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Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. |
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Eur J Med Chem |
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Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties. |
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Curr Drug Abuse Rev |
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J. Pharmacol. Exp. Ther. |
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Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization. |
2008 |
Mol. Pharmacol. |
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Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. |
2008 |
Hippocampus |
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Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. |
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Neuropharmacology |
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Gorzalka BB et al. |
Endocannabinoid modulation of male rat sexual behavior. |
2008 |
Psychopharmacology (Berl.) |
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A potential function of endocannabinoids in the selection of a navigation strategy by rats. |
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Psychopharmacology (Berl.) |
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Obesity (Silver Spring) |
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Neuropharmacology |
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Chem. Rev. |
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CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. |
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Neuropharmacology |
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Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. |
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Br. J. Pharmacol. |
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Trends Pharmacol. Sci. |
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Anandamide and neutrophil function in patients with fibromyalgia. |
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Psychoneuroendocrinology |
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Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. |
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Mol. Pharmacol. |
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The endocannabinoid system in brain reward processes. |
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Br. J. Pharmacol. |
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Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. |
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Arthritis Res. Ther. |
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Biosynthesis, degradation and pharmacological importance of the fatty acid amides. |
2008 |
Drug Discov. Today |
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Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents. |
2008 |
Neuroimage |
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Biochem. Pharmacol. |
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Development of novel tail-modified anandamide analogs. |
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Bioorg. Med. Chem. Lett. |
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Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. |
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Ther Apher Dial |
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Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. |
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J. Biochem. |
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The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain. |
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Neuroscience |
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Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). |
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Mol Pain |
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The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. |
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Am. J. Physiol. Gastrointest. Liver Physiol. |
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Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. |
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Eur. J. Pharmacol. |
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Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. |
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FEBS J. |
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Nippon Yakurigaku Zasshi |
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Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. |
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Br. J. Pharmacol. |
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Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. |
2008 |
Eur Neuropsychopharmacol |
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Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? |
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Pharmacol. Res. |
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Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. |
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J Anesth |
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Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. |
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Eur. J. Pharmacol. |
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IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei. |
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J. Mol. Cell. Cardiol. |
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High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. |
2008 |
Hum. Reprod. |
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Anandamide as a marker of human disease. |
2008 |
JAMA |
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Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. |
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J. Neurochem. |
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Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. |
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Eur. J. Pharmacol. |
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Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. |
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J. Endocrinol. |
pmid:18755884
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Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. |
2008 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:18096608
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The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. |
2008 |
Neuropharmacology |
pmid:17904589
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Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice. |
2008 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:18029443
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The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor. |
2008 |
J. Physiol. (Lond.) |
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Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. |
2008 |
Cereb. Cortex |
pmid:17921459
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Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. |
2008 |
Biol. Psychiatry |
pmid:18814866
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An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. |
2008 |
Anal. Biochem. |
pmid:17981259
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Thiemann G et al. |
The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. |
2008 |
Behav. Brain Res. |
pmid:17988751
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Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). |
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Biochem. J. |
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