| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alveolar Bone Loss | D016301 | 10 associated lipids |
| Learning Disorders | D007859 | 11 associated lipids |
| Hyperkinesis | D006948 | 11 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Muscle Spasticity | D009128 | 5 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hillard CJ et al. | Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. | 1995 | Biochim. Biophys. Acta | pmid:7647100 |
| Di Marzo V | 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. | 1998 | Biochim. Biophys. Acta | pmid:9630590 |
| Hampson AJ et al. | Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor. | 1995 | Biochim. Biophys. Acta | pmid:7488638 |
| Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
| Hansen HS et al. | Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture. | 1995 | Biochim. Biophys. Acta | pmid:7548201 |
| Ortega-Gutiérrez S et al. | Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. | 2004 | Biochemistry | pmid:15209515 |
| Martin GG et al. | Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. | 2017 | Biochemistry | pmid:28853554 |
| Mulder AM and Cravatt BF | Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. | 2006 | Biochemistry | pmid:16981687 |
| Kozak KR et al. | Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. | 2003 | Biochemistry | pmid:12885237 |
| Bornheim LM et al. | Microsomal cytochrome P450-mediated liver and brain anandamide metabolism. | 1995 | Biochem. Pharmacol. | pmid:7669071 |
| Childers SR et al. | Effects of anandamide on cannabinoid receptors in rat brain membranes. | 1994 | Biochem. Pharmacol. | pmid:8129747 |
| Mbvundula EC et al. | Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. | 2005 | Biochem. Pharmacol. | pmid:15670582 |
| Fowler CJ and Tiger G | Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | 2005 | Biochem. Pharmacol. | pmid:15794945 |
| Fowler CJ et al. | Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. | 2001 | Biochem. Pharmacol. | pmid:11585048 |
| Shivachar AC | Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes. | 2007 | Biochem. Pharmacol. | pmid:17445778 |
| Fowler CJ et al. | Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. | 2003 | Biochem. Pharmacol. | pmid:12948856 |
| Hansen HS and Diep TA | N-acylethanolamines, anandamide and food intake. | 2009 | Biochem. Pharmacol. | pmid:19413995 |
| Ortar G et al. | Novel selective and metabolically stable inhibitors of anandamide cellular uptake. | 2003 | Biochem. Pharmacol. | pmid:12732359 |
| Mechoulam R et al. | Search for endogenous ligands of the cannabinoid receptor. | 1994 | Biochem. Pharmacol. | pmid:7980618 |
| Goparaju SK et al. | Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. | 1999 | Biochem. Pharmacol. | pmid:9933030 |
| De Bank PA et al. | A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. | 2005 | Biochem. Pharmacol. | pmid:15794939 |
| Burstein SH et al. | Relationships between eicosanoids and cannabinoids. Are eicosanoids cannabimimetic agents?. | 1995 | Biochem. Pharmacol. | pmid:8615850 |
| Shivachar AC et al. | Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride]. | 1996 | Biochem. Pharmacol. | pmid:8615904 |
| Burstein SH et al. | Regulation of anandamide tissue levels by N-arachidonylglycine. | 2002 | Biochem. Pharmacol. | pmid:12234618 |
| Guzmán M et al. | Effects of anandamide on hepatic fatty acid metabolism. | 1995 | Biochem. Pharmacol. | pmid:7575652 |
| Mechoulam R et al. | Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. | 1995 | Biochem. Pharmacol. | pmid:7605349 |
| Burstein SH and Hunter SA | Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). | 1995 | Biochem. Pharmacol. | pmid:7702643 |
| Deutsch DG and Chin SA | Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. | 1993 | Biochem. Pharmacol. | pmid:8373432 |
| Yang Z et al. | Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. | 2008 | Biochem. Pharmacol. | pmid:18755158 |
| Correa F et al. | A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. | 2009 | Biochem. Pharmacol. | pmid:18848818 |
| Thumser AE et al. | A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis. | 1997 | Biochem. Pharmacol. | pmid:9065749 |
| Tiger G et al. | Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate. | 2000 | Biochem. Pharmacol. | pmid:10677581 |
| Lo YK et al. | Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells. | 2003 | Biochem. Pharmacol. | pmid:12566085 |
| Lanzafame AA et al. | Effects of anandamide on the binding and signaling properties of M1 muscarinic acetylcholine receptors. | 2004 | Biochem. Pharmacol. | pmid:15498511 |
| Fernández-Ruiz JJ et al. | Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. | 1997 | Biochem. Pharmacol. | pmid:9256167 |
| Ferrer B et al. | Regulation of brain anandamide by acute administration of ethanol. | 2007 | Biochem. J. | pmid:17302558 |
| Wisnoskey BJ et al. | Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry. | 2003 | Biochem. J. | pmid:12608892 |
| Di Marzo V et al. | Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. | 1996 | Biochem. J. | pmid:8670178 |
| Gómez del Pulgar T et al. | The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. | 2000 | Biochem. J. | pmid:10749665 |
| Bisogno T et al. | N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. | 2000 | Biochem. J. | pmid:11042139 |
| Sun YX et al. | Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. | 2004 | Biochem. J. | pmid:14998370 |
| Ligresti A et al. | Further evidence for the existence of a specific process for the membrane transport of anandamide. | 2004 | Biochem. J. | pmid:14969584 |
| Bisogno T et al. | Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells. | 1997 | Biochem. J. | pmid:9065792 |
| Di Marzo V et al. | Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. | 2001 | Biochem. J. | pmid:11485574 |
| Di Marzo V et al. | The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide. | 1998 | Biochem. J. | pmid:9512456 |
| Maccarrone M et al. | Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells. | 2002 | Biochem. J. | pmid:12010121 |
| Correa F et al. | Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). | 2008 | Biochem. J. | pmid:17961121 |
| Bisogno T et al. | Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9703957 |
| van Zadelhoff G et al. | With anandamide as substrate plant 5-lipoxygenases behave like 11-lipoxygenases. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9675081 |
| Athanasiou A et al. | Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17931597 |