Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schmid PC et al. | Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9108127 |
Plane F et al. | Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. | 1997 | Br. J. Pharmacol. | pmid:9283682 |
Langstein J et al. | cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. | 1996 Jul-Aug | Res. Immunol. | pmid:8903105 |
Derkinderen P et al. | Regulation of a neuronal form of focal adhesion kinase by anandamide. | 1996 | Science | pmid:8781236 |
Shimasue K et al. | Effects of anandamide and arachidonic acid on specific binding of (+) -PN200-110, diltiazem and (-) -desmethoxyverapamil to L-type Ca2+ channel. | 1996 | Eur. J. Pharmacol. | pmid:8904088 |
Sugiura T et al. | Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8573114 |
Jarho P et al. | Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide. | 1996 | Life Sci. | pmid:8602110 |
Skaper SD et al. | The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8633002 |
Wise ML et al. | Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. | 1996 | Experientia | pmid:8575565 |
Pan X et al. | Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system. | 1996 | Mol. Pharmacol. | pmid:8609900 |
Fride E and Mechoulam R | Developmental aspects of anandamide: ontogeny of response and prenatal exposure. | 1996 | Psychoneuroendocrinology | pmid:8774060 |
Showalter VM et al. | Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819477 |
Felder CC et al. | Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. | 1996 | FEBS Lett. | pmid:8814296 |
di Tomaso E et al. | Brain cannabinoids in chocolate. | 1996 | Nature | pmid:8751435 |
Cadas H et al. | Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP. | 1996 | J. Neurosci. | pmid:8656287 |
Kempe K et al. | Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue. | 1996 | J. Biol. Chem. | pmid:8663381 |
Shivachar AC et al. | Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride]. | 1996 | Biochem. Pharmacol. | pmid:8615904 |
Stefano GB et al. | Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes. | 1996 | J. Biol. Chem. | pmid:8702604 |
Di Marzo V et al. | Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. | 1996 | Biochem. J. | pmid:8670178 |
Cravatt BF et al. | Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. | 1996 | Nature | pmid:8900284 |
Sugiura T et al. | N-arachidonoylethanolamine (anandamide), an endogenous cannabinoid receptor ligand, and related lipid molecules in the nervous tissues. | 1996 | J Lipid Mediat Cell Signal | pmid:8906545 |
Ueda N et al. | Enzymes for anandamide biosynthesis and metabolism. | 1996 | J Lipid Mediat Cell Signal | pmid:8906546 |
Yang ZM et al. | Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development. | 1996 | Biol. Reprod. | pmid:8879486 |
Varga K et al. | Mechanism of the hypotensive action of anandamide in anesthetized rats. | 1996 | Hypertension | pmid:8843898 |
Poling JS et al. | Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels. | 1996 | Neuropharmacology | pmid:8938728 |
Di Marzo V et al. | Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8858137 |
Ishac EJ et al. | Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. | 1996 | Br. J. Pharmacol. | pmid:8864538 |
Fride E and Mechoulam R | Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. | 1996 | Brain Res. Dev. Brain Res. | pmid:8873985 |
Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
Stein EA et al. | Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat. | 1996 | Br. J. Pharmacol. | pmid:8872363 |
James JS | Marijuana and chocolate. | 1996 | AIDS Treat News | pmid:11363932 |
Thomas BF et al. | Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore. | 1996 | J. Med. Chem. | pmid:8558515 |
Boring DL et al. | Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931121 |
Berdyshev EV et al. | Anandamide--a new look on fatty acid ethanolamides. | 1996 | J Lipid Mediat Cell Signal | pmid:9029374 |
Randall MD et al. | An endogenous cannabinoid as an endothelium-derived vasorelaxant. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954092 |
Paria BC et al. | The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period. | 1996 | Mol. Reprod. Dev. | pmid:8914076 |
Khanolkar AD et al. | Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. | 1996 | J. Med. Chem. | pmid:8893848 |
Sugiura T et al. | Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine. | 1996 | Eur. J. Biochem. | pmid:8797835 |
Koga D et al. | High-performance liquid chromatography and fluorometric detection of arachidonylethanolamide (anandamide) and its analogues, derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulp honyl-2,1 ,3- benzoxadiazole (DBD-COCl). | 1995 Jan-Feb | Biomed. Chromatogr. | pmid:7734936 |
Edgemond WS et al. | The binding of novel phenolic derivatives of anandamide to brain cannabinoid receptors. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784462 |
Hillard CJ et al. | Characterization of ligand binding to the cannabinoid receptor of rat brain membranes using a novel method: application to anandamide. | 1995 | J. Neurochem. | pmid:7830060 |
Wartmann M et al. | The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide. | 1995 | FEBS Lett. | pmid:7867785 |
Bornheim LM et al. | Microsomal cytochrome P450-mediated liver and brain anandamide metabolism. | 1995 | Biochem. Pharmacol. | pmid:7669071 |
Ueda N and Yamamoto S | [Anandamide: a marijuana-like compound produced in animal tissues]. | 1995 | Tanpakushitsu Kakusan Koso | pmid:8532892 |
Maurelli S et al. | Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'. | 1995 | FEBS Lett. | pmid:8543025 |
Pate DW et al. | Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits. | 1995 | Curr. Eye Res. | pmid:8529418 |
Lee M et al. | Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7473135 |
Schmid PC et al. | Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. | 1995 | FEBS Lett. | pmid:7498458 |
Burstein SH and Hunter SA | Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). | 1995 | Biochem. Pharmacol. | pmid:7702643 |
Pertwee RG et al. | Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations. | 1995 | Eur. J. Pharmacol. | pmid:7713152 |