Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Spinal Cord Injuries D013119 34 associated lipids
Epilepsy D004827 35 associated lipids
Fever D005334 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Hypotension D007022 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Davies JW et al. Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population. 2010 Br J Anaesth pmid:20354008
Jarzimski C et al. Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol? 2012 Br J Clin Pharmacol pmid:22242687
Morgan CJ et al. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. 2013 Br J Psychiatry pmid:23580381
Koethe D et al. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. 2009 Br J Psychiatry pmid:19336792
Pei R et al. Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. 2017 Br. J. Nutr. pmid:29179781
Okine BN et al. Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. 2012 Br. J. Pharmacol. pmid:22595021
Grainger J and Boachie-Ansah G Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. 2001 Br. J. Pharmacol. pmid:11682448
Ross RA Anandamide and vanilloid TRPV1 receptors. 2003 Br. J. Pharmacol. pmid:14517174
Vandevoorde S and Fowler CJ Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. 2005 Br. J. Pharmacol. pmid:15895107
Sun Y et al. Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. 2007 Br. J. Pharmacol. pmid:17906680
Malinowska B et al. Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? 2012 Br. J. Pharmacol. pmid:22022923
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. 2007 Br. J. Pharmacol. pmid:17876302
Ross RA et al. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. 2001 Br. J. Pharmacol. pmid:11159715
White R and Hiley CR The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery. 1998 Br. J. Pharmacol. pmid:9806337
Köfalvi A et al. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. 2007 Br. J. Pharmacol. pmid:17435795
Zoratti C et al. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. 2003 Br. J. Pharmacol. pmid:14645143
Roberts LA et al. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. 2002 Br. J. Pharmacol. pmid:12359623
Taddei S Evolving the concept of regulation of vascular tone in humans. 2005 Br. J. Pharmacol. pmid:15997231
Izzo AA et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. 2012 Br. J. Pharmacol. pmid:22300105
White R et al. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. 2001 Br. J. Pharmacol. pmid:11606334
Mombouli JV et al. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. 1999 Br. J. Pharmacol. pmid:10323591
Tucker RC et al. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. 2001 Br. J. Pharmacol. pmid:11226144
Hind WH et al. Endocannabinoids modulate human blood-brain barrier permeability in vitro. 2015 Br. J. Pharmacol. pmid:25651941
Woodhams SG et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. 2012 Br. J. Pharmacol. pmid:22924700
Akerman S et al. Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors. 2004 Br. J. Pharmacol. pmid:15277315
Ghasemi M et al. Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. 2007 Br. J. Pharmacol. pmid:17486141
Ameri A et al. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. 1999 Br. J. Pharmacol. pmid:10372827
Klegeris A et al. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. 2003 Br. J. Pharmacol. pmid:12813001
Fraga D et al. Endogenous cannabinoids induce fever through the activation of CB1 receptors. 2009 Br. J. Pharmacol. pmid:19681872
Thors L and Fowler CJ Is there a temperature-dependent uptake of anandamide into cells? 2006 Br. J. Pharmacol. pmid:16865094
Van den Bossche I and Vanheel B Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta. 2000 Br. J. Pharmacol. pmid:10960073
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Hillard CJ and Jarrahian A Cellular accumulation of anandamide: consensus and controversy. 2003 Br. J. Pharmacol. pmid:12970089
O'Sullivan SE et al. Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries. 2004 Br. J. Pharmacol. pmid:15148250
Randall MD et al. The complexities of the cardiovascular actions of cannabinoids. 2004 Br. J. Pharmacol. pmid:15131000
Al Kury LT et al. Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes. 2014 Br. J. Pharmacol. pmid:24758718
Thors L et al. The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. 2007 Br. J. Pharmacol. pmid:17325653
Gardener MJ et al. Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries. 2004 Br. J. Pharmacol. pmid:15066906
Romano MR and Lograno MD Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels. 2006 Br. J. Pharmacol. pmid:16474412
Chicca A et al. The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. 2012 Br. J. Pharmacol. pmid:22646533
Brighton PJ et al. Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. 2011 Br. J. Pharmacol. pmid:21486283
Ruiz-Llorente L et al. Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. 2004 Br. J. Pharmacol. pmid:14718261
Di Marzo V et al. The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. 2008 Br. J. Pharmacol. pmid:18223666
Vandevoorde S et al. Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. 2007 Br. J. Pharmacol. pmid:17143303
De Petrocellis L et al. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. 2012 Br. J. Pharmacol. pmid:22861649
Ho WS and Randall MD Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. 2007 Br. J. Pharmacol. pmid:17245358
Wheal AJ et al. Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. 2007 Br. J. Pharmacol. pmid:17245361
Izzo AA et al. Effect of vanilloid drugs on gastrointestinal transit in mice. 2001 Br. J. Pharmacol. pmid:11264233
Gauldie SD et al. Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. 2001 Br. J. Pharmacol. pmid:11159713
Stewart JL and McMahon LR The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. 2011 Br. J. Pharmacol. pmid:21449917
Makwana R et al. Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation. 2010 Br. J. Pharmacol. pmid:20233228
Patel S et al. The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. 2003 Br. J. Pharmacol. pmid:12839875
Gamaleddin I et al. The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. 2011 Br. J. Pharmacol. pmid:21501143
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Thors L et al. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. 2010 Br. J. Pharmacol. pmid:20590565
Booker L et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. 2012 Br. J. Pharmacol. pmid:21506952
Mukhopadhyay P et al. CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. 2010 Br. J. Pharmacol. pmid:20590569
Rajesh M et al. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. 2010 Br. J. Pharmacol. pmid:20590572
Jamshidi N and Taylor DA Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. 2001 Br. J. Pharmacol. pmid:11704633
Costa B et al. AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. 2006 Br. J. Pharmacol. pmid:16770320
Solinas M et al. The endocannabinoid system in brain reward processes. 2008 Br. J. Pharmacol. pmid:18414385
Shouman B et al. Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage. 2006 Br. J. Pharmacol. pmid:16682966
Smith PJ and McQueen DS Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat. 2001 Br. J. Pharmacol. pmid:11588121
McHugh D et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. 2012 Br. J. Pharmacol. pmid:21595653
O'Sullivan SE et al. The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. 2005 Br. J. Pharmacol. pmid:15821751
De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011 Br. J. Pharmacol. pmid:21175579
Randall MD The cardiovascular actions of anandamide: more targets? 2005 Br. J. Pharmacol. pmid:15834438
Kwolek G et al. Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats. 2005 Br. J. Pharmacol. pmid:15834445
Mang CF et al. Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. 2001 Br. J. Pharmacol. pmid:11522608
Jonsson KO et al. Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. 2001 Br. J. Pharmacol. pmid:11498512
Guindon J et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. 2011 Br. J. Pharmacol. pmid:21198549
Li Q et al. Electrophysiological effects of anandamide on rat myocardium. 2009 Br. J. Pharmacol. pmid:20050190
Craib SJ et al. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. 2001 Br. J. Pharmacol. pmid:11522594
Underdown NJ et al. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. 2005 Br. J. Pharmacol. pmid:16158067
White R and Hiley CR A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. 1997 Br. J. Pharmacol. pmid:9422801
Zygmunt PM et al. Studies on the effects of anandamide in rat hepatic artery. 1997 Br. J. Pharmacol. pmid:9422814
Andrag E and Curtis MJ Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids. 2013 Br. J. Pharmacol. pmid:23713981
Ford WR et al. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. 2002 Br. J. Pharmacol. pmid:11877326
Scherma M et al. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. 2012 Br. J. Pharmacol. pmid:21557729
Lever IJ and Malcangio M CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord. 2002 Br. J. Pharmacol. pmid:11786475
Mair KM et al. Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. 2010 Br. J. Pharmacol. pmid:20718749
Moezi L et al. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. 2006 Br. J. Pharmacol. pmid:17043671
Oliveira L et al. Effects of some isoprostanes on the human umbilical artery in vitro. 2000 Br. J. Pharmacol. pmid:10711349
Steffens M et al. Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex. 2004 Br. J. Pharmacol. pmid:14993102
Jacobsson SO and Fowler CJ Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. 2001 Br. J. Pharmacol. pmid:11309246
Spicuzza L et al. Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves. 2000 Br. J. Pharmacol. pmid:10928980
Thors L et al. Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. 2008 Br. J. Pharmacol. pmid:18552875
Izzo AA et al. Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. 2009 Br. J. Pharmacol. pmid:19371345
Ligresti A et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. 2006 Br. J. Pharmacol. pmid:16284631
Holt S et al. Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen. 2001 Br. J. Pharmacol. pmid:11399668
Maione S et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. 2008 Br. J. Pharmacol. pmid:18660824
Ho WS et al. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. 2008 Br. J. Pharmacol. pmid:18695637
Ghafouri N et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. 2004 Br. J. Pharmacol. pmid:15492019
Lee MG et al. Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. 2005 Br. J. Pharmacol. pmid:16056239
Plane F et al. Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. 1997 Br. J. Pharmacol. pmid:9283682
Soria-Gómez E et al. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. 2007 Br. J. Pharmacol. pmid:17549045
Kagaya M et al. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. 2002 Br. J. Pharmacol. pmid:12183329
Gardiner SM et al. Complex regional haemodynamic effects of anandamide in conscious rats. 2002 Br. J. Pharmacol. pmid:11959791
Jia Y et al. Anandamide induces cough in conscious guinea-pigs through VR1 receptors. 2002 Br. J. Pharmacol. pmid:12411414
Geraghty DP and Mazzone SB Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide. 2002 Br. J. Pharmacol. pmid:12411424