Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Liver Cirrhosis D008103 67 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Lam PM et al. Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma. 2008 Anal. Biochem. pmid:18555789
Horvath G et al. The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level. 2008 Pain pmid:17533116
Zolese G et al. Effect of acylethanolamides on lipid peroxidation and paraoxonase activity. 2008 Biofactors pmid:19478424
Panagis G et al. Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties. 2008 Curr Drug Abuse Rev pmid:19630731
Ortar G et al. Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. 2008 Eur J Med Chem pmid:17452063
Malvindi MA et al. Rod-shaped nanocrystals elicit neuronal activity in vivo. 2008 Small pmid:18844306
Liu J et al. Multiple pathways involved in the biosynthesis of anandamide. 2008 Neuropharmacology pmid:17631919
Shaladi AM et al. [Cannabinoids in the control of pain]. 2008 Recenti Prog Med pmid:19388223
Xiong W et al. Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization. 2008 Mol. Pharmacol. pmid:17993512
Hill MN et al. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. 2008 Hippocampus pmid:18058925
Egertová M et al. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. 2008 J. Comp. Neurol. pmid:18067139
Rossi C et al. Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels. 2008 Eur. J. Clin. Pharmacol. pmid:18004553
Di Marzo V et al. The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. 2008 Br. J. Pharmacol. pmid:18223666
Simon GM and Cravatt BF Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. 2008 J. Biol. Chem. pmid:18227059
Burstein S The elmiric acids: biologically active anandamide analogs. 2008 Neuropharmacology pmid:18187165
Maccarrone M et al. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. 2008 Nat. Neurosci. pmid:18204441
Paradisi A et al. Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. 2008 J. Biol. Chem. pmid:18165231
Jackson SN et al. Volatile anesthetics and endogenous cannabinoid anandamide have additive and independent inhibitory effects on alpha(7)-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. 2008 Eur. J. Pharmacol. pmid:18242598
Butt C et al. Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. 2008 J. Neurochem. pmid:18194436
Oddi S et al. Evidence for the intracellular accumulation of anandamide in adiposomes. 2008 Cell. Mol. Life Sci. pmid:18213445
Baldassano S et al. Cannabinoid CB(1) receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle. 2008 Eur. J. Pharmacol. pmid:18234188
Starowicz KM et al. Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. 2008 Obesity (Silver Spring) pmid:18239598
Gorzalka BB et al. Endocannabinoid modulation of male rat sexual behavior. 2008 Psychopharmacology (Berl.) pmid:17694389
Rueda-Orozco PE et al. A potential function of endocannabinoids in the selection of a navigation strategy by rats. 2008 Psychopharmacology (Berl.) pmid:17805517
Engeli S et al. Peripheral endocannabinoid system activity in patients treated with sibutramine. 2008 Obesity (Silver Spring) pmid:18356837
Kurtuncu M et al. Effects of cocaine in 5-lipoxygenase-deficient mice. 2008 J Neural Transm pmid:18327533
Habayeb OM et al. Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage. 2008 JAMA pmid:18334688
Oláh M et al. The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. 2008 Mol. Cell. Endocrinol. pmid:18308464
Potvin S et al. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. 2008 J. Psychopharmacol. (Oxford) pmid:18308802
Hill MN et al. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. 2008 Pharmacopsychiatry pmid:18311684
Migliarini B and Carnevali O Anandamide modulates growth and lipid metabolism in the zebrafish Danio rerio. 2008 Mol. Cell. Endocrinol. pmid:18342434
Wise LE et al. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. 2008 Neuropharmacology pmid:17675189
De Oliveira Alvares L et al. Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms. 2008 Neurobiol Learn Mem pmid:18342551
Palkovits M et al. Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. 2008 Neuroscience pmid:18343585
Fezza F et al. Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation. 2008 J. Lipid Res. pmid:18316795
Gertsch J Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system. 2008 Planta Med. pmid:18275004
Roberts LA et al. Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. 2008 Neuropharmacology pmid:17631916
Gonçalves P et al. Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. 2008 Pharmacology pmid:18431074
McFarland MJ et al. RNA interference-mediated knockdown of dynamin 2 reduces endocannabinoid uptake into neuronal dCAD cells. 2008 Mol. Pharmacol. pmid:18436710
Nomura DK et al. Activation of the endocannabinoid system by organophosphorus nerve agents. 2008 Nat. Chem. Biol. pmid:18438404
Ortar G et al. New tetrazole-based selective anandamide uptake inhibitors. 2008 Bioorg. Med. Chem. Lett. pmid:18424134
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Capasso R and Izzo AA Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. 2008 J. Neuroendocrinol. pmid:18426498
Ahn K et al. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. 2008 Chem. Rev. pmid:18429637
Engel MA et al. Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide. 2008 J. Physiol. Pharmacol. pmid:19212003
Mallat A and Lotersztajn S Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis. 2008 Diabetes Metab. pmid:19195630
Palmer JA et al. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. 2008 Neuroscience pmid:18541380
Yang Z et al. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. 2008 Biochem. Pharmacol. pmid:18755158
Di Marzo V Endocannabinoids: synthesis and degradation. 2008 Rev. Physiol. Biochem. Pharmacol. pmid:18481028
Pertwee RG Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. 2008 Addict Biol pmid:18482430
Rueda-Orozco PE et al. Impairment of endocannabinoids activity in the dorsolateral striatum delays extinction of behavior in a procedural memory task in rats. 2008 Neuropharmacology pmid:18501388
Di Filippo M et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. 2008 J. Neurol. Neurosurg. Psychiatr. pmid:18535023
Ashton JC et al. Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. 2008 Curr. Med. Chem. pmid:18537620
Njie YF et al. N-arachidonylethanolamide-induced increase in aqueous humor outflow facility. 2008 Invest. Ophthalmol. Vis. Sci. pmid:18539938
Feizi A et al. The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney. 2008 Exp. Toxicol. Pathol. pmid:18571910
Woo DH et al. Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). 2008 Mol Pain pmid:18826653
Habayeb OM et al. Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. 2008 Endocrinology pmid:18599552
DeMorrow S et al. The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18832445
Waldeck-Weiermair M et al. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. 2008 J. Cell. Sci. pmid:18445684
Resstel LB et al. Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. 2008 Psychopharmacology (Berl.) pmid:18446325
Cippitelli A et al. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. 2008 Psychopharmacology (Berl.) pmid:18446329
Bambico FR and Gobbi G The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets. 2008 Expert Opin. Ther. Targets pmid:18851692
Liu HY et al. [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18578993
Dembiński A et al. Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. 2008 Eur. J. Pharmacol. pmid:18593574
Khasabova IA et al. A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. 2008 J. Neurosci. pmid:18971457
Hill MN et al. Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. 2008 J Neural Transm pmid:18974922
Lisboa SF et al. Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. 2008 Eur. J. Pharmacol. pmid:18691568
Currie S et al. IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei. 2008 J. Mol. Cell. Cardiol. pmid:18692061
Turco MY et al. High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. 2008 Hum. Reprod. pmid:18614613
Maccarrone M Anandamide as a marker of human disease. 2008 JAMA pmid:18632539
Hill MN et al. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. 2008 J. Neurochem. pmid:18643796
Kudo R and Hatake K [Effect of ethanol on anandamide-induced sensory nerve dependent vasorelaxation (the second report)]. 2008 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:18646646
Maione S et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. 2008 Br. J. Pharmacol. pmid:18660824
Fowler CJ "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. 2008 Curr. Pharm. Des. pmid:18781976
McPartland JM et al. Cannabimimetic effects modulated by cholinergic compounds. 2008 Addict Biol pmid:18782385
Ferreri C et al. Synthesis of all-trans anandamide: a substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation. 2008 Bioorg. Med. Chem. pmid:18782671
Rácz I et al. Anandamide effects on 5-HT(3) receptors in vivo. 2008 Eur. J. Pharmacol. pmid:18775693
Neelands TR et al. Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons. 2008 Inflamm. Res. pmid:18777111
Placzek EA et al. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. 2008 J. Neurochem. pmid:18778304
Scherma M et al. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. 2008 J. Pharmacol. Exp. Ther. pmid:18725543
Ho WS et al. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. 2008 Br. J. Pharmacol. pmid:18695637
Woodward DF et al. The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products. 2008 Pharmacol. Ther. pmid:18700152
Williams JL et al. K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18703414
Moezi L et al. Endocannabinoids and liver disease. V. endocannabinoids as mediators of vascular and cardiac abnormalities in cirrhosis. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18703639
de Oliveira Alvares L et al. Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. 2008 Neuroscience pmid:18554811
Cella M et al. Dual effect of anandamide on rat placenta nitric oxide synthesis. 2008 Placenta pmid:18561998
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289
Nakata M and Yada T Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. 2008 Regul. Pept. pmid:17884194
Haller VL et al. Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. 2008 Eur. J. Pharmacol. pmid:18762181
Astarita G et al. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. 2008 J. Lipid Res. pmid:17957091
Qin N et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. 2008 J. Neurosci. pmid:18550765
Lehtonen M et al. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. 2008 Chem. Biodivers. pmid:19035572
Scherma M et al. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. 2008 Neuropharmacology pmid:17904589
Bjursell M et al. Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18029443
Butler RK et al. Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates. 2008 Pain pmid:19004548
Williams MA et al. The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor. 2008 J. Physiol. (Lond.) pmid:18063665
Gyires K and Zádori Z [Analysis of central mechanisms involved in gastric mucosal integrity]. 2008 Neuropsychopharmacol Hung pmid:18956615
Justinova Z et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. 2008 Biol. Psychiatry pmid:18814866
Thiemann G et al. The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. 2008 Behav. Brain Res. pmid:17988751
Correa F et al. Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). 2008 Biochem. J. pmid:17961121