Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Liao YS et al. | [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575494 |
Wu WJ et al. | [Membrane cholesterol mediates the endocannabinoids-anandamide affection on HepG2 cells]. | 2010 | Zhonghua Gan Zang Bing Za Zhi | pmid:20380798 |
Liu HY et al. | [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18578993 |
Waku K | [Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol]. | 2006 | Yakugaku Zasshi | pmid:16462096 |
Ueda N et al. | Alkaline and acid amidases hydrolyzing anandamide and other N-acylethanolamines. | 2001 | World Rev Nutr Diet | pmid:11935959 |
Hansen HS et al. | When and where are N-acylethanolamine phospholipids and anandamide formed? | 2001 | World Rev Nutr Diet | pmid:11935960 |
Roser P et al. | Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. | 2010 | World J. Biol. Psychiatry | pmid:20218784 |
Okamoto Y et al. | Enzymatic formation of anandamide. | 2009 | Vitam. Horm. | pmid:19647106 |
Yates ML and Barker EL | Organized trafficking of anandamide and related lipids. | 2009 | Vitam. Horm. | pmid:19647107 |
Goodfellow CE and Glass M | Anandamide receptor signal transduction. | 2009 | Vitam. Horm. | pmid:19647109 |
Brown AJ and Robin Hiley C | Is GPR55 an anandamide receptor? | 2009 | Vitam. Horm. | pmid:19647110 |
Correa FG et al. | The endocannabinoid anandamide from immunomodulation to neuroprotection. Implications for multiple sclerosis. | 2009 | Vitam. Horm. | pmid:19647114 |
Tóth A et al. | Anandamide and the vanilloid receptor (TRPV1). | 2009 | Vitam. Horm. | pmid:19647120 |
Pasquariello N et al. | Regulation of gene transcription and keratinocyte differentiation by anandamide. | 2009 | Vitam. Horm. | pmid:19647122 |
Alpini G and Demorrow S | Changes in the endocannabinoid system may give insight into new and effective treatments for cancer. | 2009 | Vitam. Horm. | pmid:19647123 |
Glaser ST et al. | Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. | 2005 Nov-Dec | Vis. Neurosci. | pmid:16469181 |
Cruz F | Mechanisms involved in new therapies for overactive bladder. | 2004 | Urology | pmid:15013655 |
Devane WA | New dawn of cannabinoid pharmacology. | 1994 | Trends Pharmacol. Sci. | pmid:8165721 |
Fowler CJ | Anandamide uptake explained? | 2012 | Trends Pharmacol. Sci. | pmid:22297258 |
Zygmunt PM et al. | Anandamide - the other side of the coin. | 2000 | Trends Pharmacol. Sci. | pmid:10664604 |
Di Marzo V and Maccarrone M | FAAH and anandamide: is 2-AG really the odd one out? | 2008 | Trends Pharmacol. Sci. | pmid:18394720 |
Smart D and Jerman JC | Anandamide: an endogenous activator of the vanilloid receptor. | 2000 | Trends Pharmacol. Sci. | pmid:10740287 |
Szolcsányi J | Anandamide and the question of its functional role for activation of capsaicin receptors. | 2000 | Trends Pharmacol. Sci. | pmid:10838604 |
Piomelli D et al. | The endocannabinoid system as a target for therapeutic drugs. | 2000 | Trends Pharmacol. Sci. | pmid:10838609 |
Fowler CJ | Has FLAT fallen flat? | 2014 | Trends Pharmacol. Sci. | pmid:24398120 |
Randall MD and Kendall DA | Endocannabinoids: a new class of vasoactive substances. | 1998 | Trends Pharmacol. Sci. | pmid:9550942 |
Gunduz-Cinar O et al. | Amygdala FAAH and anandamide: mediating protection and recovery from stress. | 2013 | Trends Pharmacol. Sci. | pmid:24325918 |
Di Marzo V et al. | Anandamide: some like it hot. | 2001 | Trends Pharmacol. Sci. | pmid:11431028 |
Szallasi A and Di Marzo V | New perspectives on enigmatic vanilloid receptors. | 2000 | Trends Neurosci. | pmid:11006466 |
Alhouayek M and Muccioli GG | The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. | 2012 | Trends Mol Med | pmid:22917662 |
Gaetani S et al. | Anandamide hydrolysis: a new target for anti-anxiety drugs? | 2003 | Trends Mol Med | pmid:14604824 |
Maccarrone M | Inhibition of anandamide hydrolysis: cells also know how to do it. | 2004 | Trends Mol Med | pmid:14720580 |
Mechoulam R et al. | Cannabinoids and brain injury: therapeutic implications. | 2002 | Trends Mol Med | pmid:11815270 |
Maccarrone M et al. | Intracellular trafficking of anandamide: new concepts for signaling. | 2010 | Trends Biochem. Sci. | pmid:20570522 |
Bluett RJ et al. | Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. | 2014 | Transl Psychiatry | pmid:25004388 |
Leweke FM et al. | Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. | 2012 | Transl Psychiatry | pmid:22832859 |
Hsu SS et al. | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | 2007 | Toxicology | pmid:17222495 |
Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
Carr RL et al. | Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. | 2013 | Toxicol. Sci. | pmid:23761300 |
Kodani SD et al. | Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. | 2016 | Toxicol. Lett. | pmid:27659731 |
Kaplan BL et al. | Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15893538 |
Kondakala S et al. | Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29097212 |
Quistad GB et al. | Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11350214 |
Vilela LR et al. | Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25933444 |
Matsuda K et al. | The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. | 2005 | Tohoku J. Exp. Med. | pmid:16141678 |
Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
Maccarrone M | The blissful state of endothelium. | 2003 | Thromb. Haemost. | pmid:12719771 |
Maccarrone M et al. | Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. | 2006 | Thromb. Haemost. | pmid:16543970 |
Harada N et al. | Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. | 2006 | Thromb. Haemost. | pmid:16732381 |