Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Millns PJ et al. Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors. 2006 Eur. J. Neurosci. pmid:17229097
Mechoulam R et al. Endocannabinoids, feeding and suckling--from our perspective. 2006 Int J Obes (Lond) pmid:16570101
Matias I et al. Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. 2006 Int J Obes (Lond) pmid:16570107
Schiano Moriello A et al. Development of the first potential covalent inhibitors of anandamide cellular uptake. 2006 J. Med. Chem. pmid:16570928
Appendino G et al. Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. 2006 J. Med. Chem. pmid:16570929
Chang L et al. Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. 2006 Br. J. Pharmacol. pmid:16501580
Fezza F et al. Methods to assay anandamide hydrolysis and transport in synaptosomes. 2006 Methods Mol. Med. pmid:16506407
Kaczocha M et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. 2006 J. Biol. Chem. pmid:16461355
Waku K [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. 2006 Yakugaku Zasshi pmid:16462096
Petersen G et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. 2006 Biochim. Biophys. Acta pmid:16478679
Guindon J et al. Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. 2006 Pain pmid:16480822
Busch L et al. Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16487271
Schelling G et al. Effects of general anesthesia on anandamide blood levels in humans. 2006 Anesthesiology pmid:16436846
Guindon J and Beaulieu P Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. 2006 Neuropharmacology pmid:16442133
Bermúdez-Siva FJ et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. 2006 Eur. J. Pharmacol. pmid:16423347
Guagnini F et al. Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. 2006 Gut pmid:16423891
Meuth SG et al. The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. 2006 Mol. Pharmacol. pmid:16424077
Prestifilippo JP et al. Inhibition of salivary secretion by activation of cannabinoid receptors. 2006 Exp. Biol. Med. (Maywood) pmid:16946411
Spoto B et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. 2006 Biochimie pmid:16949718
Vlachou S et al. Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. 2006 Psychopharmacology (Berl.) pmid:16953388
Mulder AM and Cravatt BF Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. 2006 Biochemistry pmid:16981687
Hong Z et al. Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. 2006 Circulation pmid:16982938
Stefano GB and Salamon EJ Nitric oxide and anandamide in OMT research. 2006 J Am Osteopath Assoc pmid:17122026
Lambert RC et al. Modulation of neuronal T-type calcium channels. 2006 CNS Neurol Disord Drug Targets pmid:17168746
Fowler CJ The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. 2006 Fundam Clin Pharmacol pmid:17109648
Giuliano M et al. Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. 2006 Int. J. Mol. Med. pmid:16596265
Di Marzo M et al. Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics. 2006 J. Pept. Sci. pmid:16534762
Cobellis G et al. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. 2006 Biol. Reprod. pmid:16611862
Solinas M et al. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. 2006 J. Neurochem. pmid:16805835
Vinod KY et al. Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system. 2006 Neurochem. Int. pmid:16822589
Ghasemi M et al. Effect of anandamide on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum. 2006 Eur. J. Pharmacol. pmid:16824514
Wagner JA et al. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. 2006 J. Cardiovasc. Pharmacol. pmid:16775503
Bonechi C et al. Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. 2006 Eur J Med Chem pmid:16837109
Costa B et al. AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. 2006 Br. J. Pharmacol. pmid:16770320
Felder CC et al. Cannabinoids biology: the search for new therapeutic targets. 2006 Mol. Interv. pmid:16809476
Yeh JH et al. Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16623868
Laviolette SR and Grace AA The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. 2006 Cell. Mol. Life Sci. pmid:16699809
Balas L et al. Synthesis of a potential photoactivatable anandamide analog. 2006 Bioorg. Med. Chem. Lett. pmid:16682198
Shouman B et al. Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. 2006 Br. J. Pharmacol. pmid:16682966
Zaniewska M et al. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. 2006 Eur. J. Pharmacol. pmid:16730696
Harada N et al. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. 2006 Thromb. Haemost. pmid:16732381
Li J and Wang DH Differential mechanisms mediating depressor and diuretic effects of anandamide. 2006 J. Hypertens. pmid:17053550
Krishtal O et al. The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids. 2006 Pflugers Arch. pmid:16741755
Wang Y et al. A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening. 2006 Anal. Biochem. pmid:16707086
Schmidt A et al. Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. 2006 Biomed. Chromatogr. pmid:16189813
Bai X et al. TASK channel expression in human placenta and cytotrophoblast cells. 2006 J. Soc. Gynecol. Investig. pmid:16378911
Hejazi N et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. 2006 Mol. Pharmacol. pmid:16332990
Bojesen IN and Hansen HS Effect of an unstirred layer on the membrane permeability of anandamide. 2006 J. Lipid Res. pmid:16365480
Dembiński A et al. Cannabinoids in acute gastric damage and pancreatitis. 2006 J. Physiol. Pharmacol. pmid:17218765
D'Argenio G et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. 2006 FASEB J. pmid:16403786
Nakajima Y et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. 2006 FEBS Lett. pmid:16406050
Suplita RL et al. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. 2006 Neuropharmacology pmid:16316669
Avelino A and Cruz F TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16721555
Murillo-Rodriguez E et al. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. 2006 Life Sci. pmid:16434061
Juan-Picó P et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. 2006 Cell Calcium pmid:16321437
Cannizzaro C et al. Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus. 2006 Neurochem. Int. pmid:16325966
de Lago E et al. UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. 2006 Eur Neuropsychopharmacol pmid:16006105
Ligresti A et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. 2006 Br. J. Pharmacol. pmid:16284631
Bir LS and Ercan S Effects of intrathecal anandamide on somatosensory evoked responses in rats. 2006 Exp. Neurol. pmid:16289169
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Glaser ST et al. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. 2006 J. Pharmacol. Exp. Ther. pmid:16278311
Malfitano AM et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. 2006 J. Neuroimmunol. pmid:16239036
Lynch DL and Reggio PH Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. 2006 Jul-Aug J. Comput. Aided Mol. Des. pmid:17106765
Dickason-Chesterfield AK et al. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. 2006 Jul-Aug Cell. Mol. Neurobiol. pmid:16736384
Battista N et al. The endocannabinoid system in neurodegeneration. 2006 Sep-Dec Ital. J. Biochem. pmid:17274532
Mahler SV et al. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. 2007 Neuropsychopharmacology pmid:17406653
Kopczyńska B The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats. 2007 Life Sci. pmid:17379256
Ferrer B et al. Regulation of brain anandamide by acute administration of ethanol. 2007 Biochem. J. pmid:17302558
Naidu PS et al. Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. 2007 Psychopharmacology (Berl.) pmid:17279376
Sun Y et al. Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. 2007 Br. J. Pharmacol. pmid:17906680
Rubio M et al. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. 2007 Neurosci. Lett. pmid:17574742
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. 2007 Br. J. Pharmacol. pmid:17876302
Mulè F et al. Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon. 2007 Pharmacol. Res. pmid:17574859
Karsak M et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. 2007 Science pmid:17556587
Bátkai S et al. Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17557913
Williams J et al. Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. 2007 Anal. Chem. pmid:17600384
Esposito G et al. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. 2007 J. Pharmacol. Exp. Ther. pmid:17545311
Sit SY et al. Novel inhibitors of fatty acid amide hydrolase. 2007 Bioorg. Med. Chem. Lett. pmid:17459705
Lory P and Chemin J Towards the discovery of novel T-type calcium channel blockers. 2007 Expert Opin. Ther. Targets pmid:17465728
Ryan D et al. Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. 2007 Eur. J. Neurosci. pmid:17419758
Gonthier MP et al. Identification of endocannabinoids and related compounds in human fat cells. 2007 Obesity (Silver Spring) pmid:17426318
Raduner S et al. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. 2007 J. Nat. Prod. pmid:17497806
Wang Y and Wang DH Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. 2007 Cardiovasc Hematol Disord Drug Targets pmid:17346127
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Jia Y and Lee LY Role of TRPV receptors in respiratory diseases. 2007 Biochim. Biophys. Acta pmid:17346945
Solinas M et al. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. 2007 J. Pharmacol. Exp. Ther. pmid:17351107
Rettori V et al. Endocannabinoids in TNF-alpha and ethanol actions. 2007 Neuroimmunomodulation pmid:18073513
Cross-Mellor SK et al. Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. 2007 Psychopharmacology (Berl.) pmid:17111174
Ronco AM et al. Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid. 2007 Pharmacology pmid:17114903
Ho WS and Randall MD Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. 2007 Br. J. Pharmacol. pmid:17245358
Wheal AJ et al. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. 2007 Br. J. Pharmacol. pmid:17245361
Snider NT et al. Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. 2007 J. Pharmacol. Exp. Ther. pmid:17272674
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Solinas M et al. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. 2007 J. Pharmacol. Exp. Ther. pmid:17210800
Pisanti S et al. Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. 2007 J. Cell. Physiol. pmid:17192847
Ekins S et al. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. 2007 Drug Metab. Dispos. pmid:17194716
Schreiber D et al. Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. 2007 Anal. Biochem. pmid:17196922
Kreutz S et al. Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. 2007 Exp. Neurol. pmid:17010339
Degenhardt BF et al. Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. 2007 J Am Osteopath Assoc pmid:17908831
Xu H et al. Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene. 2007 Am. J. Physiol. Renal Physiol. pmid:17913835