Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Hyperinsulinism D006946 27 associated lipids
Endotoxemia D019446 27 associated lipids
Neuralgia D009437 28 associated lipids
Obesity D009765 29 associated lipids
Catalepsy D002375 30 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Iversen L Pharmacology. Endogenous cannabinoids. 1994 Nature pmid:7990950
Di Marzo V et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. 1994 Nature pmid:7990962
Zygmunt PM et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. 1999 Nature pmid:10440374
di Tomaso E et al. Brain cannabinoids in chocolate. 1996 Nature pmid:8751435
Rodríguez de Fonseca F et al. An anorexic lipid mediator regulated by feeding. 2001 Nature pmid:11700558
Cravatt BF et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. 1996 Nature pmid:8900284
Calignano A et al. Bidirectional control of airway responsiveness by endogenous cannabinoids. 2000 Nature pmid:11081515
Mechoulam R Todd's achievement. 1997 Nature pmid:9126725
Wagner JA et al. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. 1997 Nature pmid:9394002
Balas L et al. Synthesis of a photoactivatable probe of the anandamide re-uptake. 2005 Nat. Prod. Res. pmid:15938150
Kim J and Alger BE Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. 2004 Nat. Neurosci. pmid:15184902
Marsicano G and Chaouloff F Moving bliss: a new anandamide transporter. 2012 Nat. Neurosci. pmid:22193249
Self DW Anandamide: a candidate neurotransmitter heads for the big leagues. 1999 Nat. Neurosci. pmid:10204533
Giuffrida A et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. 1999 Nat. Neurosci. pmid:10204543
Kim J and Alger BE Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. 2010 Nat. Neurosci. pmid:20348918
Maccarrone M et al. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. 2008 Nat. Neurosci. pmid:18204441
Di Marzo V Anandamide serves two masters in the brain. 2010 Nat. Neurosci. pmid:21102567
Clapper JR et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. 2010 Nat. Neurosci. pmid:20852626
Di Marzo V Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. 2011 Nat. Neurosci. pmid:21187849
Chávez AE et al. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. 2010 Nat. Neurosci. pmid:21076423
Fu J et al. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. 2012 Nat. Neurosci. pmid:22101642
Gerdeman GL et al. Postsynaptic endocannabinoid release is critical to long-term depression in the striatum. 2002 Nat. Neurosci. pmid:11976704
Fields HL and Meng ID Watching the pot boil. 1998 Nat. Med. pmid:9734389
Stock K et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. 2012 Nat. Med. pmid:22820645
Piomelli D THC: moderation during implantation. 2004 Nat. Med. pmid:14702623
Kathuria S et al. Modulation of anxiety through blockade of anandamide hydrolysis. 2003 Nat. Med. pmid:12461523
Jourdan T et al. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. 2013 Nat. Med. pmid:23955712
Bátkai S et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. 2001 Nat. Med. pmid:11433348
Nomura DK et al. Activation of the endocannabinoid system by organophosphorus nerve agents. 2008 Nat. Chem. Biol. pmid:18438404
Long JZ et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. 2009 Nat. Chem. Biol. pmid:19029917
Voets T et al. Sensing with TRP channels. 2005 Nat. Chem. Biol. pmid:16408004
Mechoulam R and Ben-Shabat S From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis. 1999 Nat Prod Rep pmid:10331283
Pastuhov SI et al. Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling. 2012 Nat Commun pmid:23072806
Alpár A et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. 2014 Nat Commun pmid:25030704
Pryce G et al. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. 2013 Mult. Scler. pmid:23625705
Pisani V et al. Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients. 2010 Mov. Disord. pmid:20461809
Muccioli GG et al. The endocannabinoid system links gut microbiota to adipogenesis. 2010 Mol. Syst. Biol. pmid:20664638
Schuel H et al. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. 2002 Mol. Reprod. Dev. pmid:12237954
Paria BC et al. The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period. 1996 Mol. Reprod. Dev. pmid:8914076
Neumeister A et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. 2013 Mol. Psychiatry pmid:23670490
Gunduz-Cinar O et al. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. 2013 Mol. Psychiatry pmid:22688188
Zhang X et al. Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. 2012 Mol. Pharmacol. pmid:22328719
Snider NT et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. 2009 Mol. Pharmacol. pmid:19171674
Spivak CE et al. The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors. 2007 Mol. Pharmacol. pmid:17628012
Yates ML and Barker EL Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. 2009 Mol. Pharmacol. pmid:19389920
Mackie K et al. Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. 1993 Mol. Pharmacol. pmid:8371711
McFarland MJ et al. RNA interference-mediated knockdown of dynamin 2 reduces endocannabinoid uptake into neuronal dCAD cells. 2008 Mol. Pharmacol. pmid:18436710
Guo J and Ikeda SR Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. 2004 Mol. Pharmacol. pmid:14978245
Breivogel CS et al. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. 2001 Mol. Pharmacol. pmid:11408610
Edgemond WS et al. Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. 1998 Mol. Pharmacol. pmid:9658204