Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Izumi Y and Zorumski CF NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. 2012 Neuropsychopharmacology pmid:21993209
Malinowska B et al. Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? 2012 Br. J. Pharmacol. pmid:22022923
Jarzimski C et al. Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol? 2012 Br J Clin Pharmacol pmid:22242687
Umathe SN et al. Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. 2012 Neuropharmacology pmid:22248639
Battista N et al. Abnormal anandamide metabolism in celiac disease. 2012 J. Nutr. Biochem. pmid:22209002
Schulte K et al. Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. 2012 Naunyn Schmiedebergs Arch. Pharmacol. pmid:22215206
Wu X et al. Alteration of endocannabinoid system in human gliomas. 2012 J. Neurochem. pmid:22176552
Starowicz K et al. Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. 2012 Neuropharmacology pmid:22178705
Harvey BS et al. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. 2012 Neurotoxicology pmid:22233683
Gatta-Cherifi B et al. Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. 2012 Int J Obes (Lond) pmid:21844878
Willibald J et al. Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells. 2012 J. Am. Chem. Soc. pmid:22812910
Chicca A et al. The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. 2012 Br. J. Pharmacol. pmid:22646533
Hernangómez M et al. CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. 2012 Glia pmid:22653796
Tsumura M et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. 2012 Cell Calcium pmid:22656960
Fogaça MV et al. Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. 2012 Braz. J. Med. Biol. Res. pmid:22392189
Lisboa SF and Guimarães FS Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. 2012 Neuropharmacology pmid:22394688
Manna SS and Umathe SN Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. 2012 Epilepsy Res. pmid:22386872
Lara-Celador I et al. Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. 2012 Brain Res. pmid:22841538
Méndez-Díaz M et al. The endocannabinoid system modulates the valence of the emotion associated to food ingestion. 2012 Addict Biol pmid:21182571
Whyte LS et al. Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. 2012 Br. J. Pharmacol. pmid:21649637
Berger WT et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. 2012 PLoS ONE pmid:23236415
Roa-Coria JE et al. N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception. 2012 Life Sci. pmid:23069585
Schmidt W et al. Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia. 2012 Neuroscience pmid:23069763
Pastuhov SI et al. Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling. 2012 Nat Commun pmid:23072806
Reyes-Cabello C et al. Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration. 2012 Pharmacol. Biochem. Behav. pmid:22133635
Goonawardena AV et al. Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. 2011 Oct-Nov Neuropharmacology pmid:21767554
Frazier CJ Key questions of endocannabinoid signalling in the CNS: which, where and when? 2011 J. Physiol. (Lond.) pmid:22001725
Ito T et al. Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells. 2011 Kurume Med J pmid:22027193
Hayase T Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. 2011 BMC Pharmacol. pmid:21767384
Andrianova EL et al. In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. 2011 Bull. Exp. Biol. Med. pmid:22442796
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Brighton PJ et al. Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. 2011 Br. J. Pharmacol. pmid:21486283
Walentiny DM et al. The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. 2011 Eur. J. Pharmacol. pmid:21300050
Naidoo V et al. A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. 2011 J. Mol. Neurosci. pmid:21069475
Gomes FV et al. Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice. 2011 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:21111767
Cassano T et al. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. 2011 Psychopharmacology (Berl.) pmid:21042794
Bari M et al. Characterization of the endocannabinoid system in mouse embryonic stem cells. 2011 Stem Cells Dev. pmid:20446814
Martín-Couce L et al. Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. 2011 J. Med. Chem. pmid:21675776
Romani R et al. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? 2011 Biochimie pmid:21664223
Weller K et al. TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release. 2011 Neuropeptides pmid:21868092
Khanna IK and Alexander CW Fatty acid amide hydrolase inhibitors--progress and potential. 2011 CNS Neurol Disord Drug Targets pmid:21631410
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Warzecha Z et al. Role of sensory nerves in gastroprotective effect of anandamide in rats. 2011 J. Physiol. Pharmacol. pmid:21673369
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Munguba H et al. Pre-training anandamide infusion within the basolateral amygdala impairs plus-maze discriminative avoidance task in rats. 2011 Neurobiol Learn Mem pmid:21440651
Stewart JL and McMahon LR The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. 2011 Br. J. Pharmacol. pmid:21449917
Aberturas MR et al. Anandamide-loaded nanoparticles: preparation and characterization. 2011 J Microencapsul pmid:21425945
Pinar-Sueiro S et al. [Cannabinoid applications in glaucoma]. 2011 Arch Soc Esp Oftalmol pmid:21414525
Mukhopadhyay B et al. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21383171
Rossi S et al. Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. 2011 Brain Behav. Immun. pmid:21473912
Gamaleddin I et al. The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. 2011 Br. J. Pharmacol. pmid:21501143
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Carr RL et al. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. 2011 Toxicol. Sci. pmid:21507991
Qi J et al. Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. 2011 J. Immunol. pmid:21515789
Steiner AA et al. The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. 2011 J. Physiol. (Lond.) pmid:21486787
Izzo AA and Deutsch DG Unique pathway for anandamide synthesis and liver regeneration. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21490298
Chiba T et al. A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. 2011 J. Pharm. Pharmacol. pmid:21492165
Huang L et al. Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. 2011 Lab. Invest. pmid:21464819
Ishiguro H et al. Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. 2011 Synapse pmid:20506567
Garami A et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. 2011 J. Neurosci. pmid:21289181
Wang W et al. Enhancement of apamin-sensitive medium afterhyperpolarization current by anandamide and its role in excitability control in cultured hippocampal neurons. 2011 Neuropharmacology pmid:21272594
Reis GM et al. Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. 2011 Life Sci. pmid:21277864
Kawahara H et al. Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. 2011 Br. J. Pharmacol. pmid:21175570
De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011 Br. J. Pharmacol. pmid:21175579
Jumpertz R et al. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. 2011 J. Clin. Endocrinol. Metab. pmid:21177788
De Petrocellis L et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. 2011 Pharmacol. Res. pmid:21215315
Kotsikorou E et al. Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55. 2011 Chem. Phys. Lipids pmid:21185816
Zaccagnino P et al. Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. 2011 FEBS Lett. pmid:21187088
Di Marzo V Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. 2011 Nat. Neurosci. pmid:21187849
Bari M et al. The manifold actions of endocannabinoids on female and male reproductive events. 2011 Front Biosci (Landmark Ed) pmid:21196184
Guindon J et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. 2011 Br. J. Pharmacol. pmid:21198549
Liao YS et al. [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts]. 2011 Zhonghua Zhong Liu Za Zhi pmid:21575494
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Umathe SN et al. Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. 2011 Behav. Brain Res. pmid:21549765
Arias-Carrión O et al. Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors. 2011 J. Neurosci. Res. pmid:21557294
Sordelli MS et al. The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. 2011 PLoS ONE pmid:21559512
Engel MA et al. Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. 2011 Neuropeptides pmid:21514666
Hutchins HL et al. Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. 2011 J. Nutr. Biochem. pmid:20951563
Gervasi MG et al. Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. 2011 PLoS ONE pmid:21347292
Quercioli A et al. Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. 2011 Eur. Heart J. pmid:21303779
Correa F et al. The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. 2011 Brain Behav. Immun. pmid:21310228
Latek D et al. Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR. 2011 J Mol Model pmid:21365223
Signorello MG et al. The anandamide effect on NO/cGMP pathway in human platelets. 2011 J. Cell. Biochem. pmid:21328466
Greco R et al. Effects of anandamide in migraine: data from an animal model. 2011 J Headache Pain pmid:21331757
Tsuboi K et al. Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. 2011 Biochim. Biophys. Acta pmid:21801852
Chianese R et al. Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. 2011 Gen. Comp. Endocrinol. pmid:21802420
Clugston RD et al. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. 2011 J. Lipid Res. pmid:21856784
Dollery C Investigative clinical pharmacology. 2011 Clin. Pharmacol. Ther. pmid:21862965
Kopczyńska B et al. Anandamide enhances expression of heat shock proteins Hsp70 and Hsp25 in rat lungs. 2011 Eur. J. Pharmacol. pmid:21756900
Yoshino H et al. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. 2011 J. Physiol. (Lond.) pmid:21807615
Theile JW and Cummins TR Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. 2011 Mol. Pharmacol. pmid:21788423
Ndong C et al. Cloning and pharmacological characterization of the dog cannabinoid CBâ‚‚receptor. 2011 Eur. J. Pharmacol. pmid:21871882
Altinsoy A et al. A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. 2011 J Ocul Pharmacol Ther pmid:21848425
Mestre L et al. Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. 2011 J Neuroinflammation pmid:21851608
Feledziak M et al. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. 2011 J. Med. Chem. pmid:21899370
Palermo G et al. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. 2011 J. Med. Chem. pmid:21830831
Khasabova IA et al. Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. 2011 Pharmacol. Res. pmid:21440630
Zoerner AA et al. Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma. 2011 Clin. Pharmacol. Ther. pmid:21716266
Brailoiu GC et al. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. 2011 J. Biol. Chem. pmid:21719698
Catanzaro G et al. Effect of capacitation on the endocannabinoid system of mouse sperm. 2011 Mol. Cell. Endocrinol. pmid:21723369