Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kelley BG and Thayer SA | Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors. | 2004 | Eur. J. Pharmacol. | pmid:15288572 |
McFarland MJ et al. | A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. | 2004 | J. Biol. Chem. | pmid:15292270 |
Lazzarin N et al. | Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. | 2004 | Gynecol. Endocrinol. | pmid:15293893 |
Do Y et al. | Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. | 2004 | J. Immunol. | pmid:15294950 |
Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
Parkkari T et al. | Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15149681 |
Pacher P et al. | Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. | 2004 | J. Physiol. (Lond.) | pmid:15121805 |
Van Der Stelt M and Di Marzo V | Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. | 2004 | Eur. J. Biochem. | pmid:15128293 |
Randall MD et al. | The complexities of the cardiovascular actions of cannabinoids. | 2004 | Br. J. Pharmacol. | pmid:15131000 |
Huitron-Resendiz S et al. | Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. | 2004 | Sleep | pmid:15453543 |
Piomelli D | The endogenous cannabinoid system and the treatment of marijuana dependence. | 2004 | Neuropharmacology | pmid:15464150 |
Fernández-Rodriguez CM et al. | Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis. | 2004 | Liver Int. | pmid:15482346 |
Nilsson O et al. | Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures. | 2003 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:14659458 |
Ross RA | Anandamide and vanilloid TRPV1 receptors. | 2003 | Br. J. Pharmacol. | pmid:14517174 |
McAllister SD et al. | An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. | 2003 | J. Med. Chem. | pmid:14613317 |
Han B et al. | Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. | 2003 | J. Nat. Prod. | pmid:14575438 |
Chen N et al. | Inhibition by arachidonic acid and other fatty acids of dopamine uptake at the human dopamine transporter. | 2003 | Eur. J. Pharmacol. | pmid:14575792 |
Farquhar-Smith WP and Rice AS | A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia. | 2003 | Anesthesiology | pmid:14639155 |
Jones S and Howl J | Cannabinoid receptor systems: therapeutic targets for tumour intervention. | 2003 | Expert Opin. Ther. Targets | pmid:14640910 |
Zoratti C et al. | Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. | 2003 | Br. J. Pharmacol. | pmid:14645143 |
Wang H et al. | Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14645706 |
Gurney AM et al. | Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. | 2003 | Circ. Res. | pmid:14551239 |
Biswas KK et al. | Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. | 2003 | Hepatology | pmid:14578855 |
Vandevoorde S et al. | Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. | 2003 | J. Med. Chem. | pmid:14521402 |
Oz M et al. | The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12766252 |
Campanucci VA et al. | A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. | 2003 | J. Physiol. (Lond.) | pmid:12640017 |
Sarker KP et al. | ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. | 2003 | J. Neurochem. | pmid:12641726 |
Li J et al. | Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. | 2003 | Hypertension | pmid:12623992 |
Holt S and Fowler CJ | Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:12644895 |
Vásquez C et al. | Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774849 |
Han J et al. | Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. | 2003 | J. Physiol. (Lond.) | pmid:12807991 |
Fowler CJ et al. | Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. | 2003 | Biochem. Pharmacol. | pmid:12948856 |
Patel S et al. | Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12808005 |
Shiraishi T et al. | The presence of ceramidase activity in liver nuclear membrane. | 2003 | Biol. Pharm. Bull. | pmid:12808285 |
Klegeris A et al. | Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | 2003 | Br. J. Pharmacol. | pmid:12813001 |
Juntunen J et al. | Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. | 2003 | Eur J Pharm Sci | pmid:12729860 |
Wilson SJ et al. | A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase. | 2003 | Anal. Biochem. | pmid:12814631 |
Maccarrone M et al. | The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. | 2003 | J. Biol. Chem. | pmid:12815050 |
Obata T et al. | Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12829006 |
Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
Pearlman RJ et al. | Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. | 2003 | J. Neurochem. | pmid:12558979 |
Perrier JF et al. | 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. | 2003 | J. Physiol. (Lond.) | pmid:12626670 |
Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
Ahluwalia J et al. | Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. | 2003 | Eur. J. Neurosci. | pmid:12823468 |
El Fangour S et al. | Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12781177 |
Tarzia G et al. | Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. | 2003 | J. Med. Chem. | pmid:12773040 |
Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
del Carmen GarcÃa M et al. | Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14504685 |
Segall Y et al. | Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12951114 |
Mimeault M et al. | Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. | 2003 | Prostate | pmid:12746841 |
López-RodrÃguez ML et al. | Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. | 2003 | Eur J Med Chem | pmid:12750028 |
Derkinderen P et al. | Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | 2003 | J. Neurosci. | pmid:12657697 |
Jonsson KO et al. | AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. | 2003 | Arch. Toxicol. | pmid:12698235 |
López-RodrÃguez ML et al. | Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. | 2003 | J. Med. Chem. | pmid:12672252 |
Maccarrone M | The blissful state of endothelium. | 2003 | Thromb. Haemost. | pmid:12719771 |
Murillo-Rodriguez E et al. | Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. | 2003 | Sleep | pmid:14746372 |
Yamaji K et al. | Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. | 2003 | Thromb. Haemost. | pmid:12719786 |
Basavarajappa BS et al. | Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. | 2003 | Eur. J. Pharmacol. | pmid:12679143 |
Ortar G et al. | Novel selective and metabolically stable inhibitors of anandamide cellular uptake. | 2003 | Biochem. Pharmacol. | pmid:12732359 |
Clement AB et al. | Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. | 2003 | J. Neurosci. | pmid:12736361 |
Hermann H et al. | Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. | 2003 | Cell. Mol. Life Sci. | pmid:12737320 |
Fowler CJ et al. | Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. | 2003 | J Enzyme Inhib Med Chem | pmid:12751821 |
Kasai HF et al. | Analyses of anandamide and endocannabinoid-like compounds using collision-induced dissociation in fast atom bombardment ionization-mass spectrometry and gas chromatography/chemical ionization-mass spectrometry. | 2003 | Anal Sci | pmid:14696920 |
Gaetani S et al. | Anandamide hydrolysis: a new target for anti-anxiety drugs? | 2003 | Trends Mol Med | pmid:14604824 |
Ahern GP | Activation of TRPV1 by the satiety factor oleoylethanolamide. | 2003 | J. Biol. Chem. | pmid:12761211 |
Maccarrone M et al. | Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. | 2003 | J. Neurochem. | pmid:12716433 |
Marinelli S et al. | Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. | 2003 | J. Neurosci. | pmid:12716921 |
McVey DC et al. | Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538826 |
Scorticati C et al. | The effect of anandamide on prolactin secretion is modulated by estrogen. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12578974 |
Ahluwalia J et al. | Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. | 2003 | J. Neurochem. | pmid:12558978 |
Sancho R et al. | Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. | 2003 | Mol. Pharmacol. | pmid:12527815 |
Jennings EA et al. | The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. | 2003 | J. Physiol. (Lond.) | pmid:12562891 |
Randall MD | A new endothelial target for cannabinoids. | 2003 | Mol. Pharmacol. | pmid:12606752 |
Wisnoskey BJ et al. | Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry. | 2003 | Biochem. J. | pmid:12608892 |
Higgs S et al. | Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. | 2003 | Psychopharmacology (Berl.) | pmid:12447606 |
Facchinetti F et al. | Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. | 2003 | Glia | pmid:12509806 |
Kathuria S et al. | Modulation of anxiety through blockade of anandamide hydrolysis. | 2003 | Nat. Med. | pmid:12461523 |
Németh J et al. | Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. | 2003 | Neurosci. Lett. | pmid:12499047 |
Maccarrone M and Finazzi-Agró A | The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. | 2003 | Cell Death Differ. | pmid:12934069 |
González S et al. | Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent rats. | 2003 | Addict Biol | pmid:12850774 |
Dogulu FH et al. | Intra-arterial simultaneous administration of anandamide attenuates endothelin-1 induced vasospasm in rabbit basilar arteries. | 2003 | Acta Neurochir (Wien) | pmid:12910401 |
Fasia L et al. | Uptake and metabolism of [3H]anandamide by rabbit platelets. Lack of transporter? | 2003 | Eur. J. Biochem. | pmid:12919314 |
Sarker KP and Maruyama I | Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. | 2003 | Cell. Mol. Life Sci. | pmid:12861385 |
Bojesen IN and Hansen HS | Binding of anandamide to bovine serum albumin. | 2003 | J. Lipid Res. | pmid:12837852 |
Patel S et al. | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. | 2003 | Br. J. Pharmacol. | pmid:12839875 |
Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
Watanabe H et al. | Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. | 2003 | Nature | pmid:12879072 |
Kozak KR et al. | Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. | 2003 | Biochemistry | pmid:12885237 |
Sparling PB et al. | Exercise activates the endocannabinoid system. | 2003 | Neuroreport | pmid:14625449 |
Mechoulam R and Lichtman AH | Neuroscience. Stout guards of the central nervous system. | 2003 | Science | pmid:14526067 |
Marsicano G et al. | CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | 2003 | Science | pmid:14526074 |
Veldhuis WB et al. | Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | 2003 | J. Neurosci. | pmid:12764100 |
Glaser ST et al. | Evidence against the presence of an anandamide transporter. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12655057 |
Lo YK et al. | Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells. | 2003 | Biochem. Pharmacol. | pmid:12566085 |
Steffens M et al. | Quantitative measurement of depolarization-induced anandamide release in human and rat neocortex. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14566450 |
Vandevoorde S et al. | Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide. | 2003 | J. Med. Chem. | pmid:12672243 |
Wenger T et al. | The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice. | 2003 | Neuroendocrinology | pmid:14688442 |
Tóth A et al. | Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. | 2003 | Life Sci. | pmid:12759142 |
Chu CJ et al. | N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. | 2003 | J. Biol. Chem. | pmid:12569099 |
Fowler CJ et al. | Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin. | 2003 | J Enzyme Inhib Med Chem | pmid:14506913 |