| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anorexia | D000855 | 8 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Urinary Bladder Diseases | D001745 | 4 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zenor BN et al. | Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. | 1999 | Life Sci. | pmid:10416818 |
| Pate DW et al. | Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. | 1998 | Life Sci. | pmid:9851310 |
| Reis GM et al. | Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide. | 2009 | Life Sci. | pmid:19576231 |
| Mallet PE and Beninger RJ | Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance. | 1998 | Life Sci. | pmid:9651110 |
| Berdyshev E et al. | Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. | 1998 | Life Sci. | pmid:9718090 |
| Arizzi MN et al. | Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. | 2004 | Life Sci. | pmid:14672756 |
| Soneji ND et al. | Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators. | 2010 | Life Sci. | pmid:20598325 |
| Roa-Coria JE et al. | N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception. | 2012 | Life Sci. | pmid:23069585 |
| Reis GM et al. | Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. | 2011 | Life Sci. | pmid:21277864 |
| González S et al. | Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. | 1999 | Life Sci. | pmid:10447218 |
| Wiley JL et al. | Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects. | 2000 | Life Sci. | pmid:10983852 |
| Tóth A et al. | Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. | 2003 | Life Sci. | pmid:12759142 |
| Mazzola C et al. | Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. | 2009 | Learn. Mem. | pmid:19403796 |
| Gurwitz D and Weizman A | Fatty acid amide hydrolase inhibitors and the marijuana debate. | 2001 | Lancet | pmid:11705595 |
| Senior K | Endogenously produced cannabinoids and liver cirrhosis. | 2001 | Lancet | pmid:11454385 |
| Bradbury J | Small part of cannabis puzzle solved by animal studies. | 2001 | Lancet | pmid:11498223 |
| Lockwood CJ | Prediction of pregnancy loss. | 2000 | Lancet | pmid:10776739 |
| Maccarrone M et al. | Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage. | 2000 | Lancet | pmid:10776746 |
| Huang L et al. | Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. | 2011 | Lab. Invest. | pmid:21464819 |
| Ito T et al. | Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells. | 2011 | Kurume Med J | pmid:22027193 |
| Haruta C | [Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells]. | 2012 | Kokubyo Gakkai Zasshi | pmid:22568077 |
| Kurihara J et al. | 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves. | 2001 | Jpn. J. Pharmacol. | pmid:11676206 |
| Mikawa Y et al. | Ocular activity of topically administered anandamide in the rabbit. | 1997 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9304433 |
| Habayeb OM et al. | Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage. | 2008 | JAMA | pmid:18334688 |
| Maccarrone M | Anandamide as a marker of human disease. | 2008 | JAMA | pmid:18632539 |
| Gratzke C et al. | Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder. | 2009 | J. Urol. | pmid:19237169 |
| Miyato H et al. | Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. | 2009 | J. Surg. Res. | pmid:19394652 |
| Maia J et al. | The endocannabinoid system expression in the female reproductive tract is modulated by estrogen. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28743542 |
| Bai X et al. | TASK channel expression in human placenta and cytotrophoblast cells. | 2006 | J. Soc. Gynecol. Investig. | pmid:16378911 |
| Vinklerová J et al. | Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251. | 2002 | J. Psychopharmacol. (Oxford) | pmid:12095072 |
| Ashton CH et al. | Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. | 2005 | J. Psychopharmacol. (Oxford) | pmid:15888515 |
| Aguilar DD et al. | THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia. | 2016 | J. Psychopharmacol. (Oxford) | pmid:26510449 |
| Almeida-Santos AF et al. | 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | 2017 | J. Psychopharmacol. (Oxford) | pmid:28440729 |
| Pamplona FA and Takahashi RN | Psychopharmacology of the endocannabinoids: far beyond anandamide. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21652605 |
| Potvin S et al. | Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. | 2008 | J. Psychopharmacol. (Oxford) | pmid:18308802 |
| Butler RK et al. | Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21926424 |
| Warzecha Z et al. | Role of sensory nerves in gastroprotective effect of anandamide in rats. | 2011 | J. Physiol. Pharmacol. | pmid:21673369 |
| Engel MA et al. | Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide. | 2008 | J. Physiol. Pharmacol. | pmid:19212003 |
| Grzeda E et al. | Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. | 2015 | J. Physiol. Pharmacol. | pmid:26084216 |
| Dembiński A et al. | Cannabinoids in acute gastric damage and pancreatitis. | 2006 | J. Physiol. Pharmacol. | pmid:17218765 |
| Gamelin FX et al. | Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. | 2016 | J. Physiol. Biochem. | pmid:26880264 |
| Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
| Chaytor AT et al. | The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. | 1999 | J. Physiol. (Lond.) | pmid:10523421 |
| Kollarik M and Undem BJ | Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice. | 2004 | J. Physiol. (Lond.) | pmid:14634201 |
| Campanucci VA et al. | A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. | 2003 | J. Physiol. (Lond.) | pmid:12640017 |
| Han J et al. | Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. | 2003 | J. Physiol. (Lond.) | pmid:12807991 |
| Szabo B et al. | Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. | 2006 | J. Physiol. (Lond.) | pmid:16973696 |
| Perrier JF et al. | 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. | 2003 | J. Physiol. (Lond.) | pmid:12626670 |
| Pacher P et al. | Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. | 2004 | J. Physiol. (Lond.) | pmid:15121805 |
| Jennings EA et al. | The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. | 2003 | J. Physiol. (Lond.) | pmid:12562891 |
| Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
| Steiner AA et al. | The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. | 2011 | J. Physiol. (Lond.) | pmid:21486787 |
| Poblete IM et al. | Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. | 2005 | J. Physiol. (Lond.) | pmid:16081483 |
| Vellani V et al. | Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. | 2001 | J. Physiol. (Lond.) | pmid:11483711 |
| Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
| Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
| Harris D et al. | Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. | 2002 | J. Physiol. (Lond.) | pmid:11897858 |
| Lin YS and Lee LY | Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. | 2002 | J. Physiol. (Lond.) | pmid:11897863 |
| Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
| Di S et al. | Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. | 2005 | J. Physiol. (Lond.) | pmid:16239276 |
| Van der Kloot W et al. | Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions. | 1998 | J. Physiol. (Lond.) | pmid:9508830 |
| Alger BE | Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. | 2012 | J. Physiol. (Lond.) | pmid:22289914 |
| Williams MA et al. | The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor. | 2008 | J. Physiol. (Lond.) | pmid:18063665 |
| Tamaki C et al. | Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilatation in the rat mesenteric vascular bed. | 2012 | J. Pharmacol. Sci. | pmid:22510966 |
| Sun Y et al. | Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes. | 2012 | J. Pharmacol. Sci. | pmid:22293299 |
| Walker VJ et al. | Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27000802 |
| Oz M et al. | Additive effects of endogenous cannabinoid anandamide and ethanol on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15687372 |
| Porter AC et al. | Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12023533 |
| Vanheel B and Van de Voorde J | Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11160613 |
| Aceto MD et al. | Anandamide, an endogenous cannabinoid, has a very low physical dependence potential. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808686 |
| Darmani NA | The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752094 |
| Appendino G et al. | Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15356216 |
| Snider NT et al. | The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18698000 |
| McDougle DR et al. | Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25277139 |
| Fride E et al. | Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7853184 |
| Miller LL et al. | Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514333 |
| Caprioli A et al. | The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514334 |
| Adams IB et al. | Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791088 |
| Welch SP et al. | Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791096 |
| Ishioka N and Bukoski RD | A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10087011 |
| Akerman S et al. | Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14718591 |
| McVey DC et al. | Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538826 |
| McAllister SD et al. | Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10525080 |
| Glaser ST and Kaczocha M | Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20702753 |
| Orliac ML et al. | Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490589 |
| McCollum L et al. | Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17379772 |
| Wang Y et al. | Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17308041 |
| Showalter VM et al. | Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819477 |
| Snider NT et al. | Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17272674 |
| Solinas M et al. | The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17210800 |
| Lake KD et al. | Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190833 |
| Willoughby KA et al. | The biodisposition and metabolism of anandamide in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9223560 |
| Hillard CJ | Endocannabinoids and vascular function. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871291 |
| Song ZH and Zhong M | CB1 cannabinoid receptor-mediated cell migration. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871313 |
| Di Marzo V et al. | A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11861807 |
| Glaser ST et al. | Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16278311 |
| Adams IB et al. | Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495885 |
| Fowler CJ et al. | Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9353392 |
| Li G et al. | Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27189966 |
| Thomas KC et al. | Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17332266 |