Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Hyperinsulinism D006946 27 associated lipids
Endotoxemia D019446 27 associated lipids
Neuralgia D009437 28 associated lipids
Obesity D009765 29 associated lipids
Catalepsy D002375 30 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Memory Disorders D008569 33 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Fever D005334 35 associated lipids
Epilepsy D004827 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Hypotension D007022 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Canseco-Alba A and Rodríguez-Manzo G Anandamide transforms noncopulating rats into sexually active animals. 2013 J Sex Med pmid:22906359
Vance JE and Tasseva G Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. 2013 Biochim. Biophys. Acta pmid:22960354
Gervasi MG et al. Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. 2013 PLoS ONE pmid:23977311
Zhang J et al. Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. 2013 Sheng Li Xue Bao pmid:23598867
Kim HY and Spector AA Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22959887
Silvestri C et al. Anandamide-derived prostamide F2α negatively regulates adipogenesis. 2013 J. Biol. Chem. pmid:23801328
Pryce G et al. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. 2013 Mult. Scler. pmid:23625705
Amoako AA et al. Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. 2013 Hum. Reprod. pmid:23697839
Abán C et al. Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. 2013 Placenta pmid:23122699
Romero TR et al. Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors. 2013 Life Sci. pmid:23123446
Guindon J et al. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. 2013 Pharmacol. Res. pmid:23127915
Buczynski MW et al. The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area. 2013 Neuropsychopharmacology pmid:23169348
De-May CL and Ali AB Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. 2013 J. Neurophysiol. pmid:23054605
Coppola M and Mondola R Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. 2013 Med. Hypotheses pmid:23896215
Lisboa SF et al. Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. 2013 Neuropharmacology pmid:23899460
Ilayan E et al. Do cannabinoids exhibit a tyramine-like effect? 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23900610
Khasabova IA et al. Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. 2013 Neurobiol. Dis. pmid:23644187
Gesell FK et al. Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. 2013 BMC Vet. Res. pmid:24370333
Sagie S et al. [Short-and long-term effects of cannabinoids on memory, cognition and mental illness]. 2013 Harefuah pmid:24483000
Fonseca BM et al. Endogenous cannabinoids revisited: a biochemistry perspective. 2013 Apr-May Prostaglandins Other Lipid Mediat. pmid:23474290
Chauvet C et al. Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats. 2014 Int. J. Neuropsychopharmacol. pmid:25522382
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Bluett RJ et al. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. 2014 Transl Psychiatry pmid:25004388
Dong W et al. Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. 2014 PLoS ONE pmid:24949851
Wiley JL et al. Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. 2014 Eur. J. Pharmacol. pmid:24858366
Pietrzak RH et al. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. 2014 Neuropsychopharmacology pmid:24820537
Ravi J et al. FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway. 2014 Oncotarget pmid:24811863
Hama AT et al. Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain. 2014 PLoS ONE pmid:24788435
Al Kury LT et al. Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes. 2014 Br. J. Pharmacol. pmid:24758718
Nader J et al. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. 2014 Neuropharmacology pmid:24709540
Kaczocha M et al. Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia. 2014 PLoS ONE pmid:24705380
Sun LJ et al. Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. 2014 Int. J. Infect. Dis. pmid:24704332
Jackson AR et al. Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction. 2014 PLoS ONE pmid:24699635
Hoyer FF et al. Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. 2014 J. Mol. Cell. Cardiol. pmid:24286707
Pertwee RG Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. 2014 Proc Nutr Soc pmid:24135210
Ohno-Shosaku T and Kano M Endocannabinoid-mediated retrograde modulation of synaptic transmission. 2014 Curr. Opin. Neurobiol. pmid:24747340
Sousa-Valente J et al. Anandamide in primary sensory neurons: too much of a good thing? 2014 Eur. J. Neurosci. pmid:24494681
Chianese R et al. Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. 2014 Gen. Comp. Endocrinol. pmid:24566122
Rea K et al. Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. 2014 Eur. J. Neurosci. pmid:24494683
Zheng Y et al. Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. 2014 Eur. J. Pharmacol. pmid:24508383
Al Kury LT et al. Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes. 2014 Cell Calcium pmid:24472666
Krishnan G and Chatterjee N Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. 2014 Mol. Cell. Neurosci. pmid:24418364
Björklund E et al. Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations. 2014 PLoS ONE pmid:24466356
Yu S et al. Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. 2014 J. Biol. Chem. pmid:24644281
Mahavadi S et al. Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinase. 2014 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:24407588
Jackson AR et al. Characterization of endocannabinoid-mediated induction of myeloid-derived suppressor cells involving mast cells and MCP-1. 2014 J. Leukoc. Biol. pmid:24319288
Okura D et al. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes. 2014 Anesth. Analg. pmid:24557103
Harvey BS et al. Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model. 2014 Cytokine pmid:24238999