Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Lam PM et al. Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma. 2008 Anal. Biochem. pmid:18555789
Horvath G et al. The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level. 2008 Pain pmid:17533116
Moloney GP et al. Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. 2008 Eur J Med Chem pmid:17582659
Zolese G et al. Effect of acylethanolamides on lipid peroxidation and paraoxonase activity. 2008 Biofactors pmid:19478424
Malvindi MA et al. Rod-shaped nanocrystals elicit neuronal activity in vivo. 2008 Small pmid:18844306
Liu J et al. Multiple pathways involved in the biosynthesis of anandamide. 2008 Neuropharmacology pmid:17631919
Shaladi AM et al. [Cannabinoids in the control of pain]. 2008 Recenti Prog Med pmid:19388223
Baldassano S et al. Cannabinoid CB(1) receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle. 2008 Eur. J. Pharmacol. pmid:18234188
Starowicz KM et al. Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. 2008 Obesity (Silver Spring) pmid:18239598
Roberts LA et al. Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. 2008 Neuropharmacology pmid:17631916
Gonçalves P et al. Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. 2008 Pharmacology pmid:18431074
McFarland MJ et al. RNA interference-mediated knockdown of dynamin 2 reduces endocannabinoid uptake into neuronal dCAD cells. 2008 Mol. Pharmacol. pmid:18436710
Nomura DK et al. Activation of the endocannabinoid system by organophosphorus nerve agents. 2008 Nat. Chem. Biol. pmid:18438404
Ortar G et al. New tetrazole-based selective anandamide uptake inhibitors. 2008 Bioorg. Med. Chem. Lett. pmid:18424134
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Capasso R and Izzo AA Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. 2008 J. Neuroendocrinol. pmid:18426498
Ahn K et al. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. 2008 Chem. Rev. pmid:18429637
Rubio M et al. CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. 2008 Neuropharmacology pmid:18371990
Evans RM et al. Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. 2008 Br. J. Pharmacol. pmid:18376419
Palmer JA et al. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. 2008 Neuroscience pmid:18541380
Feizi A et al. The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney. 2008 Exp. Toxicol. Pathol. pmid:18571910
Habayeb OM et al. Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. 2008 Endocrinology pmid:18599552
Waldeck-Weiermair M et al. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. 2008 J. Cell. Sci. pmid:18445684
Resstel LB et al. Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. 2008 Psychopharmacology (Berl.) pmid:18446325
Cippitelli A et al. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. 2008 Psychopharmacology (Berl.) pmid:18446329
Liu HY et al. [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18578993
Dembiński A et al. Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. 2008 Eur. J. Pharmacol. pmid:18593574
Stark K et al. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. 2008 FEBS J. pmid:18549450
de Oliveira Alvares L et al. Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. 2008 Neuroscience pmid:18554811
Cella M et al. Dual effect of anandamide on rat placenta nitric oxide synthesis. 2008 Placenta pmid:18561998
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289
Haller VL et al. Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. 2008 Eur. J. Pharmacol. pmid:18762181
Astarita G et al. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. 2008 J. Lipid Res. pmid:17957091
da Veiga MA et al. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. 2008 J. Endocrinol. pmid:18755884
Scherma M et al. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. 2008 Neuropharmacology pmid:17904589
Sakamoto Y et al. Effectiveness of continuous hemodiafiltration using a polymethylmethacrylate membrane hemofilter after polymyxin B-immobilized fiber column therapy of septic shock. 2008 Jan-Feb ASAIO J. pmid:18204329
Lissoni P et al. The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. 2008 Nov-Dec Anticancer Res. pmid:19189659
Kurjak M et al. Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. 2008 Oct-Dec Neuropeptides pmid:18829105
Adermark L et al. Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. 2009 Eur. J. Neurosci. pmid:19120438
Wang J and Ueda N Biology of endocannabinoid synthesis system. 2009 Prostaglandins Other Lipid Mediat. pmid:19126434
Acone G et al. Low type I cannabinoid receptor levels characterize placental villous in labouring delivery. 2009 Placenta pmid:19097644
Wheal AJ and Randall MD Effects of hypertension on vasorelaxation to endocannabinoids in vitro. 2009 Eur. J. Pharmacol. pmid:19100733
Escartín-Pérez RE et al. Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. 2009 Physiol. Behav. pmid:19150453
Eckardt K et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. 2009 Diabetologia pmid:19089403
Karbarz MJ et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. 2009 Anesth. Analg. pmid:19095868
Vignali M et al. The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. 2009 Glia pmid:19031444
Fernandez-Solari J et al. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. 2009 Braz. J. Med. Biol. Res. pmid:19448903
Ribeiro A et al. Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. 2009 Braz. J. Med. Biol. Res. pmid:19448906
Li D et al. Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. 2009 J. Hypertens. pmid:19462497
Mahmud A et al. Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. 2009 Neuroscience pmid:19463903
Vann RE et al. Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. 2009 Eur. J. Pharmacol. pmid:19470387
Guasti L et al. Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. 2009 Mol Pain pmid:19570201
Bittner S et al. TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. 2009 Brain pmid:19570851
Grimaldi P et al. The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19541620
Grider JR et al. Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19589944
Batetta B et al. Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. 2009 J. Nutr. pmid:19549757
Catanzaro G et al. Anandamide increases swelling and reduces calcium sensitivity of mitochondria. 2009 Biochem. Biophys. Res. Commun. pmid:19679102
Fraga D et al. Endogenous cannabinoids induce fever through the activation of CB1 receptors. 2009 Br. J. Pharmacol. pmid:19681872
Lozovaya N et al. Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. 2009 Cell Calcium pmid:19682741
Okamoto Y et al. Enzymatic formation of anandamide. 2009 Vitam. Horm. pmid:19647106
Yates ML and Barker EL Organized trafficking of anandamide and related lipids. 2009 Vitam. Horm. pmid:19647107
Goodfellow CE and Glass M Anandamide receptor signal transduction. 2009 Vitam. Horm. pmid:19647109
Brown AJ and Robin Hiley C Is GPR55 an anandamide receptor? 2009 Vitam. Horm. pmid:19647110
Correa FG et al. The endocannabinoid anandamide from immunomodulation to neuroprotection. Implications for multiple sclerosis. 2009 Vitam. Horm. pmid:19647114
Yang YY et al. Inhibition of hepatic tumour necrosis factor-alpha attenuates the anandamide-induced vasoconstrictive response in cirrhotic rat livers. 2009 Liver Int. pmid:19413671
Hansen HS and Diep TA N-acylethanolamines, anandamide and food intake. 2009 Biochem. Pharmacol. pmid:19413995
Zoerner AA et al. Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19414283
Di Pasquale E et al. The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. 2009 PLoS ONE pmid:19330032
Pelorosso FG et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. 2009 Eur. J. Pharmacol. pmid:19022239
Abalo R et al. Postnatal maturation of the gastrointestinal tract: a functional and immunohistochemical study in the guinea-pig ileum at weaning. 2009 Neurosci. Lett. pmid:19819299
Järbe TU et al. Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. 2009 Psychopharmacology (Berl.) pmid:18521574
Bajo M et al. Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. 2009 J. Neurosci. Res. pmid:18816788
Long JZ et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. 2009 Nat. Chem. Biol. pmid:19029917
Musella A et al. TRPV1 channels facilitate glutamate transmission in the striatum. 2009 Mol. Cell. Neurosci. pmid:18930149
Meuth SG et al. The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. 2009 Neurobiol. Dis. pmid:18930826
Sun X et al. Genetic loss of Faah compromises male fertility in mice. 2009 Biol. Reprod. pmid:18987328
Marczylo TH et al. A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices. 2009 Anal. Biochem. pmid:18823934
Long JZ et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19918051
Hong S et al. Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. 2009 Gut pmid:18936104
Correa F et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. 2009 Biochem. Pharmacol. pmid:18848818
Cottone E et al. Goldfish CB1 mRNA expression is affected by fasting and anandamide administration. 2009 Neuroreport pmid:19293731
Villanueva A et al. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. 2009 Shock pmid:19295473
Clapper JR et al. The endocannabinoid system as a target for the treatment of cannabis dependence. 2009 Neuropharmacology pmid:18691603
Catani MV et al. Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. 2009 J. Mol. Med. pmid:18820887
Hill MN et al. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. 2009 Neuropsychopharmacology pmid:19710634
Yusifzade K et al. The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig. 2009 Bratisl Lek Listy pmid:19711821
Thors L and Fowler CJ Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. 2009 Eur. J. Pharmacol. pmid:19715690
Kaufmann I et al. Enhanced anandamide plasma levels in patients with complex regional pain syndrome following traumatic injury: a preliminary report. 2009 Eur Surg Res pmid:19729930
Shinohara Y et al. Cannabinoid in the nucleus accumbens enhances the intake of palatable solution. 2009 Neuroreport pmid:19734811
Campos AC and Guimarães FS Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:19735690
Wyffels L et al. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. 2009 J. Med. Chem. pmid:19719235
Di Marzo V et al. Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. 2009 Eur. J. Endocrinol. pmid:19745037
Cano C et al. Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. 2009 Eur J Med Chem pmid:19762126
Centonze D et al. Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. 2009 Neurol. Sci. pmid:19768368
Jean-Gilles L et al. Plasma endocannabinoid levels in multiple sclerosis. 2009 J. Neurol. Sci. pmid:19695579
Wyffels L et al. Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. 2009 Bioorg. Med. Chem. pmid:19054678
Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. 2009 Bone pmid:19059369
Jiang LS et al. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. 2009 Cardiovasc. Res. pmid:19074161
Aneetha H et al. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. 2009 Bioorg. Med. Chem. Lett. pmid:19013794
Mato S et al. CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. 2009 Glia pmid:18814177