Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Alveolar Bone Loss D016301 10 associated lipids
Learning Disorders D007859 11 associated lipids
Hyperkinesis D006948 11 associated lipids
Hyperinsulinism D006946 27 associated lipids
Muscle Spasticity D009128 5 associated lipids
Hypothermia D007035 19 associated lipids
Celiac Disease D002446 16 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Hypertension, Portal D006975 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
Levin M and Mercola M Expression of connexin 30 in Xenopus embryos and its involvement in hatching gland function. 2000 Dev. Dyn. pmid:10974676
Van den Bossche I and Vanheel B Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta. 2000 Br. J. Pharmacol. pmid:10960073
Smart D and Jerman JC Anandamide: an endogenous activator of the vanilloid receptor. 2000 Trends Pharmacol. Sci. pmid:10740287
Beltramo M et al. Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. 2000 J. Neurosci. pmid:10777802
Gonsiorek W et al. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. 2000 Mol. Pharmacol. pmid:10779390
Costa B and Colleoni M Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol. 2000 Eur. J. Pharmacol. pmid:10781666
Reggio PH and Traore H Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. 2000 Chem. Phys. Lipids pmid:11106780
Howlett AC and Mukhopadhyay S Cellular signal transduction by anandamide and 2-arachidonoylglycerol. 2000 Chem. Phys. Lipids pmid:11106782
Schmid HH Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? 2000 Chem. Phys. Lipids pmid:11106783
Hillard CJ and Jarrahian A The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. 2000 Chem. Phys. Lipids pmid:11106786
Kunos G et al. Endocannabinoids as cardiovascular modulators. 2000 Chem. Phys. Lipids pmid:11106789
Maccarrone M et al. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. 2000 J. Biol. Chem. pmid:10913156
Rakhshan F et al. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. 2000 J. Pharmacol. Exp. Ther. pmid:10688610
De Petrocellis L et al. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. 2000 FEBS Lett. pmid:11033355
Arai Y et al. Sensitive determination of anandamide in rat brain utilizing a coupled-column HPLC with fluorimetric detection. 2000 Biomed. Chromatogr. pmid:10694706
González S et al. Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. 2000 Biochem. Biophys. Res. Commun. pmid:10733937
Muthian S et al. Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. 2000 J. Pharmacol. Exp. Ther. pmid:10734181
Premkumar LS and Ahern GP Induction of vanilloid receptor channel activity by protein kinase C. 2000 Dec 21-28 Nature pmid:11140687
Hungund BL and Basavarajappa BS Are anandamide and cannabinoid receptors involved in ethanol tolerance? A review of the evidence. 2000 Mar-Apr Alcohol Alcohol. pmid:10787386
Grainger J and Boachie-Ansah G Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. 2001 Br. J. Pharmacol. pmid:11682448
Vanheel B and Van de Voorde J Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries. 2001 J. Pharmacol. Exp. Ther. pmid:11160613
Farquhar-Smith WP and Rice AS Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder. 2001 Anesthesiology pmid:11374613
White R et al. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. 2001 Br. J. Pharmacol. pmid:11606334
Tucker RC et al. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. 2001 Br. J. Pharmacol. pmid:11226144
Maingret F et al. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. 2001 EMBO J. pmid:11226154
Wagner JA et al. Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors. 2001 Eur. J. Pharmacol. pmid:11448486
Boger DL et al. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. 2001 Bioorg. Med. Chem. Lett. pmid:11412972
Mendizábal VE et al. Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed. 2001 Eur. J. Pharmacol. pmid:11567656
Izzo AA et al. Effect of vanilloid drugs on gastrointestinal transit in mice. 2001 Br. J. Pharmacol. pmid:11264233
Baker D et al. Endocannabinoids control spasticity in a multiple sclerosis model. 2001 FASEB J. pmid:11156943
Gauldie SD et al. Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. 2001 Br. J. Pharmacol. pmid:11159713
Tognetto M et al. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. 2001 J. Neurosci. pmid:11160380
MacCarrone M et al. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. 2001 Eur. J. Biochem. pmid:11168423
Hansen HH et al. Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. 2001 J. Neurochem. pmid:11145976
Matias I et al. Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis. 2001 Brain Res. Mol. Brain Res. pmid:11245916
Kurihara J et al. 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves. 2001 Jpn. J. Pharmacol. pmid:11676206
Nogueron MI et al. Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. 2001 J. Neurochem. pmid:11677265
van der Stelt M et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. 2001 J. Neurosci. pmid:11698588
Hayase T et al. Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms. 2001 J. Pharm. Pharmacol. pmid:11732755
Hansen HH et al. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. 2001 J. Neurochem. pmid:11579150
Smith PJ and McQueen DS Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat. 2001 Br. J. Pharmacol. pmid:11588121
Maccarrone M et al. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. 2001 Arch. Biochem. Biophys. pmid:11556820
Crozier Willi G et al. Lipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods. 2001 Nestle Nutr Workshop Ser Clin Perform Programme pmid:11510437
Stella N and Piomelli D Receptor-dependent formation of endogenous cannabinoids in cortical neurons. 2001 Eur. J. Pharmacol. pmid:11513837
Vellani V et al. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. 2001 J. Physiol. (Lond.) pmid:11483711
Maccarrone M et al. Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. 2001 J. Neurochem. pmid:11461969
Ueda N et al. Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. 2001 J. Biol. Chem. pmid:11463796
Cravatt BF et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11470906
Senior K Endogenously produced cannabinoids and liver cirrhosis. 2001 Lancet pmid:11454385
Stanford SJ et al. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. 2001 Br. J. Pharmacol. pmid:11454655
Mang CF et al. Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. 2001 Br. J. Pharmacol. pmid:11522608
Bradbury J Small part of cannabis puzzle solved by animal studies. 2001 Lancet pmid:11498223
Jonsson KO et al. Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. 2001 Br. J. Pharmacol. pmid:11498512
Berger A et al. Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353819
Craib SJ et al. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. 2001 Br. J. Pharmacol. pmid:11522594
Hayase T et al. Protective effects of cannabinoid receptor ligands analogous to anandamide against cocaine toxicity. 2001 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:11828716
Deutsch DG et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. 2001 J. Biol. Chem. pmid:11118429
Garcia N et al. Systemic and portal hemodynamic effects of anandamide. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11123193
Al-Hayani A et al. The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. 2001 Neuropharmacology pmid:11747904
Izzo AA et al. The gastrointestinal pharmacology of cannabinoids. 2001 Curr Opin Pharmacol pmid:11757815
Huang SM et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. 2001 J. Biol. Chem. pmid:11518719
Chemin J et al. Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. 2001 EMBO J. pmid:11742980
Bifulco M et al. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. 2001 FASEB J. pmid:11687506
De Petrocellis L et al. Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. 2001 FEBS Lett. pmid:11602256
Bisogno T et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. 2001 Br. J. Pharmacol. pmid:11606325
D'Souza DC and Kosten TR Cannabinoid antagonists: a treatment in search of an illness. 2001 Arch. Gen. Psychiatry pmid:11296092
Mechoulam R and Fride E Physiology. A hunger for cannabinoids. 2001 Nature pmid:11298428
Smart D et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. 2001 Eur. J. Pharmacol. pmid:11301059
Bueb JL et al. Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. 2001 Biochim. Biophys. Acta pmid:11336796
Kim D and Thayer SA Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. 2001 J. Neurosci. pmid:11319244
Kagota S et al. 2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor. 2001 Eur. J. Pharmacol. pmid:11275004
Bisogno T et al. The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. 2001 Eur. J. Biochem. pmid:11277920
De Petrocellis L et al. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. 2001 J. Biol. Chem. pmid:11278420
Jacobsson SO and Fowler CJ Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. 2001 Br. J. Pharmacol. pmid:11309246
Quistad GB et al. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. 2001 Toxicol. Appl. Pharmacol. pmid:11350214
Day TA et al. Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. 2001 Mol. Pharmacol. pmid:11353795
Kobayashi Y et al. Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. 2001 J. Biochem. pmid:11328586
Möhle R et al. Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. 2001 Ann. N. Y. Acad. Sci. pmid:11458515
Chang YH et al. Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. 2001 J. Cell. Biochem. pmid:11329626
Olah Z et al. Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. 2001 J. Biol. Chem. pmid:11333266
Calignano A et al. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. 2001 Eur. J. Pharmacol. pmid:11426841
Di Marzo V et al. Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands. 2001 Biochem. Biophys. Res. Commun. pmid:11181068
Fride E et al. Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. 2001 Eur. J. Pharmacol. pmid:11426843
Di Marzo V et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. 2001 Biochem. J. pmid:11485574
Porter AC and Felder CC The endocannabinoid nervous system: unique opportunities for therapeutic intervention. 2001 Pharmacol. Ther. pmid:11448725
Laine K et al. Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits. 2001 Pharm. Res. pmid:11451037
Holt S et al. Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen. 2001 Br. J. Pharmacol. pmid:11399668
Di Marzo V et al. Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. 2001 Eur. J. Pharmacol. pmid:11408034
Breivogel CS et al. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. 2001 Mol. Pharmacol. pmid:11408610
Wang Y et al. Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. 2001 Anal. Biochem. pmid:11412008
De Petrocellis L et al. The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. 2001 J. Neurochem. pmid:11413249
Morisset V and Urban L Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. 2001 J. Neurophysiol. pmid:11431486
Bátkai S et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. 2001 Nat. Med. pmid:11433348
Maccarrone M et al. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. 2001 J. Immunol. pmid:11390466
Wenger T et al. The central cannabinoid receptor inactivation suppresses endocrine reproductive functions. 2001 Biochem. Biophys. Res. Commun. pmid:11394887
Maccarrone M et al. Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture. 2001 J. Neurochem. pmid:11208922
Di Marzo V et al. Anandamide: some like it hot. 2001 Trends Pharmacol. Sci. pmid:11431028
Ueda N et al. Alkaline and acid amidases hydrolyzing anandamide and other N-acylethanolamines. 2001 World Rev Nutr Diet pmid:11935959
Hansen HS et al. When and where are N-acylethanolamine phospholipids and anandamide formed? 2001 World Rev Nutr Diet pmid:11935960
Berdyshev EV et al. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. 2001 FASEB J. pmid:11641243