Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Anorexia D000855 8 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Ataxia D001259 20 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Body Weight D001835 333 associated lipids
Bradycardia D001919 13 associated lipids
Brain Concussion D001924 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bulimia D002032 3 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Catalepsy D002375 30 associated lipids
Celiac Disease D002446 16 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cough D003371 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Epilepsy D004827 35 associated lipids
Fatty Liver D005234 48 associated lipids
Fever D005334 35 associated lipids
Fibromyalgia D005356 4 associated lipids
Glioma D005910 112 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Hyperemia D006940 25 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hyperkinesis D006948 11 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypotension D007022 41 associated lipids
Hypothermia D007035 19 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Intestinal Pseudo-Obstruction D007418 5 associated lipids
Learning Disorders D007859 11 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Zhang X et al. Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. 2012 Mol. Pharmacol. pmid:22328719
Snider NT et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. 2009 Mol. Pharmacol. pmid:19171674
Yates ML and Barker EL Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. 2009 Mol. Pharmacol. pmid:19389920
Meuth SG et al. The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. 2006 Mol. Pharmacol. pmid:16424077
Xiong W et al. Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization. 2008 Mol. Pharmacol. pmid:17993512
Sancho R et al. Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. 2003 Mol. Pharmacol. pmid:12527815
Randall MD A new endothelial target for cannabinoids. 2003 Mol. Pharmacol. pmid:12606752
Pan X et al. Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system. 1996 Mol. Pharmacol. pmid:8609900
Hegde VL et al. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. 2008 Mol. Pharmacol. pmid:18388242
Felder CC et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. 1995 Mol. Pharmacol. pmid:7565624
Hejazi N et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. 2006 Mol. Pharmacol. pmid:16332990
Day TA et al. Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. 2001 Mol. Pharmacol. pmid:11353795
Theile JW and Cummins TR Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. 2011 Mol. Pharmacol. pmid:21788423
Priller J et al. Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors. 1995 Mol. Pharmacol. pmid:7651362
Edgemond WS et al. Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. 1998 Mol. Pharmacol. pmid:9658204
van der Stelt M et al. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. 2002 Oct-Dec Mol. Neurobiol. pmid:12428763
Luchicchi A and Pistis M Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. 2012 Mol. Neurobiol. pmid:22801993
Kim SR et al. Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity. 2007 Mol. Neurobiol. pmid:17917113
Felder CC et al. Cannabinoids biology: the search for new therapeutic targets. 2006 Mol. Interv. pmid:16809476
Sanchez AM et al. The molecular connections between the cannabinoid system and endometriosis. 2012 Mol. Hum. Reprod. pmid:22923487
Oh HA et al. Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos. 2013 Mol. Hum. Reprod. pmid:23112252
Maccarrone M et al. Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. 2005 Mol. Hum. Reprod. pmid:15563449
Maccarrone M et al. Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. 2002 Mol. Hum. Reprod. pmid:11818522
Brighton PJ et al. Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells. 2009 Mol. Endocrinol. pmid:19477951
Musella A et al. TRPV1 channels facilitate glutamate transmission in the striatum. 2009 Mol. Cell. Neurosci. pmid:18930149
Fezza F et al. Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. 2014 Mol. Cell. Neurosci. pmid:25064144
Krishnan G and Chatterjee N Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. 2014 Mol. Cell. Neurosci. pmid:24418364
González-Mariscal I et al. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. 2016 Mol. Cell. Endocrinol. pmid:26724516
Battista N et al. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. 2012 Mol. Cell. Endocrinol. pmid:22305972
Cavuoto P et al. Effects of cannabinoid receptors on skeletal muscle oxidative pathways. 2007 Mol. Cell. Endocrinol. pmid:17270342
Oláh M et al. The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. 2008 Mol. Cell. Endocrinol. pmid:18308464
Migliarini B and Carnevali O Anandamide modulates growth and lipid metabolism in the zebrafish Danio rerio. 2008 Mol. Cell. Endocrinol. pmid:18342434
Catanzaro G et al. Effect of capacitation on the endocannabinoid system of mouse sperm. 2011 Mol. Cell. Endocrinol. pmid:21723369
Triggle CR et al. The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. 2004 Mol. Cell. Biochem. pmid:15524164
Qureshi J et al. Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol. 1998 Mol. Cell. Biochem. pmid:9562238
Kuc C et al. Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. 2012 Mol. Carcinog. pmid:21432910
Van Dross RT Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. 2009 Mol. Carcinog. pmid:19148897
Guasti L et al. Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. 2009 Mol Pain pmid:19570201
Woo DH et al. Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). 2008 Mol Pain pmid:18826653
Banni S and Di Marzo V Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. 2010 Mol Nutr Food Res pmid:20013888
Rajaraman G et al. G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. 2016 Mol Nutr Food Res pmid:26337420
Gurwitz D and Kloog Y Do endogenous cannabinoids contribute to HIV-mediated immune failure? 1998 Mol Med Today pmid:9612798
Ma C et al. Anti-carcinogenic activity of anandamide on human glioma in vitro and in vivo. 2016 Mol Med Rep pmid:26707955
Lu W et al. Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons. 2014 Mol Brain pmid:24886791
Bari M et al. New insights into endocannabinoid degradation and its therapeutic potential. 2006 Mini Rev Med Chem pmid:16515464
Marco EM and Viveros MP The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. 2009 Mini Rev Med Chem pmid:19929814
Chen P et al. Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. 2005 Microvasc. Res. pmid:15797258
Fezza F et al. Methods to assay anandamide hydrolysis and transport in synaptosomes. 2006 Methods Mol. Med. pmid:16506407
Kudalkar SN et al. Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. 2016 Methods Mol. Biol. pmid:27245906
van Zadelhoff G and van der Stelt M Oxygenation of Anandamide by Lipoxygenases. 2016 Methods Mol. Biol. pmid:27245907
Schlabritz-Loutsevitch N et al. Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. 2016 Med. Hypotheses pmid:27959272
Coppola M and Mondola R Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. 2013 Med. Hypotheses pmid:23896215
Zohrabi-Kalantari V et al. 4-Aminocyclopentane-1,3-diols as platforms for diversity: synthesis of anandamide analogs. 2013 Med Chem pmid:23157226
Piyanova A et al. Age-related changes in the endocannabinoid system in the mouse hippocampus. 2015 Mech. Ageing Dev. pmid:26278494
Yang YY et al. Inhibition of hepatic tumour necrosis factor-alpha attenuates the anandamide-induced vasoconstrictive response in cirrhotic rat livers. 2009 Liver Int. pmid:19413671
Caraceni P et al. Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. 2010 Liver Int. pmid:19840245
Yang YY et al. Role of Ca2+-dependent potassium channels in in vitro anandamide-mediated mesenteric vasorelaxation in rats with biliary cirrhosis. 2007 Liver Int. pmid:17845532
Ying-Ying Y and Lin HC Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. 2010 Liver Int. pmid:20408944
Fernández-Rodriguez CM et al. Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis. 2004 Liver Int. pmid:15482346
Naccarato M et al. Possible Anandamide and Palmitoylethanolamide involvement in human stroke. 2010 Lipids Health Dis pmid:20470384
Berge K et al. Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. 2013 Lipids Health Dis pmid:23706001
Annuzzi G et al. Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. 2010 Lipids Health Dis pmid:20426869
Quartu M et al. Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. 2017 Lipids Health Dis pmid:28103941
Forsell PK et al. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. 2012 Lipids pmid:22684912
Di Marzo V et al. Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments. 1999 Lipids pmid:10419192
Hansen HS et al. Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity. 1999 Lipids pmid:10419193
Schmid PC et al. Anandamide and other N-acylethanolamines in human tumors. 2002 Lipids pmid:12458627
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Hunter SA and Burstein SH Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis. 1997 Life Sci. pmid:9126878
Zenor BN et al. Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. 1999 Life Sci. pmid:10416818
Kopczyńska B The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats. 2007 Life Sci. pmid:17379256
Pate DW et al. Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. 1998 Life Sci. pmid:9851310
Glaser ST et al. Anandamide transport: a critical review. 2005 Life Sci. pmid:15979096
Reis GM et al. Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide. 2009 Life Sci. pmid:19576231
Ueda N et al. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines. 2005 Life Sci. pmid:15949819
Lam FF et al. Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. 2007 Life Sci. pmid:17275857
De Petrocellis L and Di Marzo V Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. 2005 Life Sci. pmid:15936040
Wiley JL et al. Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. 2006 Life Sci. pmid:16978656
Mallet PE and Beninger RJ Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance. 1998 Life Sci. pmid:9651110
Helyes Z et al. Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat. 2003 Life Sci. pmid:12941436
Berdyshev E et al. Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. 1998 Life Sci. pmid:9718090
Musty RE et al. A review of recent advances in cannabinoid research and the 1994 International Symposium on Cannabis and the Cannabinoids. 1995 Life Sci. pmid:7776816
Kraft B et al. Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide. 2004 Life Sci. pmid:15193957
Cabral GA et al. Anandamide inhibits macrophage-mediated killing of tumor necrosis factor-sensitive cells. 1995 Life Sci. pmid:7776833
Arizzi MN et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. 2004 Life Sci. pmid:14672756
Martin BR et al. Discovery and characterization of endogenous cannabinoids. 1999 Life Sci. pmid:10462059
Jarho P et al. Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide. 1996 Life Sci. pmid:8602110
Soneji ND et al. Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators. 2010 Life Sci. pmid:20598325
Tóth A et al. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. 2005 Life Sci. pmid:15820503
Roa-Coria JE et al. N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception. 2012 Life Sci. pmid:23069585
Reis GM et al. Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. 2011 Life Sci. pmid:21277864
Wenger T et al. The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats. 2002 Life Sci. pmid:11883716
González S et al. Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. 1999 Life Sci. pmid:10447218
Wiley JL et al. Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects. 2000 Life Sci. pmid:10983852
Murillo-Rodriguez E et al. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. 2006 Life Sci. pmid:16434061
Wenger T et al. Effects of anandamide on gestation in pregnant rats. 1997 Life Sci. pmid:9199480
Holt S et al. Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase. 2004 Life Sci. pmid:15530507
Czikora Á et al. Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation. 2012 Life Sci. pmid:22285599
Habayeb OM et al. Endogenous cannabinoids: metabolism and their role in reproduction. 2002 Life Sci. pmid:12148689
Liu WM et al. Effects of anandamide on embryo implantation in the mouse. 2002 Life Sci. pmid:12137909