Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Anorexia D000855 8 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ataxia D001259 20 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Body Weight D001835 333 associated lipids
Bradycardia D001919 13 associated lipids
Brain Concussion D001924 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bulimia D002032 3 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Catalepsy D002375 30 associated lipids
Celiac Disease D002446 16 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Feizi A et al. The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney. 2008 Exp. Toxicol. Pathol. pmid:18571910
Wise ML et al. Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. 1996 Experientia pmid:8575565
Jones S and Howl J Cannabinoid receptor systems: therapeutic targets for tumour intervention. 2003 Expert Opin. Ther. Targets pmid:14640910
Lory P and Chemin J Towards the discovery of novel T-type calcium channel blockers. 2007 Expert Opin. Ther. Targets pmid:17465728
Bambico FR and Gobbi G The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets. 2008 Expert Opin. Ther. Targets pmid:18851692
van der Stelt M et al. A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. 2005 FASEB J. pmid:15894565
Mascolo N et al. The endocannabinoid system and the molecular basis of paralytic ileus in mice. 2002 FASEB J. pmid:12397089
Varga K et al. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. 1998 FASEB J. pmid:9707176
Bátkai S et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. 2007 FASEB J. pmid:17327359
Karwad MA et al. The role of CB in intestinal permeability and inflammation. 2017 FASEB J. pmid:28404744
Baker D et al. Endocannabinoids control spasticity in a multiple sclerosis model. 2001 FASEB J. pmid:11156943
D'Argenio G et al. Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. 2006 FASEB J. pmid:16403786
Bifulco M et al. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. 2001 FASEB J. pmid:11687506
Di Marzo V et al. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. 2000 FASEB J. pmid:10877836
Berdyshev EV et al. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. 2001 FASEB J. pmid:11641243
Fowler CJ Transport of endocannabinoids across the plasma membrane and within the cell. 2013 FEBS J. pmid:23441874
Stark K et al. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. 2008 FEBS J. pmid:18549450
Wartmann M et al. The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide. 1995 FEBS Lett. pmid:7867785
Molina-Holgado F et al. The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. 1998 FEBS Lett. pmid:9738948
Kiss Z Anandamide stimulates phospholipase D activity in PC12 cells but not in NIH 3T3 fibroblasts. 1999 FEBS Lett. pmid:10214947
Maccarrone M et al. Anandamide activates human platelets through a pathway independent of the arachidonate cascade. 1999 FEBS Lett. pmid:10214961
Murillo-Rodríguez E et al. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. 2006 FEBS Lett. pmid:16844117
Kuwae T et al. Biosynthesis and turnover of anandamide and other N-acylethanolamines in peritoneal macrophages. 1999 FEBS Lett. pmid:10508930
Ueda N et al. An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. 1999 FEBS Lett. pmid:10431820
Laezza C et al. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. 2006 FEBS Lett. pmid:17055492
Migliarini B et al. Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics. 2006 FEBS Lett. pmid:16519888
Felder CC et al. Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. 1996 FEBS Lett. pmid:8814296
Melck D et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. 1999 FEBS Lett. pmid:10606728
Maurelli S et al. Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'. 1995 FEBS Lett. pmid:8543025
Karava V et al. Anandamide amidohydrolase activity, released in the medium by Tetrahymena pyriformis. Identification and partial characterization. 2001 FEBS Lett. pmid:11728445
Schmid PC et al. Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. 1995 FEBS Lett. pmid:7498458
Sarker KP et al. Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. 2000 FEBS Lett. pmid:10781801
Braud S et al. Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid. 2000 FEBS Lett. pmid:10760504
Zaccagnino P et al. Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. 2011 FEBS Lett. pmid:21187088
Derocq JM et al. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. 1998 FEBS Lett. pmid:9563506
Murakami T et al. Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. 2007 FEBS Lett. pmid:17184778
Flygare J et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. 2005 FEBS Lett. pmid:16337199
Nakajima Y et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition. 2006 FEBS Lett. pmid:16406050
De Petrocellis L et al. Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. 2001 FEBS Lett. pmid:11602256
van der Stelt M et al. Dioxygenation of N-linoleoyl amides by soybean lipoxygenase-1. 1997 FEBS Lett. pmid:9271222
Beltramo M et al. Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one. 1997 FEBS Lett. pmid:9091314
Maccarrone M et al. Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors. 2000 FEBS Lett. pmid:10692582
Sarnataro D et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. 2005 FEBS Lett. pmid:16263116
De Petrocellis L et al. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. 2000 FEBS Lett. pmid:11033355
Wang Y et al. Polymyxin B binds to anandamide and inhibits its cytotoxic effect. 2000 FEBS Lett. pmid:10734225
Appendino G et al. First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. 2006 FEBS Lett. pmid:16406364
Di Marzo V et al. Interactions between synthetic vanilloids and the endogenous cannabinoid system. 1998 FEBS Lett. pmid:9801167
Maccarrone M and Finazzi-Agró A Platelet activation: a new vascular activity of anandamide. 2000 FEBS Lett. pmid:11184253
Giuffrida A and Piomelli D Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma. 1998 FEBS Lett. pmid:9498819
Goparaju SK et al. Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. 1998 FEBS Lett. pmid:9475172
Opitz CA et al. Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. 2007 FEBS Lett. pmid:17904123
van der Stelt M et al. The effect of hydroxylation of linoleoyl amides on their cannabinomimetic properties. 1997 FEBS Lett. pmid:9357990
Juan CC et al. Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. 2015 Fertil. Steril. pmid:25935491
El-Talatini MR et al. The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle. 2010 Fertil. Steril. pmid:19200965
Bilmin K et al. Influence of serum and albumin on the in vitro anandamide cytotoxicity toward C6 glioma cells assessed by the MTT cell viability assay: implications for the methodology of the MTT tests. 2013 Folia Neuropathol pmid:23553136
Bari M et al. The manifold actions of endocannabinoids on female and male reproductive events. 2011 Front Biosci (Landmark Ed) pmid:21196184
Maeda N et al. Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. 2009 Fundam Clin Pharmacol pmid:19527302
Fowler CJ The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide. 2006 Fundam Clin Pharmacol pmid:17109648
Smita K et al. Anandamide: an update. 2007 Fundam Clin Pharmacol pmid:17227440
Liu J et al. Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. 2012 Gastroenterology pmid:22307032
Michalski CW et al. Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. 2007 Gastroenterology pmid:17484889
Ros J et al. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. 2002 Gastroenterology pmid:11781284
Piccinetti CC et al. Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. 2010 Gen. Comp. Endocrinol. pmid:19800340
Chianese R et al. Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. 2014 Gen. Comp. Endocrinol. pmid:24566122
Chianese R et al. Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. 2011 Gen. Comp. Endocrinol. pmid:21802420
Ohsaka Y and Nishino H 3T3-L1 adipocytes possess anandamide- and epinephrine-responsive machinery for MDM2 distribution to the plasma membrane. 2013 Gen. Physiol. Biophys. pmid:23682023
Pastuhov SI et al. Endocannabinoid signaling regulates regenerative axon navigation in Caenorhabditis elegans via the GPCRs NPR-19 and NPR-32. 2016 Genes Cells pmid:27193416
Vignali M et al. The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. 2009 Glia pmid:19031444
Ortega-Gutiérrez S et al. Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. 2005 Glia pmid:15920730
Correa F et al. Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB. 2010 Glia pmid:19565660
Krishnan G and Chatterjee N Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. 2012 Glia pmid:22807196
Hernangómez M et al. CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. 2012 Glia pmid:22653796
Facchinetti F et al. Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. 2003 Glia pmid:12509806
Mato S et al. CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. 2009 Glia pmid:18814177
Harada N and Okajima K Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. 2007 Growth Horm. IGF Res. pmid:17307377
Guagnini F et al. Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. 2006 Gut pmid:16423891
Domenicali M et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. 2005 Gut pmid:15753538
Hong S et al. Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. 2009 Gut pmid:18936104
Patsos HA et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. 2005 Gut pmid:16099783
Lazzarin N et al. Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. 2004 Gynecol. Endocrinol. pmid:15293893
Contassot E et al. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. 2004 Gynecol. Oncol. pmid:15047233
Ho WS and Hillard CJ Modulators of endocannabinoid enzymic hydrolysis and membrane transport. 2005 Handb Exp Pharmacol pmid:16596775
Elphick MR and Egertová M The phylogenetic distribution and evolutionary origins of endocannabinoid signalling. 2005 Handb Exp Pharmacol pmid:16596778
Cascio MG and Marini P Biosynthesis and Fate of Endocannabinoids. 2015 Handb Exp Pharmacol pmid:26408157
Sagie S et al. [Short-and long-term effects of cannabinoids on memory, cognition and mental illness]. 2013 Harefuah pmid:24483000
Park SW et al. Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. 2015 Head Neck pmid:24797795
Myrdal SE and Steyger PS TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. 2005 Hear. Res. pmid:15925202
Valk P et al. Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2. 2000 Hematol. J. pmid:11920199
Siegmund SV et al. Anandamide induces necrosis in primary hepatic stellate cells. 2005 Hepatology pmid:15841466
Biswas KK et al. Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. 2003 Hepatology pmid:14578855
Basavarajappa BS et al. Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. 2014 Hippocampus pmid:24648181
Hill MN et al. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. 2008 Hippocampus pmid:18058925
Yang K et al. Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. 2014 Hippocampus pmid:25087967
Edwards JG et al. A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. 2012 Hippocampus pmid:21069781
Taylor AH et al. Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. 2010 Histochem. Cell Biol. pmid:20369362
Ziegler CG et al. Expression and function of endocannabinoid receptors in the human adrenal cortex. 2010 Horm. Metab. Res. pmid:19862666
Amoako AA et al. Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. 2013 Hum. Reprod. pmid:23697839
El-Talatini MR et al. Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation. 2009 Hum. Reprod. pmid:19363040
Turco MY et al. High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. 2008 Hum. Reprod. pmid:18614613
Taylor AH et al. The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy. 2007 Sep-Oct Hum. Reprod. Update pmid:17584820