| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Gain | D015430 | 101 associated lipids |
| Ocular Hypotension | D015814 | 2 associated lipids |
| Alveolar Bone Loss | D016301 | 10 associated lipids |
| Cardiovirus Infections | D018188 | 3 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Impotence, Vasculogenic | D018783 | 4 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rajesh M et al. | Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. | 2012 | Diabetes | pmid:22315315 |
| Troy-Fioramonti S et al. | Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. | 2015 | Diabetes | pmid:25281429 |
| Engeli S et al. | Activation of the peripheral endocannabinoid system in human obesity. | 2005 | Diabetes | pmid:16186383 |
| Mallat A and Lotersztajn S | Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis. | 2008 | Diabetes Metab. | pmid:19195630 |
| Eckardt K et al. | Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. | 2009 | Diabetologia | pmid:19089403 |
| Harada N and Okajima K | Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats. | 2007 | Dig. Dis. Sci. | pmid:17211693 |
| González S et al. | Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. | 2004 | Drug Alcohol Depend | pmid:15099659 |
| Childers SR and Breivogel CS | Cannabis and endogenous cannabinoid systems. | 1998 Jun-Jul | Drug Alcohol Depend | pmid:9716939 |
| Welch SP | Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. | 1997 | Drug Alcohol Depend | pmid:9179505 |
| Muccioli GG | Endocannabinoid biosynthesis and inactivation, from simple to complex. | 2010 | Drug Discov. Today | pmid:20304091 |
| Farrell EK and Merkler DJ | Biosynthesis, degradation and pharmacological importance of the fatty acid amides. | 2008 | Drug Discov. Today | pmid:18598910 |
| Sridar C et al. | Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. | 2011 | Drug Metab. Dispos. | pmid:21289075 |
| Pratt-Hyatt M et al. | Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide. | 2010 | Drug Metab. Dispos. | pmid:20702771 |
| Ekins S et al. | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. | 2007 | Drug Metab. Dispos. | pmid:17194716 |
| Jia Y et al. | TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence. | 2005 | Drug News Perspect. | pmid:15915217 |
| Thieme U et al. | Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. | 2014 Jan-Feb | Drug Test Anal | pmid:24424856 |
| Battista N et al. | Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices. | 2014 Jan-Feb | Drug Test Anal | pmid:24218186 |
| Maingret F et al. | The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. | 2001 | EMBO J. | pmid:11226154 |
| Chemin J et al. | Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. | 2001 | EMBO J. | pmid:11742980 |
| van der Stelt M et al. | Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. | 2005 | EMBO J. | pmid:16107881 |
| Laezza C et al. | Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. | 2010 | Endocr. Relat. Cancer | pmid:20304978 |
| Karlsson C et al. | Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats. | 2015 | Endocrinology | pmid:25549047 |
| Francavilla F et al. | Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability. | 2009 | Endocrinology | pmid:19608651 |
| Forner-Piquer I et al. | Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. | 2017 | Endocrinology | pmid:28938452 |
| Maccarrone M et al. | Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. | 2003 | Endocrinology | pmid:12488326 |
| Rossi G et al. | Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. | 2007 | Endocrinology | pmid:17110429 |
| Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
| Melck D et al. | Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. | 2000 | Endocrinology | pmid:10614630 |
| Habayeb OM et al. | Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. | 2008 | Endocrinology | pmid:18599552 |
| Romigi A et al. | Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. | 2010 | Epilepsia | pmid:19817812 |
| Manna SS and Umathe SN | Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. | 2012 | Epilepsy Res. | pmid:22386872 |
| Citraro R et al. | CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. | 2013 | Epilepsy Res. | pmid:23860329 |
| Schaefer C et al. | Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. | 2014 | Eur Arch Psychiatry Clin Neurosci | pmid:24253425 |
| Moloney GP et al. | Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. | 2008 | Eur J Med Chem | pmid:17582659 |
| Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
| López-RodrÃguez ML et al. | Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. | 2003 | Eur J Med Chem | pmid:12750028 |
| Bonechi C et al. | Nuclear magnetic resonance for studying recognition processes between anandamide and cannabinoid receptors. | 2006 | Eur J Med Chem | pmid:16837109 |
| Cano C et al. | Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. | 2009 | Eur J Med Chem | pmid:19762126 |
| Monteleone AM et al. | Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. | 2016 | Eur J Nutr | pmid:26759262 |
| Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
| Juntunen J et al. | Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. | 2003 | Eur J Pharm Sci | pmid:12729860 |
| Karlsson M et al. | Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments. | 2004 | Eur J Pharm Sci | pmid:15158903 |
| McLaughlin RJ et al. | Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. | 2012 | Eur Neuropsychopharmacol | pmid:22325231 |
| Manduca A et al. | Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. | 2015 | Eur Neuropsychopharmacol | pmid:25914159 |
| de Lago E et al. | UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. | 2006 | Eur Neuropsychopharmacol | pmid:16006105 |
| Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
| Kaufmann I et al. | Enhanced anandamide plasma levels in patients with complex regional pain syndrome following traumatic injury: a preliminary report. | 2009 | Eur Surg Res | pmid:19729930 |
| Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |
| Raichlen DA et al. | Exercise-induced endocannabinoid signaling is modulated by intensity. | 2013 | Eur. J. Appl. Physiol. | pmid:22990628 |
| Feuerecker M et al. | Effects of exercise stress on the endocannabinoid system in humans under field conditions. | 2012 | Eur. J. Appl. Physiol. | pmid:22101870 |
| Bisogno T et al. | Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation. | 1998 | Eur. J. Biochem. | pmid:9688276 |
| Van Der Stelt M and Di Marzo V | Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. | 2004 | Eur. J. Biochem. | pmid:15128293 |
| MacCarrone M et al. | Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. | 2001 | Eur. J. Biochem. | pmid:11168423 |
| Fasia L et al. | Uptake and metabolism of [3H]anandamide by rabbit platelets. Lack of transporter? | 2003 | Eur. J. Biochem. | pmid:12919314 |
| Bisogno T et al. | The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. | 2001 | Eur. J. Biochem. | pmid:11277920 |
| Salzet M et al. | Comparative biology of the endocannabinoid system possible role in the immune response. | 2000 | Eur. J. Biochem. | pmid:10931174 |
| Sugiura T et al. | Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine. | 1996 | Eur. J. Biochem. | pmid:8797835 |
| Matias I et al. | Presence and regulation of the endocannabinoid system in human dendritic cells. | 2002 | Eur. J. Biochem. | pmid:12153574 |
| Kapoor S | Modulation of intracellular pathways by anandamide and its evolving role in oncology. | 2013 | Eur. J. Cancer | pmid:23434147 |
| Laezza C et al. | Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells. | 2013 | Eur. J. Cancer | pmid:23434151 |
| Rossi C et al. | Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels. | 2008 | Eur. J. Clin. Pharmacol. | pmid:18004553 |
| Di Marzo V et al. | Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. | 2009 | Eur. J. Endocrinol. | pmid:19745037 |
| Adermark L et al. | Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. | 2009 | Eur. J. Neurosci. | pmid:19120438 |
| Millns PJ et al. | Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1-mediated calcium responses in adult DRG neurons; the role of CB receptors. | 2006 | Eur. J. Neurosci. | pmid:17229097 |
| Sharkey KA et al. | Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. | 2007 | Eur. J. Neurosci. | pmid:17459108 |
| Ryan D et al. | Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. | 2007 | Eur. J. Neurosci. | pmid:17419758 |
| Ahluwalia J et al. | Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. | 2003 | Eur. J. Neurosci. | pmid:12823468 |
| Sagan S et al. | Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes. | 1999 | Eur. J. Neurosci. | pmid:10051770 |
| Cippitelli A et al. | The anandamide transport inhibitor AM404 reduces ethanol self-administration. | 2007 | Eur. J. Neurosci. | pmid:17650118 |
| Ali AB and Todorova M | Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1. | 2010 | Eur. J. Neurosci. | pmid:20345910 |
| Lemak MS et al. | Cannabinoid regulation in identified synapse of terrestrial snail. | 2007 | Eur. J. Neurosci. | pmid:18028114 |
| Béquet F et al. | CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. | 2007 | Eur. J. Neurosci. | pmid:18052990 |
| Rivera P et al. | Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats. | 2013 | Eur. J. Neurosci. | pmid:23033907 |
| Sousa-Valente J et al. | Anandamide in primary sensory neurons: too much of a good thing? | 2014 | Eur. J. Neurosci. | pmid:24494681 |
| Rea K et al. | Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. | 2014 | Eur. J. Neurosci. | pmid:24494683 |
| Maccarrone M et al. | Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. | 2002 | Eur. J. Neurosci. | pmid:11982628 |
| Rodella LF et al. | AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation. | 2005 | Eur. J. Pharmacol. | pmid:15680264 |
| Vann RE et al. | Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. | 2009 | Eur. J. Pharmacol. | pmid:19470387 |
| Ralevic V et al. | Cannabinoid activation of recombinant and endogenous vanilloid receptors. | 2001 | Eur. J. Pharmacol. | pmid:11672565 |
| O'Sullivan SE et al. | Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. | 2005 | Eur. J. Pharmacol. | pmid:15659311 |
| Wheal AJ et al. | Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries. | 2012 | Eur. J. Pharmacol. | pmid:22154756 |
| Bouaboula M et al. | Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. | 2005 | Eur. J. Pharmacol. | pmid:15987634 |
| Wiley JL et al. | Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. | 2014 | Eur. J. Pharmacol. | pmid:24858366 |
| GarcÃa Mdel C et al. | Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats. | 2006 | Eur. J. Pharmacol. | pmid:16472800 |
| Walentiny DM et al. | The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. | 2011 | Eur. J. Pharmacol. | pmid:21300050 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Zygmunt PM et al. | The anandamide transport inhibitor AM404 activates vanilloid receptors. | 2000 | Eur. J. Pharmacol. | pmid:10822052 |
| Costa B and Colleoni M | Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol. | 2000 | Eur. J. Pharmacol. | pmid:10781666 |
| Alptekin A et al. | The effects of anandamide transport inhibitor AM404 on voltage-dependent calcium channels. | 2010 | Eur. J. Pharmacol. | pmid:20171208 |
| Randall MD et al. | Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. | 1997 | Eur. J. Pharmacol. | pmid:9314035 |
| Begg M et al. | Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum. | 2002 | Eur. J. Pharmacol. | pmid:11755170 |
| Giuffrida A et al. | Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404. | 2000 | Eur. J. Pharmacol. | pmid:11080522 |
| Marichal-Cancino BA et al. | Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats. | 2013 | Eur. J. Pharmacol. | pmid:24076186 |
| Adinolfi B et al. | Anticancer activity of anandamide in human cutaneous melanoma cells. | 2013 | Eur. J. Pharmacol. | pmid:24041928 |
| Calignano A et al. | Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. | 2001 | Eur. J. Pharmacol. | pmid:11426841 |
| Fride E et al. | Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. | 2001 | Eur. J. Pharmacol. | pmid:11426843 |
| Lay L et al. | Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse. | 2000 | Eur. J. Pharmacol. | pmid:10720647 |
| Someya A et al. | Arachidonic acid release and prostaglandin F(2alpha) formation induced by anandamide and capsaicin in PC12 cells. | 2002 | Eur. J. Pharmacol. | pmid:12206851 |
| Rácz I et al. | Anandamide effects on 5-HT(3) receptors in vivo. | 2008 | Eur. J. Pharmacol. | pmid:18775693 |
| Berdyshev EV et al. | Influence of fatty acid ethanolamides and delta9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells. | 1997 | Eur. J. Pharmacol. | pmid:9253958 |