Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Bronchial Spasm D001986 18 associated lipids
Morphine Dependence D009021 9 associated lipids
Shock, Septic D012772 11 associated lipids
Cough D003371 19 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Catalepsy D002375 30 associated lipids
Migraine Disorders D008881 11 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Hillard CJ et al. Characterization of ligand binding to the cannabinoid receptor of rat brain membranes using a novel method: application to anandamide. 1995 J. Neurochem. pmid:7830060
Lam PM et al. Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death. 2007 J. Neurochem. pmid:17442052
Subbanna S et al. Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. 2015 J. Neurochem. pmid:25857698
Yang HY et al. GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat. 1999 J. Neurochem. pmid:10217273
Pearlman RJ et al. Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. 2003 J. Neurochem. pmid:12558979
Maccarrone M et al. Enhanced anandamide degradation is associated with neuronal apoptosis induced by the HIV-1 coat glycoprotein gp120 in the rat neocortex. 2004 J. Neurochem. pmid:15147522
Ahluwalia J et al. Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. 2003 J. Neurochem. pmid:12558978
Basavarajappa BS and Hungund BL Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells. 1999 J. Neurochem. pmid:9930723
De Lago E et al. Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. 2006 J. Neurochem. pmid:16899063
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Vogel Z et al. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. 1993 J. Neurochem. pmid:8515284
Jarrahian A et al. Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. 2000 J. Neurochem. pmid:10820223
Hansen HH et al. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. 2001 J. Neurochem. pmid:11579150
Di Marzo V et al. Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats. 2000 J. Neurochem. pmid:10737621
Maccarrone M et al. Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. 2001 J. Neurochem. pmid:11461969
Di Marzo V et al. Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. 2000 J. Neurochem. pmid:11080195
Rubino T et al. Loss of cannabinoid-stimulated guanosine 5'-O-(3-[(35)S]Thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats. 2000 J. Neurochem. pmid:11080200
Wiles AL et al. N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. 2006 J. Neurochem. pmid:16899062
Hill MN et al. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. 2008 J. Neurochem. pmid:18643796
Placzek EA et al. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. 2008 J. Neurochem. pmid:18778304
Martin GG et al. FABP-1 gene ablation impacts brain endocannabinoid system in male mice. 2016 J. Neurochem. pmid:27167970
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Capasso R and Izzo AA Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. 2008 J. Neuroendocrinol. pmid:18426498
Stefano GB Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release. 1998 J. Neuroimmunol. pmid:9610675
Eisenstein TK et al. Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. 2007 J. Neuroimmunol. pmid:17640739
Schwarz H et al. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. 1994 J. Neuroimmunol. pmid:7962480
De Laurentiis A et al. The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide. 2010 J. Neuroimmunol. pmid:20207018
Hollis JH et al. The endocannabinoid arachidonylethanolamide attenuates aspects of lipopolysaccharide-induced changes in energy intake, energy expenditure and hypothalamic Fos expression. 2011 J. Neuroimmunol. pmid:21262543
Malfitano AM et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. 2006 J. Neuroimmunol. pmid:16239036
Di Filippo M et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. 2008 J. Neurol. Neurosurg. Psychiatr. pmid:18535023
Jean-Gilles L et al. Plasma endocannabinoid levels in multiple sclerosis. 2009 J. Neurol. Sci. pmid:19695579
Contassot E et al. Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. 2004 J. Neuropathol. Exp. Neurol. pmid:15453094
Ali AB Presynaptic Inhibition of GABAA receptor-mediated unitary IPSPs by cannabinoid receptors at synapses between CCK-positive interneurons in rat hippocampus. 2007 J. Neurophysiol. pmid:17567776
Fischbach T et al. Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats. 2007 J. Neurophysiol. pmid:17581853
Uhelski ML et al. Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. 2015 J. Neurophysiol. pmid:25505113
Fan P Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons. 1995 J. Neurophysiol. pmid:7760148
Fisyunov A et al. Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. 2006 J. Neurophysiol. pmid:16738209
De-May CL and Ali AB Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. 2013 J. Neurophysiol. pmid:23054605
Morisset V and Urban L Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. 2001 J. Neurophysiol. pmid:11431486
Twitchell W et al. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. 1997 J. Neurophysiol. pmid:9242259
Ahern GP et al. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. 2005 J. Neurosci. pmid:15917451
Tabatadze N et al. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. 2015 J. Neurosci. pmid:26269634
Gómez R et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. 2002 J. Neurosci. pmid:12417686
Gray JM et al. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. 2015 J. Neurosci. pmid:25740517
Wang ZJ et al. Cannabinoid receptor-mediated regulation of neuronal activity and signaling in glomeruli of the main olfactory bulb. 2012 J. Neurosci. pmid:22723687
Xiong W et al. A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. 2012 J. Neurosci. pmid:22496565
Franklin A et al. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. 2003 J. Neurosci. pmid:12944505
Shen Y et al. A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. 2009 J. Neurosci. pmid:19439586
Derkinderen P et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. 2003 J. Neurosci. pmid:12657697
Clement AB et al. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. 2003 J. Neurosci. pmid:12736361
Marinelli S et al. Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. 2003 J. Neurosci. pmid:12716921
Massa F et al. Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. 2010 J. Neurosci. pmid:20445053
Tognetto M et al. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. 2001 J. Neurosci. pmid:11160380
Cadas H et al. Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP. 1996 J. Neurosci. pmid:8656287
van der Stelt M et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. 2001 J. Neurosci. pmid:11698588
Beltramo M et al. Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. 2000 J. Neurosci. pmid:10777802
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Garami A et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. 2011 J. Neurosci. pmid:21289181
Justinova Z et al. The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. 2005 J. Neurosci. pmid:15944392
Subbanna S et al. Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. 2013 J. Neurosci. pmid:23575834
Dinis P et al. Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. 2004 J. Neurosci. pmid:15601931
Akerman S et al. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. 2013 J. Neurosci. pmid:24027286
Ade KK and Lovinger DM Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. 2007 J. Neurosci. pmid:17329438
Khlaifia A et al. Anandamide, cannabinoid type 1 receptor, and NMDA receptor activation mediate non-Hebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers. 2013 J. Neurosci. pmid:23904599
Kim D and Thayer SA Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. 2001 J. Neurosci. pmid:11319244
Khasabova IA et al. A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. 2008 J. Neurosci. pmid:18971457
Veldhuis WB et al. Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. 2003 J. Neurosci. pmid:12764100
Cadas H et al. Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. 1997 J. Neurosci. pmid:9006968
Khasabova IA et al. Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. 2012 J. Neurosci. pmid:22593077
Qin N et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. 2008 J. Neurosci. pmid:18550765
Chemin J et al. Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line. 2002 J. Neurosci. pmid:12177183
Gubellini P et al. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. 2002 J. Neurosci. pmid:12177188
Kim SR et al. Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. 2005 J. Neurosci. pmid:15659603
Thomas EA et al. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. 1997 J. Neurosci. Res. pmid:9452020
Bari M et al. Cholesterol-dependent modulation of type 1 cannabinoid receptors in nerve cells. 2005 J. Neurosci. Res. pmid:15920744
Molina-Holgado F et al. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. 2002 J. Neurosci. Res. pmid:11891798
Arias-Carrión O et al. Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors. 2011 J. Neurosci. Res. pmid:21557294
Bajo M et al. Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. 2009 J. Neurosci. Res. pmid:18816788
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Bannerman P et al. Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. 2000 J. Neurosci. Res. pmid:10972957
Mennella I et al. Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. 2015 J. Nutr. pmid:26180248
Batetta B et al. Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. 2009 J. Nutr. pmid:19549757
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Battista N et al. Abnormal anandamide metabolism in celiac disease. 2012 J. Nutr. Biochem. pmid:22209002
Hutchins HL et al. Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. 2011 J. Nutr. Biochem. pmid:20951563
Gómez R et al. Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes. 2014 J. Orthop. Res. pmid:24902823
Di Marzo M et al. Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics. 2006 J. Pept. Sci. pmid:16534762
Chiba T et al. A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. 2011 J. Pharm. Pharmacol. pmid:21492165
Hayase T et al. Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms. 2001 J. Pharm. Pharmacol. pmid:11732755
Esposito G et al. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. 2007 J. Pharmacol. Exp. Ther. pmid:17545311
Anikwue R et al. Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. 2002 J. Pharmacol. Exp. Ther. pmid:12235269
Rockwell CE and Kaminski NE A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. 2004 J. Pharmacol. Exp. Ther. pmid:15284281
Solinas M et al. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. 2007 J. Pharmacol. Exp. Ther. pmid:17351107
Ritter JK et al. Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. 2012 J. Pharmacol. Exp. Ther. pmid:22685343
Ishioka N and Bukoski RD A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation. 1999 J. Pharmacol. Exp. Ther. pmid:10087011
Varvel SA et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. 2006 J. Pharmacol. Exp. Ther. pmid:16352706
Rösch S et al. R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. 2006 J. Pharmacol. Exp. Ther. pmid:16330497
Muthian S et al. Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. 2000 J. Pharmacol. Exp. Ther. pmid:10734181
Scherma M et al. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. 2008 J. Pharmacol. Exp. Ther. pmid:18725543
Adams IB et al. Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain. 1998 J. Pharmacol. Exp. Ther. pmid:9495885