Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Anorexia D000855 8 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ataxia D001259 20 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Body Weight D001835 333 associated lipids
Bradycardia D001919 13 associated lipids
Brain Concussion D001924 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Brain Edema D001929 20 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Wang H et al. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14645706
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Brown WH et al. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22912404
Scorticati C et al. The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15280536
Grimaldi P et al. The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19541620
Alger BE Endocannabinoids: getting the message across. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15173576
Liu J et al. A biosynthetic pathway for anandamide. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16938887
Járai Z et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570211
Boger DL et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10805767
De Petrocellis L et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9653194
Fegley D et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15138300
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Walker JM et al. Pain modulation by release of the endogenous cannabinoid anandamide. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518599
Schuel H et al. Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8052642
Scorticati C et al. The effect of anandamide on prolactin secretion is modulated by estrogen. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12578974
Felder CC et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8395053
Das SK et al. Cannabinoid ligand-receptor signaling in the mouse uterus. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7753807
Facci L et al. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7724569
Hill MN et al. Endogenous cannabinoid signaling is essential for stress adaptation. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20439721
Skaper SD et al. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8633002
Devane WA and Axelrod J Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8022836
Mukhopadhyay B et al. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21383171
Izzo AA and Deutsch DG Unique pathway for anandamide synthesis and liver regeneration. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21490298
Zhang N et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15764707
Paria BC et al. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7568154
Berger A et al. Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353819
Mechoulam R and Deutsch DG Toward an anandamide transporter. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16314567
Liu J et al. Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24191036
Wenzel D et al. Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24167249
Gobbi G et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16352709
Long JZ et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19918051
Fernández-Solari J et al. Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14981261
Schmid PC et al. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9108127
Glaser ST et al. Evidence against the presence of an anandamide transporter. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12655057
Kaczocha M et al. Identification of intracellular carriers for the endocannabinoid anandamide. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19307565
Collin C et al. Long-term synaptic transformation of hippocampal CA1 gamma-aminobutyric acid synapses and the effect of anandamide. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7479747
Dinh TP et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12136125
Klein TW et al. The cannabinoid system and cytokine network. 2000 Proc. Soc. Exp. Biol. Med. pmid:10998193
Calignano A et al. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. 2000 Prog. Brain Res. pmid:11098711
Iannotti FA et al. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. 2016 Prog. Lipid Res. pmid:26965148
Brown I et al. Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators. 2013 Prog. Lipid Res. pmid:23103355
Ueda N et al. N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). 2010 Prog. Lipid Res. pmid:20152858
Umathe SN et al. Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:19580839
Gomes FV et al. Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice. 2011 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:21111767
Bystrowska B et al. Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training. 2014 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:24334211
Campos AC and Guimarães FS Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:19735690
Gould GG et al. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. 2012 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:22542870
Edgemond WS et al. The binding of novel phenolic derivatives of anandamide to brain cannabinoid receptors. 1995 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:7784462
Mechoulam R Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052029
Sugiura T et al. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052034
Fowler CJ and Jacobsson SO Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052035
Deutsch DG et al. The fatty acid amide hydrolase (FAAH). 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052036
Fride E Endocannabinoids in the central nervous system--an overview. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052038
Pinto L et al. Endocannabinoids and the gut. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052047
Högestätt ED and Zygmunt PM Cardiovascular pharmacology of anandamide. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052048
Di Marzo V et al. Anandamide receptors. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052051
Matias I et al. Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:17011761
Johnson DE et al. Isolation, identification and synthesis of an endogenous arachidonic amide that inhibits calcium channel antagonist 1,4-dihydropyridine binding. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8341720
Di Marzo V and Fontana A Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone'. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7675818
Kim HY and Spector AA Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22959887
Iannotti FA et al. Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23830028
Fontana A et al. Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8577784
Jarrahian A and Hillard CJ Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9431821
Johannesson M et al. Cloning, purification and characterization of non-human primate 12/15-lipoxygenases. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106647
Boring DL et al. Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931121
Chen P et al. Metabolism of anandamide in cerebral microvascular endothelial cells. 2004 Prostaglandins Other Lipid Mediat. pmid:15165032
Wang J and Ueda N Biology of endocannabinoid synthesis system. 2009 Prostaglandins Other Lipid Mediat. pmid:19126434
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Wang H et al. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. 2007 Prostaglandins Other Lipid Mediat. pmid:17259073
Fonseca BM et al. Endogenous cannabinoids revisited: a biochemistry perspective. 2013 Apr-May Prostaglandins Other Lipid Mediat. pmid:23474290
Hillard CJ Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. 2000 Prostaglandins Other Lipid Mediat. pmid:10785538
Burstein SH et al. Oxidative metabolism of anandamide. 2000 Prostaglandins Other Lipid Mediat. pmid:10785540
Di Marzo V et al. Cannabimimetic fatty acid derivatives in cancer and inflammation. 2000 Prostaglandins Other Lipid Mediat. pmid:10785541
Kunos G et al. Cardiovascular effects of endocannabinoids--the plot thickens. 2000 Prostaglandins Other Lipid Mediat. pmid:10785543
McCue JM et al. In vitro synthesis of arachidonoyl amino acids by cytochrome c. 2009 Prostaglandins Other Lipid Mediat. pmid:19683594
Nicotra LL et al. Prostaglandin ethanolamides attenuate damage in a human explant colitis model. 2013 Prostaglandins Other Lipid Mediat. pmid:23380599
Besana A et al. Lipids and two-pore domain K+ channels in excitable cells. 2005 Prostaglandins Other Lipid Mediat. pmid:16099395
van der Stelt M and Di Marzo V Anandamide as an intracellular messenger regulating ion channel activity. 2005 Prostaglandins Other Lipid Mediat. pmid:16099396
Mimeault M et al. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. 2003 Prostate pmid:12746841
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Heyman E et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. 2012 Psychoneuroendocrinology pmid:22029953
Hill MN et al. Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. 2009 Psychoneuroendocrinology pmid:19394765
Gray JM et al. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. 2016 Psychoneuroendocrinology pmid:26821211
Marco EM et al. Emotional, endocrine and brain anandamide response to social challenge in infant male rats. 2013 Psychoneuroendocrinology pmid:23660109
Fride E and Mechoulam R Developmental aspects of anandamide: ontogeny of response and prenatal exposure. 1996 Psychoneuroendocrinology pmid:8774060
Kaufmann I et al. Anandamide and neutrophil function in patients with fibromyalgia. 2008 Psychoneuroendocrinology pmid:18395993
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
Egashira N et al. Anandamide inhibits the DOI-induced head-twitch response in mice. 2004 Psychopharmacology (Berl.) pmid:14586538
Williams CM and Kirkham TC Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. 1999 Psychopharmacology (Berl.) pmid:10353436
Vlachou S et al. Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. 2006 Psychopharmacology (Berl.) pmid:16953388
Gorzalka BB et al. Endocannabinoid modulation of male rat sexual behavior. 2008 Psychopharmacology (Berl.) pmid:17694389
Rueda-Orozco PE et al. A potential function of endocannabinoids in the selection of a navigation strategy by rats. 2008 Psychopharmacology (Berl.) pmid:17805517
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Costa B et al. Precipitated and spontaneous withdrawal in rats tolerant to anandamide. 2000 Psychopharmacology (Berl.) pmid:10805606
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
Haller J et al. The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. 2013 Psychopharmacology (Berl.) pmid:23743650
Fogaça MV et al. Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats. 2013 Psychopharmacology (Berl.) pmid:23183551
Järbe TU et al. Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. 2009 Psychopharmacology (Berl.) pmid:18521574
McMahon LR Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. 2009 Psychopharmacology (Berl.) pmid:18592221
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345