| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Movsesyan VA et al. | Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. | 2004 | Cell Death Differ. | pmid:15375383 |
| Maccarrone M and Finazzi-Agró A | The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. | 2003 | Cell Death Differ. | pmid:12934069 |
| Overton HA et al. | Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. | 2006 | Cell Metab. | pmid:16517404 |
| Oddi S et al. | Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes. | 2005 | Cell. Mol. Life Sci. | pmid:15723173 |
| Valenti M et al. | Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. | 2004 | Cell. Mol. Life Sci. | pmid:15095014 |
| Hermann H et al. | Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. | 2003 | Cell. Mol. Life Sci. | pmid:12737320 |
| Oddi S et al. | Evidence for the intracellular accumulation of anandamide in adiposomes. | 2008 | Cell. Mol. Life Sci. | pmid:18213445 |
| Catani MV et al. | Anandamide extends platelets survival through CB(1)-dependent Akt signaling. | 2010 | Cell. Mol. Life Sci. | pmid:19936621 |
| Sarker KP and Maruyama I | Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. | 2003 | Cell. Mol. Life Sci. | pmid:12861385 |
| Laviolette SR and Grace AA | The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction. | 2006 | Cell. Mol. Life Sci. | pmid:16699809 |
| van der Stelt M et al. | Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. | 2006 | Cell. Mol. Life Sci. | pmid:16732431 |
| Gasperi V et al. | Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. | 2007 | Cell. Mol. Life Sci. | pmid:17187172 |
| Dickason-Chesterfield AK et al. | Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. | 2006 Jul-Aug | Cell. Mol. Neurobiol. | pmid:16736384 |
| Stark S et al. | Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells. | 1997 | Cell. Mol. Neurobiol. | pmid:9353590 |
| Bobbala D et al. | Effect of anandamide in Plasmodium Berghei-infected mice. | 2010 | Cell. Physiol. Biochem. | pmid:20798520 |
| Jenkin KA et al. | Role for cannabinoid receptors in human proximal tubular hypertrophy. | 2010 | Cell. Physiol. Biochem. | pmid:21220919 |
| Bentzen PJ and Lang F | Effect of anandamide on erythrocyte survival. | 2007 | Cell. Physiol. Biochem. | pmid:17975305 |
| Fimiani C et al. | Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release. | 1999 | Cell. Signal. | pmid:10353693 |
| Greco R et al. | Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. | 2010 | Cephalalgia | pmid:19515121 |
| Cupini LM et al. | Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. | 2006 | Cephalalgia | pmid:16472333 |
| Rubino T et al. | Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. | 2008 | Cereb. Cortex | pmid:17921459 |
| Hanus LO | Discovery and isolation of anandamide and other endocannabinoids. | 2007 | Chem. Biodivers. | pmid:17712821 |
| Okamoto Y et al. | Biosynthetic pathways of the endocannabinoid anandamide. | 2007 | Chem. Biodivers. | pmid:17712822 |
| Lehtonen M et al. | Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. | 2008 | Chem. Biodivers. | pmid:19035572 |
| Oddi S et al. | Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins. | 2009 | Chem. Biol. | pmid:19481477 |
| Ahn K et al. | Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. | 2009 | Chem. Biol. | pmid:19389627 |
| Godlewski G et al. | Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. | 2010 | Chem. Biol. | pmid:21095576 |
| Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
| Blankman JL et al. | A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. | 2007 | Chem. Biol. | pmid:18096503 |
| Imming P | Fatty pain cures. | 2007 | Chem. Biol. | pmid:18096498 |
| King AR et al. | URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. | 2007 | Chem. Biol. | pmid:18096504 |
| Schmid PC et al. | Alternative pathways of anandamide biosynthesis in rat testes. | 1998 | Chem. Phys. Lipids | pmid:9631536 |
| Di Scala C et al. | Ceramide binding to anandamide increases its half-life and potentiates its cytotoxicity in human neuroblastoma cells. | 2017 | Chem. Phys. Lipids | pmid:28389107 |
| Palmer SL et al. | Cannabinergic ligands. | 2002 | Chem. Phys. Lipids | pmid:12505686 |
| Razdan RK and Mahadevan A | Recent advances in the synthesis of endocannabinoid related ligands. | 2002 | Chem. Phys. Lipids | pmid:12505687 |
| Kunos G et al. | The quest for a vascular endothelial cannabinoid receptor. | 2002 | Chem. Phys. Lipids | pmid:12505689 |
| Wiley JL and Martin BR | Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. | 2002 | Chem. Phys. Lipids | pmid:12505690 |
| Schmid HH et al. | Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges. | 2002 | Chem. Phys. Lipids | pmid:12505695 |
| Cravatt BF and Lichtman AH | The enzymatic inactivation of the fatty acid amide class of signaling lipids. | 2002 | Chem. Phys. Lipids | pmid:12505696 |
| Paria BC et al. | Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation. | 2002 | Chem. Phys. Lipids | pmid:12505701 |
| Sandberg A and Fowler CJ | Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin. | 2005 | Chem. Phys. Lipids | pmid:15784231 |
| Kotsikorou E et al. | Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55. | 2011 | Chem. Phys. Lipids | pmid:21185816 |
| Reggio PH and Traore H | Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. | 2000 | Chem. Phys. Lipids | pmid:11106780 |
| Howlett AC and Mukhopadhyay S | Cellular signal transduction by anandamide and 2-arachidonoylglycerol. | 2000 | Chem. Phys. Lipids | pmid:11106782 |
| Schmid HH | Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? | 2000 | Chem. Phys. Lipids | pmid:11106783 |
| Hillard CJ and Jarrahian A | The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. | 2000 | Chem. Phys. Lipids | pmid:11106786 |
| Kunos G et al. | Endocannabinoids as cardiovascular modulators. | 2000 | Chem. Phys. Lipids | pmid:11106789 |
| Schmid PC et al. | Anandamide and other N-acylethanolamines in mouse peritoneal macrophages. | 1997 | Chem. Phys. Lipids | pmid:9275307 |
| Schmid PC et al. | A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. | 2000 | Chem. Phys. Lipids | pmid:10669310 |
| Xie S et al. | Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. | 2010 | Chem. Res. Toxicol. | pmid:21049984 |
| Ahn K et al. | Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. | 2008 | Chem. Rev. | pmid:18429637 |
| Gurney AM et al. | Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. | 2003 | Circ. Res. | pmid:14551239 |
| Fernandez-Patron C et al. | Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. | 2000 | Circ. Res. | pmid:11029402 |
| Bátkai S et al. | Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. | 2004 | Circulation | pmid:15451779 |
| Hong Z et al. | Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. | 2006 | Circulation | pmid:16982938 |
| Alenmyr L et al. | TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. | 2011 | Clin Physiol Funct Imaging | pmid:21981454 |
| Cui N et al. | Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. | 2017 | Clin Ther | pmid:28291580 |
| Schroeder C et al. | Circulating endocannabinoid concentrations during orthostatic stress. | 2009 | Clin. Auton. Res. | pmid:19756829 |
| Vogeser M et al. | Release of anandamide from blood cells. | 2006 | Clin. Chem. Lab. Med. | pmid:16599845 |
| Busch L et al. | Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16487271 |
| Ruginsk SG et al. | Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion. | 2013 | Clin. Exp. Pharmacol. Physiol. | pmid:23875874 |
| Barun S et al. | Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16173925 |
| Mitchell VA et al. | Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17880375 |
| Tuboly G et al. | Antinociceptive interactions between anandamide and endomorphin-1 at the spinal level. | 2009 | Clin. Exp. Pharmacol. Physiol. | pmid:19018802 |
| Dollery C | Investigative clinical pharmacology. | 2011 | Clin. Pharmacol. Ther. | pmid:21862965 |
| Zoerner AA et al. | Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma. | 2011 | Clin. Pharmacol. Ther. | pmid:21716266 |
| Guindon J and Hohmann AG | The endocannabinoid system and pain. | 2009 | CNS Neurol Disord Drug Targets | pmid:19839937 |
| Lambert RC et al. | Modulation of neuronal T-type calcium channels. | 2006 | CNS Neurol Disord Drug Targets | pmid:17168746 |
| Khanna IK and Alexander CW | Fatty acid amide hydrolase inhibitors--progress and potential. | 2011 | CNS Neurol Disord Drug Targets | pmid:21631410 |
| GarcÃa-GarcÃa F et al. | Sleep-inducing factors. | 2009 | CNS Neurol Disord Drug Targets | pmid:19689305 |
| Nilsson O et al. | Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures. | 2003 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:14659458 |
| Després JP | The endocannabinoid system: a new target for the regulation of energy balance and metabolism. | 2007 | Crit Pathw Cardiol | pmid:17667864 |
| Kadoi Y et al. | Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. | 2005 | Crit. Care Med. | pmid:16276190 |
| Panagis G et al. | Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties. | 2008 | Curr Drug Abuse Rev | pmid:19630731 |
| Ligresti A et al. | Endocannabinoid metabolic pathways and enzymes. | 2005 | Curr Drug Targets CNS Neurol Disord | pmid:16375679 |
| Maccarrone M et al. | Endocannabinoid degradation, endotoxic shock and inflammation. | 2002 | Curr Drug Targets Inflamm Allergy | pmid:14561206 |
| Guindon J and Beaulieu P | The role of the endogenous cannabinoid system in peripheral analgesia. | 2009 | Curr Mol Pharmacol | pmid:20021453 |
| Battista N et al. | Endocannabinoids and their involvement in the neurovascular system. | 2004 | Curr Neurovasc Res | pmid:16185189 |
| Cravatt BF and Lichtman AH | Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. | 2003 | Curr Opin Chem Biol | pmid:12941421 |
| Rice AS | Cannabinoids and pain. | 2001 | Curr Opin Investig Drugs | pmid:11575713 |
| Izzo AA et al. | The gastrointestinal pharmacology of cannabinoids. | 2001 | Curr Opin Pharmacol | pmid:11757815 |
| Pate DW et al. | Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits. | 1995 | Curr. Eye Res. | pmid:8529418 |
| Di Marzo V et al. | Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids. | 1999 | Curr. Med. Chem. | pmid:10469888 |
| Reggio PH | Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | 2010 | Curr. Med. Chem. | pmid:20166921 |
| Di Marzo V and De Petrocellis L | Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs. | 2010 | Curr. Med. Chem. | pmid:20166923 |
| Ashton JC et al. | Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists. | 2008 | Curr. Med. Chem. | pmid:18537620 |
| Dainese E et al. | Modulation of the endocannabinoid system by lipid rafts. | 2007 | Curr. Med. Chem. | pmid:17979719 |
| Kreitzer AC and Regehr WG | Retrograde signaling by endocannabinoids. | 2002 | Curr. Opin. Neurobiol. | pmid:12049940 |
| Ohno-Shosaku T and Kano M | Endocannabinoid-mediated retrograde modulation of synaptic transmission. | 2014 | Curr. Opin. Neurobiol. | pmid:24747340 |
| Di Marzo V et al. | Endovanilloid signaling in pain. | 2002 | Curr. Opin. Neurobiol. | pmid:12139983 |
| Bisogno T et al. | Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. | 2002 | Curr. Pharm. Des. | pmid:11945157 |
| Leweke FM | Anandamide dysfunction in prodromal and established psychosis. | 2012 | Curr. Pharm. Des. | pmid:22716147 |
| Di Marzo T et al. | Endocannabinoids: new targets for drug development. | 2000 | Curr. Pharm. Des. | pmid:10903398 |
| Palmer SL et al. | Natural and synthetic endocannabinoids and their structure-activity relationships. | 2000 | Curr. Pharm. Des. | pmid:10903399 |
| Fowler CJ | "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. | 2008 | Curr. Pharm. Des. | pmid:18781976 |
| Harvey BS et al. | Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. | 2013 | Cytokine | pmid:23706402 |
| Harvey BS et al. | Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model. | 2014 | Cytokine | pmid:24238999 |
| Levin M and Mercola M | Gap junctions are involved in the early generation of left-right asymmetry. | 1998 | Dev. Biol. | pmid:9806775 |
| Levin M and Mercola M | Expression of connexin 30 in Xenopus embryos and its involvement in hatching gland function. | 2000 | Dev. Dyn. | pmid:10974676 |
| Buznikov GA et al. | A putative 'pre-nervous' endocannabinoid system in early echinoderm development. | 2010 | Dev. Neurosci. | pmid:19907129 |