Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Grainger J and Boachie-Ansah G | Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels. | 2001 | Br. J. Pharmacol. | pmid:11682448 |
White R and Hiley CR | The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery. | 1998 | Br. J. Pharmacol. | pmid:9806337 |
Zoratti C et al. | Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. | 2003 | Br. J. Pharmacol. | pmid:14645143 |
Taddei S | Evolving the concept of regulation of vascular tone in humans. | 2005 | Br. J. Pharmacol. | pmid:15997231 |
Izzo AA et al. | Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. | 2012 | Br. J. Pharmacol. | pmid:22300105 |
Ameri A et al. | Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. | 1999 | Br. J. Pharmacol. | pmid:10372827 |
Klegeris A et al. | Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | 2003 | Br. J. Pharmacol. | pmid:12813001 |
Moreno-Sanz G et al. | Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. | 2012 | Br. J. Pharmacol. | pmid:22774772 |
Pakdeechote P et al. | Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed. | 2007 | Br. J. Pharmacol. | pmid:17641668 |
Thors L et al. | The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake. | 2007 | Br. J. Pharmacol. | pmid:17325653 |
Fleming I et al. | Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists. | 1999 | Br. J. Pharmacol. | pmid:10193775 |
Ruiz-Llorente L et al. | Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. | 2004 | Br. J. Pharmacol. | pmid:14718261 |
Vandevoorde S et al. | Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. | 2007 | Br. J. Pharmacol. | pmid:17143303 |
Herradón E et al. | Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. | 2007 | Br. J. Pharmacol. | pmid:17704831 |
Izzo AA et al. | Effect of vanilloid drugs on gastrointestinal transit in mice. | 2001 | Br. J. Pharmacol. | pmid:11264233 |
Gauldie SD et al. | Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. | 2001 | Br. J. Pharmacol. | pmid:11159713 |
Stewart JL and McMahon LR | The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. | 2011 | Br. J. Pharmacol. | pmid:21449917 |
Patel S et al. | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. | 2003 | Br. J. Pharmacol. | pmid:12839875 |
Costa B et al. | AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. | 2006 | Br. J. Pharmacol. | pmid:16770320 |
Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
De Petrocellis L et al. | Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. | 2011 | Br. J. Pharmacol. | pmid:21175579 |
Stanford SJ et al. | Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. | 2001 | Br. J. Pharmacol. | pmid:11454655 |
Mang CF et al. | Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors. | 2001 | Br. J. Pharmacol. | pmid:11522608 |
Jonsson KO et al. | Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. | 2001 | Br. J. Pharmacol. | pmid:11498512 |
White R and Hiley CR | A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. | 1997 | Br. J. Pharmacol. | pmid:9422801 |
Zygmunt PM et al. | Studies on the effects of anandamide in rat hepatic artery. | 1997 | Br. J. Pharmacol. | pmid:9422814 |
Andrag E and Curtis MJ | Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids. | 2013 | Br. J. Pharmacol. | pmid:23713981 |
Ford WR et al. | Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. | 2002 | Br. J. Pharmacol. | pmid:11877326 |
Mair KM et al. | Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | 2010 | Br. J. Pharmacol. | pmid:20718749 |
Li H et al. | Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. | 2013 | Br. J. Pharmacol. | pmid:23347118 |
Jacobsson SO and Fowler CJ | Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. | 2001 | Br. J. Pharmacol. | pmid:11309246 |
Spicuzza L et al. | Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves. | 2000 | Br. J. Pharmacol. | pmid:10928980 |
Thors L et al. | Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. | 2008 | Br. J. Pharmacol. | pmid:18552875 |
Ligresti A et al. | New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. | 2006 | Br. J. Pharmacol. | pmid:16284631 |
Plane F et al. | Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. | 1997 | Br. J. Pharmacol. | pmid:9283682 |
Soria-Gómez E et al. | Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. | 2007 | Br. J. Pharmacol. | pmid:17549045 |
Bittner S et al. | TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. | 2009 | Brain | pmid:19570851 |
Centonze D et al. | The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. | 2007 | Brain | pmid:17626034 |
Butti E et al. | Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. | 2012 | Brain | pmid:23008234 |
Patel RR et al. | Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. | 2016 | Brain | pmid:27267376 |
Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
Rossi S et al. | Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:21473912 |
Mecha M et al. | Endocannabinoids drive the acquisition of an alternative phenotype in microglia. | 2015 | Brain Behav. Immun. | pmid:26086345 |
Correa F et al. | The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. | 2011 | Brain Behav. Immun. | pmid:21310228 |
Marco EM et al. | Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. | 2009 | Brain Res. | pmid:19133243 |
McGregor IS et al. | A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain. | 1998 | Brain Res. | pmid:9748483 |
Murillo-RodrÃguez E et al. | Anandamide modulates sleep and memory in rats. | 1998 | Brain Res. | pmid:9813364 |
Christopoulos A and Wilson K | Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. | 2001 | Brain Res. | pmid:11578621 |
González S et al. | Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. | 2002 | Brain Res. | pmid:12393235 |
Yue HY et al. | AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. | 2004 | Brain Res. | pmid:15276889 |
Borsani E et al. | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. | 2007 | Brain Res. | pmid:17459353 |
Barros DM et al. | Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems. | 2004 | Brain Res. | pmid:15234253 |
Patel NA et al. | Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. | 1998 | Brain Res. | pmid:9666136 |
Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
Prevot V et al. | Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation. | 1998 | Brain Res. | pmid:9593913 |
Stefano GB et al. | Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues. | 1998 | Brain Res. | pmid:9630717 |
Van der Kloot W | Anandamide, a naturally-occurring agonist of the cannabinoid receptor, blocks adenylate cyclase at the frog neuromuscular junction. | 1994 | Brain Res. | pmid:7953630 |
Hohmann AG et al. | Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. | 1999 | Brain Res. | pmid:10082879 |
Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
Soni N et al. | Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal. | 2017 | Brain Res. | pmid:28404451 |
Lara-Celador I et al. | Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. | 2012 | Brain Res. | pmid:22841538 |
Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
Fride E | Anandamides: tolerance and cross-tolerance to delta 9-tetrahydrocannabinol. | 1995 | Brain Res. | pmid:8593598 |
Minowa S et al. | Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. | 2005 | Brain Res. | pmid:15781048 |
de Lago E et al. | Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. | 2004 | Brain Res. | pmid:15064146 |
Stefano GB et al. | Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release. | 1997 | Brain Res. | pmid:9272829 |
Houser SJ et al. | Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide. | 2000 | Brain Res. | pmid:10700588 |
Stefano GB et al. | Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release. | 1997 | Brain Res. | pmid:9125406 |
Potenzieri C et al. | Excitation of cutaneous C nociceptors by intraplantar administration of anandamide. | 2009 | Brain Res. | pmid:19285051 |
Kim HI et al. | Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. | 2005 | Brain Res. | pmid:16256960 |
Romero J et al. | Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function. | 1995 | Brain Res. | pmid:8974649 |
Chakrabarti A et al. | Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. | 1998 | Brain Res. Bull. | pmid:9434204 |
Lin QS et al. | Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. | 2011 | Brain Res. Bull. | pmid:21801815 |
Fride E and Mechoulam R | Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. | 1996 | Brain Res. Dev. Brain Res. | pmid:8873985 |
Matias I et al. | Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis. | 2001 | Brain Res. Mol. Brain Res. | pmid:11245916 |
Golech SA et al. | Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. | 2004 | Brain Res. Mol. Brain Res. | pmid:15548432 |
Romero J et al. | Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. | 2002 | Brain Res. Mol. Brain Res. | pmid:12008024 |
Yusifzade K et al. | The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig. | 2009 | Bratisl Lek Listy | pmid:19711821 |
Fernandez-Solari J et al. | Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448903 |
Ribeiro A et al. | Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests. | 2009 | Braz. J. Med. Biol. Res. | pmid:19448906 |
Fogaça MV et al. | Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. | 2012 | Braz. J. Med. Biol. Res. | pmid:22392189 |
Kukushkin ML et al. | Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. | 2006 | Bull. Exp. Biol. Med. | pmid:17369898 |
Krylatov AV et al. | Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. | 2002 | Bull. Exp. Biol. Med. | pmid:12428277 |
Andrianova EL et al. | In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. | 2011 | Bull. Exp. Biol. Med. | pmid:22442796 |
Ugdyzhekova DS et al. | Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. | 2001 | Bull. Exp. Biol. Med. | pmid:11427912 |
Vavilin VA et al. | Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis. | 2013 | Bull. Exp. Biol. Med. | pmid:24319743 |
Vásquez C et al. | Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774849 |
Joseph J et al. | Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. | 2004 | Cancer Immunol. Immunother. | pmid:15034673 |
Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
Hiley CR and Hoi PM | Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? | 2007 | Cardiovasc Drug Rev | pmid:17445087 |
Mukhopadhyay S and Tulis DA | Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. | 2007 | Cardiovasc Hematol Agents Med Chem | pmid:17979695 |
Wang Y and Wang DH | Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. | 2007 | Cardiovasc Hematol Disord Drug Targets | pmid:17346127 |
Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. | 2010 | Cardiovasc. Res. | pmid:19942623 |
Barana A et al. | Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. | 2010 | Cardiovasc. Res. | pmid:19689982 |
Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
Kvasnicka T | [Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. | 2005 | Cas. Lek. Cesk. | pmid:15807291 |
Lozovaya N et al. | Dual modulation of CNS voltage-gated calcium channels by cannabinoids: Focus on CB1 receptor-independent effects. | 2009 | Cell Calcium | pmid:19682741 |
Tsumura M et al. | TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. | 2012 | Cell Calcium | pmid:22656960 |
Juan-Picó P et al. | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. | 2006 | Cell Calcium | pmid:16321437 |
Al Kury LT et al. | Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes. | 2014 | Cell Calcium | pmid:24472666 |