Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Rajesh M et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. 2012 Diabetes pmid:22315315
Troy-Fioramonti S et al. Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. 2015 Diabetes pmid:25281429
Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. 2005 Diabetes pmid:16186383
Mallat A and Lotersztajn S Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis. 2008 Diabetes Metab. pmid:19195630
Eckardt K et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. 2009 Diabetologia pmid:19089403
Harada N and Okajima K Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats. 2007 Dig. Dis. Sci. pmid:17211693
González S et al. Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. 2004 Drug Alcohol Depend pmid:15099659
Childers SR and Breivogel CS Cannabis and endogenous cannabinoid systems. 1998 Jun-Jul Drug Alcohol Depend pmid:9716939
Welch SP Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. 1997 Drug Alcohol Depend pmid:9179505
Muccioli GG Endocannabinoid biosynthesis and inactivation, from simple to complex. 2010 Drug Discov. Today pmid:20304091
Farrell EK and Merkler DJ Biosynthesis, degradation and pharmacological importance of the fatty acid amides. 2008 Drug Discov. Today pmid:18598910
Sridar C et al. Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. 2011 Drug Metab. Dispos. pmid:21289075
Pratt-Hyatt M et al. Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide. 2010 Drug Metab. Dispos. pmid:20702771
Ekins S et al. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. 2007 Drug Metab. Dispos. pmid:17194716
Jia Y et al. TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence. 2005 Drug News Perspect. pmid:15915217
Thieme U et al. Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. 2014 Jan-Feb Drug Test Anal pmid:24424856
Battista N et al. Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices. 2014 Jan-Feb Drug Test Anal pmid:24218186
Maingret F et al. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. 2001 EMBO J. pmid:11226154
Chemin J et al. Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. 2001 EMBO J. pmid:11742980
van der Stelt M et al. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. 2005 EMBO J. pmid:16107881
Laezza C et al. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. 2010 Endocr. Relat. Cancer pmid:20304978
Karlsson C et al. Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats. 2015 Endocrinology pmid:25549047
Francavilla F et al. Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability. 2009 Endocrinology pmid:19608651
Forner-Piquer I et al. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. 2017 Endocrinology pmid:28938452
Maccarrone M et al. Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. 2003 Endocrinology pmid:12488326
Rossi G et al. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. 2007 Endocrinology pmid:17110429
Martella A et al. Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. 2016 Endocrinology pmid:27014939
Melck D et al. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. 2000 Endocrinology pmid:10614630
Habayeb OM et al. Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. 2008 Endocrinology pmid:18599552
Romigi A et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. 2010 Epilepsia pmid:19817812
Manna SS and Umathe SN Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. 2012 Epilepsy Res. pmid:22386872
Citraro R et al. CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. 2013 Epilepsy Res. pmid:23860329
Schaefer C et al. Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. 2014 Eur Arch Psychiatry Clin Neurosci pmid:24253425
Moloney GP et al. Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. 2008 Eur J Med Chem pmid:17582659
Ortar G et al. Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. 2008 Eur J Med Chem pmid:17452063
López-Rodríguez ML et al. Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. 2003 Eur J Med Chem pmid:12750028
Bonechi C et al. Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. 2006 Eur J Med Chem pmid:16837109
Cano C et al. Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. 2009 Eur J Med Chem pmid:19762126
Monteleone AM et al. Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. 2016 Eur J Nutr pmid:26759262
Ford GK et al. Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. 2015 Eur J Pain pmid:25504741
Juntunen J et al. Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. 2003 Eur J Pharm Sci pmid:12729860
Karlsson M et al. Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments. 2004 Eur J Pharm Sci pmid:15158903
McLaughlin RJ et al. Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. 2012 Eur Neuropsychopharmacol pmid:22325231
Manduca A et al. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. 2015 Eur Neuropsychopharmacol pmid:25914159
de Lago E et al. UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. 2006 Eur Neuropsychopharmacol pmid:16006105
Ellgren M et al. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. 2008 Eur Neuropsychopharmacol pmid:18674887
Kaufmann I et al. Enhanced anandamide plasma levels in patients with complex regional pain syndrome following traumatic injury: a preliminary report. 2009 Eur Surg Res pmid:19729930
Quercioli A et al. Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. 2011 Eur. Heart J. pmid:21303779
Raichlen DA et al. Exercise-induced endocannabinoid signaling is modulated by intensity. 2013 Eur. J. Appl. Physiol. pmid:22990628
Feuerecker M et al. Effects of exercise stress on the endocannabinoid system in humans under field conditions. 2012 Eur. J. Appl. Physiol. pmid:22101870