Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Anorexia D000855 8 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ataxia D001259 20 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Body Weight D001835 333 associated lipids
Bradycardia D001919 13 associated lipids
Brain Concussion D001924 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Brain Edema D001929 20 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Mbvundula EC et al. Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. 2005 Biochem. Pharmacol. pmid:15670582
Fowler CJ and Tiger G Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. 2005 Biochem. Pharmacol. pmid:15794945
Fowler CJ et al. Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. 2001 Biochem. Pharmacol. pmid:11585048
Shivachar AC Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes. 2007 Biochem. Pharmacol. pmid:17445778
De Bank PA et al. A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. 2005 Biochem. Pharmacol. pmid:15794939
Burstein SH et al. Relationships between eicosanoids and cannabinoids. Are eicosanoids cannabimimetic agents?. 1995 Biochem. Pharmacol. pmid:8615850
Shivachar AC et al. Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride]. 1996 Biochem. Pharmacol. pmid:8615904
Mechoulam R et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. 1995 Biochem. Pharmacol. pmid:7605349
Burstein SH and Hunter SA Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). 1995 Biochem. Pharmacol. pmid:7702643
Yang Z et al. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. 2008 Biochem. Pharmacol. pmid:18755158
Correa F et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. 2009 Biochem. Pharmacol. pmid:18848818
Thumser AE et al. A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis. 1997 Biochem. Pharmacol. pmid:9065749
Tiger G et al. Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate. 2000 Biochem. Pharmacol. pmid:10677581
Ortega-Gutiérrez S et al. Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. 2004 Biochemistry pmid:15209515
Martin GG et al. Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. 2017 Biochemistry pmid:28853554
Mulder AM and Cravatt BF Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. 2006 Biochemistry pmid:16981687
Kozak KR et al. Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. 2003 Biochemistry pmid:12885237
Pestonjamasp VK and Burstein SH Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. 1998 Biochim. Biophys. Acta pmid:9795237
Hillard CJ et al. Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. 1995 Biochim. Biophys. Acta pmid:7647100
Wellner N et al. N-acylation of phosphatidylethanolamine and its biological functions in mammals. 2013 Biochim. Biophys. Acta pmid:23000428
Vance JE and Tasseva G Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. 2013 Biochim. Biophys. Acta pmid:22960354
Jia Y and Lee LY Role of TRPV receptors in respiratory diseases. 2007 Biochim. Biophys. Acta pmid:17346945
Di Marzo V 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. 1998 Biochim. Biophys. Acta pmid:9630590
Petersen G et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. 2006 Biochim. Biophys. Acta pmid:16478679
Katayama K et al. Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme. 1999 Biochim. Biophys. Acta pmid:10521704
Hampson AJ et al. Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor. 1995 Biochim. Biophys. Acta pmid:7488638
Sun YX et al. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. 2005 Biochim. Biophys. Acta pmid:16154384
Urquhart P et al. Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. 2015 Biochim. Biophys. Acta pmid:25543004
Leishman E et al. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. 2016 Biochim. Biophys. Acta pmid:26956082
Bueb JL et al. Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. 2001 Biochim. Biophys. Acta pmid:11336796
Tsuboi K et al. Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. 2011 Biochim. Biophys. Acta pmid:21801852
Bisogno T et al. Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus. 1997 Biochim. Biophys. Acta pmid:9150253
Almada M et al. Anandamide and decidual remodelling: COX-2 oxidative metabolism as a key regulator. 2015 Biochim. Biophys. Acta pmid:26335727
Hansen HS et al. Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture. 1995 Biochim. Biophys. Acta pmid:7548201
Ueda N et al. Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonist. 1995 Biochim. Biophys. Acta pmid:7827116
Karava V et al. Anandamide metabolism by Tetrahymena pyriformis in vitro. Characterization and identification of a 66 kDa fatty acid amidohydrolase. 2005 Biochimie pmid:15951097
Spoto B et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. 2006 Biochimie pmid:16949718
Romani R et al. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? 2011 Biochimie pmid:21664223
Lipina C et al. New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance. 2012 Bioessays pmid:22674489
Zolese G et al. Effect of acylethanolamides on lipid peroxidation and paraoxonase activity. 2008 Biofactors pmid:19478424
Grambow E et al. Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. 2016 Biofactors pmid:27151562
Almada M et al. Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release. 2016 Biofactors pmid:26945481
Watanabe K et al. Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride. 1999 Biol. Pharm. Bull. pmid:10328555
Shiraishi T et al. The presence of ceramidase activity in liver nuclear membrane. 2003 Biol. Pharm. Bull. pmid:12808285
Kimura T et al. Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor. 1998 Biol. Pharm. Bull. pmid:9556149
Demers CH et al. Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions. 2016 Biol. Psychiatry pmid:26923505
Lu HC and Mackie K An Introduction to the Endogenous Cannabinoid System. 2016 Biol. Psychiatry pmid:26698193
Saravia R et al. CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. 2017 Biol. Psychiatry pmid:27737762
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Tzavara ET et al. Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications. 2006 Biol. Psychiatry pmid:16199010
Justinova Z et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. 2008 Biol. Psychiatry pmid:18814866
Paria BC et al. Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period. 1999 Biol. Reprod. pmid:10208977
Wang J et al. Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development. 1999 Biol. Reprod. pmid:10084956
Cobellis G et al. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. 2006 Biol. Reprod. pmid:16611862
Yang ZM et al. Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development. 1996 Biol. Reprod. pmid:8879486
Sun X et al. Genetic loss of Faah compromises male fertility in mice. 2009 Biol. Reprod. pmid:18987328
Paria BC et al. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. 1998 Biol. Reprod. pmid:9623610
Schuel H and Burkman LJ A tale of two cells: endocannabinoid-signaling regulates functions of neurons and sperm. 2005 Biol. Reprod. pmid:16120829
Wang X et al. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. 2016 Biomed Res Int pmid:26904688
Spaziano G et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. 2015 Biomed Res Int pmid:25866824
Malek N et al. Alterations in the anandamide metabolism in the development of neuropathic pain. 2014 Biomed Res Int pmid:25276812
Koga D et al. High-performance liquid chromatography and fluorometric detection of arachidonylethanolamide (anandamide) and its analogues, derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulp honyl-2,1 ,3- benzoxadiazole (DBD-COCl). 1995 Jan-Feb Biomed. Chromatogr. pmid:7734936
Schmidt A et al. Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. 2006 Biomed. Chromatogr. pmid:16189813
Arai Y et al. Sensitive determination of anandamide in rat brain utilizing a coupled-column HPLC with fluorimetric detection. 2000 Biomed. Chromatogr. pmid:10694706
Brizzi A et al. Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17561406
Duarte CD et al. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17275312
Di Marzo V et al. The anandamide membrane transporter. Structure-activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region. 2004 Bioorg. Med. Chem. pmid:15351399
Vandevoorde S et al. N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity. 2003 Bioorg. Med. Chem. pmid:12614867
Osman NA et al. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands. 2010 Bioorg. Med. Chem. pmid:21074998
Bourne C et al. Novel, potent THC/anandamide (hybrid) analogs. 2007 Bioorg. Med. Chem. pmid:17827022
Parkkari T et al. Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide. 2006 Bioorg. Med. Chem. pmid:16644227
Kono M et al. Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. 2014 Bioorg. Med. Chem. pmid:24440478
Ferreri C et al. Synthesis of all-trans anandamide: a substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation. 2008 Bioorg. Med. Chem. pmid:18782671
Wyffels L et al. Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. 2009 Bioorg. Med. Chem. pmid:19054678
Boger DL et al. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. 2001 Bioorg. Med. Chem. Lett. pmid:11412972
Sit SY et al. Novel inhibitors of fatty acid amide hydrolase. 2007 Bioorg. Med. Chem. Lett. pmid:17459705
El Fangour S et al. Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. 2003 Bioorg. Med. Chem. Lett. pmid:12781177
Parkkari T et al. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives. 2004 Bioorg. Med. Chem. Lett. pmid:15149681
Segall Y et al. Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. 2003 Bioorg. Med. Chem. Lett. pmid:12951114
Ortar G et al. New tetrazole-based selective anandamide uptake inhibitors. 2008 Bioorg. Med. Chem. Lett. pmid:18424134
Balas L et al. Synthesis of a potential photoactivatable anandamide analog. 2006 Bioorg. Med. Chem. Lett. pmid:16682198
Yao F et al. Development of novel tail-modified anandamide analogs. 2008 Bioorg. Med. Chem. Lett. pmid:18723350
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Aneetha H et al. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. 2009 Bioorg. Med. Chem. Lett. pmid:19013794
Morefield SI et al. Drug evaluations using neuronal networks cultured on microelectrode arrays. 2000 Biosens Bioelectron pmid:11219752
Psychoyos D et al. Cannabinoid receptor 1 signaling in embryo neurodevelopment. 2012 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:22311661
Nallendran V et al. The plasma levels of the endocannabinoid, anandamide, increase with the induction of labour. 2010 BJOG pmid:20406230
Ghasemi M et al. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. 2007 BJU Int. pmid:17850365
Maccarrone M et al. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. 2002 Blood pmid:12393387
Valk P et al. Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. 1997 Blood pmid:9269762
Bradshaw HB et al. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. 2009 BMC Biochem. pmid:19460156
Neelamegan D et al. Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum. 2012 BMC Microbiol. pmid:22730904
Hayase T Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. 2011 BMC Pharmacol. pmid:21767384
Kumar S Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates. 2015 BMC Res Notes pmid:25595103
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Gesell FK et al. Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. 2013 BMC Vet. Res. pmid:24370333
Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. 2009 Bone pmid:19059369
Lam PM et al. Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. 2005 Br J Anaesth pmid:15722382
Weis F et al. Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery. 2010 Br J Anaesth pmid:20525978
Jerman JC et al. Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. 2002 Br J Anaesth pmid:12453933