PLoS ONE pmid:19238202
Osycka-Salut C et al. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. 2012 PLoS ONE pmid:22363468
Gervasi MG et al. Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. 2011 PLoS ONE pmid:21347292
Pava MJ et al. Endocannabinoid modulation of cortical up-states and NREM sleep. 2014 PLoS ONE pmid:24520411
Cippitelli A et al. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. 2011 PLoS ONE pmid:22140525
Hamtiaux L et al. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. 2011 PLoS ONE pmid:22046372
Björklund E et al. Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations. 2014 PLoS ONE pmid:24466356
Leung K et al. Role of FAAH-like anandamide transporter in anandamide inactivation. 2013 PLoS ONE pmid:24223930
Karlsson J et al. Effects of tumour necrosis factor α upon the metabolism of the endocannabinoid anandamide in prostate cancer cells. 2017 PLoS ONE pmid:28910408
Murtaza G et al. TASK-1 potassium channel is not critically involved in mediating hypoxic pulmonary vasoconstriction of murine intra-pulmonary arteries. 2017 PLoS ONE pmid:28301582
Kwolek G et al. [Influence of anandamide, the endogenous agonist of cannabinoid receptors on the circulatory system]. 2005 Postepy Hig Med Dosw (Online) pmid:15928605
Pertwee RG Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. 2014 Proc Nutr Soc pmid:24135210
Burston JJ and Woodhams SG Endocannabinoid system and pain: an introduction. 2014 Proc Nutr Soc pmid:24148358
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Scorticati C et al. The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15280536
Boger DL et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10805767
De Petrocellis L et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9653194